DK3585892T3 - Fremgangsmåder til oprensning af messenger-rna - Google Patents
Fremgangsmåder til oprensning af messenger-rna Download PDFInfo
- Publication number
- DK3585892T3 DK3585892T3 DK18711737.9T DK18711737T DK3585892T3 DK 3585892 T3 DK3585892 T3 DK 3585892T3 DK 18711737 T DK18711737 T DK 18711737T DK 3585892 T3 DK3585892 T3 DK 3585892T3
- Authority
- DK
- Denmark
- Prior art keywords
- purification
- methods
- messenger rna
- messenger
- rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463981P | 2017-02-27 | 2017-02-27 | |
| PCT/US2018/019978 WO2018157141A1 (en) | 2017-02-27 | 2018-02-27 | Methods for purification of messenger rna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3585892T3 true DK3585892T3 (da) | 2022-08-22 |
Family
ID=61683899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18711737.9T DK3585892T3 (da) | 2017-02-27 | 2018-02-27 | Fremgangsmåder til oprensning af messenger-rna |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10975369B2 (da) |
| EP (2) | EP4008783A1 (da) |
| AU (1) | AU2018224318B2 (da) |
| CA (1) | CA3054323A1 (da) |
| DK (1) | DK3585892T3 (da) |
| ES (1) | ES2925083T3 (da) |
| HU (1) | HUE059594T2 (da) |
| IL (1) | IL268856B2 (da) |
| MA (1) | MA47606A (da) |
| WO (1) | WO2018157141A1 (da) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4074693A1 (en) | 2011-06-08 | 2022-10-19 | Translate Bio, Inc. | Cleavable lipids |
| IL268856B2 (en) * | 2017-02-27 | 2024-09-01 | Translate Bio Inc | Methods for purification of messenger rna |
| WO2019036685A1 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | METHODS FOR HPLC ANALYSIS |
| EP3714048B1 (en) | 2017-11-22 | 2025-04-09 | ModernaTX, Inc. | Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
| EP3793689A1 (en) * | 2018-05-15 | 2021-03-24 | Translate Bio, Inc. | Subcutaneous delivery of messenger rna |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| WO2020165158A1 (en) * | 2019-02-11 | 2020-08-20 | Ethris Gmbh | Mrna purification by tangential flow filtration |
| WO2020168466A1 (en) | 2019-02-19 | 2020-08-27 | Stemirna Therapeutics Co., Ltd. | Modified nucleoside and synthetic methods thereof |
| MX2021011031A (es) | 2019-03-11 | 2021-12-10 | Modernatx Inc | Proceso de transcripción in vitro en lotes alimentados. |
| JP2023508881A (ja) | 2019-12-20 | 2023-03-06 | トランスレイト バイオ， インコーポレイテッド | Ｍｒｎａ担持脂質ナノ粒子を調製する改善されたプロセス |
| MX2022007756A (es) | 2019-12-20 | 2022-09-27 | Translate Bio Inc | Suministro rectal de arn mensajero. |
| CA3170319A1 (en) * | 2020-02-10 | 2021-08-19 | Translate Bio, Inc. | Methods and compositions for messenger rna purification |
| CN115427021A (zh) | 2020-02-25 | 2022-12-02 | 翻译生物公司 | 制备负载mrna的脂质纳米颗粒的改进方法 |
| WO2021226468A1 (en) | 2020-05-07 | 2021-11-11 | Translate Bio, Inc. | Improved compositions for cftr mrna therapy |
| WO2021226461A1 (en) * | 2020-05-07 | 2021-11-11 | Translate Bio, Inc. | Generation of optimized nucleotide sequences |
| WO2021226463A1 (en) | 2020-05-07 | 2021-11-11 | Translate Bio, Inc. | Composition and methods for treatment of primary ciliary dyskinesia |
| AU2021269042A1 (en) | 2020-05-07 | 2023-02-02 | Translate Bio, Inc. | Optimized nucleotide sequences encoding SARS-CoV-2 antigens |
| JP7873638B2 (ja) * | 2020-05-15 | 2026-06-12 | トランスレイト バイオ， インコーポレイテッド | ｍＲＮＡ送達のための脂質ナノ粒子製剤 |
| EP4222258A2 (en) | 2020-10-01 | 2023-08-09 | Translate Bio, Inc. | Methods for purification of messenger rna |
| CA3194863A1 (en) | 2020-10-06 | 2022-04-14 | Shrirang KARVE | Improved process and formulation of lipid nanoparticles |
| CA3198411A1 (en) | 2020-10-12 | 2022-04-21 | Translate Bio, Inc. | Improved process of preparing mrna-loaded lipid nanoparticles |
| US12678406B2 (en) | 2020-10-12 | 2026-07-14 | Translate Bio Inc. | Process of preparing ice-based lipid nanoparticles |
| MX2023004371A (es) | 2020-10-14 | 2023-07-26 | George Mason Res Foundation Inc | Lípidos ionizables, y métodos de fabricación y uso de los mismos. |
| CN116438298A (zh) | 2020-10-15 | 2023-07-14 | 翻译生物公司 | 信使rna的大规模合成 |
| US12576030B2 (en) | 2020-11-09 | 2026-03-17 | Translate Bio, Inc. | Compositions for delivery of codon-optimized mRNA |
| US20250268994A1 (en) | 2021-03-25 | 2025-08-28 | Translate Bio, Inc. | Optimized Nucleotide Sequences Encoding the Extracellular Domain of Human ACE2 Protein or a Portion Thereof |
| CA3215606A1 (en) | 2021-04-19 | 2022-10-27 | Shrirang KARVE | Improved compositions for delivery of mrna |
| US20240277872A1 (en) | 2021-05-12 | 2024-08-22 | The Broad Institute, Inc. | Modified mrna, modified non-coding rna, and uses thereof |
| US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
| EP4362920A1 (en) | 2021-07-01 | 2024-05-08 | Translate Bio, Inc. | Compositions for delivery of mrna |
| JP2024545572A (ja) | 2021-11-10 | 2024-12-10 | トランスレイト バイオ， インコーポレイテッド | 原発性線毛機能不全の治療のための組成物及び方法 |
| EP4453238A1 (en) * | 2021-12-23 | 2024-10-30 | Quantoom Biosciences S.A. | Methods and systems for capping nucleic acid molecules |
| BE1030203B1 (fr) * | 2022-01-20 | 2023-08-21 | Quantoom Biosciences S A | Méthodes et systèmes de coiffage de molécules d’acide nucléique |
| BE1030204B1 (fr) * | 2022-01-20 | 2023-08-21 | Quantoom Biosciences S A | Méthodes et systèmes de coiffage de molécules d’acide nucléique |
| WO2023118571A1 (en) * | 2021-12-23 | 2023-06-29 | Quantoom Biosciences S.A. | Methods and systems for capping nucleic acid |
| JP2025506416A (ja) * | 2022-02-03 | 2025-03-11 | モデルナティエックス インコーポレイテッド | ｍＲＮＡ精製のための連続的沈殿 |
| EP4525830A1 (en) * | 2022-05-17 | 2025-03-26 | ModernaTX, Inc. | Preparation of highly concentrated mrna |
| AU2023316794A1 (en) | 2022-07-29 | 2025-03-13 | Sanofi Pasteur Inc. | Methods for ethanol-free mrna purification |
| WO2024083345A1 (en) | 2022-10-21 | 2024-04-25 | BioNTech SE | Methods and uses associated with liquid compositions |
| EP4622630A1 (en) | 2022-11-21 | 2025-10-01 | Translate Bio, Inc. | Compositions of dry powder formulations of messenger rna and methods of use thereof |
| AU2023394992A1 (en) | 2022-12-15 | 2025-07-31 | Sanofi Pasteur Inc. | Mrna encoding influenza virus-like particle |
| TW202438514A (zh) | 2022-12-20 | 2024-10-01 | 法商賽諾菲公司 | 鼻病毒mrna疫苗 |
| JP2026503216A (ja) | 2022-12-23 | 2026-01-28 | サノフィ パスツール インコーポレイテッド | メッセンジャーｒｎａの最適化されたテーリング |
| JP2026508405A (ja) | 2023-03-07 | 2026-03-10 | サノフィ パスツール インコーポレイテッド | Ｋｐ３４ポリメラーゼを用いたメッセンジャーｒｎａの製造 |
| WO2024194767A1 (en) | 2023-03-17 | 2024-09-26 | BioNTech SE | Automated drug production system |
| MX2025012337A (es) | 2023-04-17 | 2026-02-03 | Sanofi Pasteur Inc | Formulaciones de polvo seco reconstituibles y métodos de uso de las mismas |
| WO2025017151A1 (en) | 2023-07-18 | 2025-01-23 | Sanofi | Stable poly(a)-encoding messenger rna templates |
| WO2025104351A1 (en) | 2023-11-17 | 2025-05-22 | Sanofi Pasteur Inc. | Hplc-based assays for detecting multiple mrna constructs |
| GB202319423D0 (en) * | 2023-12-18 | 2024-01-31 | BioNTech SE | Measuring and reducing protein impurities |
| AU2024413535A1 (en) | 2023-12-29 | 2026-08-13 | Sanofi Vaccines US Inc. | Modified rna polymerases |
| WO2025208142A2 (en) | 2024-03-29 | 2025-10-02 | New England Biolabs, Inc. | Compositions, kits, and methods for in vitro transcription |
| WO2026033123A1 (en) | 2024-08-08 | 2026-02-12 | Sanofi Pasteur Inc. | Lipid nanoparticle formulations for mrna delivery |
| WO2026093322A1 (en) | 2024-10-28 | 2026-05-07 | Sanofi Pasteur Inc. | Improved dna constructs for manufacturing messenger rna by in vitro transcription |
| WO2026136725A2 (en) | 2024-12-20 | 2026-06-25 | Aera Therapeutics, Inc. | Improved poly(a) tails for mrna and non-coding rna, and uses thereof |
Family Cites Families (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1292758A (en) | 1918-04-12 | 1919-01-28 | Roque Galguera Y Gonzalez | Filtering apparatus. |
| US1478660A (en) | 1921-01-20 | 1923-12-25 | Barnes Gerard Charles | Centrifugal separator |
| NL296242A (da) | 1962-10-01 | |||
| US3411631A (en) | 1966-09-09 | 1968-11-19 | Dorr Oliver Inc | Screening centrifuges |
| DE1632291B1 (de) | 1966-10-22 | 1971-07-29 | Hitachi Shipbuilding Eng Co | Kontinuierlich arbeitende Siebzentrifuge |
| US3438500A (en) | 1967-05-18 | 1969-04-15 | Francisco A Pico | Centrifugal separating apparatus |
| US3491888A (en) | 1968-12-27 | 1970-01-27 | Universal Oil Prod Co | Self-cleaning screen baskets |
| DE1911147A1 (de) | 1969-03-05 | 1970-11-19 | Ernst Heinkel Maschb Gmbh | Zentrifuge |
| US3483991A (en) | 1969-05-07 | 1969-12-16 | Pennwalt Corp | Screen centrifuge apparatus |
| US3684099A (en) | 1970-07-21 | 1972-08-15 | Carl T Kiebach | Assembly element for press |
| DE2153901C3 (de) | 1971-10-28 | 1979-12-20 | Elfo Ag Sachseln, Sachseln (Schweiz) | Siebformkörper |
| US3774769A (en) | 1971-11-22 | 1973-11-27 | Gaf Corp | Liquid filter pressurized apparatus |
| DE2709894C3 (de) | 1977-03-08 | 1982-01-07 | Heinkel Industriezentrifugen GmbH & Co, 7120 Bietigheim-Bissingen | Diskontinuierliche Filterzentrifuge |
| DE2710624C2 (de) | 1977-03-11 | 1985-09-19 | Heinkel Industriezentrifugen GmbH + Co, 7120 Bietigheim-Bissingen | Stülpfilterzentrifuge |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4381236A (en) | 1981-02-19 | 1983-04-26 | Baker Perkins Inc. | High pressure rotary centrifugal separator having apparatus for automatically cyclically reciprocating a corotating separator basket scraper |
| US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US4373071A (en) | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
| US4401796A (en) | 1981-04-30 | 1983-08-30 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
| US5153319A (en) | 1986-03-31 | 1992-10-06 | University Patents, Inc. | Process for preparing polynucleotides |
| US4944874A (en) | 1986-12-12 | 1990-07-31 | Kabushiki Kaisha Okawara Seisakusho | Centrifugal separator |
| DE3740411C2 (de) | 1987-11-28 | 1996-11-14 | Heinkel Ind Zentrifugen | Stülpfilterzentrifuge |
| DE3838108A1 (de) | 1988-11-10 | 1990-05-17 | Heinkel Ind Zentrifugen | Vorrichtung zum betreiben eines auspressfilters |
| US5262530A (en) | 1988-12-21 | 1993-11-16 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
| US5047524A (en) | 1988-12-21 | 1991-09-10 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
| DE3916383C2 (de) | 1989-05-19 | 1999-01-07 | Guntram Krettek | Vorrichtung zum Halten von Filterfolien oder Filtertüchern |
| US5004540A (en) | 1989-12-01 | 1991-04-02 | Ketema Process Equipment Division | Invertible filter-type centrifuge with improved bearing and seal assembly |
| US20070053879A1 (en) * | 1990-03-05 | 2007-03-08 | Genzyme Corporation | Diagnostic and treatment methods involving the cystic fibrosis transmembrane regulator |
| US5277804A (en) | 1990-03-24 | 1994-01-11 | Heinkel Industriezentrifugen Gmbh & Co. | Sleeve filter centrifuge |
| DE59007695D1 (de) | 1990-03-24 | 1994-12-15 | Heinkel Ind Zentrifugen | Stülpfilterzentrifuge. |
| SE9003978D0 (sv) * | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| EP0584289B1 (de) | 1991-05-04 | 1996-09-11 | Heinkel Industriezentrifugen Gmbh & Co. | Stülpfilter-zentrifuge |
| DE4230261A1 (de) | 1991-10-01 | 1993-04-08 | Krauss Maffei Ag | Diskontinuierlich arbeitende filterzentrifuge |
| US5378364A (en) | 1992-09-14 | 1995-01-03 | Baker Hughes Incorporated | Conical screen basket centrifuge |
| US5571669A (en) * | 1993-01-14 | 1996-11-05 | The University Of Pennsylvania | Transcription and nucleic acid sequence determination with short primer DNA/RNA molecules and RNA polymerase |
| US5380434A (en) | 1993-07-21 | 1995-01-10 | Tema Systems, Inc. | Centrifuge scroll with abrasion resistant inserts |
| DE59308079D1 (de) | 1993-07-22 | 1998-03-05 | Escher Wyss Ag | Doppelschubzentrifuge |
| US5397471A (en) | 1993-08-30 | 1995-03-14 | Tema Systems, Inc. | Self-cleaning scroll and screen centrifuge |
| US5433849A (en) | 1993-09-15 | 1995-07-18 | Lyco Manufacturing, Inc. | Double drum waste water screen |
| DE4337618C1 (de) | 1993-11-04 | 1995-02-16 | Krauss Maffei Ag | Stülpfilterzentrifuge (Trommelraumabdichtung) |
| EP0743950B1 (de) * | 1994-02-11 | 2001-12-12 | QIAGEN GmbH | Verfahren zur trennung von doppelstrang/einzelstrangnukleinsäurestrukturen |
| AU2215995A (en) * | 1994-04-07 | 1995-10-30 | Akzo Nobel N.V. | Freeze-dried compositions comprising rna |
| US6291189B1 (en) * | 1994-05-10 | 2001-09-18 | Carta Proteomics, Inc. | Methods for the high-resolution identification of solvent-accessible amide hydrogens in polypeptides or proteins and for characterization of the fine structure of protein binding sites |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| US5713826A (en) | 1996-05-07 | 1998-02-03 | Waterlink, Inc. | Vertical basket centrifuge with feed acceleration and a removable liner |
| US5874268A (en) * | 1996-09-23 | 1999-02-23 | Duke University | Method of introducing exogenous compounds into cells by electroporation and apparatus for same |
| IT1285052B1 (it) | 1996-10-18 | 1998-06-03 | Gennaretti S P A | Centrifuga orizzontale per l'estrazione di olio da un impasto oleoso |
| EP1021549A2 (en) * | 1997-09-19 | 2000-07-26 | Sequitur, Inc. | SENSE mRNA THERAPY |
| US7087580B2 (en) * | 1998-04-23 | 2006-08-08 | Genesense Technologies, Inc. | Neuropilin antisense oligonucleotide sequences and methods of using same to modulate cell growth |
| US6811788B2 (en) * | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| EP1326844A2 (en) * | 2000-10-16 | 2003-07-16 | Chugai Seiyaku Kabushiki Kaisha | Process for preparation of n-substituted 2-sulfanylimidazoles |
| DE10115381A1 (de) | 2001-03-28 | 2002-10-24 | Heinkel Ag | Stülpfilterzentrifuge |
| US7348418B2 (en) * | 2002-02-08 | 2008-03-25 | Memorial Sloan-Kettering Cancer Center | Carcinoma-related genes and polypeptides and methods of use thereof |
| US6736968B2 (en) | 2002-06-25 | 2004-05-18 | Tema Systems, Inc. | Horizontal scroll screen centrifuge |
| DE60334460D1 (de) * | 2002-08-14 | 2010-11-18 | Mitsubishi Chem Medience Corp | Antikörper spezifisch für das tau-protein des zentralen nervensystems |
| DE10245013A1 (de) | 2002-09-20 | 2004-04-01 | Heinkel Aktiengesellschaft | Filterzentrifuge |
| DE10311997A1 (de) | 2003-03-19 | 2004-10-07 | Johannes Gerteis | Stülpfilterzentrifuge |
| US20050048045A1 (en) * | 2003-07-02 | 2005-03-03 | Board Of Regents, The University Of Texas System | Regulation of urokinase receptor expression by phosphoglycerate kinase |
| WO2005093052A1 (en) * | 2004-03-26 | 2005-10-06 | Fuji Photo Film Co., Ltd. | Method for selectively separating and purifying rna and method for separating and purifying nucleic acid |
| US20050245381A1 (en) | 2004-04-30 | 2005-11-03 | National-Oilwell, L.P. | Centrifuge accelerator system |
| DE102004032460B3 (de) * | 2004-06-30 | 2005-08-18 | Rina-Netzwerk Rna Technologien Gmbh | Verfahren zur präparativen in vitro Proteinbiosynthese |
| FR2873596B1 (fr) | 2004-07-27 | 2006-09-22 | Weatherford Lamb | Centrifugeuse avec une bride de serrage crantee |
| EP1838353A2 (en) * | 2005-01-21 | 2007-10-03 | Introgen Therapeutics, Inc. | Topical administration permitting prolonged exposure of target cells to therapeutic and prophylactic nucleic acids |
| US20080149558A1 (en) | 2006-12-21 | 2008-06-26 | Ferrum Ag | Centrifuge drum |
| WO2008122067A1 (en) | 2007-04-05 | 2008-10-16 | Ludowici Mineral Processing Equipment Pty Ltd | Centrifugal scroll screen apparatus |
| WO2010053572A2 (en) | 2008-11-07 | 2010-05-14 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US8021289B2 (en) | 2009-02-20 | 2011-09-20 | Tema Systems, Inc. | Clean-in-place decanter centrifuge |
| US20100326827A1 (en) * | 2009-06-24 | 2010-12-30 | Shang-Chi Lin | Method and apparatus for isolating and purifying bio-molecules |
| US8326547B2 (en) | 2009-10-07 | 2012-12-04 | Nanjingjinsirui Science & Technology Biology Corp. | Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm |
| WO2011063519A1 (en) | 2009-11-27 | 2011-06-03 | Arrowcorp Inc. | Cylinder exchange device and method for solid material processor |
| SI2506857T1 (en) | 2009-12-01 | 2018-08-31 | Translate Bio, Inc. | Delivery of mRNA for the enrichment of proteins and enzymes in human genetic diseases |
| US8853377B2 (en) * | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
| KR20220025112A (ko) * | 2011-06-08 | 2022-03-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
| EP4074693A1 (en) | 2011-06-08 | 2022-10-19 | Translate Bio, Inc. | Cleavable lipids |
| US9512073B2 (en) | 2011-10-27 | 2016-12-06 | Massachusetts Institute Of Technology | Amino acid-, peptide-and polypeptide-lipids, isomers, compositions, and uses thereof |
| EP2791159A4 (en) * | 2011-12-14 | 2015-10-14 | Moderna Therapeutics Inc | MODIFIED NUCLEIC ACIDS AND ACUTE TREATMENT USES THEREOF |
| ES2923757T3 (es) * | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| WO2013151664A1 (en) * | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| US9933343B2 (en) * | 2012-03-14 | 2018-04-03 | Chromologic Llc | Integrated membrane for preservation of biomolecules |
| BR112014024131A2 (pt) | 2012-03-29 | 2017-07-25 | Shire Human Genetic Therapies | lipídios catiônicos ionizáveis |
| HK1206644A1 (en) | 2012-03-29 | 2016-01-15 | Shire Human Genetic Therapies, Inc. | Lipid-derived neutral nanoparticles |
| US10501513B2 (en) * | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| EA201492055A1 (ru) | 2012-06-08 | 2015-11-30 | Шир Хьюман Дженетик Терапис, Инк. | ИНГАЛЯЦИОННАЯ ДОСТАВКА мРНК В НЕЛЕГОЧНЫЕ КЛЕТКИ-МИШЕНИ |
| EP3536787A1 (en) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
| WO2014043541A1 (en) | 2012-09-14 | 2014-03-20 | Bilfinger Water Technologies, Inc. | Variable geometry centrifugal basket |
| US20150366997A1 (en) | 2012-12-07 | 2015-12-24 | Shire Human Genetics Therapies, Inc. | COMPOSITIONS AND METHODS FOR mRNA DELIVERY |
| WO2014152940A1 (en) | 2013-03-14 | 2014-09-25 | Shire Human Genetic Therapies, Inc. | Mrna therapeutic compositions and use to treat diseases and disorders |
| EA201591283A1 (ru) | 2013-03-14 | 2016-02-29 | Шир Хьюман Дженетик Терапис, Инк. | Количественная оценка эффективности кэп матричной рнк |
| EP3932947A1 (en) | 2013-03-14 | 2022-01-05 | Translate Bio MA, Inc. | Methods and compositions for delivering mrna coded antibodies |
| US10258698B2 (en) * | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| KR102311614B1 (ko) | 2013-03-14 | 2021-10-08 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| US10266559B2 (en) | 2013-03-14 | 2019-04-23 | Translate Bio, Inc. | Ribonucleic acids with 4′-thio-modified nucleotides and related methods |
| EA201591229A1 (ru) | 2013-03-14 | 2016-01-29 | Шир Хьюман Дженетик Терапис, Инк. | Способы очистки матричной рнк |
| MX2015011945A (es) | 2013-03-14 | 2015-12-01 | Shire Human Genetic Therapies | Evaluacion cuantitativa para la eficacia de los casquetes de arn mensajero. |
| WO2014144767A1 (en) * | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Ion exchange purification of mrna |
| CN104236289B (zh) | 2013-06-06 | 2016-03-23 | 富泰华工业（深圳）有限公司 | 脱水装置 |
| ES3032935T3 (en) | 2013-10-22 | 2025-07-29 | Translate Bio Inc | Lipid formulations for delivery of messenger rna |
| ES2707966T3 (es) | 2013-10-22 | 2019-04-08 | Translate Bio Inc | Terapia de ARNm para la deficiencia en síntesis de argininosuccinato |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
| AU2014340149B2 (en) | 2013-10-22 | 2020-12-24 | Shire Human Genetic Therapies, Inc. | CNS delivery of mRNA and uses thereof |
| US9534214B2 (en) * | 2013-10-31 | 2017-01-03 | General Electric Company | Substrates and associated methods for elution of nucleic acids |
| JP2017507946A (ja) * | 2014-02-26 | 2017-03-23 | エスリス ゲーエムベーハーｅｔｈｒｉｓ ＧｍｂＨ | Ｒｎａを胃腸内投与するための組成物 |
| PL3122878T3 (pl) | 2014-03-24 | 2019-06-28 | Translate Bio, Inc. | TERAPIA mRNA DO LECZENIA CHORÓB OCZU |
| EP4729528A3 (en) * | 2014-04-25 | 2026-06-24 | Translate Bio, Inc. | Methods for purification of messenger rna |
| WO2015184256A2 (en) | 2014-05-30 | 2015-12-03 | Shire Human Genetic Therapies, Inc. | Biodegradable lipids for delivery of nucleic acids |
| KR102559979B1 (ko) | 2014-06-24 | 2023-07-25 | 샤이어 휴먼 지네틱 테라피즈 인크. | 핵산의 전달용 입체화학적으로 풍부한 조성물 |
| WO2016004318A1 (en) | 2014-07-02 | 2016-01-07 | Shire Human Genetic Therapies, Inc. | Encapsulation of messenger rna |
| EP3177732A4 (en) * | 2014-08-08 | 2018-04-25 | ModernaTX, Inc. | Compositions and methods for the treatment of ophthalmic diseases and conditions |
| CN106999957B (zh) | 2014-08-14 | 2020-11-03 | 阿奎塞腾斯集团有限公司 | 分批式离心机过滤网 |
| DE102014119605A1 (de) | 2014-12-23 | 2016-06-23 | Andritz Kmpt Gmbh | Filterzentrifuge |
| WO2016112428A1 (en) | 2015-01-15 | 2016-07-21 | Weir Minerals Australia Ltd | Centrifugal scroll screen apparatus |
| CN107427843B (zh) | 2015-01-15 | 2019-10-25 | 伟尔矿物澳大利亚私人有限公司 | 离心式涡旋筛分装置 |
| WO2016112426A1 (en) | 2015-01-15 | 2016-07-21 | Weir Minerals Australia Ltd | Centrifugal screening apparatus |
| EP3270894B1 (en) | 2015-03-19 | 2021-02-24 | Translate Bio, Inc. | Mrna therapy for pompe disease |
| DK3303583T3 (da) * | 2015-05-29 | 2020-07-13 | Curevac Real Estate Gmbh | Fremgangsmåde til fremstilling og oprensning af rna, omfattende mindst et trin til tangential-flow-filtrering |
| US10501768B2 (en) * | 2015-07-13 | 2019-12-10 | Curevac Ag | Method of producing RNA from circular DNA and corresponding template DNA |
| EP4101930A1 (en) * | 2015-09-17 | 2022-12-14 | ModernaTX, Inc. | Polynucleotides containing a stabilizing tail region |
| US20190054112A1 (en) * | 2015-09-18 | 2019-02-21 | Moderna Therapeutics, Inc. | Polynucleotide formulations for use in the treatment of renal diseases |
| IL268856B2 (en) * | 2017-02-27 | 2024-09-01 | Translate Bio Inc | Methods for purification of messenger rna |
-
2018
- 2018-02-27 IL IL268856A patent/IL268856B2/en unknown
- 2018-02-27 MA MA047606A patent/MA47606A/fr unknown
- 2018-02-27 HU HUE18711737A patent/HUE059594T2/hu unknown
- 2018-02-27 CA CA3054323A patent/CA3054323A1/en active Pending
- 2018-02-27 EP EP22151272.6A patent/EP4008783A1/en active Pending
- 2018-02-27 WO PCT/US2018/019978 patent/WO2018157141A1/en not_active Ceased
- 2018-02-27 AU AU2018224318A patent/AU2018224318B2/en active Active
- 2018-02-27 EP EP18711737.9A patent/EP3585892B8/en active Active
- 2018-02-27 US US15/907,086 patent/US10975369B2/en active Active
- 2018-02-27 ES ES18711737T patent/ES2925083T3/es active Active
- 2018-02-27 DK DK18711737.9T patent/DK3585892T3/da active
-
2020
- 2020-12-22 US US17/130,114 patent/US12410422B2/en active Active
-
2025
- 2025-07-18 US US19/273,745 patent/US20260049299A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210180041A1 (en) | 2021-06-17 |
| EP3585892B8 (en) | 2022-07-13 |
| IL268856A (en) | 2019-10-31 |
| CA3054323A1 (en) | 2018-08-30 |
| US12410422B2 (en) | 2025-09-09 |
| IL268856B1 (en) | 2024-05-01 |
| US20260049299A1 (en) | 2026-02-19 |
| HUE059594T2 (hu) | 2022-11-28 |
| EP3585892A1 (en) | 2020-01-01 |
| IL268856B2 (en) | 2024-09-01 |
| EP3585892B1 (en) | 2022-06-01 |
| MA47606A (fr) | 2021-04-07 |
| AU2018224318A1 (en) | 2019-09-19 |
| AU2018224318B2 (en) | 2024-06-20 |
| WO2018157141A1 (en) | 2018-08-30 |
| ES2925083T3 (es) | 2022-10-13 |
| US10975369B2 (en) | 2021-04-13 |
| US20180251754A1 (en) | 2018-09-06 |
| EP4008783A1 (en) | 2022-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3585891T3 (da) | Fremgangsmåder til oprensning af messenger-rna | |
| DK3636742T3 (da) | Fremgangsmåder til oprensning af messenger-rna | |
| HUE059594T2 (hu) | Hírvivõ RNS tisztítására szolgáló eljárások | |
| DK3585886T5 (da) | Storskalasyntese af messenger-rna | |
| DK4140491T5 (da) | Fremgangsmåde til syntetisering af RNA'er med 5'-kappe | |
| DK3467108T3 (da) | Fremgangsmåder til oprensning af messenger-RNA | |
| IL263690A (en) | Purification of multispecific antibodies | |
| DK3268390T3 (da) | Fremgangsmåder til oprensning af bispecifikke antistoffer | |
| DK3445850T3 (da) | Fremgangsmåder til tilvejebringelse af enkeltstrenget rna | |
| DK3377059T3 (da) | Hæmmere af cxcr2 | |
| DK3292134T3 (da) | Metode til dyrkning af akkermansia | |
| DK3337902T3 (da) | 3'-utr-sekvenser til stabilisering af rna | |
| EP3349649A4 (en) | NAVIGATION OF TUBULAR NETWORKS | |
| DK3294885T3 (da) | Fremgangsmåde til at fremstille rna | |
| DK3463483T3 (da) | Behandling af primær ciliedyskinesi med syntetisk messenger-RNA | |
| DK3607068T3 (da) | RNA-interferensmedieret inhibering af TMPRSS6 | |
| LT3116891T (lt) | Imunoglobulino gryninimas, naudojant išankstinio valymo pakopas | |
| DK3201361T3 (da) | Fremgangsmåder til kvantificering af cellefrit DNA | |
| DK3113858T3 (da) | Fremgangsmåde til oprensning af il-15/il-15ralpha-baserede konjugater | |
| DK3609529T3 (da) | Rna til behandling af autoimmune sygdomme | |
| DK3510042T3 (da) | Fremgangsmåde til rensning af antistoffer | |
| DK3665173T3 (da) | Ny fremgangsmåde til yntetisering af amanitiner | |
| DK3680000T3 (da) | Fremgangsmåder til oprensning af antistoffer | |
| PL3268391T3 (pl) | Sposoby zmniejszania poziomów środków zawierających Fc w surowicy z zastosowaniem antagonistów FcRn | |
| DK3347481T3 (da) | Fremgangsmåde til oprensning af biomassehydrolysat |