DK320888A - Fremgangsmaade til fremstilling af proteiner ved hjaelp af inducerbare ekspressionssystemer i genetisk modificerede eukaryotiske vaertsceller opformeret in-vivo - Google Patents

Fremgangsmaade til fremstilling af proteiner ved hjaelp af inducerbare ekspressionssystemer i genetisk modificerede eukaryotiske vaertsceller opformeret in-vivo

Info

Publication number
DK320888A
DK320888A DK320888A DK320888A DK320888A DK 320888 A DK320888 A DK 320888A DK 320888 A DK320888 A DK 320888A DK 320888 A DK320888 A DK 320888A DK 320888 A DK320888 A DK 320888A
Authority
DK
Denmark
Prior art keywords
vivo
procedure
host cells
genetically modified
inducible expression
Prior art date
Application number
DK320888A
Other languages
Danish (da)
English (en)
Other versions
DK320888D0 (da
Inventor
Peter Bromley
Michel Dreano
Michel Fischbach
Xavier Fouillet
Prudent Padieu
Richard Voellmy
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Publication of DK320888D0 publication Critical patent/DK320888D0/da
Publication of DK320888A publication Critical patent/DK320888A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK320888A 1986-10-15 1988-06-13 Fremgangsmaade til fremstilling af proteiner ved hjaelp af inducerbare ekspressionssystemer i genetisk modificerede eukaryotiske vaertsceller opformeret in-vivo DK320888A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP86810455A EP0263908B1 (en) 1986-10-15 1986-10-15 Method for the production of proteins by means of inducible expression systems in genetically modified eukaryotic host-cells multiplicated in-vivo
PCT/EP1987/000599 WO1988002778A1 (en) 1986-10-15 1987-10-12 Method for the production of proteins by means of inducible expression systems in genetically modified eukaryotic host-cells multiplicated in-vivo

Publications (2)

Publication Number Publication Date
DK320888D0 DK320888D0 (da) 1988-06-13
DK320888A true DK320888A (da) 1988-06-13

Family

ID=8196470

Family Applications (1)

Application Number Title Priority Date Filing Date
DK320888A DK320888A (da) 1986-10-15 1988-06-13 Fremgangsmaade til fremstilling af proteiner ved hjaelp af inducerbare ekspressionssystemer i genetisk modificerede eukaryotiske vaertsceller opformeret in-vivo

Country Status (12)

Country Link
US (1) US5614381A (ja)
EP (2) EP0263908B1 (ja)
JP (1) JP2509271B2 (ja)
AT (1) ATE67787T1 (ja)
AU (1) AU612607B2 (ja)
CA (1) CA1319631C (ja)
DE (1) DE3681738D1 (ja)
DK (1) DK320888A (ja)
ES (1) ES2038602T3 (ja)
NO (1) NO882469D0 (ja)
WO (1) WO1988002778A1 (ja)
ZA (1) ZA877656B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85728A (en) * 1987-03-25 1993-01-14 Bio Mega Inc Fluorine containing atrial natriuretic peptides, their preparation and pharmaceutical compositions containing them
JP2796547B2 (ja) * 1987-09-11 1998-09-10 ジェネンテク，インコーポレイテッド 組換え細胞培養中でのポリペプチド発現の増大法
JPH03502882A (ja) * 1987-12-15 1991-07-04 ザ トラスティーズ オブ プリンストン ユニヴァーシティ 変異原物質および発癌物質に関するトランスジェニック試験システム
ZA892518B (en) * 1988-04-08 1989-12-27 Intracel Corp Method for the in-vivo production and testing of proteins by recombinant gene expression in selected host-cells
EP0386185A1 (fr) * 1988-07-29 1990-09-12 IntraCel Corporation Procede d'expression genetique de proteines heterologues par des cellules transfectees in vivo
GB8928884D0 (en) * 1989-12-21 1990-02-28 Feldmann Marc Transformed cell lines
GB9003791D0 (en) * 1990-02-20 1990-04-18 Ludwig Inst Cancer Res Transgenic animals,cell lines therefrom,and their use
US5866759A (en) * 1991-02-20 1999-02-02 Ludwig Institute For Cancer Research Transgenic mice expressing TSSV40 large T antigen
US5877398A (en) * 1993-01-29 1999-03-02 University Of British Columbia Biological systems incorporating stress-inducible genes and reporter constructs for environmental biomonitoring and toxicology
EP0922110B1 (en) 1996-08-15 2008-04-16 The Government of the United States of America, represented by the Secretary, Department of Health and Human Services Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat
IT1294450B1 (it) * 1997-08-28 1999-03-25 Consiglio Nazionale Ricerche Animali transgenici per lo studio di agenti tossici chimici fisici o biologici
US7098191B2 (en) * 1997-11-03 2006-08-29 The Arizona Board Of Reagents Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US6709858B1 (en) * 1997-11-03 2004-03-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US7279565B2 (en) * 1998-05-05 2007-10-09 Richard Voellmy Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress
AUPQ233799A0 (en) 1999-08-19 1999-09-09 Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales Recombinant sub-unit vaccine
US20030044398A1 (en) * 2001-03-20 2003-03-06 Robl James M. Methods for producing antibodies in mammals
CA2349506C (en) * 2001-06-14 2009-12-08 Duke University A method for selective expression of therapeutic genes by hyperthermia
US7935788B2 (en) * 2004-10-04 2011-05-03 National Research Council Of Canada Reverse cumate repressor mutant
EP1797186B1 (en) * 2004-10-04 2016-05-25 National Research Council Of Canada Expression system, components thereof and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
JPS5729294A (en) * 1980-07-30 1982-02-17 Hayashibara Biochem Lab Inc Preparation of human insulin
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
NO172595C (no) * 1983-02-07 1993-08-11 Battelle Memorial Institute Fremgangsmaate og ekspresjonsplasmid for fremstilling av hemagglutinin under kontroll av drosophila hsp-promoter
WO1987005935A1 (en) * 1986-04-04 1987-10-08 Battelle Memorial Institute At Columbus, Ohio Gene Methods and compositions for expression of competent eukaryotic gene products
PT85828B (pt) * 1986-09-30 1990-08-31 Smithkline Beecham Corp Profcesso de producao de uma linha de ceculas de mamifero, recombinante, linha de celulas assim obtida e processo de preparacao de um gene
DE3855681T2 (de) * 1987-05-01 1997-05-28 The General Hospital Corp., Boston, Mass. Transkaryotische Einpflanzung

Also Published As

Publication number Publication date
JPH01501439A (ja) 1989-05-25
DK320888D0 (da) 1988-06-13
CA1319631C (en) 1993-06-29
ES2038602T3 (es) 1993-08-01
ZA877656B (en) 1988-04-18
US5614381A (en) 1997-03-25
EP0263908B1 (en) 1991-09-25
EP0263908A1 (en) 1988-04-20
DE3681738D1 (ja) 1991-10-31
AU612607B2 (en) 1991-07-18
WO1988002778A1 (en) 1988-04-21
AU8078487A (en) 1988-05-06
EP0285642A1 (en) 1988-10-12
ATE67787T1 (de) 1991-10-15
JP2509271B2 (ja) 1996-06-19
NO882469L (no) 1988-06-03
NO882469D0 (no) 1988-06-03

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