DK3606909T3 - Natriumsalt af n-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1h-pyrazol-3-sulfonamid - Google Patents
Natriumsalt af n-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1h-pyrazol-3-sulfonamid Download PDFInfo
- Publication number
- DK3606909T3 DK3606909T3 DK19721230.1T DK19721230T DK3606909T3 DK 3606909 T3 DK3606909 T3 DK 3606909T3 DK 19721230 T DK19721230 T DK 19721230T DK 3606909 T3 DK3606909 T3 DK 3606909T3
- Authority
- DK
- Denmark
- Prior art keywords
- indacen
- hexahydro
- sulfonamide
- pyrazole
- carbamoyl
- Prior art date
Links
- MTOUOUSKXWSTAX-UHFFFAOYSA-N 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-(1-propan-2-ylpyrazol-3-yl)sulfonylurea Chemical compound C1CCC2=C(C=3CCCC=3C=C12)NC(=O)NS(=O)(=O)C1=NN(C=C1)C(C)C MTOUOUSKXWSTAX-UHFFFAOYSA-N 0.000 title 1
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1806578.9A GB201806578D0 (en) | 2018-04-23 | 2018-04-23 | Novel compound |
| PCT/EP2019/060311 WO2019206871A1 (en) | 2018-04-23 | 2019-04-23 | A sodium salt of n-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1 -isopropyl-1 h-pyrazole-3-sulfonamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3606909T3 true DK3606909T3 (da) | 2020-08-24 |
Family
ID=62236309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19721230.1T DK3606909T3 (da) | 2018-04-23 | 2019-04-23 | Natriumsalt af n-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1h-pyrazol-3-sulfonamid |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US10973803B2 (da) |
| EP (2) | EP3606909B1 (da) |
| JP (1) | JP7382958B2 (da) |
| KR (1) | KR20210005589A (da) |
| CN (1) | CN112020495B (da) |
| AR (1) | AR114827A1 (da) |
| AU (1) | AU2019257973A1 (da) |
| BR (1) | BR112020021650A2 (da) |
| CA (1) | CA3097832A1 (da) |
| CY (1) | CY1123260T1 (da) |
| DK (1) | DK3606909T3 (da) |
| ES (1) | ES2811228T3 (da) |
| GB (1) | GB201806578D0 (da) |
| HR (1) | HRP20201263T1 (da) |
| HU (1) | HUE050369T2 (da) |
| LT (1) | LT3606909T (da) |
| MA (2) | MA51082A (da) |
| MD (1) | MD3606909T2 (da) |
| ME (1) | ME03822B (da) |
| MX (1) | MX2020011196A (da) |
| PL (1) | PL3606909T3 (da) |
| PT (1) | PT3606909T (da) |
| RS (1) | RS60646B1 (da) |
| SI (1) | SI3606909T1 (da) |
| SM (1) | SMT202000448T1 (da) |
| TW (1) | TW201943704A (da) |
| UY (1) | UY38186A (da) |
| WO (1) | WO2019206871A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA126675C2 (uk) | 2017-01-23 | 2023-01-11 | Дженентек, Інк. | Хімічні сполуки як інгібітори активності інтерлейкіну-1 |
| US11840543B2 (en) | 2017-05-24 | 2023-12-12 | The University Of Queensland | Compounds and uses |
| EP3649112A1 (en) | 2017-07-07 | 2020-05-13 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors |
| TW201910317A (zh) | 2017-08-15 | 2019-03-16 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
| AU2018317800A1 (en) | 2017-08-15 | 2020-02-13 | Inflazome Limited | Novel sulfonamide carboxamide compounds |
| WO2019034697A1 (en) | 2017-08-15 | 2019-02-21 | Inflazome Limited | NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS |
| MX2020001776A (es) | 2017-08-15 | 2020-03-24 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3. |
| WO2019034693A1 (en) | 2017-08-15 | 2019-02-21 | Inflazome Limited | SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3 |
| CN111315733A (zh) | 2017-11-09 | 2020-06-19 | 英夫拉索姆有限公司 | 新颖磺酰胺甲酰胺化合物 |
| WO2019092171A1 (en) | 2017-11-09 | 2019-05-16 | Inflazome Limited | Novel sulfonamide carboxamide compounds |
| US11884645B2 (en) | 2018-03-02 | 2024-01-30 | Inflazome Limited | Sulfonyl acetamides as NLRP3 inhibitors |
| EP3759090A1 (en) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Novel compounds |
| WO2019166619A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| US12168653B2 (en) | 2018-03-02 | 2024-12-17 | Inflazome Limited | Sulfonamide derivates as NLRP3 inhibitors |
| WO2019166632A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| US11834433B2 (en) | 2018-03-02 | 2023-12-05 | Inflazome Limited | Compounds |
| GB201806578D0 (en) | 2018-04-23 | 2018-06-06 | Inflazome Ltd | Novel compound |
| MX2021000660A (es) | 2018-07-20 | 2021-03-25 | Hoffmann La Roche | Compuestos de sulfonilurea como inhibidores de la actividad de interleucina 1. |
| MA53172A (fr) | 2018-07-20 | 2021-05-26 | Hoffmann La Roche | Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1 |
| GB201817038D0 (en) | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
| EP4054563A1 (en) * | 2019-11-07 | 2022-09-14 | Inflazome Limited | Treatment and prevention of neuroinflammation or an inflammatory brain disorder |
| JP2023501319A (ja) * | 2019-11-07 | 2023-01-18 | インフレイゾーム リミテッド | 神経変性疾患の処置および予防 |
| WO2021089781A1 (en) * | 2019-11-07 | 2021-05-14 | Inflazome Limited | Treatment or prevention of psychiatric brain disorders using the nlrp3 inhibitor n-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1 -isopropyl-1 h-pyrazole-3-sulfonamide |
| JP2023501334A (ja) * | 2019-11-07 | 2023-01-18 | インフレイゾーム リミテッド | 自己炎症性疾患の処置 |
| GB201916237D0 (en) * | 2019-11-07 | 2019-12-25 | Inflazome Ltd | Novel treatment |
| WO2021089776A1 (en) * | 2019-11-07 | 2021-05-14 | Inflazome Limited | Treatment and prevention of a traumatic brain disorder |
| BR112022014480A2 (pt) | 2020-01-22 | 2022-09-13 | Hoffmann La Roche | Compostos, composições farmacêutica, método para tratar um distúrbio em um paciente, usos de um composto e de uma composição farmacêutica e kit |
| WO2022023907A1 (en) | 2020-07-31 | 2022-02-03 | Novartis Ag | Methods of selecting and treating patients at elevated risk of major adverse cardiac events |
| TW202545527A (zh) | 2024-01-16 | 2025-12-01 | 英商諾得瑟拉公司 | Ｎｌｒｐ３及ｇｌｐ－１ａ組合療法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4802908A (en) * | 1987-01-22 | 1989-02-07 | E. I. Du Pont De Nemours And Company | Herbicidal 2-(1H)-pyrazinones |
| BR0014003A (pt) * | 1999-09-14 | 2002-05-21 | Pfizer Prod Inc | Tratamento de combinação com compostos de diaril sufonil uréia e il-1ra |
| TW201311693A (zh) * | 2011-09-02 | 2013-03-16 | Kyowa Hakko Kirin Co Ltd | 化學激活激素受體活性調節劑 |
| JP6929792B2 (ja) | 2015-02-16 | 2021-09-01 | ザ ユニバーシティ オブ クィーンズランド | スルホニル尿素及び関連化合物並びにその使用 |
| FR3046933B1 (fr) | 2016-01-25 | 2018-03-02 | Galderma Research & Development | Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires |
| BR112018016671A2 (pt) | 2016-02-16 | 2018-12-26 | The University Of Queensland | sulfonilureias e compostos relacionados e uso do mesmo |
| MA44729A (fr) | 2016-04-18 | 2021-05-12 | Novartis Ag | Composés et compositions pour traiter des états associés à une activité de nlrp |
| US11447460B2 (en) | 2016-04-18 | 2022-09-20 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
| EP3272739A1 (en) | 2016-07-20 | 2018-01-24 | NodThera Limited | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity |
| GB201806578D0 (en) | 2018-04-23 | 2018-06-06 | Inflazome Ltd | Novel compound |
| GB201817038D0 (en) | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
-
2018
- 2018-04-23 GB GBGB1806578.9A patent/GB201806578D0/en not_active Ceased
-
2019
- 2019-04-23 MD MDE20200181T patent/MD3606909T2/ro not_active IP Right Cessation
- 2019-04-23 CN CN201980026640.0A patent/CN112020495B/zh active Active
- 2019-04-23 PL PL19721230T patent/PL3606909T3/pl unknown
- 2019-04-23 RS RS20200936A patent/RS60646B1/sr unknown
- 2019-04-23 PT PT197212301T patent/PT3606909T/pt unknown
- 2019-04-23 ES ES19721230T patent/ES2811228T3/es active Active
- 2019-04-23 UY UY0001038186A patent/UY38186A/es not_active Application Discontinuation
- 2019-04-23 MA MA051082A patent/MA51082A/fr unknown
- 2019-04-23 HR HRP20201263TT patent/HRP20201263T1/hr unknown
- 2019-04-23 WO PCT/EP2019/060311 patent/WO2019206871A1/en not_active Ceased
- 2019-04-23 MX MX2020011196A patent/MX2020011196A/es unknown
- 2019-04-23 SI SI201930005T patent/SI3606909T1/sl unknown
- 2019-04-23 EP EP19721230.1A patent/EP3606909B1/en active Active
- 2019-04-23 MA MA48051A patent/MA48051B1/fr unknown
- 2019-04-23 LT LTEP19721230.1T patent/LT3606909T/lt unknown
- 2019-04-23 CA CA3097832A patent/CA3097832A1/en active Pending
- 2019-04-23 DK DK19721230.1T patent/DK3606909T3/da active
- 2019-04-23 BR BR112020021650-0A patent/BR112020021650A2/pt not_active Application Discontinuation
- 2019-04-23 AU AU2019257973A patent/AU2019257973A1/en not_active Abandoned
- 2019-04-23 HU HUE19721230A patent/HUE050369T2/hu unknown
- 2019-04-23 ME MEP-2020-173A patent/ME03822B/me unknown
- 2019-04-23 EP EP20176198.8A patent/EP3722281A1/en not_active Withdrawn
- 2019-04-23 AR ARP190101056A patent/AR114827A1/es not_active Application Discontinuation
- 2019-04-23 KR KR1020207030023A patent/KR20210005589A/ko not_active Ceased
- 2019-04-23 SM SM20200448T patent/SMT202000448T1/it unknown
- 2019-04-23 TW TW108114167A patent/TW201943704A/zh unknown
- 2019-04-23 JP JP2020557902A patent/JP7382958B2/ja active Active
-
2020
- 2020-04-16 US US16/850,978 patent/US10973803B2/en active Active
- 2020-08-12 CY CY20201100756T patent/CY1123260T1/el unknown
-
2021
- 2021-03-09 US US17/196,956 patent/US20210315862A1/en not_active Abandoned
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