IL90884A0 - Process for the production of o2 2'-anhydro-1-(beta-d-arabinofuranosyl)thymine - Google Patents

Process for the production of o2 2'-anhydro-1-(beta-d-arabinofuranosyl)thymine

Info

Publication number: IL90884A0
Authority: IL; Israel
Prior art keywords: beta; arabinofuranosyl; anhydro; thymine; production
Prior art date: 1988-07-12

Application number

IL90884A

Other languages

English (en)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-12

Filing date

1989-07-05

Publication date

1990-02-09

1989-07-05 Application filed by Pfizer filed Critical Pfizer

1990-02-09 Publication of IL90884A0 publication Critical patent/IL90884A0/xx

Links

ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
YAXGBZDYGZBRBQ-UHFFFAOYSA-N 4,5-dihydro-1,3-oxazol-2-amine Chemical class NC1=NCCO1 YAXGBZDYGZBRBQ-UHFFFAOYSA-N 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

IL90884A 1988-07-12 1989-07-05 Process for the production of o2 2'-anhydro-1-(beta-d-arabinofuranosyl)thymine IL90884A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/217,906 US5008384A (en)	1988-07-12	1988-07-12	Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (1)

Publication Number	Publication Date
IL90884A0 true IL90884A0 (en)	1990-02-09

Family

ID=22812966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL90884A IL90884A0 (en)	1988-07-12	1989-07-05	Process for the production of o2 2'-anhydro-1-(beta-d-arabinofuranosyl)thymine

Country Status (21)

Country	Link
US (1)	US5008384A (fr)
EP (1)	EP0351126B1 (fr)
JP (1)	JPH075626B2 (fr)
KR (1)	KR910008112B1 (fr)
CN (1)	CN1039423A (fr)
AT (1)	ATE117314T1 (fr)
AU (1)	AU603042B2 (fr)
CA (1)	CA1315776C (fr)
DD (2)	DD284024A5 (fr)
DE (1)	DE68920648T2 (fr)
DK (1)	DK342189A (fr)
ES (1)	ES2066853T3 (fr)
FI (1)	FI893364A7 (fr)
GR (1)	GR3015293T3 (fr)
HU (1)	HUT50843A (fr)
IE (1)	IE65735B1 (fr)
IL (1)	IL90884A0 (fr)
NO (1)	NO892821L (fr)
PT (1)	PT91113B (fr)
YU (1)	YU138789A (fr)
ZA (1)	ZA895259B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3065350B2 (ja) *	1990-11-30	2000-07-17	ヤマサ醤油株式会社	１―（２，３―ジデオキシ―β―Ｄ―グリセロ―ペント―２―エノフラノシル）チミンの製造法
EP0683171B1 (fr) *	1994-05-20	1998-12-23	Council of Scientific and Industrial Research	Procédé pour la préparation de bêta-thymidine
CN102241720B (zh)	2000-11-29	2014-01-29	三井化学株式会社	L-核酸衍生物及其合成方法
IL158185A0 (en) *	2001-03-30	2004-03-28	Triangle Pharmaceuticals Inc	PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDES
DE10216426A1 (de) *	2002-04-12	2003-10-23	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
KR20060015542A (ko)	2003-04-28	2006-02-17	이데닉스 (케이만) 리미티드	산업 규모의 뉴클레오시드 합성
US20050059632A1 (en)	2003-06-30	2005-03-17	Richard Storer	Synthesis of beta-L-2'-deoxy nucleosides
US20090018325A1 (en)	2006-03-15	2009-01-15	Jacques Cercus	Process for preparing l-nucleic acid derivatives and intermediates thereof
WO2009114325A2 (fr)	2008-03-03	2009-09-17	Tosk, Incorporated	Adjuvants pour réduire la toxicité du méthotrexate, et procédés d'utilisation
US11446303B2 (en)	2019-06-21	2022-09-20	Tosk, Inc.	Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3322747A (en) *	1965-04-01	1967-05-30	Merck & Co Inc	Thionocarbonate nucleosides
US3463850A (en) *	1967-01-03	1969-08-26	Merck & Co Inc	Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) *	1969-06-06	1972-04-25	Salk Inst For Biological Studi	Aminooxazolines and products thereof and processes for synthesizing same
US3792040A (en) *	1970-03-19	1974-02-12	Syntex Corp	Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3812098A (en) *	1970-03-19	1974-05-21	Syntex Inc	O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3709874A (en) *	1970-03-19	1973-01-09	Syntex Corp	1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3920630A (en) *	1970-09-24	1975-11-18	Upjohn Co	2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) *	1971-04-15	1977-02-07	Asahi Chemical Ind	2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) *	1975-01-31	1976-08-31	The Upjohn Company	Process for preparing cyclocytidine derivatives
US4140850A (en) *	1977-08-29	1979-02-20	The Upjohn Company	2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) *	1979-09-28	1981-05-02	Yamasa Shoyu Co Ltd	Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) *	1986-06-26	1988-01-12	Sharp Corp	微細パタ−ン形成方法

1988
- 1988-07-12 US US07/217,906 patent/US5008384A/en not_active Expired - Lifetime
1989
- 1989-07-05 AT AT89306820T patent/ATE117314T1/de not_active IP Right Cessation
- 1989-07-05 DE DE68920648T patent/DE68920648T2/de not_active Expired - Fee Related
- 1989-07-05 ES ES89306820T patent/ES2066853T3/es not_active Expired - Lifetime
- 1989-07-05 EP EP89306820A patent/EP0351126B1/fr not_active Expired - Lifetime
- 1989-07-05 IL IL90884A patent/IL90884A0/xx unknown
- 1989-07-07 NO NO89892821A patent/NO892821L/no unknown
- 1989-07-10 JP JP1177876A patent/JPH075626B2/ja not_active Expired - Fee Related
- 1989-07-10 CN CN89104789A patent/CN1039423A/zh active Pending
- 1989-07-10 PT PT91113A patent/PT91113B/pt not_active IP Right Cessation
- 1989-07-10 CA CA000605243A patent/CA1315776C/fr not_active Expired - Fee Related
- 1989-07-11 HU HU893491A patent/HUT50843A/hu unknown
- 1989-07-11 FI FI893364A patent/FI893364A7/fi not_active Application Discontinuation
- 1989-07-11 ZA ZA895259A patent/ZA895259B/xx unknown
- 1989-07-11 DK DK342189A patent/DK342189A/da not_active Application Discontinuation
- 1989-07-11 DD DD89330684A patent/DD284024A5/de not_active IP Right Cessation
- 1989-07-11 YU YU01387/89A patent/YU138789A/xx unknown
- 1989-07-11 KR KR1019890009853A patent/KR910008112B1/ko not_active Expired
- 1989-07-11 DD DD89337873A patent/DD292003A5/de not_active IP Right Cessation
- 1989-07-11 AU AU38020/89A patent/AU603042B2/en not_active Ceased
- 1989-07-11 IE IE223389A patent/IE65735B1/en not_active IP Right Cessation
1995
- 1995-03-03 GR GR950400471T patent/GR3015293T3/el unknown

Also Published As

Publication number	Publication date
DE68920648D1 (de)	1995-03-02
NO892821D0 (no)	1989-07-07
AU603042B2 (en)	1990-11-01
YU138789A (en)	1990-12-31
ZA895259B (en)	1991-02-27
ES2066853T3 (es)	1995-03-16
DK342189D0 (da)	1989-07-11
DD292003A5 (de)	1991-07-18
JPH0259598A (ja)	1990-02-28
EP0351126A3 (en)	1990-10-24
JPH075626B2 (ja)	1995-01-25
CN1039423A (zh)	1990-02-07
EP0351126A2 (fr)	1990-01-17
HUT50843A (en)	1990-03-28
KR910008112B1 (ko)	1991-10-10
CA1315776C (fr)	1993-04-06
PT91113B (pt)	1995-01-31
EP0351126B1 (fr)	1995-01-18
FI893364A0 (fi)	1989-07-11
IE892233L (en)	1990-01-12
KR900001704A (ko)	1990-02-27
ATE117314T1 (de)	1995-02-15
FI893364A7 (fi)	1990-01-13
DD284024A5 (de)	1990-10-31
IE65735B1 (en)	1995-11-15
DE68920648T2 (de)	1995-05-18
US5008384A (en)	1991-04-16
PT91113A (pt)	1990-02-08
GR3015293T3 (en)	1995-06-30
DK342189A (da)	1990-01-15
AU3802089A (en)	1990-04-26
NO892821L (no)	1990-01-15

Publication	Publication Date	Title
ATE67497T1 (de)	1991-10-15	Verfahren zur herstellung von thiazolidinedionderivaten.
ATE96426T1 (de)	1993-11-15	Diphenylharnstoffderivate.
SE8302694D0 (sv)	1983-05-10	Immunomodulating agent
ZA895259B (en)	1991-02-27	Process for the production of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)thymine
IT1225484B (it)	1990-11-14	Procedimento di sintesi dell'amikacina
PT85035A (en)	1987-07-01	Process for preparing antiallergy and antiinflammatory agents of benzoxazolones of analogs
DE69410073D1 (de)	1998-06-10	Verfahren zur Herstellung von 2-Perfluoroalkyl-3-oxazolin-5-one
IL102884A0 (en)	1993-01-31	Method and intermediates for the preparation of 6-flurobenz-isothiazoles
DE3851783D1 (de)	1994-11-17	Verfahren zur Herstellung von 6-[D(-)-alpha-(4-Äthyl-2,3-dioxo-1-piperazin-carboxamido)-phenylacetamido]penicillansäure.
GB2200116B (en)	1991-06-12	Process for preparing thiazolobenzimidazoles and intermediates used therein
FI872135A0 (fi)	1987-05-14	Foerfarande foer framstaellning av kefalosporinderivat.
BR8005509A (pt)	1981-03-10	Processo de preparacao de compostos
DK0557519T3 (da)	1997-06-23	Fremgangsmåde til fremstilling af sulfonamidderivater af norbornan
DK33187A (da)	1987-07-24	Bicycliske forbindelser
KR830006284A (ko)	1983-09-20	5-치환된 옥사졸리딘-2,4-디온의 제조방법