DK3135672T3 - Sammensætninger og fremgangsmåder til behandling af alkoholforbrugslidelser, smerter og andre sygdomme - Google Patents

Sammensætninger og fremgangsmåder til behandling af alkoholforbrugslidelser, smerter og andre sygdomme Download PDF

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DK3135672T3
DK3135672T3 DK16187663.6T DK16187663T DK3135672T3 DK 3135672 T3 DK3135672 T3 DK 3135672T3 DK 16187663 T DK16187663 T DK 16187663T DK 3135672 T3 DK3135672 T3 DK 3135672T3
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pain
diseases
compositions
methods
alcohol consumption
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DK16187663.6T
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Jay Jie-Qiang Wu
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Vm Discovery Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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DK16187663.6T 2008-10-10 2009-10-12 Sammensætninger og fremgangsmåder til behandling af alkoholforbrugslidelser, smerter og andre sygdomme DK3135672T3 (da)

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US10467208P 2008-10-10 2008-10-10
EP09820030.6A EP2356109B1 (en) 2008-10-10 2009-10-12 Compositions and methods for treating alcohol use disorders, pain and other diseases

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DK09820030.6T DK2356109T3 (da) 2008-10-10 2009-10-12 Sammensætninger og fremgangsmåder til behandling af sygdomme i forbindelse med alkoholforbrug, smerter og andre sygdomme

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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202000257T1 (it) 2008-10-10 2020-07-08 Vm Discovery Inc Composizioni e metodi per il trattamento dei disturbi da uso di alcol, dolore e altre malattie
AU2011313853A1 (en) 2010-10-11 2013-05-02 Auckland Uniservices Limited Substituted benzamides and their uses
AU2012262489A1 (en) * 2011-05-27 2013-04-04 Icahn School Of Medicine At Mount Sinai Substituted 2-benzylidene-2H-benzo[b][1,4]thiazin-3(4H)-ones, derivatives thereof, and therapeutic uses thereof
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
SMT202000008T1 (it) 2012-01-23 2020-03-13 Sage Therapeutics Inc Formulazione di steroide neuroattivo comprendente un complesso di allopregnanolone e solfobutil eter beta-ciclodestrina
SG11201406518XA (en) * 2012-04-12 2014-11-27 Univ Leland Stanford Junior Substituted benzamides and their uses
PL2887944T3 (pl) * 2012-08-21 2022-02-21 Sage Therapeutics, Inc. Allopregnanolon do leczenia lekoopornego stanu padaczkowego
DK2906221T3 (da) * 2012-10-11 2019-07-22 Southern Res Inst Urinstof og amidderivater af aminoalkylpiperaziner og anvendelse deraf
ES2973320T3 (es) 2012-11-30 2024-06-19 Univ California Alopregnanolona para tratar, reducir o mitigar los síntomas de la depresión posparto
KR102280614B1 (ko) 2013-03-15 2021-07-21 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
EP3110794A1 (en) * 2014-02-27 2017-01-04 Merck Patent GmbH Heterocyclic compounds as nav channel inhibitors and uses thereof
AU2015274333A1 (en) * 2014-06-12 2017-01-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Heterocyclic compounds and methods of use thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
RU2766155C2 (ru) 2016-03-08 2022-02-08 Сейдж Терапьютикс, Инк. Нейроактивные стероиды, их композиции и применения
ES2696516B2 (es) * 2017-07-12 2019-06-19 Consejo Superior Investigacion Compuestos derivados de piperidina como inhibidores de PDE8A
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
JP7741100B2 (ja) 2020-05-04 2025-09-17 アムジェン インコーポレイテッド ミエロイド細胞に発現するトリガー受容体2アゴニストとしての複素環化合物及び使用方法
TW202208355A (zh) 2020-05-04 2022-03-01 美商安進公司 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
GB8504253D0 (en) 1985-02-19 1985-03-20 Ici Plc Electrostatic spraying apparatus
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
JP2002053566A (ja) * 2000-08-11 2002-02-19 Japan Tobacco Inc チアゾール化合物及びその医薬用途
US7241785B2 (en) 2001-03-23 2007-07-10 Takeda Pharmaceutical Company Limited Five-membered heterocyclic alkanoic acid derivative
DK1406898T3 (da) 2001-07-19 2005-05-30 Cv Therapeutics Inc Substituerede piperazinforbindelser og anvendelse af disse som fedtsyreoxidationsinhibitorer
WO2003024448A2 (en) * 2001-09-14 2003-03-27 Methylgene, Inc. Inhibitors of histone deacetylase
US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
AU2002351412B2 (en) 2001-12-21 2010-05-20 Exelixis Patent Company Llc Modulators of LXR
US7504537B2 (en) * 2001-12-27 2009-03-17 Dainippon Sumitomo Pharma Co., Ltd. Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient
AU2003262023A1 (en) 2002-09-10 2004-04-30 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
US20050038078A1 (en) * 2003-08-11 2005-02-17 Agouron Pharmaceuticals, Inc. Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use
EP1682103A1 (en) 2003-10-27 2006-07-26 Novartis AG Indolyl-pyrroledione derivatives for the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation
GB0403635D0 (en) 2004-02-18 2004-03-24 Devgen Nv Pyridinocarboxamides with improved activity as kinase inhibitors
EP1586573B1 (en) * 2004-04-01 2007-02-07 Sanofi-Aventis Deutschland GmbH Oxadiazolones, processes for their preparation and their use as pharmaceuticals
US7790720B2 (en) * 2005-03-31 2010-09-07 Ucb Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
BRPI0610177A2 (pt) 2005-05-25 2016-11-29 Nippon Chemiphar Co composto ou um sal do mesmo, e, ativador para receptor ativado por proliferador de peroxissomo
BRPI0615524A2 (pt) * 2005-07-11 2010-04-06 Devgen Nv derivados da amida como inibidores da quinase
EP1911738A4 (en) 2005-07-29 2009-12-16 Takeda Pharmaceutical COMPOUND OF PHENOXYALKANOIC ACID
CN101421265A (zh) * 2006-01-18 2009-04-29 安姆根有限公司 作为蛋白激酶b(pkb)抑制剂的噻唑化合物
WO2007107758A1 (en) * 2006-03-23 2007-09-27 Prolysis Ltd Antibacterial agents
US7795291B2 (en) * 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
WO2008038841A1 (en) 2006-09-30 2008-04-03 Japan Tobacco Inc. Thiadiazolone derivative and use thereof
WO2008053861A1 (en) * 2006-10-30 2008-05-08 Santen Pharmaceutical Co., Ltd. Novel compound having 1,4-benzoxazin-3-one skeleton
WO2008053863A1 (en) * 2006-10-30 2008-05-08 Santen Pharmaceutical Co., Ltd. Novel compound having 1,4-benzothiazin-3-one skeleton or 3,4-dihydroquinolin-2-one skeleton
WO2008117982A1 (en) 2007-03-28 2008-10-02 Crystal Genomics, Inc. Heterocyclic carboxylic acid derivatives and pharmaceutical composition for inhibiting lipid accumulation containing same
EP2190466A4 (en) * 2007-08-10 2011-12-21 Burnham Inst Medical Research Tissue-specific alkaline phosphatase (TNAP) activators and their use
US8642660B2 (en) * 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
SMT202000257T1 (it) 2008-10-10 2020-07-08 Vm Discovery Inc Composizioni e metodi per il trattamento dei disturbi da uso di alcol, dolore e altre malattie
JP6643807B2 (ja) 2015-03-09 2020-02-12 キヤノン株式会社 文書管理クライアント装置、文書管理方法

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SMT201700147T1 (it) 2017-05-08
EP2356109B1 (en) 2016-12-07
HUE033711T2 (en) 2017-12-28
SI3135672T1 (sl) 2020-07-31
HRP20170357T1 (hr) 2017-05-05
SMT202000257T1 (it) 2020-07-08
CN106243100A (zh) 2016-12-21
WO2010042925A2 (en) 2010-04-15
EP2356109A2 (en) 2011-08-17
EP3135672B9 (en) 2020-05-20
HRP20200552T1 (hr) 2020-07-10
ES2782376T3 (es) 2020-09-14
WO2010042925A3 (en) 2010-07-29
SI2356109T1 (sl) 2017-04-26
CN102177153A (zh) 2011-09-07
PL2356109T3 (pl) 2017-07-31
US8729081B2 (en) 2014-05-20
LT2356109T (lt) 2017-03-27
PT2356109T (pt) 2017-03-10
CN106243100B (zh) 2019-04-09
EP3135672A1 (en) 2017-03-01
EP2356109A4 (en) 2012-05-30
DK2356109T3 (da) 2017-03-13
PL3135672T3 (pl) 2020-11-16
LT3135672T (lt) 2020-05-25
US20110301149A1 (en) 2011-12-08
CY1118665T1 (el) 2017-07-12
CY1123625T1 (el) 2022-03-24
EP3135672B1 (en) 2020-02-19
HUE050319T2 (hu) 2020-11-30
CN102177153B (zh) 2016-09-21
PT3135672T (pt) 2020-04-02
ES2617873T3 (es) 2017-06-20

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