DK332684A - Modificerede protease-inhibitorer samt deres fremstilling og anvendelse - Google Patents

Modificerede protease-inhibitorer samt deres fremstilling og anvendelse Download PDF

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Publication number
DK332684A
DK332684A DK332684A DK332684A DK332684A DK 332684 A DK332684 A DK 332684A DK 332684 A DK332684 A DK 332684A DK 332684 A DK332684 A DK 332684A DK 332684 A DK332684 A DK 332684A
Authority
DK
Denmark
Prior art keywords
preparation
protease inhibitors
modified protease
compounds
modified
Prior art date
Application number
DK332684A
Other languages
English (en)
Other versions
DK332684D0 (da
DK165988C (da
DK165988B (da
Inventor
Ursula Seemueller
Johannes Dodt
Hans Fritz
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK332684D0 publication Critical patent/DK332684D0/da
Publication of DK332684A publication Critical patent/DK332684A/da
Publication of DK165988B publication Critical patent/DK165988B/da
Application granted granted Critical
Publication of DK165988C publication Critical patent/DK165988C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paper (AREA)
  • Pyrrole Compounds (AREA)
DK332684A 1983-07-07 1984-07-06 Modificerede egliner b og c, deres anvendelse som proteaseinhibitorer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende de modificerede egliner b og c DK165988C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3324534A DE3324534A1 (de) 1983-07-07 1983-07-07 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
DE3324534 1983-07-07

Publications (4)

Publication Number Publication Date
DK332684D0 DK332684D0 (da) 1984-07-06
DK332684A true DK332684A (da) 1985-01-08
DK165988B DK165988B (da) 1993-02-22
DK165988C DK165988C (da) 1993-07-26

Family

ID=6203414

Family Applications (1)

Application Number Title Priority Date Filing Date
DK332684A DK165988C (da) 1983-07-07 1984-07-06 Modificerede egliner b og c, deres anvendelse som proteaseinhibitorer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende de modificerede egliner b og c

Country Status (10)

Country Link
US (1) US4636489A (da)
EP (1) EP0134479B1 (da)
JP (1) JPH0670077B2 (da)
AT (1) ATE32728T1 (da)
CA (1) CA1230069A (da)
DE (2) DE3324534A1 (da)
DK (1) DK165988C (da)
ES (1) ES8601108A1 (da)
GR (1) GR82243B (da)
IE (1) IE57698B1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342373B1 (en) * 1983-11-21 2002-01-29 Ucp Gen-Pharma Ag Process for preparing recombinant eglin, protease inhibitor
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US5166134A (en) * 1986-12-24 1992-11-24 John Lezdey Treatment of allergic rhinitis
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
ATE103930T1 (de) * 1988-03-07 1994-04-15 Ciba Geigy Ag Modifizierte proteine.
IL90356A0 (en) * 1988-05-27 1989-12-15 Magainin Sciences Inc Amphiphilic peptides and pharmaceutical compositions containing them
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5459237A (en) * 1990-02-08 1995-10-17 Magainin Pharmaceuticals Inc. Peptide compositions and uses therefor
JPH07504152A (ja) * 1990-02-08 1995-05-11 マゲイニン　ファーマスーティカルズ，　インコーポレーテッド 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
JPH05507273A (ja) * 1990-05-14 1993-10-21 マゲイニン　サイエンセズ　インコーポレーテッド Ｄアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法
CA2045073A1 (en) * 1990-06-27 1991-12-28 Barry Berkowitz Composition and treatment with biologically active peptides and antibiotics which inhibit dna gyrase
US5208220A (en) * 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
DE69229552T2 (de) * 1991-05-23 1999-12-23 Merrell Pharmaceuticals Inc., Cincinnati Hemmstoffe für kathepsin-g und elastase zur verhütung von bindegewebsabbau
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
JPH07500342A (ja) * 1991-10-16 1995-01-12 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 生物学的活性ペプチドおよび抗生物質を有する組成物およびこれを用いた治療
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharmaceuticals Inc., Cincinnati Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US6579698B1 (en) 1996-09-24 2003-06-17 The Procter & Gamble Company Stabilized proteinaceous protease inhibitors and variants thereof
US7001884B2 (en) * 2001-06-18 2006-02-21 Regents Of The University Of Michigan Eglin c based drugs for treatment of disease
DE102005007313A1 (de) * 2005-02-17 2006-08-24 Wacker Chemie Ag Verfahren zur Herstellung von Entschäumerformulierungen
KR101237116B1 (ko) * 2010-11-12 2013-02-25 대한유화공업 주식회사 내충격성 및 내압특성이 우수한 폴리프로필렌 조성물
CN110551707A (zh) * 2019-10-17 2019-12-10 山西大学 一种纯化中性或碱性蛋白酶的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808396C2 (de) * 1978-02-27 1984-04-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Protease-Inhibitoren
US4250086A (en) * 1979-11-19 1981-02-10 Ortho Pharmaceutical Corporation Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2

Also Published As

Publication number Publication date
CA1230069A (en) 1987-12-08
ATE32728T1 (de) 1988-03-15
JPS60105699A (ja) 1985-06-11
DK332684D0 (da) 1984-07-06
DK165988C (da) 1993-07-26
IE57698B1 (en) 1993-03-10
US4636489A (en) 1987-01-13
EP0134479A1 (de) 1985-03-20
JPH0670077B2 (ja) 1994-09-07
DK165988B (da) 1993-02-22
ES534098A0 (es) 1985-10-16
GR82243B (da) 1984-12-13
DE3469534D1 (en) 1988-04-07
DE3324534A1 (de) 1985-01-17
IE841734L (en) 1985-01-07
ES8601108A1 (es) 1985-10-16
EP0134479B1 (de) 1988-03-02

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