DK358889A - Makrocykliske polyaza-forbindelser, der indeholder en 5- eller 6-leddet ring, fremgangsmaade til fremstilling deraf og farmaceutiske midler, der indeholder disse forbindelser - Google Patents

Makrocykliske polyaza-forbindelser, der indeholder en 5- eller 6-leddet ring, fremgangsmaade til fremstilling deraf og farmaceutiske midler, der indeholder disse forbindelser Download PDF

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Publication number
DK358889A
DK358889A DK358889A DK358889A DK358889A DK 358889 A DK358889 A DK 358889A DK 358889 A DK358889 A DK 358889A DK 358889 A DK358889 A DK 358889A DK 358889 A DK358889 A DK 358889A
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DK
Denmark
Prior art keywords
group
radical
atom
image
hydrogen
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DK358889A
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English (en)
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DK171097B1 (da
DK358889D0 (da
Inventor
Johannes Platzek
Bernd Raduechel
Heinz Gries
Hans-Joachim Weinmann
Ulrich Speck
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Schering Ag filed Critical Schering Ag
Publication of DK358889D0 publication Critical patent/DK358889D0/da
Publication of DK358889A publication Critical patent/DK358889A/da
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Publication of DK171097B1 publication Critical patent/DK171097B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
DK358889A 1988-07-20 1989-07-19 Metalkomplekser af di- og tri(carboxymethyl)-tri- og -tetra(azabicykloalkan)-derivater og salte deraf, farmaceutiske midler, der indeholder disse forbindelser, anvendelse af forbindelserne til fremstilling af midler til NMR-røntgen- eller radiodiagnostik eller til radio- eller stråleterapi samt fremmgangsmåde til fremstilling af forbindelserne DK171097B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3825040A DE3825040A1 (de) 1988-07-20 1988-07-20 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3825040 1988-07-20

Publications (3)

Publication Number Publication Date
DK358889D0 DK358889D0 (da) 1989-07-19
DK358889A true DK358889A (da) 1990-01-21
DK171097B1 DK171097B1 (da) 1996-06-03

Family

ID=6359368

Family Applications (1)

Application Number Title Priority Date Filing Date
DK358889A DK171097B1 (da) 1988-07-20 1989-07-19 Metalkomplekser af di- og tri(carboxymethyl)-tri- og -tetra(azabicykloalkan)-derivater og salte deraf, farmaceutiske midler, der indeholder disse forbindelser, anvendelse af forbindelserne til fremstilling af midler til NMR-røntgen- eller radiodiagnostik eller til radio- eller stråleterapi samt fremmgangsmåde til fremstilling af forbindelserne

Country Status (15)

Country Link
EP (1) EP0352218B1 (da)
JP (1) JP2877844B2 (da)
AT (1) ATE118775T1 (da)
CA (1) CA1341035C (da)
DE (2) DE3825040A1 (da)
DK (1) DK171097B1 (da)
ES (1) ES2068908T3 (da)
FI (1) FI893509A7 (da)
GR (1) GR3015162T3 (da)
IE (1) IE66693B1 (da)
IL (1) IL91046A (da)
NO (1) NO179104C (da)
NZ (1) NZ229996A (da)
PT (1) PT91211B (da)
ZA (1) ZA895543B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
ZA90254B (en) * 1989-01-17 1990-11-28 Cultor Oy Method for the production of xylitol
FR2652589B1 (fr) * 1989-10-04 1995-02-17 Roquette Freres Procede de fabrication de xylitol et de produits riches en xylitol.
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
EP0511275A1 (en) * 1990-01-19 1992-11-04 Nycomed Imaging As Chelating compounds
US5330737A (en) * 1991-12-06 1994-07-19 Mallinckrodt Medical, Inc. Nitrogen-sulfur ligands as opiate receptor drug mimics
DK0570575T3 (da) * 1991-12-10 1998-08-24 Dow Chemical Co Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf
US5480990A (en) * 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
ZA929578B (en) * 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclocarboxylic acid complexes their conjugates processes for their preparation and use as radiopharmaceuticals
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
DE69230970T2 (de) * 1991-12-10 2001-01-04 The Dow Chemical Co., Midland Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe
WO1994026315A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
KR20000010533A (ko) * 1996-04-19 2000-02-15 텍사스 테크 유니버시티 시각적 조직 특이성 조영제로서의 형광 킬레이트
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
EP1322340A2 (en) * 2000-09-25 2003-07-02 The Procter & Gamble Company Manganese complexes for magnetic resonance imaging
CA2625196C (fr) * 2005-10-07 2016-04-05 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
US11110186B2 (en) * 2017-12-20 2021-09-07 General Electric Company Anionic chelate compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2478456A (en) 1946-03-15 1949-08-09 Socony Vaeuum Oil Company Inc Solvent dewaxing
US3194818A (en) 1963-08-14 1965-07-13 Sterling Drug Inc Alpha-aryl or aralkyl furfurylamines
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
DE3150917A1 (de) 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
EP0232751B1 (en) 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs

Also Published As

Publication number Publication date
IL91046A0 (en) 1990-02-09
DK171097B1 (da) 1996-06-03
NO179104B (no) 1996-04-29
AU637052B2 (en) 1993-05-20
GR3015162T3 (en) 1995-05-31
EP0352218A2 (de) 1990-01-24
PT91211A (pt) 1990-02-08
CA1341035C (en) 2000-06-20
ZA895543B (en) 1990-05-30
JPH02104588A (ja) 1990-04-17
ES2068908T3 (es) 1995-05-01
ATE118775T1 (de) 1995-03-15
NZ229996A (en) 1992-05-26
DE3825040A1 (de) 1990-01-25
AU3827589A (en) 1990-02-01
JP2877844B2 (ja) 1999-04-05
IE66693B1 (en) 1996-01-24
FI893509A7 (fi) 1990-01-21
EP0352218A3 (de) 1991-01-16
IL91046A (en) 1995-10-31
NO892959L (no) 1990-01-22
IE892335L (en) 1990-01-20
DK358889D0 (da) 1989-07-19
NO892959D0 (no) 1989-07-19
PT91211B (pt) 1995-03-01
NO179104C (no) 1996-08-07
FI893509A0 (fi) 1989-07-20
EP0352218B1 (de) 1995-02-22
DE58909022D1 (de) 1995-04-06

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed