DK342189A - Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved - Google Patents

Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved Download PDF

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Publication number
DK342189A
DK342189A DK342189A DK342189A DK342189A DK 342189 A DK342189 A DK 342189A DK 342189 A DK342189 A DK 342189A DK 342189 A DK342189 A DK 342189A DK 342189 A DK342189 A DK 342189A
Authority
DK
Denmark
Prior art keywords
beta
arabinofuranosyl
anhydro
thymine
intermediates
Prior art date
Application number
DK342189A
Other languages
Danish (da)
English (en)
Other versions
DK342189D0 (da
Inventor
Charles William Murtiashaw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK342189D0 publication Critical patent/DK342189D0/da
Publication of DK342189A publication Critical patent/DK342189A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK342189A 1988-07-12 1989-07-11 Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved DK342189A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/217,906 US5008384A (en) 1988-07-12 1988-07-12 Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (2)

Publication Number Publication Date
DK342189D0 DK342189D0 (da) 1989-07-11
DK342189A true DK342189A (da) 1990-01-15

Family

ID=22812966

Family Applications (1)

Application Number Title Priority Date Filing Date
DK342189A DK342189A (da) 1988-07-12 1989-07-11 Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved

Country Status (21)

Country Link
US (1) US5008384A (fr)
EP (1) EP0351126B1 (fr)
JP (1) JPH075626B2 (fr)
KR (1) KR910008112B1 (fr)
CN (1) CN1039423A (fr)
AT (1) ATE117314T1 (fr)
AU (1) AU603042B2 (fr)
CA (1) CA1315776C (fr)
DD (2) DD284024A5 (fr)
DE (1) DE68920648T2 (fr)
DK (1) DK342189A (fr)
ES (1) ES2066853T3 (fr)
FI (1) FI893364A7 (fr)
GR (1) GR3015293T3 (fr)
HU (1) HUT50843A (fr)
IE (1) IE65735B1 (fr)
IL (1) IL90884A0 (fr)
NO (1) NO892821L (fr)
PT (1) PT91113B (fr)
YU (1) YU138789A (fr)
ZA (1) ZA895259B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065350B2 (ja) * 1990-11-30 2000-07-17 ヤマサ醤油株式会社 １―（２，３―ジデオキシ―β―Ｄ―グリセロ―ペント―２―エノフラノシル）チミンの製造法
EP0683171B1 (fr) * 1994-05-20 1998-12-23 Council of Scientific and Industrial Research Procédé pour la préparation de bêta-thymidine
CN102241720B (zh) 2000-11-29 2014-01-29 三井化学株式会社 L-核酸衍生物及其合成方法
IL158185A0 (en) * 2001-03-30 2004-03-28 Triangle Pharmaceuticals Inc PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDES
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
KR20060015542A (ko) 2003-04-28 2006-02-17 이데닉스 (케이만) 리미티드 산업 규모의 뉴클레오시드 합성
US20050059632A1 (en) 2003-06-30 2005-03-17 Richard Storer Synthesis of beta-L-2'-deoxy nucleosides
US20090018325A1 (en) 2006-03-15 2009-01-15 Jacques Cercus Process for preparing l-nucleic acid derivatives and intermediates thereof
WO2009114325A2 (fr) 2008-03-03 2009-09-17 Tosk, Incorporated Adjuvants pour réduire la toxicité du méthotrexate, et procédés d'utilisation
US11446303B2 (en) 2019-06-21 2022-09-20 Tosk, Inc. Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3463850A (en) * 1967-01-03 1969-08-26 Merck & Co Inc Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3812098A (en) * 1970-03-19 1974-05-21 Syntex Inc O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3709874A (en) * 1970-03-19 1973-01-09 Syntex Corp 1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) * 1971-04-15 1977-02-07 Asahi Chemical Ind 2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) * 1975-01-31 1976-08-31 The Upjohn Company Process for preparing cyclocytidine derivatives
US4140850A (en) * 1977-08-29 1979-02-20 The Upjohn Company 2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) * 1979-09-28 1981-05-02 Yamasa Shoyu Co Ltd Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) * 1986-06-26 1988-01-12 Sharp Corp 微細パタ−ン形成方法

Also Published As

Publication number Publication date
DE68920648D1 (de) 1995-03-02
NO892821D0 (no) 1989-07-07
AU603042B2 (en) 1990-11-01
YU138789A (en) 1990-12-31
ZA895259B (en) 1991-02-27
ES2066853T3 (es) 1995-03-16
DK342189D0 (da) 1989-07-11
DD292003A5 (de) 1991-07-18
JPH0259598A (ja) 1990-02-28
EP0351126A3 (en) 1990-10-24
JPH075626B2 (ja) 1995-01-25
CN1039423A (zh) 1990-02-07
EP0351126A2 (fr) 1990-01-17
HUT50843A (en) 1990-03-28
KR910008112B1 (ko) 1991-10-10
CA1315776C (fr) 1993-04-06
PT91113B (pt) 1995-01-31
EP0351126B1 (fr) 1995-01-18
FI893364A0 (fi) 1989-07-11
IE892233L (en) 1990-01-12
KR900001704A (ko) 1990-02-27
ATE117314T1 (de) 1995-02-15
FI893364A7 (fi) 1990-01-13
DD284024A5 (de) 1990-10-31
IE65735B1 (en) 1995-11-15
IL90884A0 (en) 1990-02-09
DE68920648T2 (de) 1995-05-18
US5008384A (en) 1991-04-16
PT91113A (pt) 1990-02-08
GR3015293T3 (en) 1995-06-30
AU3802089A (en) 1990-04-26
NO892821L (no) 1990-01-15

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