BG48811A3 - Метод за получаване на 2-бром-алфа-ергокриптини - Google Patents

Метод за получаване на 2-бром-алфа-ергокриптини

Info

Publication number: BG48811A3
Authority: BG; Bulgaria
Prior art keywords: ergocryptins; bromo; alpha; obtaining; triarylbromosilane
Prior art date: 1986-06-27

Application number

BG080325A

Other languages

Bulgarian (bg)

English (en)

Inventor

Gabor Megyeri

Tibor Keve

Lajos Kovacs

Bela Stefko

Erik Bogsch

Anna Kassai Zieger

Ferenc Trischler

Gabor Szepesi

Maria Gazdag

Original Assignee

Richter Gedeon Vegyeszeti Gyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-27

Filing date

1987-06-26

Publication date

1991-05-15

1987-06-26 Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.

1991-05-15 Publication of BG48811A3 publication Critical patent/BG48811A3/xx

Links

238000000034 method Methods 0.000 title abstract 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
IYYIVELXUANFED-UHFFFAOYSA-N bromo(trimethyl)silane Chemical compound C[Si](C)(C)Br IYYIVELXUANFED-UHFFFAOYSA-N 0.000 abstract 1
VSCMNSZBNLOXNR-UHFFFAOYSA-N bromo(triphenyl)silane Chemical compound C=1C=CC=CC=1[Si](C=1C=CC=CC=1)(Br)C1=CC=CC=C1 VSCMNSZBNLOXNR-UHFFFAOYSA-N 0.000 abstract 1
VQPFDLRNOCQMSN-UHFFFAOYSA-N bromosilane Chemical compound Br[SiH3] VQPFDLRNOCQMSN-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000007796 conventional method Methods 0.000 abstract 1
230000026030 halogenation Effects 0.000 abstract 1
238000005658 halogenation reaction Methods 0.000 abstract 1
229910000042 hydrogen bromide Inorganic materials 0.000 abstract 1
239000002831 pharmacologic agent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BG080325A 1986-06-27 1987-06-26 Метод за получаване на 2-бром-алфа-ергокриптини BG48811A3 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU862690A HU196394B (en)	1986-06-27	1986-06-27	Process for preparing 2-halogenated ergoline derivatives

Publications (1)

Publication Number	Publication Date
BG48811A3 true BG48811A3 (bg)	1991-05-15

Family

ID=10960659

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG080325A BG48811A3 (bg)	1986-06-27	1987-06-26	Метод за получаване на 2-бром-алфа-ергокриптини

Country Status (19)

Country	Link
US (1)	US4816587A (cs)
EP (1)	EP0251732B1 (cs)
JP (1)	JPH085879B2 (cs)
AR (1)	AR243194A1 (cs)
AT (1)	ATE88705T1 (cs)
AU (1)	AU597673B2 (cs)
BG (1)	BG48811A3 (cs)
CA (1)	CA1301163C (cs)
CS (1)	CS264295B2 (cs)
DD (1)	DD264430A5 (cs)
DE (1)	DE3785613T2 (cs)
DK (1)	DK328687A (cs)
ES (1)	ES2054672T3 (cs)
FI (1)	FI89048C (cs)
HU (1)	HU196394B (cs)
PL (1)	PL151562B1 (cs)
SU (1)	SU1528320A3 (cs)
UA (1)	UA5571A1 (cs)
YU (1)	YU46557B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU196598B (en) *	1986-04-25	1988-12-28	Richter Gedeon Vegyeszet	Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) *	1990-10-20	1992-04-23	Sandoz Ag	Neue ergolinderivate, ihre herstellung und verwendung
SG44845A1 (en) *	1993-01-12	1997-12-19	Biogen Inc	Recombitant anti-vla4 antibody molecules
US6723550B1 (en)	1997-07-15	2004-04-20	Genencor International, Inc.	Proteases from gram-positive organisms
US20030157642A1 (en) *	1997-07-15	2003-08-21	Caldwell Robert M.	Increasing production of proteins in gram-positive microorganisms
US6521421B1 (en) *	1997-07-16	2003-02-18	Genencor International, Inc.	Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en)	1997-09-15	2003-02-18	Genencor International, Inc.	Proteases from gram-positive organisms
US6316241B1 (en) *	1997-11-20	2001-11-13	Genencor International, Inc.	Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) *	1998-11-24	2000-12-29	Aventis Laboratoire	Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
WO2002072787A2 (en) *	2001-03-13	2002-09-19	Sierra Sciences, Inc.	Telomerase expression repressor proteins and methods of using the same
JP2004537976A (ja)	2001-03-15	2004-12-24	インターナショナルバイオイムンシステムズ，インコーポレーテッド	膵癌のモノクローナル抗体治療
WO2003005031A1 (en)	2001-07-02	2003-01-16	Sekisui Chemical Co., Ltd.	Carrier particle latex for assay reagent and assay reagent
CA2478458A1 (en) *	2004-08-20	2006-02-20	Michael Panzara	Treatment of pediatric multiple sclerosis
RU2274640C1 (ru) *	2004-09-15	2006-04-20	Всероссийский научно-исследовательский институт лекарственных и ароматических растений ("ВИЛАР")	СПОСОБ БРОМИРОВАНИЯ α И β-ЭРГОКРИПТИНОВ
ES2912934T3 (es)	2010-04-16	2022-05-30	Biogen Ma Inc	Anticuerpos anti VLA-4
US8889768B2 (en)	2010-06-11	2014-11-18	Basf Se	Laser-transparent PBT with organic additives
BR112012031483B1 (pt)	2010-06-11	2020-01-07	Basf Se	Usos de composições de moldagem termoplásticas e de moldes transparentes ao laser, processo para produzir moldes soldados, e, molde soldado
CN105560244B (zh) *	2014-10-10	2019-01-11	上海交通大学	一种γ-分泌酶抑制剂及其应用
EP3221349B1 (en)	2014-11-19	2020-11-04	Axon Neuroscience SE	Humanized tau antibodies in alzheimer's disease
EP3470842B1 (en)	2016-06-14	2021-05-12	Denka Company Limited	Membrane carrier for liquid sample test kit, liquid sample test kit, and method for producing liquid sample test kit
JP7069125B2 (ja)	2017-03-28	2022-05-17	デンカ株式会社	膜担体及びそれを用いた液体試料検査キット
CN110337589A (zh)	2017-03-28	2019-10-15	电化株式会社	膜载体以及使用其的液体试样检测试剂盒及其制造方法
CN112867394B9 (zh)	2018-06-04	2024-12-06	马萨诸塞州渤健公司	具有降低的效应功能的抗vla-4抗体
CN119731161A (zh) *	2022-05-12	2025-03-28	佛罗里达州立大学研究基金会有限公司	麦角酸衍生物及方法
WO2024145546A1 (en) *	2022-12-31	2024-07-04	Ceruvia Lifesciences Llc	Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3901894A (en) *	1974-06-06	1975-08-26	Lilly Co Eli	8-thiomethylergolines
US3992422A (en) *	1975-08-14	1976-11-16	Schering Corporation	Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) *	1976-09-15	1978-07-04	Eli Lilly And Company	Ergoline chlorination process
YU216177A (en) *	1977-09-09	1984-02-29	Rudolf Rucman	Process for preparing 2-bromo ergosine
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) *	1978-09-26	1985-04-30	Lek Tovarna Farmacevtskih	Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) *	1985-06-12	1987-09-28	Richter Gedeon Vegyeszet	Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) *	1986-04-25	1988-12-28	Richter Gedeon Vegyeszet	Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

1986
- 1986-06-27 HU HU862690A patent/HU196394B/hu not_active IP Right Cessation
1987
- 1987-06-05 US US07/058,576 patent/US4816587A/en not_active Expired - Fee Related
- 1987-06-25 YU YU119987A patent/YU46557B/sh unknown
- 1987-06-26 DK DK328687A patent/DK328687A/da not_active Application Discontinuation
- 1987-06-26 AR AR87307983A patent/AR243194A1/es active
- 1987-06-26 CS CS874791A patent/CS264295B2/cs unknown
- 1987-06-26 EP EP87305716A patent/EP0251732B1/en not_active Expired - Lifetime
- 1987-06-26 BG BG080325A patent/BG48811A3/xx unknown
- 1987-06-26 DD DD87304197A patent/DD264430A5/de not_active IP Right Cessation
- 1987-06-26 AT AT87305716T patent/ATE88705T1/de not_active IP Right Cessation
- 1987-06-26 JP JP62157949A patent/JPH085879B2/ja not_active Expired - Lifetime
- 1987-06-26 DE DE8787305716T patent/DE3785613T2/de not_active Expired - Fee Related
- 1987-06-26 FI FI872852A patent/FI89048C/fi not_active IP Right Cessation
- 1987-06-26 SU SU874202820A patent/SU1528320A3/ru active
- 1987-06-26 ES ES87305716T patent/ES2054672T3/es not_active Expired - Lifetime
- 1987-06-26 CA CA000540700A patent/CA1301163C/en not_active Expired - Lifetime
- 1987-06-26 PL PL1987266477A patent/PL151562B1/pl unknown
- 1987-06-26 UA UA4202820A patent/UA5571A1/uk unknown
- 1987-06-26 AU AU74763/87A patent/AU597673B2/en not_active Ceased

Also Published As

Publication number	Publication date
PL151562B1 (en)	1990-09-28
FI89048C (fi)	1993-08-10
HUT44541A (en)	1988-03-28
HU196394B (en)	1988-11-28
FI872852L (fi)	1987-12-28
YU46557B (sh)	1993-11-16
ATE88705T1 (de)	1993-05-15
CS479187A2 (en)	1988-09-16
YU119987A (en)	1988-06-30
DK328687D0 (da)	1987-06-26
CA1301163C (en)	1992-05-19
EP0251732B1 (en)	1993-04-28
CS264295B2 (en)	1989-06-13
AU7476387A (en)	1988-01-07
UA5571A1 (uk)	1994-12-28
FI872852A0 (fi)	1987-06-26
FI89048B (fi)	1993-04-30
AR243194A1 (es)	1993-07-30
US4816587A (en)	1989-03-28
DE3785613T2 (de)	1993-08-12
DK328687A (da)	1987-12-28
EP0251732A2 (en)	1988-01-07
ES2054672T3 (es)	1994-08-16
JPS6314783A (ja)	1988-01-21
EP0251732A3 (en)	1989-05-10
AU597673B2 (en)	1990-06-07
DE3785613D1 (de)	1993-06-03
JPH085879B2 (ja)	1996-01-24
SU1528320A3 (ru)	1989-12-07
PL266477A1 (en)	1988-07-21
DD264430A5 (de)	1989-02-01

Publication	Publication Date	Title
FI872379A0 (fi)	1987-05-28	Menetelmä farmakologisesti vaikuttavien 1,5-diaryyli-3-(w-substituoitu-alempi-alkyyli)-pyratsolien valmistamiseksi
CA1259074C (cs)	1989-09-05
FI875681L (fi)	1988-06-25	Menetelmä farmaseuttisesti aktiivisten 4-(2,6,6-trimetyyli-sykloheks-1-enyl)-but-3-en-1-ynyylisubstituoitujen yhdisteiden valmistamiseksi
NO175531C (no)	1994-10-26	Analogifremgangsmåte til fremstilling av terapeutisk aktive imidazo(4,5-b)-kinolinyloksyalkansyreamider
ATE192153T1 (de)	2000-05-15	Amino-imidazo (4,5-c) chinoline
RO85270A (ro)	1984-09-29	Procedeu pentru prepararea unor derivati de ergolinil
UA5571A1 (uk)	1994-12-28	СПОСІБ ОДЕРЖАННЯ 2-БРОМ-alРha-ЕРГОКРІПТІНУ АБО ЙОГО КИСЛОТНО-АДІТИВНИХ СОЛЕЙ
IT8521763A0 (it)	1985-07-30	Procedimento per la preparazione di derivati 3-sostituiti dall'1-amino-2-idrossi-propano.
DK90494A (da)	1994-08-03	Fremgangsmåde til fremstilling af 2,3,4,5,-tetrafluorbenzoesyre
FI871087A0 (fi)	1987-03-12	Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi
FI880467A0 (fi)	1988-02-02	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
GR870824B (en)	1987-09-30	Process for the preparation of new 1,4 - dihydropyridines useful as antithrombotic drugs
EP0207497A3 (en)	1988-05-18	Quinolonecarboxylic acid derivative and process for its preparation
FI900145L (fi)	1990-01-11	Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
FI901883A0 (fi)	1990-04-12	Menetelmä terapeuttisesti vaikuttavien 2-substituoitujen N,N'-ditrimetoksibentsoyylipiperatsiinien valmistamiseksi
FI883248A7 (fi)	1989-01-11	Menetelmä terapeuttisesti käyttökelpoisten 3,5-dihydroksikarboksyylihappojohdannaisten valmistamiseksi
FI93216C (fi)	1995-03-10	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1,3-dioksaanialkeenihappojohdannaisten valmistamiseksi
KR930004265A (ko)	1993-03-22	신규 치환 n-플루오로피리디늄술포네이트, 그의 중간체 및 그의 제조방법
EP0008950A3 (en)	1980-06-11	Pyrimido(1,6-a)indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing the derivatives and their use
IT1226045B (it)	1990-12-10	Derivati tetraidrochinolici
FR2592877B1 (fr)	1991-03-15	Derives d'ester d'acide imidazol-1-yl-carboxylique, procede pour les preparer et composition fongicide comprenant le derive comme produit actif
IT1190908B (it)	1988-02-24	Procedimento per la preparazione di 6-(3,6-diidro-1(2h)-piridil) pirimidin-3-ossidi
ES8300747A1 (es)	1982-11-01	Procedimiento para la preparacion de derivados de acido in- dolacetico
IT1191227B (it)	1988-02-24	Procedimento per la preparazione di derivati dell'alcool benzilico
FI90536C (fi)	1994-02-25	Menetelmä uusien terapeuttisesti käyttökelpoisten 2-aminotetrahydroisokinoliinijohdannaisten valmistamiseksi