DK3377534T3 - Behandling af lungecancer ved hjælp af en kombination af et anti-pd-1-antistof og et anti-ctla-4-antistof - Google Patents
Behandling af lungecancer ved hjælp af en kombination af et anti-pd-1-antistof og et anti-ctla-4-antistofInfo
- Publication number
- DK3377534T3 DK3377534T3 DK16819718.4T DK16819718T DK3377534T3 DK 3377534 T3 DK3377534 T3 DK 3377534T3 DK 16819718 T DK16819718 T DK 16819718T DK 3377534 T3 DK3377534 T3 DK 3377534T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibody
- ctla
- treatment
- combination
- lung cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562257139P | 2015-11-18 | 2015-11-18 | |
| US201662345314P | 2016-06-03 | 2016-06-03 | |
| PCT/US2016/062884 WO2017087870A1 (en) | 2015-11-18 | 2016-11-18 | Treatment of lung cancer using a combination of an anti-pd-1 antibody and an anti-ctla-4 antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3377534T3 true DK3377534T3 (da) | 2025-08-18 |
Family
ID=57680484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16819718.4T DK3377534T3 (da) | 2015-11-18 | 2016-11-18 | Behandling af lungecancer ved hjælp af en kombination af et anti-pd-1-antistof og et anti-ctla-4-antistof |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11072657B2 (da) |
| EP (2) | EP4609915A3 (da) |
| JP (3) | JP2018538263A (da) |
| KR (2) | KR20180071386A (da) |
| CN (1) | CN108350081A (da) |
| DK (1) | DK3377534T3 (da) |
| ES (1) | ES3034582T3 (da) |
| FI (1) | FI3377534T3 (da) |
| HR (1) | HRP20250902T1 (da) |
| HU (1) | HUE072729T2 (da) |
| LT (1) | LT3377534T (da) |
| PL (1) | PL3377534T3 (da) |
| PT (1) | PT3377534T (da) |
| RS (1) | RS67037B1 (da) |
| SI (1) | SI3377534T1 (da) |
| SM (1) | SMT202500282T1 (da) |
| TW (3) | TWI821748B (da) |
| WO (1) | WO2017087870A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113967253A (zh) * | 2012-05-15 | 2022-01-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
| TN2017000440A1 (en) * | 2015-04-17 | 2019-04-12 | Bristol Myers Squibb Co | Compositions comprising a combination of an anti-pd-1 antibody and another antibody |
| CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| HRP20250902T1 (hr) * | 2015-11-18 | 2025-09-26 | Bristol-Myers Squibb Company | Liječenje raka pluća korištenjem kombinacije anti‑pd‑1 antitijela i anti‑ctla‑4 antitijela |
| EP4491237A3 (en) * | 2016-10-28 | 2025-03-26 | Bristol-Myers Squibb Company | Methods of treating urothelial carcinoma using an anti-pd-1 antibody |
| US20200239577A1 (en) | 2017-10-15 | 2020-07-30 | Bristol-Myers Squibb Company | Methods of treating tumor |
| CA3081696A1 (en) * | 2017-11-07 | 2019-05-16 | Memorial Sloan Kettering Cancer Center | Inhibition of ctla-4 and/or pd-1 for regulation of t cells |
| EP3774911A1 (en) * | 2018-03-30 | 2021-02-17 | Bristol-Myers Squibb Company | Methods of treating tumor |
| EP3938396A1 (en) * | 2019-03-11 | 2022-01-19 | Jounce Therapeutics, Inc. | Anti-icos antibodies for the treatment of cancer |
| EP3937979A4 (en) * | 2019-03-13 | 2023-03-08 | Merck Sharp & Dohme LLC | COMBINATIONAL ANTI-CANCER THERAPIES WITH CTLA-4 AND PD-1 BLOCKING AGENTS |
| KR20210146348A (ko) * | 2019-03-28 | 2021-12-03 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| CN113891748A (zh) * | 2019-03-28 | 2022-01-04 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
| AR122043A1 (es) * | 2020-05-12 | 2022-08-03 | Bristol Myers Squibb Co | Dosificación y administración del anticuerpo anti-ctla-4 activable |
| US20230295301A1 (en) * | 2020-07-21 | 2023-09-21 | Shanghai Junshi Biosciences Co., Ltd. | Anti-ctla-4 antibody and use thereof |
| WO2022087402A1 (en) | 2020-10-23 | 2022-04-28 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for lung cancer |
| KR20230107309A (ko) | 2020-11-10 | 2023-07-14 | 카탈임 게엠베하 | 항-gdf15 항체 및 암 치료용 투여 용법 |
| EP4294531A4 (en) * | 2021-02-18 | 2025-07-16 | Qilu Puget Sound Biotherapeutics Corp | COMBINATIONS OF ANTI-PD1 AND ANTI-CTLA4 ANTIBODIES |
| WO2024002074A1 (zh) * | 2022-06-28 | 2024-01-04 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| EP1210428B1 (en) | 1999-08-23 | 2015-03-18 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
| IL148079A0 (en) | 1999-08-24 | 2002-09-12 | Medarex Inc | Human ctla-4 antibodies and compositions containing the same |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| EP1261376A1 (en) | 2000-01-27 | 2002-12-04 | Genetics Institute, LLC | Antibodies against ctla4(cd152), conjugates comprising same, and uses thereof |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| CA2647282A1 (en) | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
| WO2009100140A1 (en) * | 2008-02-04 | 2009-08-13 | Medarex, Inc. | Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| CN102203132A (zh) | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂的组合物和使用方法 |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| CA2777226A1 (en) * | 2009-10-12 | 2011-04-21 | Pfizer Inc. | Cancer treatment |
| NZ628923A (en) | 2009-11-24 | 2016-02-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| CA2828940C (en) | 2011-03-10 | 2024-04-16 | Provectus Pharmaceuticals, Inc. | Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer |
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들 |
| HRP20201595T1 (hr) | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| CN113967253A (zh) * | 2012-05-15 | 2022-01-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
| CA2877414A1 (en) * | 2012-07-30 | 2014-02-06 | Alex Wah Hin Yeung | Live and in-vivo tumor specified cancer vaccine system |
| US20150231241A1 (en) * | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| US9789182B2 (en) * | 2012-10-23 | 2017-10-17 | Bristol-Myers Squibb Company | Combination of anti-KIR and anti-CTLA-4 antibodies to treat cancer |
| EA034666B1 (ru) | 2013-09-13 | 2020-03-04 | Бейджин Свитзерланд Гмбх | Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела |
| EP3068425B1 (en) * | 2013-11-11 | 2021-01-27 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| EA201691376A1 (ru) | 2014-02-04 | 2017-01-30 | Пфайзер Инк. | Комбинация антагониста pd-1 и ингибитора vegfr для лечения рака |
| JP2017515859A (ja) | 2014-05-15 | 2017-06-15 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗pd−1抗体と他の抗癌剤の組み合わせを使用する肺癌の処置 |
| CA2955676A1 (en) * | 2014-08-25 | 2016-03-03 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
| US20160362489A1 (en) * | 2015-04-28 | 2016-12-15 | Bristol-Myers Squibb Company | Treatment of PD-L1-Positive Melanoma Using an Anti-PD-1 Antibody |
| CN107735097A (zh) * | 2015-04-30 | 2018-02-23 | 希斯托金公司 | 用于治疗癌症或免疫性疾病的细胞外基质组合物 |
| WO2016191751A1 (en) | 2015-05-28 | 2016-12-01 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
| JP2018522887A (ja) * | 2015-07-14 | 2018-08-16 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 免疫チェックポイント阻害剤を使用する癌の処置法 |
| HRP20250902T1 (hr) * | 2015-11-18 | 2025-09-26 | Bristol-Myers Squibb Company | Liječenje raka pluća korištenjem kombinacije anti‑pd‑1 antitijela i anti‑ctla‑4 antitijela |
| WO2017132508A1 (en) | 2016-01-27 | 2017-08-03 | Bristol-Myers Squibb Company | Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
| MA44483A (fr) * | 2016-03-24 | 2019-01-30 | Millennium Pharm Inc | Procédés pour traiter des événements indésirables gastro-intestinaux d'origine immunitaire dans des traitements oncologiques immunitaires |
| WO2017176925A1 (en) | 2016-04-05 | 2017-10-12 | Bristol-Myers Squibb Company | Cytokine profiling analysis for predicting prognosis of a patient in need of an anti-cancer treatment |
| WO2017210631A1 (en) | 2016-06-03 | 2017-12-07 | Bristol-Myers Squibb Company | Anti-pd-1 antibody for use in a method of treatment of recurrent small cell lung cancer |
| WO2017210624A1 (en) | 2016-06-03 | 2017-12-07 | Bristol-Myers Squibb Company | Anti-pd-1 antibody for use in a method of treating a tumor |
| EP3774911A1 (en) * | 2018-03-30 | 2021-02-17 | Bristol-Myers Squibb Company | Methods of treating tumor |
| JP2022505647A (ja) * | 2018-10-23 | 2022-01-14 | ブリストル-マイヤーズ スクイブ カンパニー | 腫瘍の処置方法 |
-
2016
- 2016-11-18 HR HRP20250902TT patent/HRP20250902T1/hr unknown
- 2016-11-18 RS RS20250733A patent/RS67037B1/sr unknown
- 2016-11-18 TW TW110135114A patent/TWI821748B/zh active
- 2016-11-18 JP JP2018525653A patent/JP2018538263A/ja active Pending
- 2016-11-18 FI FIEP16819718.4T patent/FI3377534T3/fi active
- 2016-11-18 EP EP25175265.5A patent/EP4609915A3/en active Pending
- 2016-11-18 TW TW105137906A patent/TWI795347B/zh active
- 2016-11-18 ES ES16819718T patent/ES3034582T3/es active Active
- 2016-11-18 CN CN201680067708.6A patent/CN108350081A/zh active Pending
- 2016-11-18 SM SM20250282T patent/SMT202500282T1/it unknown
- 2016-11-18 SI SI201631913T patent/SI3377534T1/sl unknown
- 2016-11-18 DK DK16819718.4T patent/DK3377534T3/da active
- 2016-11-18 LT LTEPPCT/US2016/062884T patent/LT3377534T/lt unknown
- 2016-11-18 TW TW112125457A patent/TWI912619B/zh active
- 2016-11-18 HU HUE16819718A patent/HUE072729T2/hu unknown
- 2016-11-18 PT PT168197184T patent/PT3377534T/pt unknown
- 2016-11-18 US US15/776,732 patent/US11072657B2/en active Active
- 2016-11-18 PL PL16819718.4T patent/PL3377534T3/pl unknown
- 2016-11-18 KR KR1020187016632A patent/KR20180071386A/ko not_active Ceased
- 2016-11-18 EP EP16819718.4A patent/EP3377534B1/en active Active
- 2016-11-18 KR KR1020267001897A patent/KR20260020215A/ko active Pending
- 2016-11-18 WO PCT/US2016/062884 patent/WO2017087870A1/en not_active Ceased
-
2021
- 2021-07-26 US US17/385,636 patent/US12528865B2/en active Active
-
2022
- 2022-02-25 JP JP2022027793A patent/JP2022068352A/ja active Pending
-
2024
- 2024-11-29 JP JP2024207937A patent/JP2025029025A/ja active Pending
-
2025
- 2025-01-16 US US19/025,586 patent/US20250154257A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20180371092A1 (en) | 2018-12-27 |
| RS67037B1 (sr) | 2025-08-29 |
| US11072657B2 (en) | 2021-07-27 |
| HRP20250902T1 (hr) | 2025-09-26 |
| TW202227132A (zh) | 2022-07-16 |
| PL3377534T3 (pl) | 2025-09-01 |
| EP3377534A1 (en) | 2018-09-26 |
| PT3377534T (pt) | 2025-07-10 |
| SMT202500282T1 (it) | 2025-09-12 |
| EP4609915A3 (en) | 2025-11-19 |
| FI3377534T3 (fi) | 2025-08-22 |
| TW201731527A (zh) | 2017-09-16 |
| TWI821748B (zh) | 2023-11-11 |
| KR20180071386A (ko) | 2018-06-27 |
| WO2017087870A1 (en) | 2017-05-26 |
| KR20260020215A (ko) | 2026-02-10 |
| JP2018538263A (ja) | 2018-12-27 |
| US20250154257A1 (en) | 2025-05-15 |
| US12528865B2 (en) | 2026-01-20 |
| ES3034582T3 (en) | 2025-08-20 |
| EP4609915A2 (en) | 2025-09-03 |
| TWI912619B (zh) | 2026-01-21 |
| TW202408573A (zh) | 2024-03-01 |
| JP2025029025A (ja) | 2025-03-05 |
| SI3377534T1 (sl) | 2025-09-30 |
| LT3377534T (lt) | 2025-08-11 |
| US20220017619A1 (en) | 2022-01-20 |
| CN108350081A (zh) | 2018-07-31 |
| JP2022068352A (ja) | 2022-05-09 |
| TWI795347B (zh) | 2023-03-11 |
| EP3377534B1 (en) | 2025-06-18 |
| HUE072729T2 (hu) | 2025-12-28 |
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