DK552684A - Desulfatohirudiner samt deres fremstilling og anvendelse - Google Patents

Desulfatohirudiner samt deres fremstilling og anvendelse Download PDF

Info

Publication number: DK552684A
Authority: DK; Denmark
Prior art keywords: preparation; hirudines; desulphato; desulfatohirudins; hirudin
Prior art date: 1983-11-22

Application number

DK552684A

Other languages

English (en)

Other versions

DK552684D0 (da

DK165696B (da

DK165696C (da

Inventor

Hans Fritz

Johannes Dodt

Ursula Seemueller

Ernst Fink

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-22

Filing date

1984-11-21

Publication date

1985-05-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6214920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK552684(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1984-11-21 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1984-11-21 Publication of DK552684D0 publication Critical patent/DK552684D0/da

1985-05-23 Publication of DK552684A publication Critical patent/DK552684A/da

1993-01-04 Publication of DK165696B publication Critical patent/DK165696B/da

1993-05-24 Application granted granted Critical

1993-05-24 Publication of DK165696C publication Critical patent/DK165696C/da

Links

102000007625 Hirudins Human genes 0.000 abstract 1
108010007267 Hirudins Proteins 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
230000023555 blood coagulation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Tropical Medicine & Parasitology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK552684A 1983-11-22 1984-11-21 Desulfatohirudiner og deres farmaceutisk acceptable salte, deres fremstilling, farmaceutisk praeparat indeholdende disse forbindelser og anvendelse af forbindelserne til fremstilling af farmaceutisk middel og som analytisk reagens DK165696C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19833342139 DE3342139A1 (de)	1983-11-22	1983-11-22	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3342139		1983-11-22

Publications (4)

Publication Number	Publication Date
DK552684D0 DK552684D0 (da)	1984-11-21
DK552684A true DK552684A (da)	1985-05-23
DK165696B DK165696B (da)	1993-01-04
DK165696C DK165696C (da)	1993-05-24

Family

ID=6214920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK552684A DK165696C (da)	1983-11-22	1984-11-21	Desulfatohirudiner og deres farmaceutisk acceptable salte, deres fremstilling, farmaceutisk praeparat indeholdende disse forbindelser og anvendelse af forbindelserne til fremstilling af farmaceutisk middel og som analytisk reagens

Country Status (19)

Country	Link
US (3)	US4654302A (da)
EP (1)	EP0142860B1 (da)
JP (1)	JP2551551B2 (da)
AT (1)	ATE56021T1 (da)
AU (1)	AU578050B2 (da)
CA (1)	CA1239606A (da)
CY (1)	CY1737A (da)
DD (1)	DD232498A5 (da)
DE (3)	DE3342139A1 (da)
DK (1)	DK165696C (da)
HK (1)	HK121293A (da)
IE (1)	IE57885B1 (da)
IL (1)	IL73570A (da)
LU (1)	LU90192I2 (da)
MX (1)	MX9203370A (da)
NL (1)	NL970045I2 (da)
NZ (1)	NZ210275A (da)
PH (1)	PH23831A (da)
ZA (1)	ZA849068B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
FR2562088B1 (fr) *	1984-03-27	1987-11-13	Transgene Sa	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
US5705355A (en) *	1984-03-27	1998-01-06	Transgene, S.A.	Hirudin, pharmaceutical compositions comprising it and their use
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
ATE64956T1 (de) *	1984-06-14	1991-07-15	Ciba Geigy Ag	Verfahren zur herstellung von thrombininhibitoren.
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
JPS6229997A (ja) *	1985-04-08	1987-02-07	Sankyo Co Ltd	Ｃ末端にプロリンアミドを有するペプチドの製法
DE3738541A1 (de) *	1987-11-13	1989-05-24	Hoechst Ag	Verfahren zur isolierung und reinigung von hirudin
EP0209061B1 (de) *	1985-07-17	1994-01-12	Hoechst Aktiengesellschaft	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.
US6005071A (en) *	1987-01-23	1999-12-21	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5789540A (en) *	1987-01-23	1998-08-04	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5236898A (en) *	1987-05-21	1993-08-17	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5192745A (en) *	1987-05-21	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
AU3098289A (en) *	1988-03-04	1989-09-07	Biogen, Inc.	Hirudin peptides
AU614121B2 (en) *	1988-05-04	1991-08-22	Novartis Ag	Improvements in the production of polypeptides
US4971953A (en) *	1988-05-10	1990-11-20	Merrell Dow Pharmaceuticals	Anticoagulant peptide alcohols
DE58907266T2 (de) *	1988-06-11	1994-09-29	Ciba Geigy Ag	Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US5268296A (en) *	1988-06-11	1993-12-07	Ciba-Geigy Corporation	DNA vector and recombinant host cell for production of hirullin P6 and P18
US5112615A (en) *	1988-08-03	1992-05-12	New England Deaconess Hospital Corporation	Soluble hirudin conjugates
US5167960A (en) *	1988-08-03	1992-12-01	New England Deaconess Hospital Corporation	Hirudin-coated biocompatible substance
GB8822147D0 (en) *	1988-09-21	1988-10-26	Ciba Geigy Ag	Pharmaceutically active combination
WO1990003391A1 (en) *	1988-09-29	1990-04-05	Biogen, Inc.	Hirudin peptides
US4994367A (en) *	1988-10-07	1991-02-19	East Carolina University	Extended shelf life platelet preparations and process for preparing the same
DE3835815A1 (de) *	1988-10-21	1990-04-26	Hoechst Ag	Neue isohirudine
WO1990006128A1 (en) *	1988-12-05	1990-06-14	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
US4861865A (en) *	1989-01-23	1989-08-29	Washington University	Novel antithrombin peptide
US5179196A (en) *	1989-05-04	1993-01-12	Sri International	Purification of proteins employing ctap-iii fusions
US6239101B1 (en) *	1989-07-05	2001-05-29	Oklahoma Medical Research Foundation	Thrombin binding polypeptides
US5192747A (en) *	1989-10-03	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
CA2035917C (en) *	1990-02-13	2001-10-02	John L. Krstenansky	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US5118790A (en) *	1990-07-24	1992-06-02	Sri International	Analogs of hirudin
US5837808A (en) *	1991-08-20	1998-11-17	Baxter International Inc.	Analogs of hirudin
DE4209110A1 (de) *	1991-11-26	1993-05-27	Basf Ag	Neue thrombininhibitorische proteine aus landblutegeln
DE4140381A1 (de) *	1991-12-07	1993-06-09	Hoechst Ag, 6230 Frankfurt, De	Neue synthetische isohirudine mit verbesserter stabilitaet
GB9401447D0 (en)	1994-01-26	1994-03-23	Ciba Geigy Ag	Pharmaceutical compositions
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
DE19607239A1 (de)	1996-02-27	1997-08-28	Behringwerke Ag	Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
KR20000070338A (ko)	1997-01-20	2000-11-25	나가시마 카쭈시게, 노미야마 아키히코	펩티드의 안정화 방법 및 당해 방법을 이용한 펩티드 함유 동결건조 의약조성물
DE19755682A1 (de) *	1997-12-15	1999-06-17	Knoll Ag	Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren
DE10149678A1 (de)	2001-10-09	2009-03-12	Novel Science International Gmbh	Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
DE10301255A1 (de)	2003-01-15	2004-07-29	Cpi Creative Pharma International Gmbh	Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel

1983
- 1983-11-22 DE DE19833342139 patent/DE3342139A1/de not_active Withdrawn
1984
- 1984-11-20 CA CA000468216A patent/CA1239606A/en not_active Expired
- 1984-11-20 IL IL73570A patent/IL73570A/xx not_active IP Right Cessation
- 1984-11-20 DD DD84269667A patent/DD232498A5/de not_active IP Right Cessation
- 1984-11-20 DE DE1997175096 patent/DE19775096I2/de active Active
- 1984-11-20 AT AT84114038T patent/ATE56021T1/de active
- 1984-11-20 EP EP84114038A patent/EP0142860B1/de not_active Expired - Lifetime
- 1984-11-20 DE DE8484114038T patent/DE3483085D1/de not_active Expired - Lifetime
- 1984-11-21 JP JP59244681A patent/JP2551551B2/ja not_active Expired - Lifetime
- 1984-11-21 IE IE2979/84A patent/IE57885B1/en not_active IP Right Cessation
- 1984-11-21 US US06/673,952 patent/US4654302A/en not_active Expired - Lifetime
- 1984-11-21 NZ NZ210275A patent/NZ210275A/xx unknown
- 1984-11-21 ZA ZA849068A patent/ZA849068B/xx unknown
- 1984-11-21 DK DK552684A patent/DK165696C/da not_active IP Right Cessation
- 1984-11-21 AU AU35759/84A patent/AU578050B2/en not_active Expired
1986
- 1986-11-13 US US06/929,710 patent/US4745177A/en not_active Expired - Lifetime
- 1986-11-20 PH PH31466A patent/PH23831A/en unknown
1988
- 1988-01-19 US US07/145,023 patent/US4801576A/en not_active Expired - Lifetime
1992
- 1992-06-25 MX MX9203370A patent/MX9203370A/es unknown
1993
- 1993-11-04 HK HK1212/93A patent/HK121293A/xx not_active IP Right Cessation
1995
- 1995-10-20 CY CY173795A patent/CY1737A/xx unknown
1997
- 1997-12-19 NL NL970045C patent/NL970045I2/nl unknown
- 1997-12-31 LU LU90192C patent/LU90192I2/fr unknown

Also Published As

Publication number	Publication date
EP0142860A2 (de)	1985-05-29
JPS60136597A (ja)	1985-07-20
JP2551551B2 (ja)	1996-11-06
IL73570A (en)	1988-05-31
IL73570A0 (en)	1985-02-28
ZA849068B (en)	1985-07-31
DK552684D0 (da)	1984-11-21
DK165696B (da)	1993-01-04
NL970045I2 (nl)	1998-08-03
DE3342139A1 (de)	1985-05-30
CA1239606A (en)	1988-07-26
CY1737A (en)	1995-10-20
US4801576A (en)	1989-01-31
AU578050B2 (en)	1988-10-13
LU90192I2 (fr)	1998-03-02
DD232498A5 (de)	1986-01-29
MX9203370A (es)	1992-09-01
EP0142860B1 (de)	1990-08-29
HK121293A (en)	1993-11-12
NZ210275A (en)	1988-08-30
ATE56021T1 (de)	1990-09-15
IE842979L (en)	1985-05-22
AU3575984A (en)	1985-05-30
DE19775096I2 (de)	2002-07-04
DK165696C (da)	1993-05-24
DE3483085D1 (de)	1990-10-04
IE57885B1 (en)	1993-05-05
US4745177A (en)	1988-05-17
EP0142860A3 (en)	1987-03-11
PH23831A (en)	1989-11-23
NL970045I1 (nl)	1998-03-02
US4654302A (en)	1987-03-31

Legal Events

Date	Code	Title	Description
1998-04-06	CTFF	Application for supplementary protection certificate (spc) filed	Free format text: CA 1997 00045, 971120
2004-12-06	PUP	Patent expired

Publication	Publication Date	Title
DK552684D0 (da)	1984-11-21	Desulfatohirudiner samt deres fremstilling og anvendelse
FI882742A7 (fi)	1988-12-11	Hoitavia aineita ja niitä sisältäviä koostumuksia.
DK573384A (da)	1985-06-06	Sphingosinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende disse derivater
FI851337A7 (fi)	1985-10-10	N-aryyli-N-(4-piperidinyyli)-amidit ja niitä sisältävät farmaseuttiset koostumukset ja niiden käyttö.
DK83388D0 (da)	1988-02-18	Farmaceutisk middel indeholdende den insulin-lignende vaekstfaktor ii (igf-ii) til topisk anvendelse til saarheling
PT77898B (en)	1986-04-11	Process for the preparation of substituted 4-amino-methylenochromanes and 4-aminomethylenecromenes acting on the blood circulation and application thereof in the preparation of pharmaceutical compositions acting on the blood circulation
ATE2271T1 (de)	1983-02-15	4-(substituierte thiazolyl)-3-hydroxy-3-pyrrolin2,5-dion-verbindungen, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzung.
DK93685A (da)	1985-09-02	Benzisoselenazolthioner, fremgangsmaade til fremstilling af disse forbindelser og farmaceutiske praeparater indeholdende disse forbindelser
DK314887D0 (da)	1987-06-19	Kompleksforbindelser, farmaceutiske midler med indhold heraf samt fremgangsmaade til fremstilling heraf
GB8727099D0 (en)	1987-12-23	Compositions containing melantonin/homologues
FI843560A7 (fi)	1984-09-11	Mevalonolaktonin analogeja ja niiden johdannaisia, menetelmiä niiden valmistamiseksi, niitä sisältäviä farmaseuttisia yhdistelmiä ja niide n käyttö farmaseuttisina aineina.
FI813912L (fi)	1982-06-10	I laekemedel anvaendbara tricykliska cytosinderivat och foerfarande foer deras framstaellning
DK133587D0 (da)	1987-03-16	2-heterocyclylthio-penemer, deres anvendelse og farmaceutisk komposition indeholdende forbindelserne
DK243280A (da)	1980-12-06	3,4,5-trihydroxypiperidinderivater deres fremstilling og anvendelse
DE69017969D1 (de)	1995-04-27	2-Cyclohexylpropionsäure oder Derivate davon enthaltende Riechstoffzusammensetzung.
DK398483D0 (da)	1983-09-01	Substiuerede tert.butanolderivater, fremgangsmader til fremstilling deraf samt antimykotiske midler indeholdende disse forbindelser
FI844645L (fi)	1985-06-11	1,7-difenyl-3-metylaza-7-cyan-8 -metyl-nonan foer anvaendning vid bekaempning av sjukdomar.
ATE109150T1 (de)	1994-08-15	Mono- und diepoxid-derivate von ll-f28249- verbindungen.
DK507684D0 (da)	1984-10-24	Thiadiazinderivater, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende disse thiadiazinderivater
IT8123540A0 (it)	1981-08-17	Procedimento per la preparazione di composti citostatici e composizioni farmaceutiche contenenti gli stessi.
DK159685C (da)	1991-04-15	Imidazothienopyrimidiner, farmaceutiske praeparater indeholdende disse, en anvendelse af forbindelserne og fremgangsmaade til deres fremstilling
ATE95061T1 (de)	1993-10-15	Schmiermittelzubereitung zur behandlung von rheuma.
DK551183A (da)	1985-06-02	Substituerede 9h-8-oxo-pyrimido(2,1-f)purin-2,4-dioner, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
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