DK3737399T5 - Atf5-peptidvarianter og anvendelser deraf - Google Patents

Atf5-peptidvarianter og anvendelser deraf Download PDF

Info

Publication number
DK3737399T5
DK3737399T5 DK19735723.9T DK19735723T DK3737399T5 DK 3737399 T5 DK3737399 T5 DK 3737399T5 DK 19735723 T DK19735723 T DK 19735723T DK 3737399 T5 DK3737399 T5 DK 3737399T5
Authority
DK
Denmark
Prior art keywords
peptide variants
atf5 peptide
atf5
variants
peptide
Prior art date
Application number
DK19735723.9T
Other languages
English (en)
Other versions
DK3737399T3 (da
Inventor
Barry Jay Kappel
Gene Merutka
Jimmy Andrew Rotolo
Original Assignee
Sapience Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapience Therapeutics Inc filed Critical Sapience Therapeutics Inc
Publication of DK3737399T3 publication Critical patent/DK3737399T3/da
Application granted granted Critical
Publication of DK3737399T5 publication Critical patent/DK3737399T5/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK19735723.9T 2018-01-03 2019-01-03 Atf5-peptidvarianter og anvendelser deraf DK3737399T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862613083P 2018-01-03 2018-01-03
PCT/US2019/012148 WO2019136125A1 (en) 2018-01-03 2019-01-03 Atf5 peptide variants and uses thereof

Publications (2)

Publication Number Publication Date
DK3737399T3 DK3737399T3 (da) 2023-10-16
DK3737399T5 true DK3737399T5 (da) 2024-08-26

Family

ID=67059159

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19735723.9T DK3737399T5 (da) 2018-01-03 2019-01-03 Atf5-peptidvarianter og anvendelser deraf

Country Status (16)

Country Link
US (4) US10525100B2 (da)
EP (2) EP3737399B1 (da)
JP (2) JP6971508B2 (da)
KR (2) KR102606176B1 (da)
CN (2) CN111655277B (da)
AU (2) AU2019205351B2 (da)
BR (1) BR112020013524A2 (da)
CA (2) CA3086768C (da)
DK (1) DK3737399T5 (da)
ES (1) ES2960784T3 (da)
FI (1) FI3737399T3 (da)
IL (3) IL290414B2 (da)
MX (1) MX2020006971A (da)
NZ (1) NZ765759A (da)
PT (1) PT3737399T (da)
WO (1) WO2019136125A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3737399B1 (en) * 2018-01-03 2023-07-26 Sapience Therapeutics, Inc. Atf5 peptide variants and uses thereof
IL299104A (en) * 2020-06-21 2023-02-01 Sapience Therapeutics Inc Intracellular administration of a CEBP antagonist and methods of use
CN113845574A (zh) * 2021-11-30 2021-12-28 百益美恒(北京)科技有限公司 一种穿透肽tdp、融合穿透肽蛋白及其制备方法和应用
US20240002806A1 (en) 2022-03-10 2024-01-04 Innocent Meat GmbH Method for differentiating adult stem cells into final tissue
CN119768418A (zh) * 2022-09-07 2025-04-04 东亚合成株式会社 载体肽片段及其用途
CN120077055A (zh) * 2022-10-17 2025-05-30 东亚合成株式会社 载体肽片段及其利用
EP4714964A1 (en) * 2023-05-17 2026-03-25 Toagosei Co., Ltd. Peptide fragment and use thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1091138A (zh) * 1992-08-27 1994-08-24 迪金研究有限公司 疫苗
US5942433A (en) 1995-07-31 1999-08-24 The United States Of America As Represented By The Department Of Health And Human Services Extension of a protein-protein interaction surface to inactivate the function of a cellular protein
US20020160002A1 (en) 1996-06-18 2002-10-31 Irwin Gelman Tumor suppressor gene
US5955593A (en) 1996-09-09 1999-09-21 Washington University BH3 interacting domain death agonist
CA2314267A1 (en) * 1997-12-10 1999-06-17 Washington University Anti-pathogen system and methods of use thereof
US6551795B1 (en) * 1998-02-18 2003-04-22 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
US6303576B1 (en) 1999-04-21 2001-10-16 Adherex Technologies Inc. Compounds and methods for modulating β-catenin mediated gene expression
WO2001016596A2 (en) * 1999-08-31 2001-03-08 Glaxo Group Limited Screening for modulators of gaba b receptor activity
US6485977B1 (en) 1999-09-13 2002-11-26 Cornell Research Foundation, Inc. Recombinant constructs and techniques for delivering to eucaryotic cells bacterial proteins that are secreted via type III secretion systems
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US6468754B1 (en) 2000-04-18 2002-10-22 Iconix Pharmaceuticals, Inc. Vector and method for targeted replacement and disruption of an integrated DNA sequence
US20050164384A1 (en) 2003-04-04 2005-07-28 Greene Lloyd A. Methods for regulating differentiation of neural cells and uses thereof
US8158420B2 (en) * 2003-04-04 2012-04-17 The Trustees Of Columbia University In The City Of New York Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5
US7611893B2 (en) * 2005-11-09 2009-11-03 Ontherix, Inc. Metal-binding therapeutic peptides
EP2468887A1 (en) 2006-12-13 2012-06-27 Oncotherapy Science, Inc. TTK as tumor marker and therapeutic target for lung cancer
US9540427B2 (en) 2007-05-30 2017-01-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Peptide-based stat inhibitor
WO2010120931A2 (en) 2009-04-14 2010-10-21 University Of Medicine And Dentistry Of New Jersey E2f as a target for treatment of hormone refractory prostate cancer
US8680246B2 (en) 2010-02-04 2014-03-25 Gilead Biologics, Inc. Antibodies that bind to lysyl oxidase-like 2 (LOXL2)
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
EP2734622B1 (en) 2011-07-19 2018-09-05 Vivoscript, Inc. Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage
EP2780017A1 (en) * 2011-11-15 2014-09-24 Novartis AG Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the janus kinase 2-signal transducer and activator of transcription 5 pathway
JP2016516669A (ja) * 2013-02-22 2016-06-09 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 転写因子ａｔｆ５の阻害により腫瘍細胞を阻害するための組成物および方法
KR102092345B1 (ko) 2013-09-30 2020-03-24 삼성전자주식회사 류신 지퍼 변이체 및 이의 용도
KR102272213B1 (ko) 2014-07-08 2021-07-01 삼성전자주식회사 표적화 부위, 절단 부위, 및 세포막 투과 부위를 포함하는 융합 단백질 및 그의 용도
US20160187319A1 (en) * 2014-12-26 2016-06-30 Nitto Denko Corporation Cell death-inducing agent, cell growth-inhibiting agent, and pharmaceutical composition for treatment of disease caused by abnormal cell growth
CA3000866A1 (en) 2015-10-05 2017-04-13 Wntrx Pharmaceuticals Inc. Stabilized bcl9 peptides for treatment of aberrant wnt signaling
WO2018152446A2 (en) * 2017-02-20 2018-08-23 Sapience Therapeutics, Inc. Cell-penetrating atf5 polypeptides and uses thereof
EP3737399B1 (en) * 2018-01-03 2023-07-26 Sapience Therapeutics, Inc. Atf5 peptide variants and uses thereof

Also Published As

Publication number Publication date
DK3737399T3 (da) 2023-10-16
EP3737399A1 (en) 2020-11-18
NZ765759A (en) 2023-07-28
JP6971508B2 (ja) 2021-11-24
CN111655277A (zh) 2020-09-11
CN113845581A (zh) 2021-12-28
IL290414B1 (en) 2024-04-01
AU2019205351B2 (en) 2020-10-08
KR102606176B1 (ko) 2023-11-27
JP2022031646A (ja) 2022-02-22
US11878047B2 (en) 2024-01-23
IL275774B (en) 2021-03-25
IL275774A (en) 2020-08-31
IL290414B2 (en) 2024-08-01
FI3737399T3 (fi) 2023-08-09
US20210061869A1 (en) 2021-03-04
CA3086768A1 (en) 2019-07-11
US12208131B2 (en) 2025-01-28
CN113845581B (zh) 2025-03-21
KR20200086374A (ko) 2020-07-16
IL281316A (en) 2021-04-29
EP4275757A2 (en) 2023-11-15
BR112020013524A2 (pt) 2020-12-08
JP7312948B2 (ja) 2023-07-24
AU2020256311A1 (en) 2020-11-12
CA3086768C (en) 2023-09-26
US20190201483A1 (en) 2019-07-04
AU2020256311B2 (en) 2022-04-21
KR102433761B1 (ko) 2022-08-22
MX2020006971A (es) 2020-09-09
AU2019205351A1 (en) 2020-07-16
CA3203983A1 (en) 2019-07-11
ES2960784T3 (es) 2024-03-06
CN111655277B (zh) 2021-10-12
EP4275757A3 (en) 2024-01-17
PT3737399T (pt) 2023-09-04
IL281316B (en) 2022-06-01
US10525100B2 (en) 2020-01-07
US20240181003A1 (en) 2024-06-06
WO2019136125A1 (en) 2019-07-11
IL290414A (en) 2022-04-01
JP2021508503A (ja) 2021-03-11
US20250127849A1 (en) 2025-04-24
KR20220116583A (ko) 2022-08-23
NZ801728A (en) 2024-03-22
EP3737399B1 (en) 2023-07-26
EP3737399A4 (en) 2021-10-06

Similar Documents

Publication Publication Date Title
DK3784283T3 (da) Cannabidiopræparater og anvendelser deraf
IL268593A (en) Polypeptide variants and uses thereof
DK3870579T3 (da) Tyk2-inhibitorer og anvendelser deraf
IL279897A (en) Fusosome compositions and uses thereof
DK3625263T3 (da) Anti-galectin- 9-antistoffer og anvendelser deraf
DK3383916T3 (da) Anti-CD73-antistoffer og anvendelser deraf
DK3737399T5 (da) Atf5-peptidvarianter og anvendelser deraf
DK3668512T3 (da) Pyruvatkinasemodulatorer og anvendelse deraf
DK3610005T3 (da) Peptidligase og anvendelse deraf
DK3596125T3 (da) Anti-PAR2-antistoffer og anvendelser deraf
EP3802852A4 (en) MANIPULATED CYCLIC PEPTIDES
IL280922A (en) Anti-her2 polypeptides and methods of use thereof
DK3660146T5 (da) Ydelsesforbedrede og opbevaringsstabile proteasevarianter
IL283942A (en) Tubulysins and protein-tubulysin conjugates
IL281297A (en) Anti-npr1 antibodies and uses thereof
DK3743106T3 (da) Influenzavirusvacciner og anvendelser deraf
DK3692009T3 (da) Biocementationsfremgangsmåde og system
IL283875A (en) Anti-il-27 antibodies and uses thereof
DK3853218T3 (da) Somatostatinmodulatorer og anvendelser deraf
DK3621694T5 (da) Lrrc33-inhibitorer og anvendelse heraf
DK3720875T3 (da) Antimikrobielle peptider og fremgangsmåder til anvendelse deraf
DK3737402T5 (da) Modificeret protein
DK3630967T3 (da) Protease og bindingspolypeptid for o-glycoproteiner
EP3480212C0 (en) IL13RALPHA2 PEPTIDE AND ITS USES
DK3841066T3 (da) Afsaltningssystem og fremgangsmåde