|
US2647121A
(en)
|
1951-02-02 |
1953-07-28 |
Ruth P Jacoby |
Diamine-bis-acetamides
|
|
US2819718A
(en)
|
1953-07-16 |
1958-01-14 |
Isidore H Goldman |
Drainage tube
|
|
US2717909A
(en)
|
1953-09-24 |
1955-09-13 |
Monsanto Chemicals |
Hydroxyethyl-keryl-alkylene-ammonium compounds
|
|
US2844629A
(en)
|
1956-04-25 |
1958-07-22 |
American Home Prod |
Fatty acid amides and derivatives thereof
|
|
US3096560A
(en)
|
1958-11-21 |
1963-07-09 |
William J Liebig |
Process for synthetic vascular implants
|
|
FR1378382A
(fr)
|
1962-12-01 |
1964-11-13 |
Sandoz Sa |
Amides de l'acide amino-propionique, utilisables en particulier pour le traitement des fibres textiles
|
|
GB1072118A
(en)
|
1962-12-01 |
1967-06-14 |
Sandoz Ag |
Amides of aminopropionic acid
|
|
JPS5141663B1
(da)
|
1966-03-12 |
1976-11-11 |
|
|
|
JPS4822365B1
(da)
|
1968-10-25 |
1973-07-05 |
|
|
|
NL143127B
(nl)
|
1969-02-04 |
1974-09-16 |
Rhone Poulenc Sa |
Versterkingsorgaan voor een defecte hartklep.
|
|
US3614954A
(en)
|
1970-02-09 |
1971-10-26 |
Medtronic Inc |
Electronic standby defibrillator
|
|
US3614955A
(en)
|
1970-02-09 |
1971-10-26 |
Medtronic Inc |
Standby defibrillator and method of operation
|
|
JPS5024216B1
(da)
|
1970-12-29 |
1975-08-14 |
|
|
|
US3945052A
(en)
|
1972-05-01 |
1976-03-23 |
Meadox Medicals, Inc. |
Synthetic vascular graft and method for manufacturing the same
|
|
US3805301A
(en)
|
1972-07-28 |
1974-04-23 |
Meadox Medicals Inc |
Tubular grafts having indicia thereon
|
|
JPS49127908A
(da)
|
1973-04-20 |
1974-12-07 |
|
|
|
JPS5624664B2
(da)
|
1973-06-28 |
1981-06-08 |
|
|
|
US4013507A
(en)
|
1973-09-18 |
1977-03-22 |
California Institute Of Technology |
Ionene polymers for selectively inhibiting the vitro growth of malignant cells
|
|
JPS5123537A
(ja)
|
1974-04-26 |
1976-02-25 |
Adeka Argus Chemical Co Ltd |
Kasozaisoseibutsu
|
|
GB1527592A
(en)
|
1974-08-05 |
1978-10-04 |
Ici Ltd |
Wound dressing
|
|
US3995623A
(en)
|
1974-12-23 |
1976-12-07 |
American Hospital Supply Corporation |
Multipurpose flow-directed catheter
|
|
JPS5813576B2
(ja)
|
1974-12-27 |
1983-03-14 |
アデカ ア−ガスカガク カブシキガイシヤ |
安定化された合成高分子組成物
|
|
DE2520814A1
(de)
|
1975-05-09 |
1976-11-18 |
Bayer Ag |
Lichtstabilisierung von polyurethanen
|
|
US4281669A
(en)
|
1975-05-09 |
1981-08-04 |
Macgregor David C |
Pacemaker electrode with porous system
|
|
JPS5210847A
(en)
|
1975-07-16 |
1977-01-27 |
Nippon Steel Corp |
Pinch roll
|
|
US4096860A
(en)
|
1975-10-08 |
1978-06-27 |
Mclaughlin William F |
Dual flow encatheter
|
|
CA1069652A
(en)
|
1976-01-09 |
1980-01-15 |
Alain F. Carpentier |
Supported bioprosthetic heart valve with compliant orifice ring
|
|
US4134402A
(en)
|
1976-02-11 |
1979-01-16 |
Mahurkar Sakharam D |
Double lumen hemodialysis catheter
|
|
US4072146A
(en)
|
1976-09-08 |
1978-02-07 |
Howes Randolph M |
Venous catheter device
|
|
US4335723A
(en)
|
1976-11-26 |
1982-06-22 |
The Kendall Company |
Catheter having inflatable retention means
|
|
US4099528A
(en)
|
1977-02-17 |
1978-07-11 |
Sorenson Research Co., Inc. |
Double lumen cannula
|
|
US4140126A
(en)
|
1977-02-18 |
1979-02-20 |
Choudhury M Hasan |
Method for performing aneurysm repair
|
|
US4265745A
(en)
|
1977-05-25 |
1981-05-05 |
Teijin Limited |
Permselective membrane
|
|
US4182833A
(en)
|
1977-12-07 |
1980-01-08 |
Celanese Polymer Specialties Company |
Cationic epoxide-amine reaction products
|
|
US4180068A
(en)
|
1978-04-13 |
1979-12-25 |
Motion Control, Incorporated |
Bi-directional flow catheter with retractable trocar/valve structure
|
|
EP0005035B1
(en)
|
1978-04-19 |
1981-09-23 |
Imperial Chemical Industries Plc |
A method of preparing a tubular product by electrostatic spinning
|
|
US4284459A
(en)
|
1978-07-03 |
1981-08-18 |
The Kendall Company |
Method for making a molded catheter
|
|
US4227533A
(en)
|
1978-11-03 |
1980-10-14 |
Bristol-Myers Company |
Flushable urinary catheter
|
|
US4375817A
(en)
|
1979-07-19 |
1983-03-08 |
Medtronic, Inc. |
Implantable cardioverter
|
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
DE3010841A1
(de)
|
1980-03-21 |
1981-10-08 |
Ulrich Dr.med. 6936 Haag Uthmann |
Katheder
|
|
US4308085A
(en)
|
1980-07-28 |
1981-12-29 |
Jenoptik Jena Gmbh |
Process for the preparation of high molecular thermoplastic epoxide-amine-polyadducts
|
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
US4668777A
(en)
|
1981-03-27 |
1987-05-26 |
University Patents, Inc. |
Phosphoramidite nucleoside compounds
|
|
US4339369A
(en)
|
1981-04-23 |
1982-07-13 |
Celanese Corporation |
Cationic epoxide-amine reaction products
|
|
US4401796A
(en)
|
1981-04-30 |
1983-08-30 |
City Of Hope Research Institute |
Solid-phase synthesis of polynucleotides
|
|
US4373071A
(en)
|
1981-04-30 |
1983-02-08 |
City Of Hope Research Institute |
Solid-phase synthesis of polynucleotides
|
|
US4406656A
(en)
|
1981-06-01 |
1983-09-27 |
Brack Gillium Hattler |
Venous catheter having collapsible multi-lumens
|
|
US4475972A
(en)
|
1981-10-01 |
1984-10-09 |
Ontario Research Foundation |
Implantable material
|
|
US4401472A
(en)
|
1982-02-26 |
1983-08-30 |
Martin Marietta Corporation |
Hydraulic cement mixes and processes for improving hydraulic cement mixes
|
|
US4568329A
(en)
|
1982-03-08 |
1986-02-04 |
Mahurkar Sakharam D |
Double lumen catheter
|
|
US4546499A
(en)
|
1982-12-13 |
1985-10-15 |
Possis Medical, Inc. |
Method of supplying blood to blood receiving vessels
|
|
US4530113A
(en)
|
1983-05-20 |
1985-07-23 |
Intervascular, Inc. |
Vascular grafts with cross-weave patterns
|
|
US4550447A
(en)
|
1983-08-03 |
1985-11-05 |
Shiley Incorporated |
Vascular graft prosthesis
|
|
US4647416A
(en)
|
1983-08-03 |
1987-03-03 |
Shiley Incorporated |
Method of preparing a vascular graft prosthesis
|
|
US5104399A
(en)
|
1986-12-10 |
1992-04-14 |
Endovascular Technologies, Inc. |
Artificial graft and implantation method
|
|
US4710169A
(en)
|
1983-12-16 |
1987-12-01 |
Christopher T Graham |
Urinary catheter with collapsible urethral tube
|
|
US4571241A
(en)
|
1983-12-16 |
1986-02-18 |
Christopher T Graham |
Urinary catheter with collapsible urethral tube
|
|
US4737518A
(en)
|
1984-04-03 |
1988-04-12 |
Takeda Chemical Industries, Ltd. |
Lipid derivatives, their production and use
|
|
US4562596A
(en)
|
1984-04-25 |
1986-01-07 |
Elliot Kornberg |
Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
|
|
US4782836A
(en)
|
1984-05-24 |
1988-11-08 |
Intermedics, Inc. |
Rate adaptive cardiac pacemaker responsive to patient activity and temperature
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4662382A
(en)
|
1985-01-16 |
1987-05-05 |
Intermedics, Inc. |
Pacemaker lead with enhanced sensitivity
|
|
US4762915A
(en)
|
1985-01-18 |
1988-08-09 |
Liposome Technology, Inc. |
Protein-liposome conjugates
|
|
US4860751A
(en)
|
1985-02-04 |
1989-08-29 |
Cordis Corporation |
Activity sensor for pacemaker control
|
|
US5223263A
(en)
|
1988-07-07 |
1993-06-29 |
Vical, Inc. |
Liponucleotide-containing liposomes
|
|
CA1320724C
(en)
|
1985-07-19 |
1993-07-27 |
Koichi Kanehira |
Terpene amino alcohols and medicinal uses thereof
|
|
US4701162A
(en)
|
1985-09-24 |
1987-10-20 |
The Kendall Company |
Foley catheter assembly
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
US5153319A
(en)
|
1986-03-31 |
1992-10-06 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
DE3616824A1
(de)
|
1986-05-17 |
1987-11-19 |
Schering Ag |
Verwendung von haertbaren kunstharzmischungen fuer oberflaechenbeschichtungen und druckfarben und verfahren zu ihrer herstellung
|
|
EP0255899B1
(de)
|
1986-07-31 |
1992-07-15 |
Werner Prof. Dr.-Ing. Irnich |
Frequenzadaptierender Herzschrittmacher
|
|
US4960409A
(en)
|
1986-09-11 |
1990-10-02 |
Catalano Marc L |
Method of using bilumen peripheral venous catheter with adapter
|
|
JPH0829776B2
(ja)
|
1986-10-29 |
1996-03-27 |
東燃化学株式会社 |
合成樹脂製容器及びその製造用金型
|
|
US4720517A
(en)
|
1986-11-24 |
1988-01-19 |
Ciba-Geigy Corporation |
Compositions stabilized with N-hydroxyiminodiacetic and dipropionic acids and esters thereof
|
|
US4920016A
(en)
|
1986-12-24 |
1990-04-24 |
Linear Technology, Inc. |
Liposomes with enhanced circulation time
|
|
DE3728917A1
(de)
|
1987-08-29 |
1989-03-09 |
Roth Hermann J |
Neue lipide mit unsymmetrisch substituierter disulfidbruecke
|
|
US4946683A
(en)
|
1987-11-18 |
1990-08-07 |
Vestar, Inc. |
Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
|
|
US4843155A
(en)
*
|
1987-11-19 |
1989-06-27 |
Piotr Chomczynski |
Product and process for isolating RNA
|
|
US5138067A
(en)
|
1987-12-17 |
1992-08-11 |
Shionogi & Co. Ltd. |
Lipid derivatives
|
|
US5047540A
(en)
|
1987-12-17 |
1991-09-10 |
Shionogi & Co., Ltd. |
Lipid derivatives
|
|
JPH01257491A
(ja)
|
1988-04-08 |
1989-10-13 |
Tosoh Corp |
不溶性融合異種蛋白質の処理方法
|
|
US4892540A
(en)
|
1988-04-21 |
1990-01-09 |
Sorin Biomedica S.P.A. |
Two-leaflet prosthetic heart valve
|
|
US5176661A
(en)
|
1988-09-06 |
1993-01-05 |
Advanced Cardiovascular Systems, Inc. |
Composite vascular catheter
|
|
US5024671A
(en)
|
1988-09-19 |
1991-06-18 |
Baxter International Inc. |
Microporous vascular graft
|
|
US5200395A
(en)
|
1988-10-18 |
1993-04-06 |
Ajinomoto Company, Inc. |
Pharmaceutical composition of BUF-5 for treating anemia
|
|
CA2001401A1
(en)
|
1988-10-25 |
1990-04-25 |
Claude Piantadosi |
Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
|
|
US5047524A
(en)
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
US6214804B1
(en)
|
1989-03-21 |
2001-04-10 |
Vical Incorporated |
Induction of a protective immune response in a mammal by injecting a DNA sequence
|
|
FR2645866B1
(fr)
|
1989-04-17 |
1991-07-05 |
Centre Nat Rech Scient |
Nouvelles lipopolyamines, leur preparation et leur emploi
|
|
US5194654A
(en)
|
1989-11-22 |
1993-03-16 |
Vical, Inc. |
Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
|
|
US20070053879A1
(en)
|
1990-03-05 |
2007-03-08 |
Genzyme Corporation |
Diagnostic and treatment methods involving the cystic fibrosis transmembrane regulator
|
|
US5670488A
(en)
*
|
1992-12-03 |
1997-09-23 |
Genzyme Corporation |
Adenovirus vector for gene therapy
|
|
US5279833A
(en)
|
1990-04-04 |
1994-01-18 |
Yale University |
Liposomal transfection of nucleic acids into animal cells
|
|
US5101824A
(en)
|
1990-04-16 |
1992-04-07 |
Siemens-Pacesetter, Inc. |
Rate-responsive pacemaker with circuitry for processing multiple sensor inputs
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
WO1992001425A1
(en)
|
1990-07-26 |
1992-02-06 |
Rodney James Lane |
Self expanding vascular endoprosthesis for aneurysms
|
|
US5693338A
(en)
|
1994-09-29 |
1997-12-02 |
Emisphere Technologies, Inc. |
Diketopiperazine-based delivery systems
|
|
JPH0765267B2
(ja)
|
1990-08-22 |
1995-07-12 |
花王株式会社 |
柔軟仕上剤
|
|
US5256294A
(en)
|
1990-09-17 |
1993-10-26 |
Genentech, Inc. |
Tangential flow filtration process and apparatus
|
|
DE9117152U1
(de)
|
1990-10-09 |
1996-07-11 |
Cook Inc., Bloomington, Ind. |
Stent
|
|
ATE120971T1
(de)
|
1990-12-19 |
1995-04-15 |
Osypka Peter |
Herzschrittmacherleitung mit einem inneren kanal und mit einem elektrodenkopf.
|
|
US5116360A
(en)
|
1990-12-27 |
1992-05-26 |
Corvita Corporation |
Mesh composite graft
|
|
US5405363A
(en)
|
1991-03-15 |
1995-04-11 |
Angelon Corporation |
Implantable cardioverter defibrillator having a smaller displacement volume
|
|
US5330768A
(en)
|
1991-07-05 |
1994-07-19 |
Massachusetts Institute Of Technology |
Controlled drug delivery using polymer/pluronic blends
|
|
US5545449A
(en)
|
1991-10-02 |
1996-08-13 |
Weyerhaeuser Company |
Polyether-reinforced fiber-based materials
|
|
US5151105A
(en)
|
1991-10-07 |
1992-09-29 |
Kwan Gett Clifford |
Collapsible vessel sleeve implant
|
|
US5284491A
(en)
|
1992-02-27 |
1994-02-08 |
Medtronic, Inc. |
Cardiac pacemaker with hysteresis behavior
|
|
US5352461A
(en)
|
1992-03-11 |
1994-10-04 |
Pharmaceutical Discovery Corporation |
Self assembling diketopiperazine drug delivery system
|
|
SE9200951D0
(sv)
|
1992-03-27 |
1992-03-27 |
Kabi Pharmacia Ab |
Pharmaceutical composition containing a defined lipid system
|
|
AU3941893A
(en)
|
1992-04-06 |
1993-11-08 |
Biosite Diagnostics Incorporated |
Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels
|
|
US6670178B1
(en)
|
1992-07-10 |
2003-12-30 |
Transkaryotic Therapies, Inc. |
In Vivo production and delivery of insulinotropin for gene therapy
|
|
EP0657534A4
(en)
|
1992-08-04 |
1997-06-04 |
Green Cross Corp |
ANTIALLERGIC AGING.
|
|
US5334761A
(en)
|
1992-08-28 |
1994-08-02 |
Life Technologies, Inc. |
Cationic lipids
|
|
US5461223A
(en)
|
1992-10-09 |
1995-10-24 |
Eastman Kodak Company |
Bar code detecting circuitry
|
|
US5300022A
(en)
|
1992-11-12 |
1994-04-05 |
Martin Klapper |
Urinary catheter and bladder irrigation system
|
|
US5496362A
(en)
|
1992-11-24 |
1996-03-05 |
Cardiac Pacemakers, Inc. |
Implantable conformal coil patch electrode with multiple conductive elements for cardioversion and defibrillation
|
|
US5552155A
(en)
|
1992-12-04 |
1996-09-03 |
The Liposome Company, Inc. |
Fusogenic lipsomes and methods for making and using same
|
|
US5716395A
(en)
|
1992-12-11 |
1998-02-10 |
W.L. Gore & Associates, Inc. |
Prosthetic vascular graft
|
|
US6020317A
(en)
|
1993-02-19 |
2000-02-01 |
Nippon Shinyaku Co. Ltd. |
Glycerol derivative, device and pharmaceutical composition
|
|
US5395619A
(en)
|
1993-03-03 |
1995-03-07 |
Liposome Technology, Inc. |
Lipid-polymer conjugates and liposomes
|
|
US5697953A
(en)
|
1993-03-13 |
1997-12-16 |
Angeion Corporation |
Implantable cardioverter defibrillator having a smaller displacement volume
|
|
US5624976A
(en)
|
1994-03-25 |
1997-04-29 |
Dentsply Gmbh |
Dental filling composition and method
|
|
US5314430A
(en)
|
1993-06-24 |
1994-05-24 |
Medtronic, Inc. |
Atrial defibrillator employing transvenous and subcutaneous electrodes and method of use
|
|
DE4325848A1
(de)
|
1993-07-31 |
1995-02-02 |
Basf Ag |
Verfahren zur Herstellung von N-(2-Hydroxyethyl)-piperazin
|
|
EP0647462A1
(en)
|
1993-10-06 |
1995-04-12 |
The Kansai Electric Power Co., Inc. |
Method for removing carbon dioxide from combustion exhaust gas
|
|
US5609624A
(en)
|
1993-10-08 |
1997-03-11 |
Impra, Inc. |
Reinforced vascular graft and method of making same
|
|
SE9303481L
(sv)
|
1993-10-22 |
1995-04-23 |
Berol Nobel Ab |
Hygienkomposition
|
|
WO1995013033A1
(en)
|
1993-11-08 |
1995-05-18 |
Lazarus Harrison M |
Intraluminal vascular graft and method
|
|
NZ277614A
(en)
|
1993-11-24 |
1998-05-27 |
Megabios Corp |
Piperazine-containing amphiphiles and their use in liposomes for delivering genetic material intracellularly
|
|
US5595756A
(en)
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
US5464924A
(en)
|
1994-01-07 |
1995-11-07 |
The Dow Chemical Company |
Flexible poly(amino ethers) for barrier packaging
|
|
US6180778B1
(en)
|
1994-02-11 |
2001-01-30 |
Qiagen Gmbh |
Process for the separation of double-stranded/single-stranded nucleic acid structures
|
|
US5844107A
(en)
|
1994-03-23 |
1998-12-01 |
Case Western Reserve University |
Compacted nucleic acids and their delivery to cells
|
|
CA2187748C
(en)
|
1994-04-12 |
2007-04-10 |
Austin Bailey |
Fusogenic liposomes and methods of making and using same
|
|
US5840576A
(en)
|
1994-07-20 |
1998-11-24 |
Cytotherapeutics, Inc. |
Methods and compositions of growth control for cells encapsulated within bioartificial organs
|
|
US5820873A
(en)
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5641665A
(en)
|
1994-11-28 |
1997-06-24 |
Vical Incorporated |
Plasmids suitable for IL-2 expression
|
|
US6071890A
(en)
|
1994-12-09 |
2000-06-06 |
Genzyme Corporation |
Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
|
|
US5965434A
(en)
|
1994-12-29 |
1999-10-12 |
Wolff; Jon A. |
Amphipathic PH sensitive compounds and delivery systems for delivering biologically active compounds
|
|
US6485726B1
(en)
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
|
EP0822835A1
(en)
|
1995-04-17 |
1998-02-11 |
Imarx Pharmaceutical Corp. |
Hybrid magnetic resonance contrast agents
|
|
US20010047091A1
(en)
|
1998-09-09 |
2001-11-29 |
Brian Miki |
Cryptic regulatory elements obtained from plants
|
|
US5772694A
(en)
|
1995-05-16 |
1998-06-30 |
Medical Carbon Research Institute L.L.C. |
Prosthetic heart valve with improved blood flow
|
|
US5700642A
(en)
|
1995-05-22 |
1997-12-23 |
Sri International |
Oligonucleotide sizing using immobilized cleavable primers
|
|
US5783383A
(en)
|
1995-05-23 |
1998-07-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method of detecting cytomegalovirus (CMV)
|
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
|
US5705385A
(en)
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
ATE285477T1
(de)
|
1995-06-07 |
2005-01-15 |
Inex Pharmaceutical Corp |
Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
|
|
US5609629A
(en)
|
1995-06-07 |
1997-03-11 |
Med Institute, Inc. |
Coated implantable medical device
|
|
US5607385A
(en)
|
1995-08-17 |
1997-03-04 |
Medtronic, Inc. |
Device and algorithm for a combined cardiomyostimulator and a cardiac pacer-carioverter-defibrillator
|
|
US5744335A
(en)
|
1995-09-19 |
1998-04-28 |
Mirus Corporation |
Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
|
|
FR2740978B1
(fr)
|
1995-11-10 |
1998-01-02 |
Ela Medical Sa |
Dispositif medical actif du type defibrillateur/cardioverteur implantable
|
|
US5874105A
(en)
|
1996-01-31 |
1999-02-23 |
Collaborative Laboratories, Inc. |
Lipid vesicles formed with alkylammonium fatty acid salts
|
|
ATE273320T1
(de)
|
1996-04-11 |
2004-08-15 |
Univ British Columbia |
Fusogene liposomen
|
|
US5935936A
(en)
|
1996-06-03 |
1999-08-10 |
Genzyme Corporation |
Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules
|
|
US5913848A
(en)
|
1996-06-06 |
1999-06-22 |
Luther Medical Products, Inc. |
Hard tip over-the-needle catheter and method of manufacturing the same
|
|
US5677124A
(en)
|
1996-07-03 |
1997-10-14 |
Ambion, Inc. |
Ribonuclease resistant viral RNA standards
|
|
US5736573A
(en)
|
1996-07-31 |
1998-04-07 |
Galat; Alexander |
Lipid and water soluble derivatives of drugs
|
|
US6011148A
(en)
*
|
1996-08-01 |
2000-01-04 |
Megabios Corporation |
Methods for purifying nucleic acids
|
|
US7288266B2
(en)
|
1996-08-19 |
2007-10-30 |
United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Liposome complexes for increased systemic delivery
|
|
PT941066E
(pt)
|
1996-08-26 |
2004-03-31 |
Transgene Sa |
Complexos de lipido cationico - acido nucleico
|
|
AU728581B2
(en)
|
1996-09-13 |
2001-01-11 |
Lipoxen Limited |
Liposomes
|
|
US5874268A
(en)
|
1996-09-23 |
1999-02-23 |
Duke University |
Method of introducing exogenous compounds into cells by electroporation and apparatus for same
|
|
TW520297B
(en)
|
1996-10-11 |
2003-02-11 |
Sequus Pharm Inc |
Fusogenic liposome composition and method
|
|
DE69735382T2
(de)
|
1996-11-04 |
2006-11-30 |
Qiagen Gmbh |
Kationische reagenzien zür transfektion
|
|
US6887665B2
(en)
|
1996-11-14 |
2005-05-03 |
Affymetrix, Inc. |
Methods of array synthesis
|
|
US5985930A
(en)
|
1996-11-21 |
1999-11-16 |
Pasinetti; Giulio M. |
Treatment of neurodegenerative conditions with nimesulide
|
|
US6204297B1
(en)
|
1996-11-26 |
2001-03-20 |
Rhodia Inc. |
Nonionic gemini surfactants
|
|
JPH10197978A
(ja)
|
1997-01-09 |
1998-07-31 |
Mitsubishi Paper Mills Ltd |
ハロゲン化銀写真感光材料
|
|
EP0853123A1
(de)
|
1997-01-10 |
1998-07-15 |
Roche Diagnostics GmbH |
Reinigung von DNA durch Cross-Flow-Filtration
|
|
FR2760193B1
(fr)
|
1997-02-28 |
1999-05-28 |
Transgene Sa |
Lipides et complexes de lipides cationiques et de substances actives, notamment pour la transfection de cellules
|
|
US5837283A
(en)
|
1997-03-12 |
1998-11-17 |
The Regents Of The University Of California |
Cationic lipid compositions targeting angiogenic endothelial cells
|
|
US5945326A
(en)
|
1997-03-20 |
1999-08-31 |
New England Biolabs, Inc. |
Method for cloning and producing the Spel restriction endonuclease
|
|
US20030104044A1
(en)
|
1997-05-14 |
2003-06-05 |
Semple Sean C. |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
CA2289702C
(en)
|
1997-05-14 |
2008-02-19 |
Inex Pharmaceuticals Corp. |
High efficiency encapsulation of charged therapeutic agents in lipid vesicles
|
|
US6835395B1
(en)
|
1997-05-14 |
2004-12-28 |
The University Of British Columbia |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
|
|
EP0994945B1
(en)
|
1997-06-02 |
2003-11-05 |
Vlaams Interuniversitair Instituut voor Biotechnologie |
Smad-interacting polypeptides and their use
|
|
JPH115786A
(ja)
|
1997-06-13 |
1999-01-12 |
Pola Chem Ind Inc |
新規アミノヒドロキシプロピルピペラジン誘導体
|
|
US6067471A
(en)
|
1998-08-07 |
2000-05-23 |
Cardiac Pacemakers, Inc. |
Atrial and ventricular implantable cardioverter-defibrillator and lead system
|
|
JPH1180142A
(ja)
|
1997-09-05 |
1999-03-26 |
Pola Chem Ind Inc |
ジフェニルアルキル化合物の製造法
|
|
US20030083272A1
(en)
|
1997-09-19 |
2003-05-01 |
Lahive & Cockfield, Llp |
Sense mrna therapy
|
|
US6165763A
(en)
|
1997-10-30 |
2000-12-26 |
Smithkline Beecham Corporation |
Ornithine carbamoyltransferase
|
|
US6096075A
(en)
|
1998-01-22 |
2000-08-01 |
Medical Carbon Research Institute, Llc |
Prosthetic heart valve
|
|
US6617171B2
(en)
|
1998-02-27 |
2003-09-09 |
The General Hospital Corporation |
Methods for diagnosing and treating autoimmune disease
|
|
US6271209B1
(en)
|
1998-04-03 |
2001-08-07 |
Valentis, Inc. |
Cationic lipid formulation delivering nucleic acid to peritoneal tumors
|
|
US6176877B1
(en)
|
1998-04-20 |
2001-01-23 |
St. Jude Medical, Inc. |
Two piece prosthetic heart valve
|
|
US6986902B1
(en)
|
1998-04-28 |
2006-01-17 |
Inex Pharmaceuticals Corporation |
Polyanionic polymers which enhance fusogenicity
|
|
DE19822602A1
(de)
|
1998-05-20 |
1999-11-25 |
Goldschmidt Ag Th |
Verfahren zur Herstellung von Polyaminosäureestern durch Veresterung von sauren Polyaminosäuren oder Umesterung von Polyaminosäureestern
|
|
NO313244B1
(no)
|
1998-07-08 |
2002-09-02 |
Crew Dev Corp |
Fremgangsmåte for isolering og produksjon av magnesitt eller magnesiumklorid
|
|
US6055454A
(en)
|
1998-07-27 |
2000-04-25 |
Cardiac Pacemakers, Inc. |
Cardiac pacemaker with automatic response optimization of a physiologic sensor based on a second sensor
|
|
CA2340652C
(en)
|
1998-08-20 |
2013-09-24 |
Cook Incorporated |
Coated implantable medical device comprising paclitaxel
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
US6656498B1
(en)
|
1998-11-25 |
2003-12-02 |
Vanderbilt University |
Cationic liposomes for gene transfer
|
|
US6740643B2
(en)
|
1999-01-21 |
2004-05-25 |
Mirus Corporation |
Compositions and methods for drug delivery using amphiphile binding molecules
|
|
US6248725B1
(en)
|
1999-02-23 |
2001-06-19 |
Amgen, Inc. |
Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
|
|
US6379698B1
(en)
|
1999-04-06 |
2002-04-30 |
Isis Pharmaceuticals, Inc. |
Fusogenic lipids and vesicles
|
|
WO2000062813A2
(en)
|
1999-04-20 |
2000-10-26 |
The University Of British Columbia |
Cationic peg-lipids and methods of use
|
|
KR100669053B1
(ko)
|
1999-04-23 |
2007-01-15 |
알자 코포레이션 |
리포좀에 사용하기 위한 절단가능 결합을 갖는 콘쥬게이트
|
|
US6169923B1
(en)
|
1999-04-23 |
2001-01-02 |
Pacesetter, Inc. |
Implantable cardioverter-defibrillator with automatic arrhythmia detection criteria adjustment
|
|
ATE369384T1
(de)
|
1999-05-19 |
2007-08-15 |
Emd Lexigen Res Ct Corp |
Expression und export von interferon-alpha proteinen als fc fusionsproteine
|
|
US6696424B1
(en)
|
1999-05-28 |
2004-02-24 |
Vical Incorporated |
Cytofectin dimers and methods of use thereof
|
|
US6346382B1
(en)
|
1999-06-01 |
2002-02-12 |
Vanderbilt University |
Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto
|
|
EP1202714A1
(en)
|
1999-07-16 |
2002-05-08 |
Purdue Research Foundation |
Vinyl ether lipids with cleavable hydrophilic headgroups
|
|
KR100669305B1
(ko)
|
1999-07-23 |
2007-01-17 |
제넨테크, 인크. |
Rna 분해효소 및 유기용매의 작용없이 접선 흐름여과를 이용한 플라스미드 dna 정제법
|
|
US6358278B1
(en)
|
1999-09-24 |
2002-03-19 |
St. Jude Medical, Inc. |
Heart valve prosthesis with rotatable cuff
|
|
US6371983B1
(en)
|
1999-10-04 |
2002-04-16 |
Ernest Lane |
Bioprosthetic heart valve
|
|
US7060291B1
(en)
|
1999-11-24 |
2006-06-13 |
Transave, Inc. |
Modular targeted liposomal delivery system
|
|
CN101041079A
(zh)
|
1999-12-30 |
2007-09-26 |
诺瓦提斯公司 |
用于基因治疗的新的胶体合成载体
|
|
CA2400634A1
(en)
|
2000-02-17 |
2001-08-23 |
Chester Li |
Genetic modification of the lung as a portal for gene delivery
|
|
US6370434B1
(en)
|
2000-02-28 |
2002-04-09 |
Cardiac Pacemakers, Inc. |
Cardiac lead and method for lead implantation
|
|
IL152527A0
(en)
|
2000-05-12 |
2003-05-29 |
Univ Southern California |
Retroviral vectors comprising an enhanced 3'transcription termination structure
|
|
US6565960B2
(en)
|
2000-06-01 |
2003-05-20 |
Shriners Hospital Of Children |
Polymer composite compositions
|
|
IL138474A0
(en)
|
2000-09-14 |
2001-10-31 |
Epox Ltd |
Highly branched water-soluble polyamine oligomers, process for their preparation and applications thereof
|
|
USRE43612E1
(en)
|
2000-10-10 |
2012-08-28 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
|
US6998115B2
(en)
|
2000-10-10 |
2006-02-14 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
|
US7427394B2
(en)
|
2000-10-10 |
2008-09-23 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
|
US7202226B2
(en)
|
2000-10-23 |
2007-04-10 |
Detroit R & D |
Augmentation of wound healing by elF-4E mRNA and EGF mRNA
|
|
AU2002214854A1
(en)
|
2000-10-25 |
2002-05-06 |
Inex Pharmaceuticals Corporation |
Lipid formulations for target delivery
|
|
GB0028361D0
(en)
|
2000-11-21 |
2001-01-03 |
Glaxo Group Ltd |
Method of separating extra chromosomal dna from other cellular components
|
|
US20020094528A1
(en)
|
2000-11-29 |
2002-07-18 |
Salafsky Joshua S. |
Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interations
|
|
JP2002167368A
(ja)
|
2000-12-01 |
2002-06-11 |
Nitto Denko Corp |
アルキル置換デンドリマーおよびその製造法
|
|
US20050004058A1
(en)
|
2000-12-07 |
2005-01-06 |
Patrick Benoit |
Sequences upstream of the carp gene, vectors containing them and uses thereof
|
|
JP4061043B2
(ja)
|
2000-12-28 |
2008-03-12 |
株式会社ポストゲノム研究所 |
invitro転写/翻訳系によるペプチド等の製造方法
|
|
EP1366196A4
(en)
|
2001-02-14 |
2004-07-07 |
Baylor College Medicine |
RNA AMPLIFICATION METHODS AND COMPOSITIONS
|
|
DE10109897A1
(de)
|
2001-02-21 |
2002-11-07 |
Novosom Ag |
Fakultativ kationische Liposomen und Verwendung dieser
|
|
US20020192721A1
(en)
|
2001-03-28 |
2002-12-19 |
Engeneos, Inc. |
Modular molecular clasps and uses thereof
|
|
US7084303B2
(en)
|
2001-04-23 |
2006-08-01 |
Shin-Etsu Chemical Co., Ltd. |
Tertiary amine compounds having an ester structure and processes for preparing same
|
|
US6585410B1
(en)
|
2001-05-03 |
2003-07-01 |
The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration |
Radiant temperature nulling radiometer
|
|
ATE490267T1
(de)
|
2001-06-05 |
2010-12-15 |
Curevac Gmbh |
Stabilisierte mrna mit erhöhtem g/c-gehalt, kodierend für ein virales antigen
|
|
EP2390331B1
(en)
|
2001-09-28 |
2018-04-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
MicroRNA molecules
|
|
JP3979996B2
(ja)
*
|
2001-10-12 |
2007-09-19 |
ジェントラ システムズ インコーポレイテッド |
固体支持体を使用してrnaを精製するための組成物および方法
|
|
WO2003040288A2
(de)
|
2001-11-09 |
2003-05-15 |
Bayer Healthcare Ag |
Isotopencodierte affinitätsmarker 3
|
|
DE10162480A1
(de)
|
2001-12-19 |
2003-08-07 |
Ingmar Hoerr |
Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
|
|
DE10207178A1
(de)
|
2002-02-19 |
2003-09-04 |
Novosom Ag |
Komponenten für die Herstellung amphoterer Liposomen
|
|
EP1485503A4
(en)
*
|
2002-03-15 |
2005-12-28 |
Arcturus Bioscience Inc |
IMPROVED NUCLEIC ACID AMPLIFICATION
|
|
DE10214983A1
(de)
|
2002-04-04 |
2004-04-08 |
TransMIT Gesellschaft für Technologietransfer mbH |
Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
|
|
GB0208390D0
(en)
|
2002-04-11 |
2002-05-22 |
Univ London |
Adeno-associated virus producer system
|
|
US20030215395A1
(en)
|
2002-05-14 |
2003-11-20 |
Lei Yu |
Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier
|
|
US7601367B2
(en)
|
2002-05-28 |
2009-10-13 |
Mirus Bio Llc |
Compositions and processes using siRNA, amphipathic compounds and polycations
|
|
US7901708B2
(en)
|
2002-06-28 |
2011-03-08 |
Protiva Biotherapeutics, Inc. |
Liposomal apparatus and manufacturing methods
|
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
|
US20040028804A1
(en)
|
2002-08-07 |
2004-02-12 |
Anderson Daniel G. |
Production of polymeric microarrays
|
|
WO2004018654A2
(en)
|
2002-08-22 |
2004-03-04 |
Celltran Limited |
Cell culture surface
|
|
US20060160759A1
(en)
|
2002-09-28 |
2006-07-20 |
Jianzhu Chen |
Influenza therapeutic
|
|
CN100457804C
(zh)
|
2002-11-04 |
2009-02-04 |
Ge拜尔硅股份有限公司 |
线性聚氨基-和/或聚铵聚硅氧烷共聚物ⅰ
|
|
CA2506843A1
(en)
|
2002-11-22 |
2004-06-10 |
Novo-Nordisk A/S |
2,5-diketopiperazines for the treatment of obesity
|
|
US7169892B2
(en)
|
2003-01-10 |
2007-01-30 |
Astellas Pharma Inc. |
Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems
|
|
EP1586983B1
(en)
|
2003-01-20 |
2013-06-05 |
Asahi Kasei EMD Corporation |
Pointing device
|
|
CA2516836A1
(en)
|
2003-02-24 |
2004-09-10 |
Gtc Biotherapeutics, Inc. |
Methods of tangential flow filtration and an apparatus therefore
|
|
TW200427695A
(en)
|
2003-03-05 |
2004-12-16 |
Senesco Technologies Inc |
Use of antisense oligonucleotides or sirna to suppress expression of eif-5a1
|
|
US20040224912A1
(en)
|
2003-05-07 |
2004-11-11 |
Isis Pharmaceuticals Inc. |
Modulation of PAI-1 mRNA-binding protein expression
|
|
US7619017B2
(en)
|
2003-05-19 |
2009-11-17 |
Wacker Chemical Corporation |
Polymer emulsions resistant to biodeterioration
|
|
EP1644479A4
(en)
|
2003-06-16 |
2008-04-23 |
Mark W Grinstaff |
FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENERAL FEEDING
|
|
US20050059024A1
(en)
|
2003-07-25 |
2005-03-17 |
Ambion, Inc. |
Methods and compositions for isolating small RNA molecules
|
|
NZ592917A
(en)
|
2003-09-15 |
2012-12-21 |
Protiva Biotherapeutics Inc |
Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates
|
|
WO2005028619A2
(en)
|
2003-09-15 |
2005-03-31 |
Massachusetts Institute Of Technology |
Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
|
|
US20050069590A1
(en)
|
2003-09-30 |
2005-03-31 |
Buehler Gail K. |
Stable suspensions for medicinal dosages
|
|
WO2005035771A2
(en)
|
2003-10-10 |
2005-04-21 |
Powderject Vaccines, Inc. |
Nucleic acid constructs
|
|
WO2005037226A2
(en)
|
2003-10-17 |
2005-04-28 |
Georgia Tech Research Corporation |
Genetically engineered enteroendocrine cells for treating glucose-related metabolic disorders
|
|
KR20060111471A
(ko)
|
2003-11-10 |
2006-10-27 |
니폰 가야꾸 가부시끼가이샤 |
디이모늄염 화합물 및 그의 용도
|
|
US8075780B2
(en)
*
|
2003-11-24 |
2011-12-13 |
Millipore Corporation |
Purification and concentration of synthetic biological molecules
|
|
DE602004026912D1
(de)
|
2003-12-16 |
2010-06-10 |
Qiagen North American Holdings |
Formulierungen und verfahren zum denaturieren von proteinen
|
|
US7022214B2
(en)
|
2004-01-21 |
2006-04-04 |
Bio-Rad Laboratories, Inc. |
Carrier ampholytes of high pH range
|
|
US7556684B2
(en)
|
2004-02-26 |
2009-07-07 |
Construction Research & Technology Gmbh |
Amine containing strength improvement admixture
|
|
US20060228404A1
(en)
|
2004-03-04 |
2006-10-12 |
Anderson Daniel G |
Compositions and methods for treatment of hypertrophic tissues
|
|
JP2006271201A
(ja)
*
|
2004-03-26 |
2006-10-12 |
Fuji Photo Film Co Ltd |
Rnaの選択的分離精製方法
|
|
EP1727900A4
(en)
|
2004-03-26 |
2008-05-28 |
Fujifilm Corp |
METHOD FOR SELECTIVELY SEPARATING AND CLEANING RNA, AND METHOD FOR SEPARATING AND CLEANING NUCLEIC ACID
|
|
US7799565B2
(en)
|
2004-06-07 |
2010-09-21 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering RNA
|
|
US7745651B2
(en)
|
2004-06-07 |
2010-06-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use
|
|
US7670595B2
(en)
|
2004-06-28 |
2010-03-02 |
Merck Patent Gmbh |
Fc-interferon-beta fusion proteins
|
|
GB0418172D0
(en)
|
2004-08-13 |
2004-09-15 |
Ic Vec Ltd |
Vector
|
|
US7361465B2
(en)
|
2004-09-07 |
2008-04-22 |
Applera Corporation |
Methods and compositions for tailing and amplifying RNA
|
|
DE102004043342A1
(de)
|
2004-09-08 |
2006-03-09 |
Bayer Materialscience Ag |
Blockierte Polyurethan-Prepolymere als Klebstoffe
|
|
EP1807050A1
(en)
|
2004-11-05 |
2007-07-18 |
Novosom AG |
Improvements in or relating to pharmaceutical compositions comprising an oligonucleotide as an active agent
|
|
AU2006211216B2
(en)
*
|
2005-01-31 |
2011-02-03 |
Merck Sharp & Dohme Llc |
Purification process for plasmid DNA
|
|
GB0502482D0
(en)
|
2005-02-07 |
2005-03-16 |
Glaxo Group Ltd |
Novel compounds
|
|
JP5042863B2
(ja)
|
2005-02-14 |
2012-10-03 |
サーナ・セラピューティクス・インコーポレイテッド |
生物学的に活性な分子をデリバリーするための脂質ナノ粒子系組成物および方法
|
|
EP1869106B1
(en)
|
2005-03-28 |
2014-06-25 |
Dendritic Nanotechnologies, Inc. |
Janus dendrimers and dendrons
|
|
US9006487B2
(en)
|
2005-06-15 |
2015-04-14 |
Massachusetts Institute Of Technology |
Amine-containing lipids and uses thereof
|
|
US20070050070A1
(en)
|
2005-08-05 |
2007-03-01 |
Pfizer Inc |
Automated batch manufactuirng
|
|
US9012219B2
(en)
|
2005-08-23 |
2015-04-21 |
The Trustees Of The University Of Pennsylvania |
RNA preparations comprising purified modified RNA for reprogramming cells
|
|
EP3611266B1
(en)
|
2005-08-23 |
2022-11-09 |
The Trustees of the University of Pennsylvania |
Rna containing modified nucleosides and methods of use thereof
|
|
WO2007031091A2
(en)
|
2005-09-15 |
2007-03-22 |
Santaris Pharma A/S |
Rna antagonist compounds for the modulation of p21 ras expression
|
|
US8101741B2
(en)
|
2005-11-02 |
2012-01-24 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
|
US7238791B1
(en)
|
2005-12-16 |
2007-07-03 |
Roche Diagnostics Operations, Inc. |
6-monoacetylmorphine derivatives useful in immunoassay
|
|
WO2007073489A2
(en)
|
2005-12-22 |
2007-06-28 |
Trustees Of Boston University |
Molecules for gene delivery and gene therapy, and methods of use thereof
|
|
CN100569877C
(zh)
|
2005-12-30 |
2009-12-16 |
财团法人工业技术研究院 |
含多uv交联反应基的分枝状结构化合物及其应用
|
|
CA2649325C
(en)
|
2006-04-14 |
2019-01-08 |
Epicentre Technologies Corporation |
Kits and methods for generating 5' capped rna
|
|
US9085778B2
(en)
|
2006-05-03 |
2015-07-21 |
VL27, Inc. |
Exosome transfer of nucleic acids to cells
|
|
US20070275923A1
(en)
|
2006-05-25 |
2007-11-29 |
Nastech Pharmaceutical Company Inc. |
CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY
|
|
WO2007143659A2
(en)
|
2006-06-05 |
2007-12-13 |
Massachusetts Institute Of Technology |
Crosslinked, degradable polymers and uses thereof
|
|
US20080113357A1
(en)
|
2006-06-29 |
2008-05-15 |
Millipore Corporation |
Filter device for the isolation of a nucleic acid
|
|
US20090186805A1
(en)
|
2006-07-06 |
2009-07-23 |
Aaron Thomas Tabor |
Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance
|
|
ES2293834B1
(es)
|
2006-07-20 |
2009-02-16 |
Consejo Superior Investig. Cientificas |
Compuesto con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas que lo comprenden y sus aplicaciones terapeuticas.
|
|
CA2658768C
(en)
|
2006-07-21 |
2016-05-17 |
Massachusetts Institute Of Technology |
End-modified poly(beta-amino esters) and uses thereof
|
|
EP3192788A1
(en)
|
2006-10-03 |
2017-07-19 |
Arbutus Biopharma Corporation |
Lipid containing formulations
|
|
DE102006051516A1
(de)
|
2006-10-31 |
2008-05-08 |
Curevac Gmbh |
(Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins
|
|
CN101611145B
(zh)
|
2006-12-21 |
2013-08-14 |
诺维信股份有限公司 |
用于在细菌细胞中表达基因的修饰型信使rna稳定化序列
|
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
US20100092572A1
(en)
|
2007-01-29 |
2010-04-15 |
Peter Kaeuper |
Chitosan-based colloidal particles for rna delivery
|
|
US8859229B2
(en)
|
2007-02-02 |
2014-10-14 |
Yale University |
Transient transfection with RNA
|
|
WO2008113364A2
(en)
|
2007-03-20 |
2008-09-25 |
Recepticon Aps |
Amino derivatives to prevent nephrotoxicity and cancer
|
|
JP5186126B2
(ja)
|
2007-03-29 |
2013-04-17 |
公益財団法人地球環境産業技術研究機構 |
新規トリアジン誘導体ならびにその製法およびそのガス分離膜としての用途
|
|
NZ580973A
(en)
|
2007-04-18 |
2011-10-28 |
Cornerstone Pharmaceuticals Inc |
Pharmaceutical formulations containing lipoic acid derivatives
|
|
US8678686B2
(en)
|
2007-05-01 |
2014-03-25 |
Pgr-Solutions |
Multi-chain lipophilic polyamines
|
|
US20090163705A1
(en)
|
2007-05-21 |
2009-06-25 |
Alnylam Pharmaceuticals, Inc. |
Cationic lipids
|
|
CA2701274A1
(en)
|
2007-10-02 |
2009-04-09 |
Mdrna, Inc. |
Lipopeptides for delivery of nucleic acids
|
|
WO2009082607A2
(en)
|
2007-12-04 |
2009-07-02 |
Alnylam Pharmaceuticals, Inc. |
Targeting lipids
|
|
CA2710983A1
(en)
|
2007-12-27 |
2009-10-01 |
The Ohio State University Research Foundation |
Lipid nanoparticle compositions and methods of making and using the same
|
|
WO2009082817A1
(en)
|
2007-12-27 |
2009-07-09 |
Protiva Biotherapeutics, Inc. |
Silencing of polo-like kinase expression using interfering rna
|
|
CA3252166A1
(en)
|
2008-01-02 |
2025-11-29 |
Arbutus Biopharma Corporation |
Screening method for selected amino lipid-containing compositions
|
|
FR2926560A1
(fr)
|
2008-01-21 |
2009-07-24 |
Millipore Corp |
Procede d'extraction et de purification d'acides nucleiques sur membrane
|
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
AU2009238175C1
(en)
|
2008-04-15 |
2023-11-30 |
Arbutus Biopharma Corporation |
Novel lipid formulations for nucleic acid delivery
|
|
US20090263407A1
(en)
|
2008-04-16 |
2009-10-22 |
Abbott Laboratories |
Cationic Lipids and Uses Thereof
|
|
WO2009127230A1
(en)
|
2008-04-16 |
2009-10-22 |
Curevac Gmbh |
MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
|
|
CA2726052A1
(en)
|
2008-06-04 |
2009-12-10 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small rna targeting of gene promoters
|
|
US20100012012A1
(en)
|
2008-07-19 |
2010-01-21 |
Mark Schaefbauer |
Positioning apparatus
|
|
JP5024216B2
(ja)
|
2008-07-23 |
2012-09-12 |
トヨタ自動車株式会社 |
内燃機関の点火時期制御装置及び点火時期制御方法
|
|
US20100035249A1
(en)
|
2008-08-05 |
2010-02-11 |
Kabushiki Kaisha Dnaform |
Rna sequencing and analysis using solid support
|
|
CN102203605B
(zh)
|
2008-08-27 |
2014-07-23 |
生命技术公司 |
处理生物样品的设备和方法
|
|
JP2010053108A
(ja)
*
|
2008-08-29 |
2010-03-11 |
Asahi Kasei Corp |
荷電を有する限外濾過膜を用いた生体成分の分離方法およびモジュール、装置
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
CN104119242B
(zh)
|
2008-10-09 |
2017-07-07 |
泰米拉制药公司 |
改善的氨基脂质和递送核酸的方法
|
|
CN102231979B
(zh)
|
2008-10-16 |
2014-10-29 |
玛瑞纳生物技术有限公司 |
基因沉默治疗剂的脂质体有效递送方法和组合物
|
|
US9080211B2
(en)
|
2008-10-24 |
2015-07-14 |
Epicentre Technologies Corporation |
Transposon end compositions and methods for modifying nucleic acids
|
|
WO2010062322A2
(en)
|
2008-10-27 |
2010-06-03 |
Massachusetts Institute Of Technology |
Modulation of the immune response
|
|
CN102204077B
(zh)
|
2008-11-05 |
2014-05-28 |
株式会社日立医疗器械 |
相移型逆变电路、使用该电路的x射线高压装置、x射线ct装置和x射线摄影装置
|
|
ES2646630T3
(es)
|
2008-11-07 |
2017-12-14 |
Massachusetts Institute Of Technology |
Lipidoides aminoalcohólicos y usos de los mismos
|
|
HUE037082T2
(hu)
|
2008-11-10 |
2018-08-28 |
Arbutus Biopharma Corp |
Új lipidek és készítmények terápiás hatóanyagok szállítására
|
|
TW201019969A
(en)
|
2008-11-17 |
2010-06-01 |
Enzon Pharmaceuticals Inc |
Branched cationic lipids for nucleic acids delivery system
|
|
JP2012511531A
(ja)
|
2008-12-09 |
2012-05-24 |
エフ.ホフマン−ラ ロシュ アーゲー |
賦形剤不含抗体溶液を得るための方法
|
|
CA2750561C
(en)
|
2009-01-26 |
2017-10-10 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein c-iii expression
|
|
US20100222489A1
(en)
|
2009-02-27 |
2010-09-02 |
Jiang Dayue D |
Copolymer composition, membrane article, and methods thereof
|
|
AU2010223967B2
(en)
|
2009-03-12 |
2015-07-30 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
|
|
WO2010114789A1
(en)
|
2009-04-02 |
2010-10-07 |
The Siemon Company |
Telecommunications patch panel
|
|
EP3569254B1
(en)
|
2009-04-17 |
2022-07-20 |
Oxford University Innovation Limited |
Composition for delivery of genetic material
|
|
US20100273220A1
(en)
|
2009-04-22 |
2010-10-28 |
Massachusetts Institute Of Technology |
Innate immune suppression enables repeated delivery of long rna molecules
|
|
KR20180094137A
(ko)
|
2009-05-05 |
2018-08-22 |
알닐람 파마슈티칼스 인코포레이티드 |
지질 조성물
|
|
MX342785B
(es)
|
2009-06-10 |
2016-10-12 |
Alnylam Pharmaceuticals Inc |
Formulacion mejorada de lipido.
|
|
NZ597504A
(en)
|
2009-06-15 |
2013-10-25 |
Alnylam Pharmaceuticals Inc |
Lipid formulated dsrna targeting the pcsk9 gene
|
|
WO2010147992A1
(en)
|
2009-06-15 |
2010-12-23 |
Alnylam Pharmaceuticals, Inc. |
Methods for increasing efficacy of lipid formulated sirna
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
US8236943B2
(en)
|
2009-07-01 |
2012-08-07 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein B
|
|
WO2011011447A1
(en)
|
2009-07-20 |
2011-01-27 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing ebola virus gene expression
|
|
BR112012002134B8
(pt)
|
2009-07-30 |
2021-05-25 |
Salvat Lab Sa |
compostos inibidores de apaf-1
|
|
BR112012002291A2
(pt)
|
2009-07-31 |
2016-11-29 |
Ethris Gmbh |
"polirribonucleotídeo com uma sequência que codifica uma proteína ou fragmento de proteína, implante, e, processo para a seleção de sequências de nucleotídeos"
|
|
JP5769173B2
(ja)
|
2009-08-19 |
2015-08-26 |
国立大学法人 奈良先端科学技術大学院大学 |
環境ストレス下の翻訳抑制を回避する5’utrをコードする組換えdna分子
|
|
DE102009043342A1
(de)
|
2009-09-29 |
2011-03-31 |
Bayer Technology Services Gmbh |
Stoffe für selbstorganisierte Träger zur kontrollierten Freisetzung eines Wirkstoffs
|
|
CN102575233B
(zh)
*
|
2009-10-15 |
2014-07-16 |
克鲁塞尔荷兰公司 |
从高细胞密度培养物纯化腺病毒的方法
|
|
HUE042177T2
(hu)
|
2009-12-01 |
2019-06-28 |
Translate Bio Inc |
Szteroidszármazék mRNS szállítására humán genetikai betegségekben
|
|
KR20240136456A
(ko)
|
2009-12-07 |
2024-09-13 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
세포 리프로그래밍을 위한 정제된 변형 rna를 포함하는 rna 제제
|
|
CA2784568A1
(en)
|
2009-12-18 |
2011-06-23 |
The University Of British Columbia |
Lipid particles for delivery of nucleic acids
|
|
WO2011076807A2
(en)
|
2009-12-23 |
2011-06-30 |
Novartis Ag |
Lipids, lipid compositions, and methods of using them
|
|
US9315802B2
(en)
|
2009-12-30 |
2016-04-19 |
Quest Diagnostics Investments Incorporated |
RNA isolation from soluble urine fractions
|
|
WO2011141705A1
(en)
|
2010-05-12 |
2011-11-17 |
Protiva Biotherapeutics, Inc. |
Novel cationic lipids and methods of use thereof
|
|
SG186085A1
(en)
|
2010-06-03 |
2013-01-30 |
Alnylam Pharmaceuticals Inc |
Biodegradable lipids for the delivery of active agents
|
|
CN101863544B
(zh)
|
2010-06-29 |
2011-09-28 |
湖南科技大学 |
一种氰尿酸基重金属螯合絮凝剂及其制备方法
|
|
WO2012000104A1
(en)
|
2010-06-30 |
2012-01-05 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
|
WO2012019168A2
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2012019630A1
(en)
|
2010-08-13 |
2012-02-16 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
|
|
EP2609135A4
(en)
|
2010-08-26 |
2015-05-20 |
Massachusetts Inst Technology |
POLY (BETA AMINO ALCOHOLS), THEIR PREPARATION AND USES THEREOF
|
|
US9303255B2
(en)
|
2010-08-26 |
2016-04-05 |
Aisin Seiki Kabushiki Kaisha |
Electrode having enzyme crystals immobilized thereon, method for producing electrode having enzyme crystals immobilized thereon, and biological fuel cell and biosensor provided with electrode having enzyme crystals immobilized thereon
|
|
WO2012031294A2
(en)
|
2010-09-03 |
2012-03-08 |
University Of Maryland, College Park |
Methods for determining protein ligand binding
|
|
TWI441591B
(zh)
*
|
2010-09-07 |
2014-06-21 |
Univ Nat Central |
使植物表現後天性高溫逆境耐受性狀的方法及其應用
|
|
RU2013120302A
(ru)
|
2010-10-01 |
2014-11-20 |
Модерна Терапьютикс, Инк. |
Сконструированные нуклеиновые кислоты и способы их применения
|
|
WO2012075040A2
(en)
|
2010-11-30 |
2012-06-07 |
Shire Human Genetic Therapies, Inc. |
mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
|
|
SG191089A1
(en)
*
|
2010-12-10 |
2013-07-31 |
Tracy Thompson |
Compositions for separation methods
|
|
US9238716B2
(en)
|
2011-03-28 |
2016-01-19 |
Massachusetts Institute Of Technology |
Conjugated lipomers and uses thereof
|
|
EP2691101A2
(en)
|
2011-03-31 |
2014-02-05 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
WO2012133737A1
(ja)
|
2011-03-31 |
2012-10-04 |
公益財団法人地球環境産業技術研究機構 |
架橋性アミン化合物、該化合物を用いた高分子膜及びその製造方法
|
|
EP2705152B1
(en)
|
2011-05-04 |
2017-10-25 |
The Broad Institute, Inc. |
Multiplexed genetic reporter assays and compositions
|
|
WO2012158736A1
(en)
|
2011-05-17 |
2012-11-22 |
modeRNA Therapeutics |
Engineered nucleic acids and methods of use thereof for non-human vertebrates
|
|
EP2532649B1
(en)
|
2011-06-07 |
2015-04-08 |
Incella GmbH |
Amino lipids, their synthesis and uses thereof
|
|
EP3354644A1
(en)
|
2011-06-08 |
2018-08-01 |
Translate Bio, Inc. |
Cleavable lipids
|
|
PL3586861T3
(pl)
|
2011-06-08 |
2022-05-23 |
Translate Bio, Inc. |
Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna
|
|
US9862926B2
(en)
|
2011-06-27 |
2018-01-09 |
Cellscript, Llc. |
Inhibition of innate immune response
|
|
JP2014520533A
(ja)
*
|
2011-06-30 |
2014-08-25 |
シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー |
Cmp−n−アセチルノイラミン酸ヒドロキシラーゼおよび/または糖タンパク質アルファ−1,3−ガラクトシルトランスフェラーゼを欠損する細胞
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2755986A4
(en)
|
2011-09-12 |
2015-05-20 |
Moderna Therapeutics Inc |
MANIPULATED NUCLEIC ACIDS AND METHOD OF APPLICATION THEREFOR
|
|
EP3384938A1
(en)
|
2011-09-12 |
2018-10-10 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
RU2648950C2
(ru)
|
2011-10-03 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
|
|
US8999950B2
(en)
|
2011-10-05 |
2015-04-07 |
Protiva Biotherapeutics Inc. |
Compositions and methods for silencing aldehyde dehydrogenase
|
|
KR102451116B1
(ko)
|
2011-10-27 |
2022-10-06 |
메사추세츠 인스티튜트 오브 테크놀로지 |
약물 캡슐화 마이크로스피어를 형성할 수 있는, n-말단 상에 관능화된 아미노산 유도체
|
|
WO2013090186A1
(en)
|
2011-12-14 |
2013-06-20 |
modeRNA Therapeutics |
Modified nucleic acids, and acute care uses thereof
|
|
US20140378538A1
(en)
|
2011-12-14 |
2014-12-25 |
Moderma Therapeutics, Inc. |
Methods of responding to a biothreat
|
|
CN104114572A
(zh)
|
2011-12-16 |
2014-10-22 |
现代治疗公司 |
经修饰的核苷、核苷酸和核酸组合物
|
|
JP2015510495A
(ja)
|
2011-12-21 |
2015-04-09 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
器官または器官移植片の生存可能性または寿命を延長する方法
|
|
EP2797634A4
(en)
|
2011-12-29 |
2015-08-05 |
Moderna Therapeutics Inc |
MODIFIED MRNAS FOR THE CODING OF CELL-PENETRATING POLYPEPTIDES
|
|
EP4721752A2
(en)
|
2011-12-30 |
2026-04-08 |
Cellscript, Llc |
Herstellung und verwendung von in vitro-synthetisierter ssrna zur einführung in säugetierzellen zur induktion einer biologischen oder biochemischen wirkung
|
|
SG11201405157PA
(en)
|
2012-02-24 |
2014-10-30 |
Protiva Biotherapeutics Inc |
Trialkyl cationic lipids and methods of use thereof
|
|
HK1206644A1
(en)
|
2012-03-29 |
2016-01-15 |
Shire Human Genetic Therapies, Inc. |
Lipid-derived neutral nanoparticles
|
|
ES2762873T3
(es)
|
2012-03-29 |
2020-05-26 |
Translate Bio Inc |
Lípidos catiónicos ionizables
|
|
US20150050354A1
(en)
|
2012-04-02 |
2015-02-19 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the treatment of otic diseases and conditions
|
|
US20140275229A1
(en)
|
2012-04-02 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Modified polynucleotides encoding udp glucuronosyltransferase 1 family, polypeptide a1
|
|
AU2013243948A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins associated with human disease
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
CA2868391A1
(en)
|
2012-04-02 |
2013-10-10 |
Stephane Bancel |
Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
|
|
EP3536787A1
(en)
|
2012-06-08 |
2019-09-11 |
Translate Bio, Inc. |
Nuclease resistant polynucleotides and uses thereof
|
|
US10245229B2
(en)
|
2012-06-08 |
2019-04-02 |
Translate Bio, Inc. |
Pulmonary delivery of mRNA to non-lung target cells
|
|
EP2674167A1
(en)
|
2012-06-14 |
2013-12-18 |
PLS-Design GmbH |
Controlled activation of complement components for use as endogenous adjuvant
|
|
EP2882706A1
(en)
|
2012-08-13 |
2015-06-17 |
Massachusetts Institute of Technology |
Amine-containing lipidoids and uses thereof
|
|
US20140093952A1
(en)
|
2012-10-02 |
2014-04-03 |
David Serway |
Bioreactor Tangential Flow Perfusion Filter System
|
|
WO2014093924A1
(en)
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified nucleic acid molecules and uses thereof
|
|
RU2627156C2
(ru)
*
|
2012-11-21 |
2017-08-03 |
Серум Инститьют Оф Индия Прайват Лтд. |
Высокоэффективный способ получения бактериального полисахарида, получение конъюгата на его основе и иммуногенная композиция
|
|
WO2014081507A1
(en)
|
2012-11-26 |
2014-05-30 |
Moderna Therapeutics, Inc. |
Terminally modified rna
|
|
EP4331620A3
(en)
|
2012-12-07 |
2024-12-04 |
Translate Bio, Inc. |
Lipidic nanoparticles for mrna delivery
|
|
WO2014093574A1
(en)
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for altering cell phenotype
|
|
EP2941629B1
(en)
|
2013-01-03 |
2018-10-10 |
Exosome Diagnostics Inc. |
Methods for isolating microvesicles
|
|
US20140200261A1
(en)
|
2013-01-17 |
2014-07-17 |
Moderna Therapeutics, Inc. |
Signal-sensor polynucleotides for the alteration of cellular phenotypes
|
|
US20160022774A1
(en)
|
2013-03-12 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Diagnosis and treatment of fibrosis
|
|
EP2968391A1
(en)
|
2013-03-13 |
2016-01-20 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
|
KR20210122917A
(ko)
|
2013-03-14 |
2021-10-12 |
샤이어 휴먼 지네틱 테라피즈 인크. |
Cftr mrna 조성물 및 관련 방법 및 사용
|
|
CN105051213A
(zh)
|
2013-03-14 |
2015-11-11 |
夏尔人类遗传性治疗公司 |
信使rna加帽效率的定量评估
|
|
DK2971098T3
(da)
|
2013-03-14 |
2019-02-18 |
Translate Bio Inc |
Kvantitativ bedømmelse for kappe-effektivitet af messenger rna
|
|
SG11201507474QA
(en)
|
2013-03-14 |
2015-10-29 |
Shire Human Genetic Therapies |
RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS
|
|
EP2971010B1
(en)
|
2013-03-14 |
2020-06-10 |
ModernaTX, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
|
PL3467108T3
(pl)
*
|
2013-03-14 |
2024-09-30 |
Translate Bio, Inc. |
Sposoby oczyszczania informacyjnego rna
|
|
US20160184458A1
(en)
|
2013-03-14 |
2016-06-30 |
Shire Human Genetic Therapies, Inc. |
Mrna therapeutic compositions and use to treat diseases and disorders
|
|
DK2970456T3
(da)
|
2013-03-14 |
2021-07-05 |
Translate Bio Inc |
Fremgangsmåder og sammensætninger til levering af mrna-kodede antistoffer
|
|
WO2014144711A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Analysis of mrna heterogeneity and stability
|
|
PT2970948T
(pt)
*
|
2013-03-15 |
2019-03-20 |
Glaxosmithkline Biologicals Sa |
Métodos de purificação de arn
|
|
WO2014152030A1
(en)
|
2013-03-15 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Removal of dna fragments in mrna production process
|
|
WO2014152027A1
(en)
*
|
2013-03-15 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Manufacturing methods for production of rna transcripts
|
|
US20160032273A1
(en)
|
2013-03-15 |
2016-02-04 |
Moderna Therapeutics, Inc. |
Characterization of mrna molecules
|
|
WO2014152031A1
(en)
|
2013-03-15 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Ribonucleic acid purification
|
|
WO2014144767A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Ion exchange purification of mrna
|
|
US10130649B2
(en)
|
2013-03-15 |
2018-11-20 |
Translate Bio, Inc. |
Synergistic enhancement of the delivery of nucleic acids via blended formulations
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
WO2014179562A1
(en)
|
2013-05-01 |
2014-11-06 |
Massachusetts Institute Of Technology |
1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
|
|
US9895443B2
(en)
|
2013-06-26 |
2018-02-20 |
Massachusetts Institute Of Technology |
Multi-tailed lipids and uses thereof
|
|
SMT202100691T1
(it)
|
2013-07-11 |
2022-01-10 |
Modernatx Inc |
Composizioni 5 comprendenti polinucleotidi sintetici che codificano proteine correlate a crispr e sgrna sintetici e metodi d'uso
|
|
WO2015011633A1
(en)
|
2013-07-23 |
2015-01-29 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for delivering messenger rna
|
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
US20160194625A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
|
US10023626B2
(en)
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
EP3052479A4
(en)
|
2013-10-02 |
2017-10-25 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
WO2015051169A2
(en)
|
2013-10-02 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
AU2014337156A1
(en)
|
2013-10-18 |
2016-05-12 |
Modernatx, Inc. |
Compositions and methods for tolerizing cellular systems
|
|
ES2707966T3
(es)
|
2013-10-22 |
2019-04-08 |
Translate Bio Inc |
Terapia de ARNm para la deficiencia en síntesis de argininosuccinato
|
|
AU2014340149B2
(en)
|
2013-10-22 |
2020-12-24 |
Shire Human Genetic Therapies, Inc. |
CNS delivery of mRNA and uses thereof
|
|
EA034103B1
(ru)
|
2013-10-22 |
2019-12-27 |
Транслейт Био, Инк. |
СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
|
|
US20170173128A1
(en)
|
2013-12-06 |
2017-06-22 |
Moderna TX, Inc. |
Targeted adaptive vaccines
|
|
US20150167017A1
(en)
|
2013-12-13 |
2015-06-18 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
US20170002060A1
(en)
|
2014-01-08 |
2017-01-05 |
Moderna Therapeutics, Inc. |
Polynucleotides for the in vivo production of antibodies
|
|
SG10201912038TA
(en)
|
2014-04-23 |
2020-02-27 |
Modernatx Inc |
Nucleic acid vaccines
|
|
PT3134506T
(pt)
|
2014-04-25 |
2019-10-31 |
Translate Bio Inc |
Métodos de purificação de rna mensageiro
|
|
JP6347163B2
(ja)
|
2014-07-10 |
2018-06-27 |
株式会社リコー |
定着装置及び画像形成装置
|
|
BR112017006679A2
(pt)
|
2014-10-02 |
2017-12-26 |
Protiva Biotherapeutics Inc |
moléculas, composição, partícula, composição farmacêutica, métodos para silenciar a expressão de um gene, usos de uma partícula, métodos para melhorar um ou mais sintomas, métodos para tratar uma infecção, usos de uma composição, método para inibir a replicação do vírus da hepatite d
|
|
WO2016071857A1
(en)
|
2014-11-07 |
2016-05-12 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing ebola virus expression
|
|
EP3461904A1
(en)
|
2014-11-10 |
2019-04-03 |
ModernaTX, Inc. |
Alternative nucleic acid molecules containing reduced uracil content and uses thereof
|
|
WO2016077123A1
(en)
|
2014-11-10 |
2016-05-19 |
Moderna Therapeutics, Inc. |
Multiparametric nucleic acid optimization
|
|
US20180000953A1
(en)
|
2015-01-21 |
2018-01-04 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
|
WO2016118725A1
(en)
|
2015-01-23 |
2016-07-28 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
|
CA2979998A1
(en)
|
2015-03-20 |
2016-09-29 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for treating hypertriglyceridemia
|
|
WO2016164762A1
(en)
|
2015-04-08 |
2016-10-13 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor egf-a and intracellular domain mutants and methods of using the same
|
|
WO2016183366A2
(en)
|
2015-05-12 |
2016-11-17 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing expression of hepatitis d virus rna
|
|
PL4108769T3
(pl)
*
|
2015-05-29 |
2024-02-05 |
CureVac Manufacturing GmbH |
Sposób wytwarzania i oczyszczania rna obejmujący co najmniej jeden etap filtracji o przepływie stycznym
|
|
US10626393B2
(en)
|
2015-06-04 |
2020-04-21 |
Arbutus Biopharma Corporation |
Delivering CRISPR therapeutics with lipid nanoparticles
|
|
US20180245074A1
(en)
|
2015-06-04 |
2018-08-30 |
Protiva Biotherapeutics, Inc. |
Treating hepatitis b virus infection using crispr
|
|
EP3307305A4
(en)
|
2015-06-10 |
2019-05-22 |
Modernatx, Inc. |
TARGETED ADAPTIVE VACCINES
|
|
EP3423595A1
(en)
|
2016-03-03 |
2019-01-09 |
CureVac AG |
Rna analysis by total hydrolysis
|
|
WO2018157133A1
(en)
|
2017-02-27 |
2018-08-30 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
AU2020220357B2
(en)
|
2019-02-11 |
2025-06-26 |
Ethris Gmbh |
mRNA purification by tangential flow filtration
|