DK358889D0 - Makrocykliske polyaza-forbindelser, der indeholder en 5- eller 6-leddet ring, fremgangsmaade til fremstilling deraf og farmaceutiske midler, der indeholder disse forbindelser - Google Patents

Makrocykliske polyaza-forbindelser, der indeholder en 5- eller 6-leddet ring, fremgangsmaade til fremstilling deraf og farmaceutiske midler, der indeholder disse forbindelser

Info

Publication number: DK358889D0
Authority: DK; Denmark
Prior art keywords: group; radical; atom; image; hydrogen
Prior art date: 1988-07-20

Application number

DK358889A

Other languages

English (en)

Other versions

DK358889A (da

DK171097B1 (da

Inventor

Johannes Platzek

Bernd Raduechel

Heinz Gries

Hans-Joachim Weinmann

Ulrich Speck

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-20

Filing date

1989-07-19

Publication date

1989-07-19

1989-07-19 Application filed by Schering Ag filed Critical Schering Ag

1989-07-19 Publication of DK358889D0 publication Critical patent/DK358889D0/da

1990-01-21 Publication of DK358889A publication Critical patent/DK358889A/da

1996-06-03 Application granted granted Critical

1996-06-03 Publication of DK171097B1 publication Critical patent/DK171097B1/da

Links

150000001875 compounds Chemical class 0.000 title 2
239000008177 pharmaceutical agent Substances 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
125000001424 substituent group Chemical group 0.000 abstract 6
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
229910052757 nitrogen Inorganic materials 0.000 abstract 4
125000004430 oxygen atom Chemical group O* 0.000 abstract 4
150000002678 macrocyclic compounds Chemical class 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical class NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000000032 diagnostic agent Substances 0.000 abstract 1
229940039227 diagnostic agent Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001841 imino group Chemical class [H]N=* 0.000 abstract 1
150000007529 inorganic bases Chemical class 0.000 abstract 1
229910021645 metal ion Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Radiology & Medical Imaging (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Polyesters Or Polycarbonates (AREA)
Medicinal Preparation (AREA)

DK358889A 1988-07-20 1989-07-19 Metalkomplekser af di- og tri(carboxymethyl)-tri- og -tetra(azabicykloalkan)-derivater og salte deraf, farmaceutiske midler, der indeholder disse forbindelser, anvendelse af forbindelserne til fremstilling af midler til NMR-røntgen- eller radiodiagnostik eller til radio- eller stråleterapi samt fremmgangsmåde til fremstilling af forbindelserne DK171097B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3825040A DE3825040A1 (de)	1988-07-20	1988-07-20	5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3825040		1988-07-20

Publications (3)

Publication Number	Publication Date
DK358889D0 true DK358889D0 (da)	1989-07-19
DK358889A DK358889A (da)	1990-01-21
DK171097B1 DK171097B1 (da)	1996-06-03

Family

ID=6359368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK358889A DK171097B1 (da)	1988-07-20	1989-07-19	Metalkomplekser af di- og tri(carboxymethyl)-tri- og -tetra(azabicykloalkan)-derivater og salte deraf, farmaceutiske midler, der indeholder disse forbindelser, anvendelse af forbindelserne til fremstilling af midler til NMR-røntgen- eller radiodiagnostik eller til radio- eller stråleterapi samt fremmgangsmåde til fremstilling af forbindelserne

Country Status (15)

Country	Link
EP (1)	EP0352218B1 (da)
JP (1)	JP2877844B2 (da)
AT (1)	ATE118775T1 (da)
CA (1)	CA1341035C (da)
DE (2)	DE3825040A1 (da)
DK (1)	DK171097B1 (da)
ES (1)	ES2068908T3 (da)
FI (1)	FI893509A7 (da)
GR (1)	GR3015162T3 (da)
IE (1)	IE66693B1 (da)
IL (1)	IL91046A (da)
NO (1)	NO179104C (da)
NZ (1)	NZ229996A (da)
PT (1)	PT91211B (da)
ZA (1)	ZA895543B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4001655A1 (de) *	1990-01-18	1991-07-25	Schering Ag	6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5334371A (en) *	1988-07-20	1994-08-02	Schering Aktiengesellschaft	Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
ES2088425T3 (es) *	1989-01-17	1996-08-16	Xyrofin Oy	Metodo de produccion de xilitol a partir de mezclas que contienen xilosa.
FR2652589B1 (fr) *	1989-10-04	1995-02-17	Roquette Freres	Procede de fabrication de xylitol et de produits riches en xylitol.
JP3131219B2 (ja) *	1990-01-19	2001-01-31	ニユコメド・イメージング・アクシエセルカペト	キレート化合物
GB9001245D0 (en) *	1990-01-19	1990-03-21	Salutar Inc	Compounds
US5330737A (en) *	1991-12-06	1994-07-19	Mallinckrodt Medical, Inc.	Nitrogen-sulfur ligands as opiate receptor drug mimics
US5428139A (en) *	1991-12-10	1995-06-27	The Dow Chemical Company	Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5480990A (en) *	1991-12-10	1996-01-02	The Dow Chemical Company	Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
CA2103553A1 (en) *	1991-12-10	1993-06-11	Garry E. Kiefer	Bicyclopolyazamacrocyclocarboxylic acid complexes their conjugates, processes for their preparation, and use as radiopharmaceuticals
MX9207164A (es) *	1991-12-10	1993-07-01	Dow Chemical Co	Complejos de acido biciclopoliazamacrociclocarboxilico, sus conjugados, procedimientos para su preparacion y su uso como agentes de contraste.
SG46598A1 (en) *	1991-12-10	1998-02-20	Dow Chemical Co	Bicycloazamacroyclophosphonic acid conjugates contrast agents and preparation
US5739294A (en) *	1991-12-10	1998-04-14	The Dow Chemical Company	Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
FI933506A7 (fi) *	1993-05-06	1994-11-07	Dow Global Technologies Inc	Bisyklopolyatsamakrosyklokarboksyylihappokomplekseja, niiden konjugaat teja, menetelmä niiden valmistamiseksi ja käyttö varjoaineina
US5385893A (en) *	1993-05-06	1995-01-31	The Dow Chemical Company	Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
WO1994026315A1 (en) *	1993-05-06	1994-11-24	The Dow Chemical Company	Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5480970A (en) *	1993-12-22	1996-01-02	Resolution Pharmaceuticals	Metal chelators
US5569745A (en) *	1994-02-25	1996-10-29	Resolution Pharmaceuticals Inc.	Peptide-Chelator conjugates
KR20000010533A (ko) *	1996-04-19	2000-02-15	텍사스 테크 유니버시티	시각적 조직 특이성 조영제로서의 형광 킬레이트
FR2794744B1 (fr) *	1999-06-09	2001-09-21	Guerbet Sa	Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
JP2004509924A (ja) *	2000-09-25	2004-04-02	ザ、プロクター、エンド、ギャンブル、カンパニー	Ｍｒｉ画像増強組成物
EP1940841B9 (fr) *	2005-10-07	2017-04-19	Guerbet	Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
FR2891830B1 (fr) *	2005-10-07	2011-06-24	Guerbet Sa	Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US8986650B2 (en)	2005-10-07	2015-03-24	Guerbet	Complex folate-NOTA-Ga68
GB201610738D0 (en)	2016-06-20	2016-08-03	Ge Healthcare As	Chelate compounds
EP3728168B1 (en) *	2017-12-20	2022-03-30	General Electric Company	Anionic chelate compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2478456A (en)	1946-03-15	1949-08-09	Socony Vaeuum Oil Company Inc	Solvent dewaxing
US3194818A (en)	1963-08-14	1965-07-13	Sterling Drug Inc	Alpha-aryl or aralkyl furfurylamines
DE3129906C3 (de) *	1981-07-24	1996-12-19	Schering Ag	Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
DE3150917A1 (de)	1981-12-18	1983-06-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	"2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
NL194579C (nl) *	1983-01-21	2002-08-05	Schering Ag	Diagnostisch middel.
DE3324235A1 (de) *	1983-07-01	1985-01-10	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue komplexbildner, komplexe und komplexsalze
SE8502573D0 (sv) *	1985-05-23	1985-05-23	Jouko Kanakre	Fluorescent lanthanide chelates useful as labels of physiologically active materials
DE3772785D1 (de)	1986-01-23	1991-10-17	Squibb & Sons Inc	1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.

1988
- 1988-07-20 DE DE3825040A patent/DE3825040A1/de not_active Withdrawn
1989
- 1989-07-18 DE DE58909022T patent/DE58909022D1/de not_active Expired - Lifetime
- 1989-07-18 ES ES89730165T patent/ES2068908T3/es not_active Expired - Lifetime
- 1989-07-18 EP EP89730165A patent/EP0352218B1/de not_active Expired - Lifetime
- 1989-07-18 AT AT89730165T patent/ATE118775T1/de active
- 1989-07-19 IE IE233589A patent/IE66693B1/en not_active IP Right Cessation
- 1989-07-19 PT PT91211A patent/PT91211B/pt not_active IP Right Cessation
- 1989-07-19 NO NO892959A patent/NO179104C/no not_active IP Right Cessation
- 1989-07-19 IL IL9104689A patent/IL91046A/en not_active IP Right Cessation
- 1989-07-19 CA CA000606159A patent/CA1341035C/en not_active Expired - Fee Related
- 1989-07-19 NZ NZ229996A patent/NZ229996A/en unknown
- 1989-07-19 DK DK358889A patent/DK171097B1/da not_active IP Right Cessation
- 1989-07-20 FI FI893509A patent/FI893509A7/fi not_active Application Discontinuation
- 1989-07-20 ZA ZA895543A patent/ZA895543B/xx unknown
- 1989-07-20 JP JP1186190A patent/JP2877844B2/ja not_active Expired - Lifetime
1995
- 1995-02-23 GR GR950400281T patent/GR3015162T3/el unknown

Also Published As

Publication number	Publication date
NZ229996A (en)	1992-05-26
EP0352218A2 (de)	1990-01-24
IE66693B1 (en)	1996-01-24
NO179104B (no)	1996-04-29
ZA895543B (en)	1990-05-30
FI893509A0 (fi)	1989-07-20
PT91211B (pt)	1995-03-01
JP2877844B2 (ja)	1999-04-05
GR3015162T3 (en)	1995-05-31
CA1341035C (en)	2000-06-20
EP0352218A3 (de)	1991-01-16
ES2068908T3 (es)	1995-05-01
IE892335L (en)	1990-01-20
DE58909022D1 (de)	1995-04-06
JPH02104588A (ja)	1990-04-17
DK358889A (da)	1990-01-21
ATE118775T1 (de)	1995-03-15
FI893509A7 (fi)	1990-01-21
AU3827589A (en)	1990-02-01
AU637052B2 (en)	1993-05-20
NO892959D0 (no)	1989-07-19
IL91046A (en)	1995-10-31
IL91046A0 (en)	1990-02-09
EP0352218B1 (de)	1995-02-22
PT91211A (pt)	1990-02-08
DK171097B1 (da)	1996-06-03
NO179104C (no)	1996-08-07
NO892959L (no)	1990-01-22
DE3825040A1 (de)	1990-01-25

Legal Events

Date	Code	Title	Description
1996-06-03	B1	Patent granted (law 1993)
2002-03-04	PBP	Patent lapsed

Publication	Publication Date	Title
DK358889D0 (da)	1989-07-19	Makrocykliske polyaza-forbindelser, der indeholder en 5- eller 6-leddet ring, fremgangsmaade til fremstilling deraf og farmaceutiske midler, der indeholder disse forbindelser
NO910191D0 (no)	1991-01-17	Makrocykliske tetraazaforbindelser som inneholder en seksring, fremgangsmaate for fremstilling derav, samt farmasoeytiske midler som inneholder slike.
FR2662162B1 (fr)	1995-01-20	Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
WO1994013658A3 (en)	1994-08-04	Benzocycloheptenes, benzoxepines and benzothiepines
DE69305276D1 (de)	1996-11-14	Arylglycinamidderivate, Verfahren zur deren Herstellung und deren Verwendung zur Therapie der Dysurie
ES8701721A1 (es)	1986-12-01	Procedimiento para la obtencion de tetrahidrobenzindoles
NO304114B1 (no)	1998-10-26	Taxanderivater og fremstilling derav
DK0406119T3 (da)	1994-03-21	Hidtil ukendte peptidderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
DK640489D0 (da)	1989-12-18	C63-amidderivater af 34-de-(acetylglucosaminyl)-34-deoxy-teicoplaniner
IT1230595B (it)	1991-10-28	Perossiacidi immido derivati
TW259785B (en)	1995-10-11	Chemical compounds
ES2156901T3 (es)	2001-08-01	Antidepresor.
DE69625795D1 (de)	2003-02-20	Thiazolidinedionderivate mit antidiabetischen, hypolipidämischen und antihypertensiven Eigenschaften, Verfahren zu deren Herstellung und pharmazeutischen Zusammenstellungen, die sie enthalten
NO179835C (no)	1996-12-27	Aminderivater med fungicid aktivitet og anvendelse som fungicider
MX9700008A (es)	1997-04-30	1,2,4,6,-tiatriazinas herbicidas.