DK3662926T3 - Biologisk aktive insulinderivater - Google Patents
Biologisk aktive insulinderivater Download PDFInfo
- Publication number
- DK3662926T3 DK3662926T3 DK19208086.9T DK19208086T DK3662926T3 DK 3662926 T3 DK3662926 T3 DK 3662926T3 DK 19208086 T DK19208086 T DK 19208086T DK 3662926 T3 DK3662926 T3 DK 3662926T3
- Authority
- DK
- Denmark
- Prior art keywords
- biologically active
- insulin derivatives
- active insulin
- derivatives
- biologically
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1321489.5A GB201321489D0 (en) | 2013-12-05 | 2013-12-05 | Biologically active insulin derivatives |
| EP14833536.7A EP3076990B1 (en) | 2013-12-05 | 2014-12-04 | Biologically active insulin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3662926T3 true DK3662926T3 (da) | 2023-12-11 |
Family
ID=50000217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14833536.7T DK3076990T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
| DK19208086.9T DK3662926T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14833536.7T DK3076990T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10195287B2 (da) |
| EP (2) | EP3076990B1 (da) |
| JP (1) | JP6798883B2 (da) |
| CN (3) | CN105793283A (da) |
| AU (2) | AU2014358699A1 (da) |
| DK (2) | DK3076990T3 (da) |
| ES (2) | ES2965765T3 (da) |
| GB (1) | GB201321489D0 (da) |
| HK (1) | HK1223834A1 (da) |
| IL (1) | IL245983B (da) |
| PL (1) | PL3662926T3 (da) |
| WO (1) | WO2015083114A2 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201321489D0 (en) | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
| EP3509625A1 (en) * | 2016-09-06 | 2019-07-17 | Chemical & Biopharmaceutical Laboratories of Patras S.A. | Proinsulin derivatives |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3847893A (en) * | 1972-03-01 | 1974-11-12 | Bayer Ag | Process for the preparation of insulin derivatives cross-linked by a dicarboxylic acid group at the amino a-1 glycine and amino b-29 lysine |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| WO1995016708A1 (en) | 1993-12-17 | 1995-06-22 | Novo Nordisk A/S | Proinsulin-like compounds |
| EP0741188A3 (en) | 1995-05-05 | 1999-07-14 | Eli Lilly And Company | Single chain insulin with high bioactivity |
| GB9812675D0 (en) | 1998-06-11 | 1998-08-12 | Univ Edinburgh | Peptides |
| EP1193272B1 (en) | 2000-10-02 | 2004-06-30 | Yonsei University | Single-chain insulin analogs |
| EP1692168B1 (en) * | 2003-12-03 | 2011-07-20 | Novo Nordisk A/S | Single-chain insulin |
| JP2008528549A (ja) * | 2005-01-27 | 2008-07-31 | ノボ ノルディスク アクティーゼルスカブ | 構造的に充分に定義された分岐ポリマーと接合されたインスリン誘導体 |
| JP2008533100A (ja) | 2005-03-18 | 2008-08-21 | ノボ ノルディスク アクティーゼルスカブ | Ｐｅｇ化された単鎖インスリン |
| US20090069216A1 (en) | 2006-02-21 | 2009-03-12 | Novo Nordisk A/S | Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof |
| JP2009530243A (ja) | 2006-03-13 | 2009-08-27 | ノボ・ノルデイスク・エー／エス | アシル化単鎖インスリン |
| WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| US9150633B2 (en) * | 2007-08-15 | 2015-10-06 | Novo Nordisk A/S | Insulin analogues with an acyl and alkylene glycol moiety |
| US8618049B2 (en) * | 2009-09-08 | 2013-12-31 | Stephen B. H. Kent | Ester insulin |
| JP5969469B2 (ja) * | 2010-06-16 | 2016-08-17 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト |
| BR112014015156A2 (pt) * | 2011-12-20 | 2020-10-27 | Indiana University Research And Technology Corporation | análogos de insulina à base de ctp, seus métodos de produção e uso no tratamento de hiperglicemia, bem como sequência de ácido nucleico e célula hospedeira |
| GB201321489D0 (en) | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
-
2013
- 2013-12-05 GB GBGB1321489.5A patent/GB201321489D0/en not_active Ceased
-
2014
- 2014-12-04 CN CN201480066338.5A patent/CN105793283A/zh active Pending
- 2014-12-04 HK HK16112107.7A patent/HK1223834A1/zh unknown
- 2014-12-04 EP EP14833536.7A patent/EP3076990B1/en active Active
- 2014-12-04 ES ES19208086T patent/ES2965765T3/es active Active
- 2014-12-04 EP EP19208086.9A patent/EP3662926B1/en active Active
- 2014-12-04 PL PL19208086.9T patent/PL3662926T3/pl unknown
- 2014-12-04 CN CN202410997092.9A patent/CN118909080A/zh active Pending
- 2014-12-04 US US15/101,597 patent/US10195287B2/en active Active
- 2014-12-04 DK DK14833536.7T patent/DK3076990T3/da active
- 2014-12-04 JP JP2016536147A patent/JP6798883B2/ja active Active
- 2014-12-04 WO PCT/IB2014/066588 patent/WO2015083114A2/en not_active Ceased
- 2014-12-04 ES ES14833536T patent/ES2773960T3/es active Active
- 2014-12-04 CN CN202410996682.XA patent/CN118909079A/zh active Pending
- 2014-12-04 DK DK19208086.9T patent/DK3662926T3/da active
- 2014-12-04 AU AU2014358699A patent/AU2014358699A1/en not_active Abandoned
-
2016
- 2016-06-02 IL IL245983A patent/IL245983B/en active IP Right Grant
-
2017
- 2017-10-19 AU AU2017248496A patent/AU2017248496B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2965765T3 (es) | 2024-04-16 |
| IL245983B (en) | 2020-03-31 |
| CA2931439A1 (en) | 2015-06-11 |
| JP2017501991A (ja) | 2017-01-19 |
| GB201321489D0 (en) | 2014-01-22 |
| WO2015083114A2 (en) | 2015-06-11 |
| ES2773960T3 (es) | 2020-07-15 |
| CN118909080A (zh) | 2024-11-08 |
| US10195287B2 (en) | 2019-02-05 |
| AU2014358699A1 (en) | 2016-06-09 |
| US20160375146A1 (en) | 2016-12-29 |
| AU2017248496B2 (en) | 2019-08-29 |
| PL3662926T3 (pl) | 2024-05-13 |
| AU2017248496A1 (en) | 2017-11-09 |
| EP3076990A2 (en) | 2016-10-12 |
| CN105793283A (zh) | 2016-07-20 |
| HK1223834A1 (zh) | 2017-08-11 |
| EP3662926B1 (en) | 2023-10-25 |
| IL245983A0 (en) | 2016-07-31 |
| DK3076990T3 (da) | 2020-03-16 |
| EP3076990B1 (en) | 2020-01-22 |
| JP6798883B2 (ja) | 2020-12-09 |
| WO2015083114A3 (en) | 2015-11-26 |
| CN118909079A (zh) | 2024-11-08 |
| EP3662926A1 (en) | 2020-06-10 |
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