DK3662926T3 - Biologisk aktive insulinderivater - Google Patents
Biologisk aktive insulinderivater Download PDFInfo
- Publication number
- DK3662926T3 DK3662926T3 DK19208086.9T DK19208086T DK3662926T3 DK 3662926 T3 DK3662926 T3 DK 3662926T3 DK 19208086 T DK19208086 T DK 19208086T DK 3662926 T3 DK3662926 T3 DK 3662926T3
- Authority
- DK
- Denmark
- Prior art keywords
- biologically active
- insulin derivatives
- active insulin
- derivatives
- biologically
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1321489.5A GB201321489D0 (en) | 2013-12-05 | 2013-12-05 | Biologically active insulin derivatives |
| EP14833536.7A EP3076990B1 (en) | 2013-12-05 | 2014-12-04 | Biologically active insulin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3662926T3 true DK3662926T3 (da) | 2023-12-11 |
Family
ID=50000217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14833536.7T DK3076990T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
| DK19208086.9T DK3662926T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14833536.7T DK3076990T3 (da) | 2013-12-05 | 2014-12-04 | Biologisk aktive insulinderivater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10195287B2 (da) |
| EP (2) | EP3076990B1 (da) |
| JP (1) | JP6798883B2 (da) |
| CN (3) | CN118909080A (da) |
| AU (2) | AU2014358699A1 (da) |
| DK (2) | DK3076990T3 (da) |
| ES (2) | ES2965765T3 (da) |
| GB (1) | GB201321489D0 (da) |
| HK (1) | HK1223834A1 (da) |
| IL (1) | IL245983B (da) |
| PL (1) | PL3662926T3 (da) |
| WO (1) | WO2015083114A2 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201321489D0 (en) | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
| BR112019004314A2 (pt) * | 2016-09-06 | 2019-05-28 | Chemical & Biopharmaceutical Laboratories Of Patras S A | derivados pró-insulina |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3847893A (en) * | 1972-03-01 | 1974-11-12 | Bayer Ag | Process for the preparation of insulin derivatives cross-linked by a dicarboxylic acid group at the amino a-1 glycine and amino b-29 lysine |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| WO1995016708A1 (en) | 1993-12-17 | 1995-06-22 | Novo Nordisk A/S | Proinsulin-like compounds |
| AU5724996A (en) | 1995-05-05 | 1996-11-21 | Eli Lilly And Company | Single chain insulin with high bioactivity |
| GB9812675D0 (en) | 1998-06-11 | 1998-08-12 | Univ Edinburgh | Peptides |
| ATE270306T1 (de) | 2000-10-02 | 2004-07-15 | Univ Yonsei Seoul | Einkettige insulinanaloge |
| JP5697831B2 (ja) * | 2003-12-03 | 2015-04-08 | ノヴォ ノルディスク アー／エス | 単鎖インシュリン |
| WO2006079641A2 (en) * | 2005-01-27 | 2006-08-03 | Novo Nordisk A/S | Insulin derivatives conjugated with structurally well defined branched polymers |
| JP2008533100A (ja) | 2005-03-18 | 2008-08-21 | ノボ ノルディスク アクティーゼルスカブ | Ｐｅｇ化された単鎖インスリン |
| EP1991575A1 (en) | 2006-02-21 | 2008-11-19 | Novo Nordisk A/S | Single-chain insulin analogues and pharmaceutical formulations thereof |
| JP2009530243A (ja) | 2006-03-13 | 2009-08-27 | ノボ・ノルデイスク・エー／エス | アシル化単鎖インスリン |
| WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| ES2548304T3 (es) * | 2007-08-15 | 2015-10-15 | Novo Nordisk A/S | Análogos de la insulina que contienen una fracción acilo y alquilenglicol |
| US8618049B2 (en) * | 2009-09-08 | 2013-12-31 | Stephen B. H. Kent | Ester insulin |
| EP2582719B1 (en) * | 2010-06-16 | 2016-08-10 | Indiana University Research and Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| CN104114183A (zh) * | 2011-12-20 | 2014-10-22 | 印第安纳大学研究及科技有限公司 | 用于治疗糖尿病的基于ctp的胰岛素类似物 |
| GB201321489D0 (en) | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
-
2013
- 2013-12-05 GB GBGB1321489.5A patent/GB201321489D0/en not_active Ceased
-
2014
- 2014-12-04 DK DK14833536.7T patent/DK3076990T3/da active
- 2014-12-04 DK DK19208086.9T patent/DK3662926T3/da active
- 2014-12-04 EP EP14833536.7A patent/EP3076990B1/en active Active
- 2014-12-04 US US15/101,597 patent/US10195287B2/en active Active
- 2014-12-04 HK HK16112107.7A patent/HK1223834A1/zh unknown
- 2014-12-04 EP EP19208086.9A patent/EP3662926B1/en active Active
- 2014-12-04 WO PCT/IB2014/066588 patent/WO2015083114A2/en not_active Ceased
- 2014-12-04 PL PL19208086.9T patent/PL3662926T3/pl unknown
- 2014-12-04 JP JP2016536147A patent/JP6798883B2/ja active Active
- 2014-12-04 AU AU2014358699A patent/AU2014358699A1/en not_active Abandoned
- 2014-12-04 CN CN202410997092.9A patent/CN118909080A/zh active Pending
- 2014-12-04 CN CN201480066338.5A patent/CN105793283A/zh active Pending
- 2014-12-04 ES ES19208086T patent/ES2965765T3/es active Active
- 2014-12-04 CN CN202410996682.XA patent/CN118909079A/zh active Pending
- 2014-12-04 ES ES14833536T patent/ES2773960T3/es active Active
-
2016
- 2016-06-02 IL IL245983A patent/IL245983B/en active IP Right Grant
-
2017
- 2017-10-19 AU AU2017248496A patent/AU2017248496B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2773960T3 (es) | 2020-07-15 |
| CN105793283A (zh) | 2016-07-20 |
| PL3662926T3 (pl) | 2024-05-13 |
| JP6798883B2 (ja) | 2020-12-09 |
| HK1223834A1 (zh) | 2017-08-11 |
| IL245983B (en) | 2020-03-31 |
| AU2014358699A1 (en) | 2016-06-09 |
| US10195287B2 (en) | 2019-02-05 |
| EP3076990B1 (en) | 2020-01-22 |
| AU2017248496A1 (en) | 2017-11-09 |
| ES2965765T3 (es) | 2024-04-16 |
| AU2017248496B2 (en) | 2019-08-29 |
| EP3662926A1 (en) | 2020-06-10 |
| DK3076990T3 (da) | 2020-03-16 |
| JP2017501991A (ja) | 2017-01-19 |
| CN118909080A (zh) | 2024-11-08 |
| IL245983A0 (en) | 2016-07-31 |
| EP3076990A2 (en) | 2016-10-12 |
| WO2015083114A3 (en) | 2015-11-26 |
| GB201321489D0 (en) | 2014-01-22 |
| EP3662926B1 (en) | 2023-10-25 |
| WO2015083114A2 (en) | 2015-06-11 |
| CN118909079A (zh) | 2024-11-08 |
| CA2931439A1 (en) | 2015-06-11 |
| US20160375146A1 (en) | 2016-12-29 |
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