DK3097120T3 - Humane antistoffer mod PD-L1 - Google Patents
Humane antistoffer mod PD-L1 Download PDFInfo
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- DK3097120T3 DK3097120T3 DK15703380.4T DK15703380T DK3097120T3 DK 3097120 T3 DK3097120 T3 DK 3097120T3 DK 15703380 T DK15703380 T DK 15703380T DK 3097120 T3 DK3097120 T3 DK 3097120T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (18)
1. Isoleret antistof eller antigenbindende fragment deraf, der binder til humant programmeret døds-ligand 1- (PD-L1) protein, hvor det isolerede antistof eller antigenbindende fragment deraf omfatter tre komplementaritetsbestemmende regioner (CDR) af en variabel tung kædereg ion (HCVR) med en aminosyresekvens ifølge SEQ ID NO: 82, og tre CDR af en variabel letkæderegion (LCVR) med en aminosyresekvens ifølge SEQ ID NO: 90.
2. Isoleret antistof eller antigenbindende fragment deraf ifølge krav 1, hvor antistoffet eller det antigenbindende fragment deraf omfatter en HCDR1 med en aminosyresekvens ifølge SEQ ID NO: 84, en HCDR2 med en aminosyresekvens ifølge SEQ ID NO: 86, en HCDR3 med en aminosyresekvens ifølge SEQ ID NO: 88, en LCDR1 med en aminosyresekvens ifølge SEQ ID NO: 92, en LCDR2 med en aminosyresekvens ifølge SEQ ID NO: 94 og en LCDR3 med en aminosyresekvens ifølge SEQ ID NO: 96.
3. Isoleret antistof eller antigenbindende fragment deraf ifølge krav 1 eller 2, der omfatter et HCVR/LCVR-aminosyresekvenspar ifølge SEQ ID NO: 82/90.
4. Isoleret antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 -3, der er et IgG1 eller lgG4.
5. Isoleret antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 - 4, hvor antistoffet eller det antigenbindende fragment deraf er et multispecifikt antigenbindende molekyle.
6. Farmaceutisk sammensætning, der omfatter et isoleret antistof eller antigenbindende fragment deraf, der binder til PD-L1 ifølge et hvilket som helst af kravene 1 - 5 og en farmaceutisk acceptabel bærer eller fortynder.
7. Isoleret polynukleotidmolekyle, der koder for et antistof eller antigenbindende fragment ifølge krav 3.
8. Vektor, der omfatter polynukleotidet ifølge krav 7.
9. Celle, der udtrykket vektoren ifølge krav 8.
10. Fremgangsmåde til fremstilling af et anti-PD-L1-antistof eller antigenbindende fragment deraf, hvilken fremgangsmåde omfatter vækst af cellen ifølge krav 9 under betingelser, der muliggør fremstilling af antistoffet eller fragmentet og genvinding af det således frembragte antistof eller fragment.
11. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1-5 eller en farmaceutisk sammensætning ifølge krav 6 til anvendelse i forbedring af et immunrespons hos et individ eller til forbedring af T-celleaktivering hos et individ.
12. Antistof, antigenbindende fragment deraf, eller farmaceutisk sammensætning til anvendelse ifølge krav 11, hvor individet har en tumor.
13. Antistof, antigenbindende fragment deraf, eller farmaceutisk sammensætning til anvendelse ifølge krav 11, hvor individet har en virusinfektion, eventuelt hvor virusinfektionen er en HIV-, HBV-, HCV-, HPV-, LCMV- eller SIV-infektion.
14. Antistof ifølge et hvilket som helst af kravene 1 - 5 eller en farmaceutisk sammensætning ifølge krav 6 til anvendelse i en fremgangsmåde til hæmning af væksten af en tumor eller tumorcelle.
15. Antistof, antigenbindende fragment deraf, eller farmaceutisk sammensætning til anvendelse ifølge krav 12 eller 14, hvor tumoren omfatter nyrecellekarcinom, hjernecancer, pladeepitelcellekarcinom i hoved og hals, gastrisk cancer, nyrecancer, brystcancer, ovariecancer, prostatacancer, ikke-småcellet lungecancer, colorektal cancer, multipelt myelom eller melanom.
16. Antistof, antigenbindende fragment deraf, eller farmaceutisk sammensætning til anvendelse ifølge krav 14 eller 15, hvor antistoffet eller det antigenbindende fragment deraf, eller den farmaceutiske sammensætning omfattende antistoffet eller det antigenbindende fragment deraf, er til administration til individet i kombination med et andet terapeutisk middel, eventuelt hvor det andet terapeutiske middel omfatter et NSAID, et corticosteroid, et antistof mod en T-celle-co-hæmmer, et antistof mod et tumorspecifikt antigen, et antistof mod PD-1, en indoleamin-2,3-dioxygelnasehæmmer, en Ang2-hæmmer, en cancervaccine, en EGFR-hæmmer, en TGFp-hæmmer, et kosttilskud, såsom en antioxidant, en VEGF-antagonist, såsom et anti-VEGF-antistof, en småmolekyle-kinase-hæmmer af VEGF-receptor eller et VEGF-hæmmende fusionsprotein, kirurgi, stråling, et kemoterapeutisk middel, et cytotoksisk middel eller en kombination deraf.
17. Antistof, antigenbindende fragment deraf, eller farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 11-16, hvor antistoffet eller det antigenbindende fragment deraf er til administration subkutant, intravenøst, intradermalt, intraperitonealt, oralt, intramuskulært eller intrakranielt.
18. Antistof, antigenbindende fragment deraf, eller farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 11-17, hvor antistoffet eller det antigenbindende fragment er til administration ved en dosis på ca. 0,1 mg/kg kropsvægt til ca. 60 mg/kg af individets kropsvægt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461930582P | 2014-01-23 | 2014-01-23 | |
| US201462089549P | 2014-12-09 | 2014-12-09 | |
| PCT/US2015/012595 WO2015112805A1 (en) | 2014-01-23 | 2015-01-23 | Human antibodies to pd-l1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3097120T3 true DK3097120T3 (da) | 2019-03-18 |
Family
ID=52463178
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15703380.4T DK3097120T3 (da) | 2014-01-23 | 2015-01-23 | Humane antistoffer mod PD-L1 |
| DK18206830.4T DK3473648T3 (da) | 2014-01-23 | 2015-01-23 | Humane antistoffer mod PD-L1 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18206830.4T DK3473648T3 (da) | 2014-01-23 | 2015-01-23 | Humane antistoffer mod PD-L1 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9938345B2 (da) |
| EP (2) | EP3097120B1 (da) |
| JP (2) | JP2017507650A (da) |
| KR (1) | KR102182925B1 (da) |
| CN (1) | CN106103482B (da) |
| AU (1) | AU2015209238B2 (da) |
| BR (1) | BR112016016207B1 (da) |
| CA (1) | CA2937343C (da) |
| CL (1) | CL2016001879A1 (da) |
| CY (2) | CY1122005T1 (da) |
| DK (2) | DK3097120T3 (da) |
| EA (1) | EA034695B1 (da) |
| ES (2) | ES2711450T3 (da) |
| HR (1) | HRP20190749T1 (da) |
| HU (2) | HUE043672T2 (da) |
| IL (1) | IL246661B (da) |
| LT (1) | LT3097120T (da) |
| ME (1) | ME03642B (da) |
| MX (1) | MX373790B (da) |
| MY (1) | MY188355A (da) |
| PH (1) | PH12016501384B1 (da) |
| PL (2) | PL3097120T3 (da) |
| PT (2) | PT3473648T (da) |
| RS (1) | RS58638B1 (da) |
| SG (1) | SG11201605908WA (da) |
| SI (1) | SI3097120T1 (da) |
| SM (1) | SMT201900222T1 (da) |
| TW (1) | TWI680138B (da) |
| UY (1) | UY35965A (da) |
| WO (1) | WO2015112805A1 (da) |
Families Citing this family (343)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| EP2734205B1 (en) | 2011-07-21 | 2018-03-21 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
| AU2013355054B2 (en) | 2012-12-07 | 2017-08-24 | Chemocentryx, Inc. | Diazole lactams |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| US10570204B2 (en) | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
| MX375378B (es) | 2013-09-27 | 2025-03-06 | Genentech Inc | Formulaciones de anticuerpos anti-pdl1. |
| TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| SG10201900002QA (en) | 2014-01-24 | 2019-02-27 | Dana Farber Cancer Institue Inc | Antibody molecules to pd-1 and uses thereof |
| EP3099717B1 (en) | 2014-01-31 | 2019-03-27 | Novartis AG | Antibody molecules to tim-3 and uses thereof |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US20150259420A1 (en) | 2014-03-14 | 2015-09-17 | Novartis Ag | Antibody molecules to lag-3 and uses thereof |
| WO2016030455A1 (en) * | 2014-08-28 | 2016-03-03 | Medimmune Limited | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer |
| ES2771926T3 (es) | 2014-09-13 | 2020-07-07 | Novartis Ag | Terapias de combinación |
| TWI716362B (zh) | 2014-10-14 | 2021-01-21 | 瑞士商諾華公司 | 針對ｐｄ－ｌ１之抗體分子及其用途 |
| HUE052606T2 (hu) * | 2014-12-09 | 2021-05-28 | Regeneron Pharma | Humanizált differenciációs klaszter 274 génnel rendelkezõ nem humán állatok |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| ES2739749T3 (es) | 2015-05-18 | 2020-02-03 | Tolero Pharmaceuticals Inc | Profármacos de alvocidib que tienen biodisponibilidad aumentada |
| ES2904252T3 (es) | 2015-05-21 | 2022-04-04 | Chemocentryx Inc | Moduladores de CCR2 |
| MA44594B1 (fr) | 2015-05-29 | 2020-09-30 | Memorial Sloan Kettering Cancer Center | Anticorps anti-ctla-4 et méthodes d'utilisation de ceux-ci |
| DK3317301T3 (da) | 2015-07-29 | 2021-06-28 | Immutep Sas | Kombinationsterapier omfattende antistofmolekyler mod lag-3 |
| TW202440904A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（二） |
| LT3353212T (lt) | 2015-09-23 | 2021-12-27 | Regeneron Pharmaceuticals, Inc. | Optimizuoti anti-cd3 bispecifiniai antikūnai ir jų naudojimas |
| JP6954648B2 (ja) | 2015-10-19 | 2021-10-27 | シージー オンコロジー， インコーポレイテッド | 併用療法による固形腫瘍又はリンパ系腫瘍の治療方法 |
| EP3370768B9 (en) | 2015-11-03 | 2022-03-16 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and their uses |
| JP7126941B2 (ja) | 2015-12-22 | 2022-08-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | がんを治療するための抗ｐｄ－１抗体と二重特異性抗ｃｄ２０／抗ｃｄ３抗体の組合せ |
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| KR20190003938A (ko) | 2016-02-25 | 2019-01-10 | 셀 메디카 스위처란트 아게 | 면역치료를 위한 변형된 세포 |
| WO2017152088A1 (en) | 2016-03-04 | 2017-09-08 | JN Biosciences, LLC | Antibodies to tigit |
| JP6432121B2 (ja) | 2016-03-04 | 2018-12-05 | シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド | Ｐｄｌ−１抗体、その医薬組成物及びその使用 |
| PL3426271T3 (pl) | 2016-03-10 | 2025-11-24 | Cg Oncology, Inc. | Sposoby leczenia guzów litych terapią skojarzoną |
| CN116196412A (zh) * | 2016-03-15 | 2023-06-02 | 中外制药株式会社 | 使用pd-1轴结合拮抗剂和抗gpc3抗体治疗癌症的方法 |
| US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
| CN109310677A (zh) | 2016-04-07 | 2019-02-05 | 凯莫森特里克斯股份有限公司 | 通过联合施用ccr1拮抗剂与pd-1抑制剂或pd-l1拮抗剂降低肿瘤负荷 |
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| TWI755395B (zh) | 2016-05-13 | 2022-02-21 | 美商再生元醫藥公司 | 抗-pd-1抗體與輻射治療癌症之組合 |
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