DK357589A - Glycoprotein, dna-sekvens kodende derfor, replikerbart kloningshjaelpemiddel, farmaceutisk praeparat indeholdende glycoproteinet og fremgangsmaade til rensning af glycoprotein - Google Patents

Glycoprotein, dna-sekvens kodende derfor, replikerbart kloningshjaelpemiddel, farmaceutisk praeparat indeholdende glycoproteinet og fremgangsmaade til rensning af glycoprotein Download PDF

Info

Publication number
DK357589A
DK357589A DK357589A DK357589A DK357589A DK 357589 A DK357589 A DK 357589A DK 357589 A DK357589 A DK 357589A DK 357589 A DK357589 A DK 357589A DK 357589 A DK357589 A DK 357589A
Authority
DK
Denmark
Prior art keywords
glycoprotein
dna sequence
aid
procedure
purifying
Prior art date
Application number
DK357589A
Other languages
English (en)
Other versions
DK357589D0 (da
DK176140B1 (da
Inventor
Le Thi Duong
Paul A Friedman
Stephen J Gardell
John W Jacobs
Richard A F Dixon
Bruce L Daugherty
George E Mark
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK357589D0 publication Critical patent/DK357589D0/da
Publication of DK357589A publication Critical patent/DK357589A/da
Application granted granted Critical
Publication of DK176140B1 publication Critical patent/DK176140B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK198903575A 1988-07-20 1989-07-19 Flagermusspyt-plasminogenaktivatorer DK176140B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22169788A 1988-07-20 1988-07-20
US22169788 1988-07-20
US37722189A 1989-07-13 1989-07-13
US37722189 1989-07-13

Publications (3)

Publication Number Publication Date
DK357589D0 DK357589D0 (da) 1989-07-19
DK357589A true DK357589A (da) 1990-01-23
DK176140B1 DK176140B1 (da) 2006-09-25

Family

ID=26916041

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198903575A DK176140B1 (da) 1988-07-20 1989-07-19 Flagermusspyt-plasminogenaktivatorer

Country Status (17)

Country Link
US (1) US5830849A (da)
EP (1) EP0352119B1 (da)
JP (1) JP2713467B2 (da)
KR (1) KR0138997B1 (da)
AT (1) ATE126269T1 (da)
AU (1) AU621389B2 (da)
CA (1) CA1341090C (da)
DE (1) DE68923741T2 (da)
DK (1) DK176140B1 (da)
ES (1) ES2076965T3 (da)
FI (1) FI100403B (da)
GR (1) GR3017587T3 (da)
IE (1) IE69054B1 (da)
IL (1) IL91059A (da)
NO (2) NO302954B1 (da)
NZ (1) NZ230017A (da)
PT (1) PT91236B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01500322A (ja) * 1986-03-28 1989-02-09 クリエイティブ　バイオモレクレス，インコーポレーテッド 組織プラスミノーゲンアクテイベーター類縁蛋白質
CA2046632C (en) * 1989-02-13 1999-05-11 Schering Aktiengesellschaft Thrombolytic from vampire bat saliva
US6008019A (en) * 1989-02-13 1999-12-28 Schering Aktiengesellschaft Plasminogen activator from saliva of the vampire bat
DE3943241A1 (de) * 1989-12-22 1991-06-27 Schering Ag Thrombolytisch wirkendes kombinationspraeparat
EP0455424A3 (en) 1990-05-02 1992-04-29 Merck & Co. Inc. Mammalian inducible promoter cascade system
DE59204945D1 (de) * 1991-04-16 1996-02-15 Boehringer Mannheim Gmbh Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US5945432A (en) * 1995-12-22 1999-08-31 The University Of Vermont And State Agricultural College Thrombolytic agents and thienopyridine derivatives in acute stroke
US5731186A (en) * 1996-02-05 1998-03-24 Schering Aktiengesellschaft Method for the production of rDSPA α1
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
CA2524573A1 (en) * 2003-05-02 2004-11-11 Paion Deutschland Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
US20060135425A1 (en) * 2003-05-02 2006-06-22 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
AU2003227721A1 (en) * 2003-05-02 2004-11-23 Paion Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
AR068914A1 (es) * 2007-10-18 2009-12-16 Paion Deutschland Gmbh Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
EP2289541A1 (en) 2009-08-31 2011-03-02 PAION Deutschland GmbH Treatment of neurological or neurodegenerative disorders
EP2289542A1 (en) 2009-08-31 2011-03-02 PAION Deutschland GmbH Treatment of neurological or neurodegenerative disorders
KR20240046168A (ko) 2017-02-03 2024-04-08 액티코어 바이오테크 항-인간 gpvi 항체를 이용한 혈소판 응집의 억제
WO2018210860A1 (en) 2017-05-16 2018-11-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of acute ischemic stroke
WO2019238933A1 (en) 2018-06-15 2019-12-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity
EP3921294A4 (en) * 2019-02-05 2022-10-26 Dyno Nobel Asia Pacific Pty Limited STABILIZED PHASE AMMONIUM NITRATE PELLETS, RELATED PRODUCTS AND METHODS
WO2021148439A1 (en) 2020-01-21 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stimulating cerebrovascular function
EP4161579A1 (en) 2020-06-09 2023-04-12 Institut National de la Santé et de la Recherche Médicale (INSERM) Fucoidan-functionalized polysaccharide particles with t-pa for targeted thrombolytic therapy
WO2023156683A1 (en) 2022-02-21 2023-08-24 Acticor Biotech Treatment of cardiovascular diseases using anti-human gpvi antibodies
EP4556492A1 (en) 2023-11-14 2025-05-21 Acticor Biotech Treatment of cardiovascular diseases using anti-human gpvi antibodies in subpopulations of subjects

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US5010002A (en) * 1983-01-19 1991-04-23 Genentech, Inc. Human t-PA production using vectors coding DHFR protein
ATE90967T1 (de) * 1986-03-28 1993-07-15 Creative Biomolecules Inc Proteinanaloge des gewebs-plasminogenaktivators.
ATE103332T1 (de) * 1987-10-09 1994-04-15 Monsanto Co Modifizierter gewebeplasminogenaktivator.
CA2046632C (en) * 1989-02-13 1999-05-11 Schering Aktiengesellschaft Thrombolytic from vampire bat saliva

Also Published As

Publication number Publication date
US5830849A (en) 1998-11-03
IE892354L (en) 1990-01-20
DE68923741T2 (de) 1996-02-15
EP0352119A3 (en) 1990-07-04
NZ230017A (en) 1992-05-26
NO314548B1 (no) 2003-04-07
CA1341090C (en) 2000-08-29
JPH02167075A (ja) 1990-06-27
NO970603L (no) 1990-01-22
NO892976D0 (no) 1989-07-20
KR0138997B1 (ko) 1998-04-30
ATE126269T1 (de) 1995-08-15
IE69054B1 (en) 1996-08-07
DE68923741D1 (de) 1995-09-14
AU621389B2 (en) 1992-03-12
FI100403B (fi) 1997-11-28
JP2713467B2 (ja) 1998-02-16
NO302954B1 (no) 1998-05-11
IL91059A0 (en) 1990-02-09
NO892976L (no) 1990-01-22
FI893500A0 (fi) 1989-07-19
KR910003094A (ko) 1991-02-26
PT91236B (pt) 1995-03-01
NO970603D0 (no) 1997-02-10
DK357589D0 (da) 1989-07-19
ES2076965T3 (es) 1995-11-16
PT91236A (pt) 1990-02-08
AU3891589A (en) 1990-01-25
FI893500L (fi) 1990-01-21
GR3017587T3 (en) 1995-12-31
IL91059A (en) 1995-06-29
EP0352119B1 (en) 1995-08-09
EP0352119A2 (en) 1990-01-24
DK176140B1 (da) 2006-09-25

Similar Documents

Publication Publication Date Title
DK357589A (da) Glycoprotein, dna-sekvens kodende derfor, replikerbart kloningshjaelpemiddel, farmaceutisk praeparat indeholdende glycoproteinet og fremgangsmaade til rensning af glycoprotein
AU603983B2 (en) Expression of factor vii and ix activities in mammalian cells
DK306386A (da) Fibronectin og polypeptidsekvenser omfattende de collagenbindende og/eller fibrinbindende dele deraf, cdna-sekvenser, som koder herfor, vektorer indeholdende cdna-sekvenserne mikroorganismer transformeret dermed og fremgangsmaade til rensning af stoffer
ES2018729A6 (es) Un metodo para preparar una variante de activador de plasmogeno de tejido.
AU6683086A (en) Novel peptide plasminogen activators
EP0814154A3 (en) Recombinant alphavirus vectors
EP0339830A3 (en) Improved biological nitrogen fixation
NO179754C (no) Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekveks som koder for t-PA-analogen, ekspresjonsvektor omfattende DNA-sekvensen samt vertscelle omfattende denne
AU692988B2 (en) Superior thrombomodulin analogs for pharmaceutical use
NL960017I2 (nl) Expressie van Factor VIII-activiteit in zoogdiercellen.
WO1988005081A3 (en) Novel plasminogen activator
NZ242124A (en) Dna encoding an enzyme having arabinan-degrading activity
DK203588D0 (da) Fremgangsmaade til fremstilling af proteiner
DK0444775T3 (da) Rekombinant-DNA-ekspressionsvektorer og DNA-forbindelser, som koder for isopenicillin-N-epimerase-ak tivitet
DK130290D0 (da) Lymfokiner, dna-sekvenser, som koder for disse lymfokiner og farmaceutiske midler indeholdende disse lymfokiner
EP0381331A3 (en) Gene sequences encoding modified residues situated in the protease domain of tpa
DK104390D0 (da) Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne

Legal Events

Date Code Title Description
PUP Patent expired