DK328187A - Fremgangsmaade til fremstilling af imidazopyridiner og mellemprodukter til brug ved fremgangsmaaden - Google Patents

Fremgangsmaade til fremstilling af imidazopyridiner og mellemprodukter til brug ved fremgangsmaaden

Info

Publication number: DK328187A
Authority: DK; Denmark
Prior art keywords: procedure; imidazopyridines; intermediates; preparation
Prior art date: 1986-06-27

Application number

DK328187A

Other languages

English (en)

Other versions

DK169505B1 (da

DK328187D0 (da

Inventor

Guy Rossey

David Long

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-27

Filing date

1987-06-26

Publication date

1987-12-28

1987-06-26 Application filed by Synthelabo filed Critical Synthelabo

1987-06-26 Publication of DK328187D0 publication Critical patent/DK328187D0/da

1987-12-28 Publication of DK328187A publication Critical patent/DK328187A/da

1994-11-14 Application granted granted Critical

1994-11-14 Publication of DK169505B1 publication Critical patent/DK169505B1/da

Links

150000005232 imidazopyridines Chemical class 0.000 title 1
239000000543 intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

DK328187A 1986-06-27 1987-06-26 Fremgangsmåde til fremstilling af imidazopyridiner og mellemprodukter til brug ved fremgangsmåden DK169505B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8609330		1986-06-27
FR8609330A FR2600650B1 (fr)	1986-06-27	1986-06-27	Procede de preparation d'imidazopyridines et composes intermediaires

Publications (3)

Publication Number	Publication Date
DK328187D0 DK328187D0 (da)	1987-06-26
DK328187A true DK328187A (da)	1987-12-28
DK169505B1 DK169505B1 (da)	1994-11-14

Family

ID=9336785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK328187A DK169505B1 (da)	1986-06-27	1987-06-26	Fremgangsmåde til fremstilling af imidazopyridiner og mellemprodukter til brug ved fremgangsmåden

Country Status (21)

Country	Link
US (1)	US4794185A (da)
EP (1)	EP0251859B1 (da)
JP (1)	JPH0653740B2 (da)
KR (1)	KR940006594B1 (da)
AR (1)	AR243188A1 (da)
AT (1)	ATE58537T1 (da)
AU (1)	AU7477287A (da)
CA (1)	CA1324138C (da)
DE (1)	DE3766300D1 (da)
DK (1)	DK169505B1 (da)
ES (1)	ES2019646B3 (da)
FI (1)	FI872850A7 (da)
FR (1)	FR2600650B1 (da)
GR (1)	GR3001118T3 (da)
HU (1)	HU204826B (da)
IE (1)	IE60467B1 (da)
IL (1)	IL82982A (da)
NO (1)	NO167392C (da)
NZ (1)	NZ220853A (da)
PT (1)	PT85188B (da)
ZA (1)	ZA874643B (da)

Families Citing this family (47)

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ATE62687T1 (de) *	1986-01-22	1991-05-15	Synthelabo	Acylaminomethylimidazo(1,2-a>pyrimidinderivate, ihre herstellung und therapeutische verwendung.
FR2615513B1 (fr) *	1987-05-21	1989-07-13	Synthelabo	Derives d'acylaminomethyl-3 tetrahydro-5,6,7,8 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
DE69910795T2 (de)	1998-06-09	2004-06-17	Takeda Chemical Industries, Ltd.	Pharmazeutische kombination mit einer trizyclischen verbindung und mindestens einer von zolpidem, zopiclone und brotizolam, zur behandlung oder verhinderung von schlafstörungen
ES2151834B1 (es) *	1998-08-06	2001-08-16	Sint Quimica Sa	Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
ATE297924T1 (de) *	1999-03-25	2005-07-15	Synthon Bv	Zolpidem salze
PT1038875E (pt)	1999-03-25	2003-10-31	Synthon Bv	Derivados de imidazopiridina e processo para os preparar
US6333345B1 (en) *	1999-05-14	2001-12-25	Sepracor, Inc.	Methods of using and compositions comprising N-desmethylzolpidem
US6399621B1 (en)	1999-08-10	2002-06-04	American Cyanamid Company	N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6485746B1 (en)	2000-08-25	2002-11-26	Neurocrine Biosciences, Inc.	Controlled-release sedative-hypnotic compositions and methods related thereto
US20030091632A1 (en) *	1999-08-26	2003-05-15	Neurocrine Biosciences, Inc.	Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) *	1999-09-02	2002-05-07	Neurocrine Biosciences, Inc.	Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
AU5066101A (en) *	2000-04-13	2001-10-30	Synthon B.V.	Modified release formulations containing a hypnotic agent
CZ20023775A3 (cs) *	2000-04-24	2003-10-15	Teva Pharmaceutical Industries Ltd.	Zolpidem hemitartrát
EP1475093B1 (en) *	2000-04-24	2006-09-06	Teva Pharmaceutical Industries Ltd.	Micronized Zolpidem hemitartrate
IT1318624B1 (it)	2000-07-14	2003-08-27	Dinamite Dipharma S P A In For	Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi.
WO2002014306A1 (en) *	2000-08-17	2002-02-21	Cilag Ag	Process for the preparation of imidazopyridines
US6596731B2 (en)	2001-03-27	2003-07-22	Hoffmann-La Roche Inc.	Substituted imidazo[1,2-A] pyridine derivatives
DE10121638A1 (de) *	2001-05-03	2002-11-14	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Imidazopyridinen
US20020183522A1 (en)	2001-05-03	2002-12-05	Markus Sauter	Process for preparing zolpidem
EP1539751B1 (en) *	2002-07-15	2008-05-07	Scinopharm Taiwan, Ltd.	Process for the preparation of imidazo(1,2-a)pyridine-3-acetamides
EP1575952B1 (en) *	2002-12-18	2009-02-18	Mallinckrodt Inc.	Synthesis of heteroaryl acetamides
US20040241100A1 (en) *	2003-03-17	2004-12-02	Fabre Kramer Pharmaceutical, Inc.	Nasally administrable compositions of zolpidem and methods of use
GB0311457D0 (en) *	2003-05-19	2003-06-25	Sciencom Ltd	New therapeutic use
US20050176680A1 (en)	2003-12-11	2005-08-11	Sepracor, Inc.	Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
CA2571491A1 (en) *	2004-06-22	2006-01-19	Mallinckrodt, Inc.	Synthesis of heteroaryl acetamides from reaction mixtures having reduced water content
WO2006008636A2 (en) *	2004-07-16	2006-01-26	Ranbaxy Laboratories Limited	Processes for the preparation of zolpidem and its hemitartrate
EP1928437A2 (en)	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
EP1948655A1 (en) *	2005-10-03	2008-07-30	Mallinckrodt, Inc.	Process for preparing zolpidem hemitartrate and tartrate polymorphs
WO2007047047A2 (en) *	2005-10-17	2007-04-26	Mallinckrodt Inc.	Polymorph transformation of zolpidem in tablet matrix
EP1940389A2 (en)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
AU2006322314A1 (en)	2005-11-18	2007-06-14	Synthon B.V.	Zolpidem tablets
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
WO2007134077A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
EP2068872A1 (en) *	2006-09-08	2009-06-17	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20080145425A1 (en) *	2006-12-15	2008-06-19	Pliva Research & Development Limited	Pharmaceutical composition of zolpidem
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
CN103360387B (zh) *	2012-03-28	2016-12-14	江苏豪森药业集团有限公司	一种制备化合物唑吡坦的方法
KR101704589B1 (ko) *	2016-07-12	2017-02-08	주식회사 뉴트라팜텍	후박 추출물 및 신이 추출물의 혼합물을 유효성분으로 함유하는 치주조직 성장 촉진용 및 치주염 예방 또는 치료용 약학적 조성물
CN107793415A (zh) *	2016-12-01	2018-03-13	湖南省食品药品检验研究院	酒石酸唑吡坦杂质的合成方法
CN106749237A (zh) *	2016-12-28	2017-05-31	江苏豪森药业集团有限公司	酒石酸唑吡坦及其中间体的制备方法
CN114057725B (zh) *	2020-07-31	2024-01-16	株洲千金药业股份有限公司	一种酒石酸唑吡坦的合成方法
CN114057726A (zh) *	2020-07-31	2022-02-18	株洲千金药业股份有限公司	一种唑吡坦盐酸盐的合成方法
CN114057727B (zh) *	2020-07-31	2024-02-27	株洲千金药业股份有限公司	一种唑吡坦中间体的合成方法
CN114249668B (zh) *	2020-09-25	2024-08-23	鲁南制药集团股份有限公司	一种唑吡坦中间体n,n-二甲基-2-氧乙酰胺的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR68765B (da) *	1979-06-20	1982-02-17	Rohm & Haas
FR2492382A1 (fr) *	1980-10-22	1982-04-23	Synthelabo	Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

1986
- 1986-06-27 FR FR8609330A patent/FR2600650B1/fr not_active Expired
1987
- 1987-06-17 AT AT87401353T patent/ATE58537T1/de active
- 1987-06-17 EP EP87401353A patent/EP0251859B1/fr not_active Expired - Lifetime
- 1987-06-17 ES ES87401353T patent/ES2019646B3/es not_active Expired - Lifetime
- 1987-06-17 DE DE8787401353T patent/DE3766300D1/de not_active Expired - Lifetime
- 1987-06-24 IL IL82982A patent/IL82982A/xx not_active IP Right Cessation
- 1987-06-26 NZ NZ220853A patent/NZ220853A/xx unknown
- 1987-06-26 AU AU74772/87A patent/AU7477287A/en not_active Abandoned
- 1987-06-26 IE IE172387A patent/IE60467B1/en not_active IP Right Cessation
- 1987-06-26 NO NO872682A patent/NO167392C/no not_active IP Right Cessation
- 1987-06-26 DK DK328187A patent/DK169505B1/da not_active IP Right Cessation
- 1987-06-26 US US07/066,530 patent/US4794185A/en not_active Expired - Lifetime
- 1987-06-26 ZA ZA874643A patent/ZA874643B/xx unknown
- 1987-06-26 KR KR1019870006538A patent/KR940006594B1/ko not_active Expired - Lifetime
- 1987-06-26 CA CA000540712A patent/CA1324138C/en not_active Expired - Fee Related
- 1987-06-26 PT PT85188A patent/PT85188B/pt unknown
- 1987-06-26 HU HU872909A patent/HU204826B/hu unknown
- 1987-06-26 JP JP62160827A patent/JPH0653740B2/ja not_active Expired - Lifetime
- 1987-06-26 FI FI872850A patent/FI872850A7/fi not_active Application Discontinuation
- 1987-06-26 AR AR87307995A patent/AR243188A1/es active
1990
- 1990-11-28 GR GR90400982T patent/GR3001118T3/el unknown

Also Published As

Publication number	Publication date
CA1324138C (en)	1993-11-09
EP0251859A2 (fr)	1988-01-07
NO167392B (no)	1991-07-22
IL82982A (en)	1992-03-29
IL82982A0 (en)	1987-12-20
JPS638384A (ja)	1988-01-14
AU7477287A (en)	1988-01-07
DK169505B1 (da)	1994-11-14
JPH0653740B2 (ja)	1994-07-20
ZA874643B (en)	1988-02-24
EP0251859A3 (en)	1989-07-19
HU204826B (en)	1992-02-28
KR940006594B1 (ko)	1994-07-23
FI872850A7 (fi)	1987-12-28
PT85188B (pt)	1990-03-30
ES2019646B3 (es)	1991-07-01
HUT44547A (en)	1988-03-28
AR243188A1 (es)	1993-07-30
NZ220853A (en)	1989-09-27
NO872682L (no)	1987-12-28
FR2600650A1 (fr)	1987-12-31
PT85188A (fr)	1987-07-01
FI872850A0 (fi)	1987-06-26
NO167392C (no)	1991-10-30
GR3001118T3 (en)	1992-05-12
ATE58537T1 (de)	1990-12-15
DE3766300D1 (de)	1991-01-03
US4794185A (en)	1988-12-27
IE60467B1 (en)	1994-07-13
EP0251859B1 (fr)	1990-11-22
NO872682D0 (no)	1987-06-26
FR2600650B1 (fr)	1988-09-09
KR880000433A (ko)	1988-03-25
IE871723L (en)	1987-12-27
DK328187D0 (da)	1987-06-26

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Legal Events

Date	Code	Title	Description
1994-11-14	B1	Patent granted (law 1993)
2007-07-16	PUP	Patent expired