DK3072978T3 - : 1l1rl-1 som kardiovaskulær sygdomsmarkør - Google Patents

: 1l1rl-1 som kardiovaskulær sygdomsmarkør Download PDF

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DK3072978T3
DK3072978T3 DK16158762.1T DK16158762T DK3072978T3 DK 3072978 T3 DK3072978 T3 DK 3072978T3 DK 16158762 T DK16158762 T DK 16158762T DK 3072978 T3 DK3072978 T3 DK 3072978T3
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Richard T Lee
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Brigham & Womens Hospital Inc
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    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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Claims (12)

1. Middel, der er et anti-inflammatorisk middel, et antitrombosemiddel, et trombocythæmmende middel, et fibrinolytikum, et lipidreducerende middel, en direkte trombinhæmmer, en glycoprotein Ilb/IIIa-receptorhæmmer, et middel, der binder til cellulære adhæsionsmolekyler og hæmmer hvide blodlegemers evne til at bindes til cellulære adhæsionsmolekyler, en calciumkanalblokker, en beta-adrenerg receptorblokker, en cyclooxygenase-2-hæmmer eller en renin-angiotensin-system- (RAS) hæmmer, til anvendelse i en fremgangsmåde til behandling af et individ for at reducere risikoen for, at en kardiovaskulær tilstand udvikles hos individet, hvor den kardiovaskulære tilstand er valgt fra hjerteinsufficiens og myokardieinfarkt, og hvor individet identificeres ved anvendelse af en fremgangsmåde in vitro, der omfatter: opnåelse af et niveau af opløseligt IL 1 RL-1-protein i en biologisk prøve fra individet; sammenligning af niveauet af opløseligt IL 1 RL-1-protein med en enkelt forudbestemt afskæringsværdi, der er specifik for diagnosen hjerteinsufficiens eller myokardieinfarkt; hvor et niveau af det opløselige IL 1 RL-1-protein svarende til eller over den enkelte forudbestemte afskæringsværdi indikerer, om individet vil drage fordel af behandling med midlet.
2. Middel til anvendelse ifølge krav 1, hvor det opløselige IL 1 RL-1-protein er et ekspressionsprodukt af en nukleinsyresekvens ifølge SEQ ID NO: 1 eller omfatter aminosyresekvensen ifølge SEQ ID NO: 2.
3. Middel til anvendelse ifølge et af kravene 1 eller 2, hvor prøven omfatter blod eller serum.
4. Middel til anvendelse ifølge et hvilket som helst af kravene 1-3, hvor bestemmelsen sker ved anvendelse af et antistof eller et antistoffragment der specifikt binder til opløseligt IL 1 RL-1-protein.
5. Middel til anvendelse ifølge krav 1, hvor midlet er et lipidreducerende middel.
6. Middel til anvendelse ifølge krav 5, hvor det lipidreducerende middel er valgt fra gruppen bestående af: gemfibrozil, cholystyramin, colestipol, nicotinsyre, probucol, lovastatin, fluvastatin, simvastatin, atorvastatin, pravastatin og cerivastatin.
7. Middel til anvendelse ifølge krav 1, hvor midlet er en beta-adrenerg receptorblokker eller en RAS-hæmmer.
8. Middel til anvendelse ifølge krav 7, hvor RAS-hæmmeren er valgt fra gruppen bestående af: en angiotensin-konverterende enzym- (ACE) hæmmer, en angiotensin II-receptorblokker (ARB), et middel, der aktiverer nedbrydningen af angiotensin II, og et middel, der forhindrer syntesen af angiotensin I.
9. Middel til anvendelse ifølge krav 7, hvor den beta-adrenerge receptorblokker er valgt fra gruppen bestående af: atenolol, acebutolol, alprenolol, befunolol, betaxolol, bunitrolol, carteolol, celiprolol, hedroxalol, indenolol, labetalol, levobunolol, mepindolol, methypranol, metindol, metoprolol, metrizoranolol, oxprenolol, pindolol, propranolol, practolol, practolol, sotalolnadolol, tiprenolol, tomalolol, timolol, bupranolol, penbutolol, trimepranol, 2-(3-(1,1-dimethylethyl)-amino-2-hydroxypropoxy)-3-pyridencarbonitril, l-butylamino-3-(2,5- dichlorphenoxy)-2-propanol, l-isopropylamino-3-(4-(2-cyclopropylmethoxyethyl)phenoxy)-2-propanol, 3-isopropylamino- l-(7-methylindan-4-yloxy)-2-butanol, 2-(3-t-butylamino-2- hydroxy-propylthio)-4-(5-carbamoyl-2-thienyl)thiazol og 7-(2-hydroxy-3-t- butylaminpropoxy)phthalid.
10. Middel til anvendelse ifølge et hvilket som helst af kravene 1-9, hvor individet er hyperkolesterolæmisk, hypertriglyceridæmisk eller hyperlipidæmisk.
11. Middel til anvendelse ifølge et hvilket som helst af kravene 1-9, hvor individet er ryger eller hypertensiv.
12. Middel til anvendelse ifølge et hvilket som helst af kravene 1-11, hvor individet er et menneske.
DK16158762.1T 2002-05-09 2003-05-09 : 1l1rl-1 som kardiovaskulær sygdomsmarkør DK3072978T3 (da)

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US37917302P 2002-05-09 2002-05-09
EP10184644.2A EP2336359B1 (en) 2002-05-09 2003-05-09 1L1RL-1 as a cardiovascular disease marker

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DK16158762.1T DK3072978T3 (da) 2002-05-09 2003-05-09 : 1l1rl-1 som kardiovaskulær sygdomsmarkør
DK03728848.7T DK1532269T3 (da) 2002-05-09 2003-05-09 1L1RL-1 som markør for kardiovaskulær sygdom

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US (8) US7670769B2 (da)
EP (4) EP3425059A1 (da)
JP (2) JP4514606B2 (da)
CN (2) CN102533972B (da)
AT (1) ATE534747T1 (da)
AU (1) AU2003234407B2 (da)
CA (1) CA2484897C (da)
DK (3) DK2336359T3 (da)
ES (3) ES2375181T3 (da)
HU (2) HUE039881T2 (da)
PT (3) PT3072978T (da)
SI (2) SI3072978T1 (da)
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