DK3793587T3 - Startdosis af pth-konjugater - Google Patents
Startdosis af pth-konjugaterInfo
- Publication number
- DK3793587T3 DK3793587T3 DK19724825.5T DK19724825T DK3793587T3 DK 3793587 T3 DK3793587 T3 DK 3793587T3 DK 19724825 T DK19724825 T DK 19724825T DK 3793587 T3 DK3793587 T3 DK 3793587T3
- Authority
- DK
- Denmark
- Prior art keywords
- starting dose
- pth
- conjugates
- pth conjugates
- dose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18173155 | 2018-05-18 | ||
| PCT/EP2019/062773 WO2019219896A1 (en) | 2018-05-18 | 2019-05-17 | Starting dose of pth conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3793587T3 true DK3793587T3 (da) | 2025-07-21 |
Family
ID=62217789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19724825.5T DK3793587T3 (da) | 2018-05-18 | 2019-05-17 | Startdosis af pth-konjugater |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20210196801A1 (da) |
| EP (2) | EP4609879A3 (da) |
| JP (2) | JP7542442B2 (da) |
| KR (2) | KR102797223B1 (da) |
| CN (1) | CN112334152A (da) |
| AU (2) | AU2019270464B2 (da) |
| BR (1) | BR112020022306A2 (da) |
| CA (1) | CA3099620A1 (da) |
| DK (1) | DK3793587T3 (da) |
| ES (1) | ES3041260T3 (da) |
| FI (1) | FI3793587T3 (da) |
| HR (1) | HRP20250963T1 (da) |
| HU (1) | HUE072823T2 (da) |
| IL (1) | IL278717B2 (da) |
| LT (1) | LT3793587T (da) |
| MA (1) | MA69295B1 (da) |
| MX (1) | MX2020012179A (da) |
| MY (2) | MY210601A (da) |
| PL (1) | PL3793587T3 (da) |
| PT (1) | PT3793587T (da) |
| RS (1) | RS67222B1 (da) |
| SG (1) | SG11202010387QA (da) |
| SI (1) | SI3793587T1 (da) |
| SM (1) | SMT202500272T1 (da) |
| WO (1) | WO2019219896A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL317744A (en) * | 2016-03-01 | 2025-02-01 | Ascendis Pharma Bone Diseases As | PTH drug agonists |
| PL3518961T3 (pl) | 2016-09-29 | 2023-08-14 | Ascendis Pharma Bone Diseases A/S | Związki pth o niskim stosunku wartości maksymalnej do minimalnej |
| FI3518982T3 (fi) | 2016-09-29 | 2025-02-11 | Ascendis Pharma Bone Diseases As | Säädellysti vapautuvia PTH-yhdisteitä |
| RS64440B1 (sr) | 2016-09-29 | 2023-09-29 | Ascendis Pharma Bone Diseases As | Režim doziranja za pth jedinjenje sa kontrolisanim oslobađanjem |
| US12403182B2 (en) | 2019-02-11 | 2025-09-02 | Ascendis Pharma Bone Diseases A/S | Liquid pharmaceutical formulations of PTH conjugates |
| CN115003320A (zh) * | 2020-01-13 | 2022-09-02 | 阿森迪斯药物骨疾病股份有限公司 | 甲状旁腺功能减退的治疗 |
| EP4217004A1 (en) * | 2020-09-28 | 2023-08-02 | Ascendis Pharma Bone Diseases A/S | Improvement of physical and mental well-being of patients with hypoparathyroidism |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| CA2521784C (en) | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| US7690003B2 (en) | 2003-08-29 | 2010-03-30 | Fuller Jeffrey C | System and method for increasing data throughput using thread scheduling |
| KR101241862B1 (ko) | 2003-09-19 | 2013-03-13 | 노보 노르디스크 에이/에스 | 신규 ｇｌｐ-1 유도체 |
| WO2005099768A2 (en) | 2004-03-23 | 2005-10-27 | Complex Biosystems Gmbh | Polymeric prodrug with a self-immolative linker |
| CN101151048A (zh) * | 2004-05-10 | 2008-03-26 | 纳斯泰克制药公司 | 增强甲状旁腺激素粘膜递送的组合物和方法 |
| GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| MX2009002859A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
| JP5351889B2 (ja) | 2007-06-21 | 2013-11-27 | テクニシェ ユニバーシタット ミュンヘン | インビボおよび／またはインビトロ安定性が増大した生物学的に活性なタンパク質 |
| EP2175878A4 (en) | 2007-07-11 | 2014-12-03 | Belrose Pharma Inc | POLYMER DRUG DISPENSING SYSTEM WITH A MULTIPLE SUBSTITUTED AROMATIC PART |
| CA2712224C (en) | 2008-02-01 | 2016-03-08 | Ascendis Pharma As | Prodrug comprising a drug linker conjugate |
| US20110105413A1 (en) | 2008-05-23 | 2011-05-05 | Enzon Pharmaceuticals, Inc. | Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides |
| CN108530543B (zh) | 2009-02-03 | 2023-06-23 | 阿穆尼克斯制药公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| US9173953B2 (en) | 2009-07-31 | 2015-11-03 | Ascendis Pharma As | Prodrugs containing an aromatic amine connected by an amido bond to a linker |
| US20120289571A1 (en) | 2009-12-31 | 2012-11-15 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates of aromatic amine containing compounds including releasable urea linker |
| WO2011089216A1 (en) | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
| WO2011089214A1 (en) | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Carrier-linked carbamate prodrug linkers |
| WO2011089215A1 (en) | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aromatic amine-containing drugs |
| EP4450523A3 (en) | 2010-04-02 | 2025-03-12 | Amunix Pharmaceuticals, Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
| WO2011140392A1 (en) | 2010-05-05 | 2011-11-10 | Prolynx Llc | Controlled drug release from solid supports |
| ES2584381T3 (es) | 2010-05-05 | 2016-09-27 | Prolynx Llc | Liberación controlada de compuestos activos desde conjugados macromoleculares |
| MX338914B (es) | 2010-05-21 | 2016-05-06 | Xl Protein Gmbh | Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos. |
| CN102959585B (zh) | 2010-06-30 | 2016-03-30 | 日本电气方案创新株式会社 | 属性确定方法、属性确定装置及属性确定系统 |
| EP2741778A1 (en) | 2011-08-12 | 2014-06-18 | Ascendis Pharma A/S | Polymeric hyperbranched carrier-linked prodrugs |
| EP2741781A1 (en) | 2011-08-12 | 2014-06-18 | Ascendis Pharma A/S | Carrier-linked treprostinil prodrugs |
| CA2843506C (en) | 2011-08-12 | 2020-05-12 | Ascendis Pharma A/S | Carrier-linked prodrugs having reversible carboxylic ester linkages |
| WO2013024049A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Protein carrier-linked prodrugs |
| WO2013036857A1 (en) | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
| AU2013254756B2 (en) | 2012-04-25 | 2017-03-30 | Ascendis Pharma A/S | Prodrugs of hydroxyl-comprising drugs |
| EP2908845A1 (en) | 2012-10-17 | 2015-08-26 | Novo Nordisk Health Care AG | Fatty acid acylated amino acids for growth hormone delivery |
| EP3193941B1 (en) | 2014-08-06 | 2024-05-22 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
| IL317744A (en) * | 2016-03-01 | 2025-02-01 | Ascendis Pharma Bone Diseases As | PTH drug agonists |
| RS64440B1 (sr) * | 2016-09-29 | 2023-09-29 | Ascendis Pharma Bone Diseases As | Režim doziranja za pth jedinjenje sa kontrolisanim oslobađanjem |
| PL3518961T3 (pl) * | 2016-09-29 | 2023-08-14 | Ascendis Pharma Bone Diseases A/S | Związki pth o niskim stosunku wartości maksymalnej do minimalnej |
| FI3518982T3 (fi) * | 2016-09-29 | 2025-02-11 | Ascendis Pharma Bone Diseases As | Säädellysti vapautuvia PTH-yhdisteitä |
-
2019
- 2019-05-17 CA CA3099620A patent/CA3099620A1/en active Pending
- 2019-05-17 FI FIEP19724825.5T patent/FI3793587T3/fi active
- 2019-05-17 ES ES19724825T patent/ES3041260T3/es active Active
- 2019-05-17 CN CN201980041822.5A patent/CN112334152A/zh active Pending
- 2019-05-17 KR KR1020207036187A patent/KR102797223B1/ko active Active
- 2019-05-17 JP JP2020564461A patent/JP7542442B2/ja active Active
- 2019-05-17 AU AU2019270464A patent/AU2019270464B2/en active Active
- 2019-05-17 HU HUE19724825A patent/HUE072823T2/hu unknown
- 2019-05-17 WO PCT/EP2019/062773 patent/WO2019219896A1/en not_active Ceased
- 2019-05-17 US US17/055,695 patent/US20210196801A1/en not_active Abandoned
- 2019-05-17 HR HRP20250963TT patent/HRP20250963T1/hr unknown
- 2019-05-17 PT PT197248255T patent/PT3793587T/pt unknown
- 2019-05-17 KR KR1020257011726A patent/KR20250057068A/ko active Pending
- 2019-05-17 DK DK19724825.5T patent/DK3793587T3/da active
- 2019-05-17 EP EP25186256.1A patent/EP4609879A3/en active Pending
- 2019-05-17 SM SM20250272T patent/SMT202500272T1/it unknown
- 2019-05-17 EP EP19724825.5A patent/EP3793587B1/en active Active
- 2019-05-17 IL IL278717A patent/IL278717B2/en unknown
- 2019-05-17 LT LTEPPCT/EP2019/062773T patent/LT3793587T/lt unknown
- 2019-05-17 BR BR112020022306-9A patent/BR112020022306A2/pt unknown
- 2019-05-17 MY MYPI2024000638A patent/MY210601A/en unknown
- 2019-05-17 RS RS20250926A patent/RS67222B1/sr unknown
- 2019-05-17 MX MX2020012179A patent/MX2020012179A/es unknown
- 2019-05-17 SI SI201930948T patent/SI3793587T1/sl unknown
- 2019-05-17 SG SG11202010387QA patent/SG11202010387QA/en unknown
- 2019-05-17 MA MA69295A patent/MA69295B1/fr unknown
- 2019-05-17 PL PL19724825.5T patent/PL3793587T3/pl unknown
- 2019-05-17 MY MYPI2020002535A patent/MY203421A/en unknown
-
2024
- 2024-05-01 JP JP2024074268A patent/JP2024105390A/ja active Pending
- 2024-12-05 AU AU2024278156A patent/AU2024278156A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3778038A4 (en) | Inhaler | |
| PL3793587T3 (pl) | Dawka początkowa koniugatów PTH | |
| EP3826775A4 (en) | ATOMIZER | |
| DK3501542T3 (da) | Esketamin til behandling af depression | |
| DK3302565T3 (da) | Faste doseringsformer af palbociclib | |
| DK3313845T3 (da) | Konjugater af cysteinmanipulerede antistoffer | |
| DK3436607T5 (da) | Indfangning af koblede dupleksmål | |
| DK3509581T3 (da) | Formuleringer af (r)-2-amino-3-phenylpropylcarbamat | |
| DK4331584T3 (da) | Terapeutiske anvendelser af deutererede derivater af lanifibranor | |
| DK3622953T3 (da) | Kombinationsbehandling af cancer | |
| DK3289832T3 (da) | Opgradering af lyskilde | |
| IL282231A (en) | Compounds containing deuterium | |
| IL282330A (en) | Therapeutic compounds | |
| EP3801553A4 (en) | PRODRUGS OF FULVESTRANT | |
| DK3474822T3 (da) | Formuleringer af brincidofovir | |
| DK3697418T3 (da) | Forbedrede formuleringer af bromocriptin | |
| DK3717503T3 (da) | Albumin-bindende prodrugs af auristatin E derivater | |
| DK3548195T3 (da) | Dannelse af cylindrisk rør | |
| DK3567245T3 (da) | Drift af vindmølle | |
| DK3297619T3 (da) | Terapeutiske anvendelser af L-4-chlorkynurenin | |
| DK3678644T3 (da) | Formuleringer af copanlisib | |
| IL282753A (en) | Immunogenic composition | |
| DK3597167T3 (da) | Nedbrydning af kropsrester | |
| DK3746279T3 (da) | Sammenkobling af formdele | |
| EP3852209C0 (en) | OPTICAL OSCILLATOR |