DK328687A - Fremgangsmaade til halogenering af ergotalkaloider i 2-stilling, saaledes halogenerede derivater og disses anvendelse - Google Patents

Fremgangsmaade til halogenering af ergotalkaloider i 2-stilling, saaledes halogenerede derivater og disses anvendelse

Info

Publication number
DK328687A
DK328687A DK328687A DK328687A DK328687A DK 328687 A DK328687 A DK 328687A DK 328687 A DK328687 A DK 328687A DK 328687 A DK328687 A DK 328687A DK 328687 A DK328687 A DK 328687A
Authority
DK
Denmark
Prior art keywords
halogening
ergotal
kaloids
halogened
derivatives
Prior art date
Application number
DK328687A
Other languages
Danish (da)
English (en)
Other versions
DK328687D0 (da
Inventor
Gabor Megyeri
Tibor Keve
Jr Lajos Kovacs
Bela Stefko
Erik Bogsch
Anna Kassai
Ferenc Trischler
Gabor Szepesi
Maria Gazdag
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK328687D0 publication Critical patent/DK328687D0/da
Publication of DK328687A publication Critical patent/DK328687A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK328687A 1986-06-27 1987-06-26 Fremgangsmaade til halogenering af ergotalkaloider i 2-stilling, saaledes halogenerede derivater og disses anvendelse DK328687A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862690A HU196394B (en) 1986-06-27 1986-06-27 Process for preparing 2-halogenated ergoline derivatives

Publications (2)

Publication Number Publication Date
DK328687D0 DK328687D0 (da) 1987-06-26
DK328687A true DK328687A (da) 1987-12-28

Family

ID=10960659

Family Applications (1)

Application Number Title Priority Date Filing Date
DK328687A DK328687A (da) 1986-06-27 1987-06-26 Fremgangsmaade til halogenering af ergotalkaloider i 2-stilling, saaledes halogenerede derivater og disses anvendelse

Country Status (19)

Country Link
US (1) US4816587A (cs)
EP (1) EP0251732B1 (cs)
JP (1) JPH085879B2 (cs)
AR (1) AR243194A1 (cs)
AT (1) ATE88705T1 (cs)
AU (1) AU597673B2 (cs)
BG (1) BG48811A3 (cs)
CA (1) CA1301163C (cs)
CS (1) CS264295B2 (cs)
DD (1) DD264430A5 (cs)
DE (1) DE3785613T2 (cs)
DK (1) DK328687A (cs)
ES (1) ES2054672T3 (cs)
FI (1) FI89048C (cs)
HU (1) HU196394B (cs)
PL (1) PL151562B1 (cs)
SU (1) SU1528320A3 (cs)
UA (1) UA5571A1 (cs)
YU (1) YU46557B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
SG44845A1 (en) * 1993-01-12 1997-12-19 Biogen Inc Recombitant anti-vla4 antibody molecules
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
US20030157642A1 (en) * 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US6521421B1 (en) * 1997-07-16 2003-02-18 Genencor International, Inc. Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
US6316241B1 (en) * 1997-11-20 2001-11-13 Genencor International, Inc. Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) * 1998-11-24 2000-12-29 Aventis Laboratoire Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
WO2002072787A2 (en) * 2001-03-13 2002-09-19 Sierra Sciences, Inc. Telomerase expression repressor proteins and methods of using the same
JP2004537976A (ja) 2001-03-15 2004-12-24 インターナショナル バイオイムン システムズ，インコーポレーテッド 膵癌のモノクローナル抗体治療
WO2003005031A1 (en) 2001-07-02 2003-01-16 Sekisui Chemical Co., Ltd. Carrier particle latex for assay reagent and assay reagent
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
RU2274640C1 (ru) * 2004-09-15 2006-04-20 Всероссийский научно-исследовательский институт лекарственных и ароматических растений ("ВИЛАР") СПОСОБ БРОМИРОВАНИЯ α И β-ЭРГОКРИПТИНОВ
ES2912934T3 (es) 2010-04-16 2022-05-30 Biogen Ma Inc Anticuerpos anti VLA-4
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
BR112012031483B1 (pt) 2010-06-11 2020-01-07 Basf Se Usos de composições de moldagem termoplásticas e de moldes transparentes ao laser, processo para produzir moldes soldados, e, molde soldado
CN105560244B (zh) * 2014-10-10 2019-01-11 上海交通大学 一种γ-分泌酶抑制剂及其应用
EP3221349B1 (en) 2014-11-19 2020-11-04 Axon Neuroscience SE Humanized tau antibodies in alzheimer's disease
EP3470842B1 (en) 2016-06-14 2021-05-12 Denka Company Limited Membrane carrier for liquid sample test kit, liquid sample test kit, and method for producing liquid sample test kit
JP7069125B2 (ja) 2017-03-28 2022-05-17 デンカ株式会社 膜担体及びそれを用いた液体試料検査キット
CN110337589A (zh) 2017-03-28 2019-10-15 电化株式会社 膜载体以及使用其的液体试样检测试剂盒及其制造方法
CN112867394B9 (zh) 2018-06-04 2024-12-06 马萨诸塞州渤健公司 具有降低的效应功能的抗vla-4抗体
CN119731161A (zh) * 2022-05-12 2025-03-28 佛罗里达州立大学研究基金会有限公司 麦角酸衍生物及方法
WO2024145546A1 (en) * 2022-12-31 2024-07-04 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) * 1978-09-26 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Also Published As

Publication number Publication date
BG48811A3 (bg) 1991-05-15
PL151562B1 (en) 1990-09-28
FI89048C (fi) 1993-08-10
HUT44541A (en) 1988-03-28
HU196394B (en) 1988-11-28
FI872852L (fi) 1987-12-28
YU46557B (sh) 1993-11-16
ATE88705T1 (de) 1993-05-15
CS479187A2 (en) 1988-09-16
YU119987A (en) 1988-06-30
DK328687D0 (da) 1987-06-26
CA1301163C (en) 1992-05-19
EP0251732B1 (en) 1993-04-28
CS264295B2 (en) 1989-06-13
AU7476387A (en) 1988-01-07
UA5571A1 (uk) 1994-12-28
FI872852A0 (fi) 1987-06-26
FI89048B (fi) 1993-04-30
AR243194A1 (es) 1993-07-30
US4816587A (en) 1989-03-28
DE3785613T2 (de) 1993-08-12
EP0251732A2 (en) 1988-01-07
ES2054672T3 (es) 1994-08-16
JPS6314783A (ja) 1988-01-21
EP0251732A3 (en) 1989-05-10
AU597673B2 (en) 1990-06-07
DE3785613D1 (de) 1993-06-03
JPH085879B2 (ja) 1996-01-24
SU1528320A3 (ru) 1989-12-07
PL266477A1 (en) 1988-07-21
DD264430A5 (de) 1989-02-01

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AHS Application shelved for other reasons than non-payment