DK3227458T3 - Epigenetisk fremgangsmåde til identifikation af follikulære T-hjælpe-(TFH-)celler - Google Patents
Epigenetisk fremgangsmåde til identifikation af follikulære T-hjælpe-(TFH-)celler Download PDFInfo
- Publication number
- DK3227458T3 DK3227458T3 DK15805467.6T DK15805467T DK3227458T3 DK 3227458 T3 DK3227458 T3 DK 3227458T3 DK 15805467 T DK15805467 T DK 15805467T DK 3227458 T3 DK3227458 T3 DK 3227458T3
- Authority
- DK
- Denmark
- Prior art keywords
- tfh
- helper
- cells
- epigenetic method
- follicular
- Prior art date
Links
- 230000001973 epigenetic effect Effects 0.000 title 1
- 230000003325 follicular Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196613.5A EP3029150B1 (en) | 2014-12-05 | 2014-12-05 | Epigenetic method for the identification of follicular T-helper-(TFH-) cells |
| PCT/EP2015/078725 WO2016087663A1 (en) | 2014-12-05 | 2015-12-04 | Epigenetic method for the identification of follicular t-helper-(tfh-) cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3227458T3 true DK3227458T3 (da) | 2020-03-02 |
Family
ID=52003680
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14196613.5T DK3029150T3 (da) | 2014-12-05 | 2014-12-05 | Epigenetisk fremgangsmåde til identifikation af follikulære T-hjælpeceller (TFH-celler) |
| DK15805467.6T DK3227458T3 (da) | 2014-12-05 | 2015-12-04 | Epigenetisk fremgangsmåde til identifikation af follikulære T-hjælpe-(TFH-)celler |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14196613.5T DK3029150T3 (da) | 2014-12-05 | 2014-12-05 | Epigenetisk fremgangsmåde til identifikation af follikulære T-hjælpeceller (TFH-celler) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11725243B2 (da) |
| EP (2) | EP3029150B1 (da) |
| JP (1) | JP6778190B2 (da) |
| CN (1) | CN107002143B (da) |
| CA (1) | CA2969370A1 (da) |
| DK (2) | DK3029150T3 (da) |
| ES (2) | ES2695179T3 (da) |
| PL (2) | PL3029150T3 (da) |
| WO (1) | WO2016087663A1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102017125019B4 (de) | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | PDCD1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere PD1+ Zellen |
| DE102018112644B4 (de) * | 2018-05-25 | 2020-06-10 | Epiontis Gmbh | CXCR3 als epigenetischer Marker zur Identifizierung von inflammatorischen Immunzellen, insbesondere CD8+ Gedächnis-T-Zellen |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002083162A1 (en) | 2001-04-13 | 2002-10-24 | University Of Chicago | Use of a cd8+ t cell inhibitory agent in the presence of a cd4+ t cell inhibitory agent for inhibition of transplant rejection |
| US20090298054A1 (en) * | 2004-07-18 | 2009-12-03 | Epigenomics Ag | Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders |
| DK1826279T3 (da) * | 2006-02-28 | 2011-09-05 | Charite Universitaetsmedizin | Detektering og kvalitetskontrol af regulatoriske t-celler vha. DNA-metyleringsanalyse af FoxP3--genet |
| JP5746016B2 (ja) * | 2008-04-30 | 2015-07-08 | サンバイオ，インコーポレイティド | Ｄｎａメチル化における改変を伴う神経再生細胞連邦政府の援助に関する申告適用なし |
| EP2141245A1 (en) * | 2008-07-03 | 2010-01-06 | Ivana Türbachova | DNA methylation analysis of regulatory T cells through DNA-methylation analysis of the TSDR region of the gene foxP3 |
| US20110028333A1 (en) * | 2009-05-01 | 2011-02-03 | Brown University | Diagnosing, prognosing, and early detection of cancers by dna methylation profiling |
| JPWO2012063875A1 (ja) * | 2010-11-11 | 2014-05-12 | シスメックス株式会社 | ヒト濾胞ヘルパーｔ細胞検出用マーカーおよびヒト濾胞ヘルパーｔ細胞の検出方法 |
| WO2012096851A1 (en) | 2011-01-12 | 2012-07-19 | Baylor Research Institute | Compositions and methods of alteration of autoimmune diseases |
| US9926599B2 (en) * | 2012-03-12 | 2018-03-27 | Epiontis Gmbh | Epigenetic marker for the identification of CD3CD4 positive T lymphocytes |
| US10208346B2 (en) * | 2013-04-19 | 2019-02-19 | Epiontis Gmbh | Method for identifying the quantitative cellular composition in a biological sample |
| CN103421800B (zh) * | 2013-09-05 | 2015-07-22 | 新乡医学院 | 用于治疗脊髓损伤的重组基因、重组载体和重组细胞 |
| CN103487572B (zh) * | 2013-10-08 | 2017-03-29 | 北京大学人民医院 | 滤泡辅助性T淋巴细胞(Tfh)在自身免疫性疾病病情预警中的应用 |
-
2014
- 2014-12-05 PL PL14196613T patent/PL3029150T3/pl unknown
- 2014-12-05 ES ES14196613T patent/ES2695179T3/es active Active
- 2014-12-05 DK DK14196613.5T patent/DK3029150T3/da active
- 2014-12-05 EP EP14196613.5A patent/EP3029150B1/en active Active
-
2015
- 2015-12-04 WO PCT/EP2015/078725 patent/WO2016087663A1/en not_active Ceased
- 2015-12-04 US US15/526,632 patent/US11725243B2/en active Active
- 2015-12-04 JP JP2017529294A patent/JP6778190B2/ja not_active Expired - Fee Related
- 2015-12-04 CN CN201580064819.7A patent/CN107002143B/zh active Active
- 2015-12-04 ES ES15805467T patent/ES2770077T3/es active Active
- 2015-12-04 DK DK15805467.6T patent/DK3227458T3/da active
- 2015-12-04 EP EP15805467.6A patent/EP3227458B1/en active Active
- 2015-12-04 CA CA2969370A patent/CA2969370A1/en active Pending
- 2015-12-04 PL PL15805467T patent/PL3227458T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3227458B1 (en) | 2019-11-20 |
| PL3029150T3 (pl) | 2019-03-29 |
| DK3029150T3 (da) | 2018-12-10 |
| CN107002143A (zh) | 2017-08-01 |
| CN107002143B (zh) | 2021-03-30 |
| JP6778190B2 (ja) | 2020-10-28 |
| HK1245343A1 (en) | 2018-08-24 |
| WO2016087663A1 (en) | 2016-06-09 |
| CA2969370A1 (en) | 2016-06-09 |
| ES2695179T3 (es) | 2019-01-02 |
| EP3029150A1 (en) | 2016-06-08 |
| EP3227458A1 (en) | 2017-10-11 |
| ES2770077T3 (es) | 2020-06-30 |
| JP2017537623A (ja) | 2017-12-21 |
| PL3227458T3 (pl) | 2020-06-01 |
| US11725243B2 (en) | 2023-08-15 |
| US20190100800A1 (en) | 2019-04-04 |
| EP3029150B1 (en) | 2018-08-15 |
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