DK332684A - Modificerede protease-inhibitorer samt deres fremstilling og anvendelse - Google Patents

Modificerede protease-inhibitorer samt deres fremstilling og anvendelse Download PDF

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Publication number
DK332684A
DK332684A DK332684A DK332684A DK332684A DK 332684 A DK332684 A DK 332684A DK 332684 A DK332684 A DK 332684A DK 332684 A DK332684 A DK 332684A DK 332684 A DK332684 A DK 332684A
Authority
DK
Denmark
Prior art keywords
preparation
protease inhibitors
modified protease
compounds
modified
Prior art date
Application number
DK332684A
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English (en)
Other versions
DK165988B (da
DK332684D0 (da
DK165988C (da
Inventor
Ursula Seemueller
Johannes Dodt
Hans Fritz
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK332684D0 publication Critical patent/DK332684D0/da
Publication of DK332684A publication Critical patent/DK332684A/da
Publication of DK165988B publication Critical patent/DK165988B/da
Application granted granted Critical
Publication of DK165988C publication Critical patent/DK165988C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Paper (AREA)
DK332684A 1983-07-07 1984-07-06 Modificerede egliner b og c, deres anvendelse som proteaseinhibitorer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende de modificerede egliner b og c DK165988C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3324534 1983-07-07
DE3324534A DE3324534A1 (de) 1983-07-07 1983-07-07 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel

Publications (4)

Publication Number Publication Date
DK332684D0 DK332684D0 (da) 1984-07-06
DK332684A true DK332684A (da) 1985-01-08
DK165988B DK165988B (da) 1993-02-22
DK165988C DK165988C (da) 1993-07-26

Family

ID=6203414

Family Applications (1)

Application Number Title Priority Date Filing Date
DK332684A DK165988C (da) 1983-07-07 1984-07-06 Modificerede egliner b og c, deres anvendelse som proteaseinhibitorer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende de modificerede egliner b og c

Country Status (10)

Country Link
US (1) US4636489A (da)
EP (1) EP0134479B1 (da)
JP (1) JPH0670077B2 (da)
AT (1) ATE32728T1 (da)
CA (1) CA1230069A (da)
DE (2) DE3324534A1 (da)
DK (1) DK165988C (da)
ES (1) ES8601108A1 (da)
GR (1) GR82243B (da)
IE (1) IE57698B1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342373B1 (en) * 1983-11-21 2002-01-29 Ucp Gen-Pharma Ag Process for preparing recombinant eglin, protease inhibitor
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US5166134A (en) * 1986-12-24 1992-11-24 John Lezdey Treatment of allergic rhinitis
EP0332576B1 (de) * 1988-03-07 1994-04-06 Ciba-Geigy Ag Modifizierte Proteine
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
ATE115146T1 (de) * 1988-05-27 1994-12-15 Philadelphia Children Hospital Amphiphile peptide und deren verwendung.
EP0347376B1 (en) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Novel polypeptides with an anticoagulant activity
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
US5459237A (en) * 1990-02-08 1995-10-17 Magainin Pharmaceuticals Inc. Peptide compositions and uses therefor
EP0514464A4 (en) * 1990-02-08 1993-04-28 Magainin Sciences, Inc. Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell
JPH05507273A (ja) * 1990-05-14 1993-10-21 マゲイニン　サイエンセズ　インコーポレーテッド Ｄアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法
US5208220A (en) * 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
JPH05507718A (ja) * 1990-06-27 1993-11-04 マゲイニン　サイエンセズ　インコーポレーテッド 生物活性ペプチドおよびｄｎａギラーゼを阻害する抗生物質よりなる組成物と治療法
WO1992020357A1 (en) * 1991-05-23 1992-11-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of cathepsin g and elastase for preventing connective tissue degradation
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
AU2901692A (en) * 1991-10-16 1993-05-21 Children's Hospital Of Philadelphia, The Composition and treatment with biologically active peptides and antibiotic
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharmaceuticals Inc., Cincinnati Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
EP0763055B1 (en) * 1994-06-02 1999-11-03 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
WO1998013387A1 (en) 1996-09-24 1998-04-02 The Procter & Gamble Company Stabilized proteinaceous protease inhibitors and variants thereof
US7001884B2 (en) * 2001-06-18 2006-02-21 Regents Of The University Of Michigan Eglin c based drugs for treatment of disease
DE102005007313A1 (de) * 2005-02-17 2006-08-24 Wacker Chemie Ag Verfahren zur Herstellung von Entschäumerformulierungen
KR101237116B1 (ko) * 2010-11-12 2013-02-25 대한유화공업 주식회사 내충격성 및 내압특성이 우수한 폴리프로필렌 조성물
CN110551707A (zh) * 2019-10-17 2019-12-10 山西大学 一种纯化中性或碱性蛋白酶的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808396C2 (de) * 1978-02-27 1984-04-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Protease-Inhibitoren
US4250086A (en) * 1979-11-19 1981-02-10 Ortho Pharmaceutical Corporation Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2

Also Published As

Publication number Publication date
ES534098A0 (es) 1985-10-16
DE3324534A1 (de) 1985-01-17
JPH0670077B2 (ja) 1994-09-07
JPS60105699A (ja) 1985-06-11
DK165988B (da) 1993-02-22
DE3469534D1 (en) 1988-04-07
DK332684D0 (da) 1984-07-06
IE57698B1 (en) 1993-03-10
ATE32728T1 (de) 1988-03-15
CA1230069A (en) 1987-12-08
DK165988C (da) 1993-07-26
EP0134479B1 (de) 1988-03-02
US4636489A (en) 1987-01-13
IE841734L (en) 1985-01-07
ES8601108A1 (es) 1985-10-16
GR82243B (da) 1984-12-13
EP0134479A1 (de) 1985-03-20

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