DK3378862T3 - Dihydropyrimidinoisoquinolinoner og farmaceutiske sammensætninger deraf til behandlingen af multipel sklerose - Google Patents

Dihydropyrimidinoisoquinolinoner og farmaceutiske sammensætninger deraf til behandlingen af multipel sklerose Download PDF

Info

Publication number: DK3378862T3
Authority: DK; Denmark
Prior art keywords: dihydropyrimidinoisoquinolinons; treatment; pharmaceutical compositions; multiple sclerosis; sclerosis
Prior art date: 2011-12-22

Application number

DK17184834.4T

Other languages

English (en)

Inventor

Frédéric Gilbert Labéguère

Gregory John Robert Newsome

Luke Jonathan Alvey

Laurent Raymond Maurice Sanière

Stephen Robert Fletcher

Original Assignee

Galapagos Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-22

Filing date

2012-12-20

Publication date

2022-04-11

2012-12-20 Application filed by Galapagos Nv filed Critical Galapagos Nv

2022-04-11 Application granted granted Critical

2022-04-11 Publication of DK3378862T3 publication Critical patent/DK3378862T3/da

Links

201000006417 multiple sclerosis Diseases 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK17184834.4T 2011-12-22 2012-12-20 Dihydropyrimidinoisoquinolinoner og farmaceutiske sammensætninger deraf til behandlingen af multipel sklerose DK3378862T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161578979P	2011-12-22	2011-12-22
EP12812237.1A EP2794604B1 (en)	2011-12-22	2012-12-20	Novel dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Publications (1)

Publication Number	Publication Date
DK3378862T3 true DK3378862T3 (da)	2022-04-11

Family

ID=47520068

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK12812237.1T DK2794604T3 (da)	2011-12-22	2012-12-20	Hidtil ukendte dihydropyrimidinoisoquinolinoner og farmaceutiske sammensætninger deraf til behandlingen af inflammatoriske lidelse
DK17184834.4T DK3378862T3 (da)	2011-12-22	2012-12-20	Dihydropyrimidinoisoquinolinoner og farmaceutiske sammensætninger deraf til behandlingen af multipel sklerose

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK12812237.1T DK2794604T3 (da)	2011-12-22	2012-12-20	Hidtil ukendte dihydropyrimidinoisoquinolinoner og farmaceutiske sammensætninger deraf til behandlingen af inflammatoriske lidelse

Country Status (34)

Country	Link
US (5)	US8927543B2 (da)
EP (3)	EP2794604B1 (da)
JP (1)	JP6062453B2 (da)
KR (1)	KR102012268B1 (da)
CN (1)	CN103998448B (da)
AR (1)	AR089284A1 (da)
AU (1)	AU2012357067B2 (da)
BR (1)	BR112014015142B1 (da)
CA (1)	CA2859578C (da)
CL (1)	CL2014001664A1 (da)
CO (1)	CO7010835A2 (da)
CR (1)	CR20140305A (da)
CY (2)	CY1119434T1 (da)
DK (2)	DK2794604T3 (da)
EA (1)	EA023826B1 (da)
ES (2)	ES2911449T3 (da)
HR (2)	HRP20171404T1 (da)
HU (1)	HUE12812237T4 (da)
IL (2)	IL233212B (da)
IN (1)	IN2014MN01033A (da)
LT (2)	LT2794604T (da)
MX (1)	MX351681B (da)
NI (1)	NI201400060A (da)
PE (1)	PE20141685A1 (da)
PH (1)	PH12014501178B1 (da)
PL (2)	PL2794604T3 (da)
PT (2)	PT2794604T (da)
SG (1)	SG11201403169PA (da)
SI (2)	SI2794604T1 (da)
TW (1)	TWI567073B (da)
UA (1)	UA111767C2 (da)
UY (1)	UY34545A (da)
WO (1)	WO2013092791A1 (da)
ZA (1)	ZA201404607B (da)

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AR089284A1 (es)	2011-12-22	2014-08-13	Galapagos Nv	Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios
SG10201610936RA (en)	2011-12-22	2017-02-27	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9708312B2 (en)	2012-12-20	2017-07-18	Galapagos Nv	Dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders (GPR84 antagonists)
GB201319677D0 (en) *	2013-11-07	2013-12-25	Eth Z Rich	Cyclopropanation
GB201411241D0 (en) *	2014-06-25	2014-08-06	Galapagos Nv	Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201506894D0 (en) *	2015-04-23	2015-06-10	Galapagos Nv	Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
US11098071B2 (en)	2017-03-06	2021-08-24	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	GPR84 receptor antagonist and use thereof
EP3403649A1 (en)	2017-05-16	2018-11-21	Bayer Pharma Aktiengesellschaft	Inhibitors and antagonists of gpr84 for the treatment of endometriosis
CN111343986A (zh)	2017-11-15	2020-06-26	加拉帕戈斯股份有限公司	用于治疗纤维化疾病的化合物及其药物组合物
GEP20247585B (en)	2019-12-19	2024-01-25	Bayer Ag	Furoindazole derivatives
WO2021123394A1 (en)	2019-12-20	2021-06-24	University Of Copenhagen	G protein-coupled receptor modulators and a pharmaceutical composition
JP2023553295A (ja)	2020-11-24	2023-12-21	ガラパゴス・ナムローゼ・フェンノートシャップ	線維性疾患の治療における使用のための化合物及び線維性疾患の治療方法
JP2024506858A (ja)	2021-02-02	2024-02-15	リミナル・バイオサイエンシーズ・リミテッド	Ｇｐｒ８４アンタゴニストおよびその使用
KR20230153387A (ko)	2021-02-02	2023-11-06	리미널 바이오사이언시스 리미티드	Gpr84 길항제 및 이의 용도
CA3211437A1 (en)	2021-02-23	2022-09-01	Bayer Aktiengesellschaft	Furoindazole derivatives as gpr84 antagonists
CN115109072A (zh) *	2021-03-18	2022-09-27	武汉人福创新药物研发中心有限公司	一种gpr84拮抗剂及其制备方法和用途
WO2022218372A1 (zh) *	2021-04-14	2022-10-20	武汉人福创新药物研发中心有限公司	一种二氢嘧啶并异喹啉酮类衍生物及用途
US20240239804A1 (en)	2021-04-29	2024-07-18	Bayer Aktiengesellschaft	Furoindazole derivatives as antagonists or inhibitors of gpr84
EP4355743A1 (en)	2021-06-18	2024-04-24	University of Copenhagen	Polysubstituted 4-hydroxypyridine and 4-hydroxyquinoline derivatives as gpr84 antagonists
EP4361151A4 (en) *	2021-06-21	2025-06-11	Wuhan Humanwell Innovative Drug Research and Development Center Limited Company	Tricyclic compound as a GPR84 antagonist
CN115611944A (zh)	2021-07-15	2023-01-17	中国科学院上海药物研究所	不对称gpr84拮抗剂及其用途
WO2023076668A1 (en) *	2021-10-29	2023-05-04	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Compositions and methods for treatment of cancer
GB202202297D0 (en)	2022-02-21	2022-04-06	Verona Pharma Plc	Formulation production process
WO2024083705A1 (en)	2022-10-18	2024-04-25	Bayer Aktiengesellschaft	Furoindazole derivatives for the treatment of pain
CN120569392A (zh) *	2022-12-30	2025-08-29	广州市联瑞制药有限公司	三环类化合物及其制备方法和应用
EP4698177A2 (en) *	2023-04-17	2026-02-25	The Board of Trustees of the Leland Stanford Junior University	Method for detecting innate immune action in vivo using gpr84-pet
CN121620356A (zh)	2023-06-26	2026-03-06	维罗纳制药公司	包含恩塞芬汀的颗粒组合物

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WO2005050225A2 (en)	2003-10-31	2005-06-02	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 84 (gpr84)
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JP2011088847A (ja) *	2009-10-21	2011-05-06	Takeda Chem Ind Ltd	三環性化合物およびその用途
AR089284A1 (es)	2011-12-22	2014-08-13	Galapagos Nv	Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios
MY170922A (en)	2011-12-22	2019-09-18	Novartis Ag	Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
MY192815A (en)	2011-12-22	2022-09-09	Connexios Life Sciences Pvt Ltd	Derivatives of aza adamantanes and uses thereof
AU2012372019B2 (en)	2011-12-22	2017-06-15	Connexios Life Sciences Pvt. Ltd.	Cyclic amide derivatives as inhibitors of 11 - beta - hydroxysteroid dehydrogenase and uses thereof
US9708312B2 (en)	2012-12-20	2017-07-18	Galapagos Nv	Dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders (GPR84 antagonists)

2012
- 2012-12-17 AR ARP120104774A patent/AR089284A1/es active IP Right Grant
- 2012-12-20 EA EA201491245A patent/EA023826B1/ru not_active IP Right Cessation
- 2012-12-20 BR BR112014015142-3A patent/BR112014015142B1/pt not_active IP Right Cessation
- 2012-12-20 PL PL12812237T patent/PL2794604T3/pl unknown
- 2012-12-20 PL PL17184834T patent/PL3378862T3/pl unknown
- 2012-12-20 US US13/721,788 patent/US8927543B2/en active Active
- 2012-12-20 JP JP2014547997A patent/JP6062453B2/ja not_active Expired - Fee Related
- 2012-12-20 PT PT128122371T patent/PT2794604T/pt unknown
- 2012-12-20 DK DK12812237.1T patent/DK2794604T3/da active
- 2012-12-20 SG SG11201403169PA patent/SG11201403169PA/en unknown
- 2012-12-20 AU AU2012357067A patent/AU2012357067B2/en not_active Ceased
- 2012-12-20 IN IN1033MUN2014 patent/IN2014MN01033A/en unknown
- 2012-12-20 SI SI201231087T patent/SI2794604T1/sl unknown
- 2012-12-20 HR HRP20171404TT patent/HRP20171404T1/hr unknown
- 2012-12-20 TW TW101148765A patent/TWI567073B/zh not_active IP Right Cessation
- 2012-12-20 EP EP12812237.1A patent/EP2794604B1/en active Active
- 2012-12-20 PT PT171848344T patent/PT3378862T/pt unknown
- 2012-12-20 HU HUE12812237A patent/HUE12812237T4/hu unknown
- 2012-12-20 DK DK17184834.4T patent/DK3378862T3/da active
- 2012-12-20 ES ES17184834T patent/ES2911449T3/es active Active
- 2012-12-20 HR HRP20220456TT patent/HRP20220456T1/hr unknown
- 2012-12-20 KR KR1020147020306A patent/KR102012268B1/ko not_active Expired - Fee Related
- 2012-12-20 EP EP22155038.7A patent/EP4019519A1/en not_active Withdrawn
- 2012-12-20 MX MX2014007363A patent/MX351681B/es active IP Right Grant
- 2012-12-20 PE PE2014000988A patent/PE20141685A1/es active IP Right Grant
- 2012-12-20 CA CA2859578A patent/CA2859578C/en active Active
- 2012-12-20 EP EP17184834.4A patent/EP3378862B1/en active Active
- 2012-12-20 SI SI201231991T patent/SI3378862T1/sl unknown
- 2012-12-20 WO PCT/EP2012/076275 patent/WO2013092791A1/en not_active Ceased
- 2012-12-20 CN CN201280061536.3A patent/CN103998448B/zh not_active Expired - Fee Related
- 2012-12-20 LT LTEP12812237.1T patent/LT2794604T/lt unknown
- 2012-12-20 UA UAA201408294A patent/UA111767C2/uk unknown
- 2012-12-20 LT LTEP17184834.4T patent/LT3378862T/lt unknown
- 2012-12-20 ES ES12812237.1T patent/ES2643379T3/es active Active
- 2012-12-21 UY UY0001034545A patent/UY34545A/es unknown
2014
- 2014-01-06 US US14/148,057 patent/US9255095B2/en active Active
- 2014-05-26 PH PH12014501178A patent/PH12014501178B1/en unknown
- 2014-06-18 IL IL233212A patent/IL233212B/en active IP Right Grant
- 2014-06-19 NI NI201400060A patent/NI201400060A/es unknown
- 2014-06-20 CL CL2014001664A patent/CL2014001664A1/es unknown
- 2014-06-23 ZA ZA2014/04607A patent/ZA201404607B/en unknown
- 2014-06-24 CR CR20140305A patent/CR20140305A/es unknown
- 2014-07-22 CO CO14158655A patent/CO7010835A2/es unknown
2015
- 2015-12-11 US US14/966,879 patent/US10047083B2/en active Active
2017
- 2017-10-11 CY CY20171101053T patent/CY1119434T1/el unknown
2018
- 2018-02-18 IL IL257581A patent/IL257581A/en unknown
- 2018-05-04 US US15/971,245 patent/US11220499B2/en active Active
2021
- 2021-11-12 US US17/454,712 patent/US20220227751A1/en not_active Abandoned
2022
- 2022-04-18 CY CY20221100292T patent/CY1125167T1/el unknown

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ZA201404607B (en)	2020-02-26
BR112014015142B1 (pt)	2022-03-29
IL257581A (en)	2018-04-30
NZ626473A (en)	2016-03-31
MX2014007363A (es)	2014-08-01
HRP20220456T1 (hr)	2022-05-27
EP2794604A1 (en)	2014-10-29
US20220227751A1 (en)	2022-07-21
HRP20171404T1 (hr)	2017-11-17
PH12014501178A1 (en)	2014-10-20
SG11201403169PA (en)	2014-07-30
PL3378862T3 (pl)	2022-05-16
CO7010835A2 (es)	2014-07-31
PE20141685A1 (es)	2014-11-25
UY34545A (es)	2013-07-31
DK2794604T3 (da)	2017-11-06
LT2794604T (lt)	2017-10-25
CA2859578C (en)	2020-03-10
CY1125167T1 (el)	2024-09-20
HK1201528A1 (en)	2015-09-04
PL2794604T3 (pl)	2017-12-29
JP2015500861A (ja)	2015-01-08
CY1119434T1 (el)	2018-03-07
IL233212B (en)	2018-03-29
EP3378862A1 (en)	2018-09-26
US8927543B2 (en)	2015-01-06
SI2794604T1 (sl)	2017-12-29
AU2012357067B2 (en)	2017-01-05
KR102012268B1 (ko)	2019-08-21
NI201400060A (es)	2015-04-27
EP2794604B1 (en)	2017-09-13
WO2013092791A1 (en)	2013-06-27
US10047083B2 (en)	2018-08-14
US11220499B2 (en)	2022-01-11
PT2794604T (pt)	2017-10-23
CR20140305A (es)	2014-07-23
ES2643379T9 (es)	2018-01-05
HUE12812237T4 (hu)	2017-12-28
EA023826B1 (ru)	2016-07-29
CL2014001664A1 (es)	2014-10-03
EA201491245A1 (ru)	2014-10-30
TWI567073B (zh)	2017-01-21
US20130165437A1 (en)	2013-06-27
EP4019519A1 (en)	2022-06-29
US20140121204A1 (en)	2014-05-01
JP6062453B2 (ja)	2017-01-18
BR112014015142A2 (pt)	2017-06-13
TW201331201A (zh)	2013-08-01
LT3378862T (lt)	2022-04-25
AU2012357067A1 (en)	2014-07-10
US9255095B2 (en)	2016-02-09
ES2643379T3 (es)	2017-11-22
IL233212A0 (en)	2014-08-31
IN2014MN01033A (da)	2015-05-01
UA111767C2 (uk)	2016-06-10
KR20140117427A (ko)	2014-10-07
SI3378862T1 (sl)	2022-05-31
CN103998448B (zh)	2016-04-20
ES2911449T3 (es)	2022-05-19
US20160244442A1 (en)	2016-08-25
CN103998448A (zh)	2014-08-20
CA2859578A1 (en)	2013-06-27
MX351681B (es)	2017-10-25
PH12014501178B1 (en)	2014-10-20
PT3378862T (pt)	2022-04-11
AR089284A1 (es)	2014-08-13
EP3378862B1 (en)	2022-03-16
US20190002458A1 (en)	2019-01-03

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