DK3076990T3 - Biologisk aktive insulinderivater - Google Patents
Biologisk aktive insulinderivater Download PDFInfo
- Publication number
- DK3076990T3 DK3076990T3 DK14833536.7T DK14833536T DK3076990T3 DK 3076990 T3 DK3076990 T3 DK 3076990T3 DK 14833536 T DK14833536 T DK 14833536T DK 3076990 T3 DK3076990 T3 DK 3076990T3
- Authority
- DK
- Denmark
- Prior art keywords
- biological active
- insulin derivatives
- active insulin
- derivatives
- biological
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1321489.5A GB201321489D0 (en) | 2013-12-05 | 2013-12-05 | Biologically active insulin derivatives |
| PCT/IB2014/066588 WO2015083114A2 (en) | 2013-12-05 | 2014-12-04 | Biologically active insulin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3076990T3 true DK3076990T3 (da) | 2020-03-16 |
Family
ID=50000217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19208086.9T DK3662926T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
| DK14833536.7T DK3076990T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19208086.9T DK3662926T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10195287B2 (da) |
| EP (2) | EP3662926B1 (da) |
| JP (1) | JP6798883B2 (da) |
| CN (3) | CN118909079A (da) |
| AU (2) | AU2014358699A1 (da) |
| DK (2) | DK3662926T3 (da) |
| ES (2) | ES2965765T3 (da) |
| GB (1) | GB201321489D0 (da) |
| HK (1) | HK1223834A1 (da) |
| IL (1) | IL245983B (da) |
| PL (1) | PL3662926T3 (da) |
| WO (1) | WO2015083114A2 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201321489D0 (en) | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
| BR112019004314A2 (pt) * | 2016-09-06 | 2019-05-28 | Chemical & Biopharmaceutical Laboratories Of Patras S A | derivados pró-insulina |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3847893A (en) * | 1972-03-01 | 1974-11-12 | Bayer Ag | Process for the preparation of insulin derivatives cross-linked by a dicarboxylic acid group at the amino a-1 glycine and amino b-29 lysine |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| WO1995016708A1 (en) | 1993-12-17 | 1995-06-22 | Novo Nordisk A/S | Proinsulin-like compounds |
| IL118127A0 (en) | 1995-05-05 | 1996-09-12 | Lilly Co Eli | Single chain insulin with high bioactivity |
| GB9812675D0 (en) | 1998-06-11 | 1998-08-12 | Univ Edinburgh | Peptides |
| DE60104069T2 (de) | 2000-10-02 | 2005-08-25 | Yonsei University | Einkettige Insulinanaloge |
| ES2369895T3 (es) * | 2003-12-03 | 2011-12-07 | Novo Nordisk A/S | Insulina monocatenaria. |
| US20090036353A1 (en) * | 2005-01-27 | 2009-02-05 | Novo Nordisk A/S | Insulin Derivatives Conjugated with Structurally Well Defined Branched Polymers |
| EP1863840A1 (en) | 2005-03-18 | 2007-12-12 | Novo Nordisk A/S | Pegylated single-chain insulin |
| WO2007096332A1 (en) | 2006-02-21 | 2007-08-30 | Novo Nordisk A/S | Single-chain insulin analogues and pharmaceutical formulations thereof |
| EP1996709A2 (en) | 2006-03-13 | 2008-12-03 | Novo Nordisk A/S | Acylated single chain insulin |
| EP2074140B8 (en) | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| AU2008288413B2 (en) * | 2007-08-15 | 2013-09-26 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
| US8618049B2 (en) * | 2009-09-08 | 2013-12-31 | Stephen B. H. Kent | Ester insulin |
| JP5969469B2 (ja) * | 2010-06-16 | 2016-08-17 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト |
| CN104114183A (zh) * | 2011-12-20 | 2014-10-22 | 印第安纳大学研究及科技有限公司 | 用于治疗糖尿病的基于ctp的胰岛素类似物 |
| GB201321489D0 (en) | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
-
2013
- 2013-12-05 GB GBGB1321489.5A patent/GB201321489D0/en not_active Ceased
-
2014
- 2014-12-04 PL PL19208086.9T patent/PL3662926T3/pl unknown
- 2014-12-04 EP EP19208086.9A patent/EP3662926B1/en active Active
- 2014-12-04 CN CN202410996682.XA patent/CN118909079A/zh active Pending
- 2014-12-04 CN CN202410997092.9A patent/CN118909080A/zh active Pending
- 2014-12-04 WO PCT/IB2014/066588 patent/WO2015083114A2/en not_active Ceased
- 2014-12-04 CN CN201480066338.5A patent/CN105793283A/zh active Pending
- 2014-12-04 AU AU2014358699A patent/AU2014358699A1/en not_active Abandoned
- 2014-12-04 ES ES19208086T patent/ES2965765T3/es active Active
- 2014-12-04 US US15/101,597 patent/US10195287B2/en active Active
- 2014-12-04 JP JP2016536147A patent/JP6798883B2/ja active Active
- 2014-12-04 DK DK19208086.9T patent/DK3662926T3/da active
- 2014-12-04 HK HK16112107.7A patent/HK1223834A1/zh unknown
- 2014-12-04 EP EP14833536.7A patent/EP3076990B1/en active Active
- 2014-12-04 DK DK14833536.7T patent/DK3076990T3/da active
- 2014-12-04 ES ES14833536T patent/ES2773960T3/es active Active
-
2016
- 2016-06-02 IL IL245983A patent/IL245983B/en active IP Right Grant
-
2017
- 2017-10-19 AU AU2017248496A patent/AU2017248496B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2931439A1 (en) | 2015-06-11 |
| CN105793283A (zh) | 2016-07-20 |
| DK3662926T3 (da) | 2023-12-11 |
| PL3662926T3 (pl) | 2024-05-13 |
| EP3076990B1 (en) | 2020-01-22 |
| WO2015083114A2 (en) | 2015-06-11 |
| CN118909080A (zh) | 2024-11-08 |
| JP2017501991A (ja) | 2017-01-19 |
| IL245983B (en) | 2020-03-31 |
| EP3076990A2 (en) | 2016-10-12 |
| WO2015083114A3 (en) | 2015-11-26 |
| ES2965765T3 (es) | 2024-04-16 |
| CN118909079A (zh) | 2024-11-08 |
| US20160375146A1 (en) | 2016-12-29 |
| US10195287B2 (en) | 2019-02-05 |
| EP3662926A1 (en) | 2020-06-10 |
| GB201321489D0 (en) | 2014-01-22 |
| HK1223834A1 (zh) | 2017-08-11 |
| AU2017248496A1 (en) | 2017-11-09 |
| IL245983A0 (en) | 2016-07-31 |
| JP6798883B2 (ja) | 2020-12-09 |
| AU2017248496B2 (en) | 2019-08-29 |
| ES2773960T3 (es) | 2020-07-15 |
| AU2014358699A1 (en) | 2016-06-09 |
| EP3662926B1 (en) | 2023-10-25 |
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