MA69295B1 - Dose de départ de conjugués de pth - Google Patents
Dose de départ de conjugués de pthInfo
- Publication number
- MA69295B1 MA69295B1 MA69295A MA69295A MA69295B1 MA 69295 B1 MA69295 B1 MA 69295B1 MA 69295 A MA69295 A MA 69295A MA 69295 A MA69295 A MA 69295A MA 69295 B1 MA69295 B1 MA 69295B1
- Authority
- MA
- Morocco
- Prior art keywords
- pth
- fragment
- starting dose
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne un conjugué de la PTH, dans lequel un fragment de la PTH est conjugué de manière réversible à un fragment polymère ou à un fragment à base d'acide gras, ou un sel pharmaceutiquement acceptable correspondant ou une composition pharmaceutique comprenant ledit conjugué de la PTH ou un sel pharmaceutiquement acceptable correspondant, destiné(e) à être utilisé(e) dans le traitement, le contrôle, le retard ou la prévention d'une maladie qui peut être traitée, contrôlée, retardée ou empêchée par la PTH, la dose initiale étant comprise entre 0,8 et 4,9 nmoles/jour et les procédés de traitement respectifs.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18173155 | 2018-05-18 | ||
| EP19724825.5A EP3793587B1 (fr) | 2018-05-18 | 2019-05-17 | Dose de départ de conjugués de pth |
| PCT/EP2019/062773 WO2019219896A1 (fr) | 2018-05-18 | 2019-05-17 | Dose initiale de conjugués de la pth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA69295B1 true MA69295B1 (fr) | 2025-10-31 |
Family
ID=62217789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA69295A MA69295B1 (fr) | 2018-05-18 | 2019-05-17 | Dose de départ de conjugués de pth |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20210196801A1 (fr) |
| EP (2) | EP4609879A3 (fr) |
| JP (2) | JP7542442B2 (fr) |
| KR (2) | KR20250057068A (fr) |
| CN (1) | CN112334152A (fr) |
| AU (2) | AU2019270464B2 (fr) |
| BR (1) | BR112020022306A2 (fr) |
| CA (1) | CA3099620A1 (fr) |
| DK (1) | DK3793587T3 (fr) |
| ES (1) | ES3041260T3 (fr) |
| FI (1) | FI3793587T3 (fr) |
| HR (1) | HRP20250963T1 (fr) |
| HU (1) | HUE072823T2 (fr) |
| IL (1) | IL278717B2 (fr) |
| LT (1) | LT3793587T (fr) |
| MA (1) | MA69295B1 (fr) |
| MX (1) | MX2020012179A (fr) |
| MY (2) | MY203421A (fr) |
| PL (1) | PL3793587T3 (fr) |
| PT (1) | PT3793587T (fr) |
| RS (1) | RS67222B1 (fr) |
| SG (1) | SG11202010387QA (fr) |
| SI (1) | SI3793587T1 (fr) |
| SM (1) | SMT202500272T1 (fr) |
| WO (1) | WO2019219896A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202400423T1 (it) | 2016-03-01 | 2024-11-15 | Ascendis Pharma Bone Diseases As | Profarmaci di pth |
| HUE063235T2 (hu) | 2016-09-29 | 2024-01-28 | Ascendis Pharma Bone Diseases As | Adagolási rendszer szabályozott leadású PTH vegyülethez |
| SMT202300124T1 (it) | 2016-09-29 | 2023-05-12 | Ascendis Pharma Bone Diseases As | Composti pth con bassi rapporti picco/valle |
| HUE070273T2 (hu) | 2016-09-29 | 2025-05-28 | Ascendis Pharma Bone Diseases As | Szabályozott hatóanyag-leadású PTH vegyületek |
| WO2020165087A1 (fr) | 2019-02-11 | 2020-08-20 | Ascendis Pharma Bone Diseases A/S | Formulations pharmaceutiques liquides de conjugués pth |
| EP4090357A1 (fr) * | 2020-01-13 | 2022-11-23 | Ascendis Pharma Bone Diseases A/S | Traitement de l'hypoparathyroïdisme |
| JP2023543265A (ja) * | 2020-09-28 | 2023-10-13 | アセンディス ファーマ ボーン ディジージズ エー／エス | 副甲状腺機能低下症を有する患者の身体的及び精神的ウェルビーイングの改善 |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| CA2843439A1 (fr) | 2003-04-08 | 2004-10-21 | Yeda Research And Development Co. Ltd | Medicaments pegyles reversibles |
| US7690003B2 (en) | 2003-08-29 | 2010-03-30 | Fuller Jeffrey C | System and method for increasing data throughput using thread scheduling |
| CA2539253A1 (fr) | 2003-09-19 | 2005-03-31 | Novo Nordisk A/S | Nouveaux derives de glp-1 |
| JP4950022B2 (ja) | 2004-03-23 | 2012-06-13 | コンプレックス バイオシステムズ ゲーエムベーハー | 自壊性リンカーを有する高分子プロドラッグ |
| RU2006143544A (ru) * | 2004-05-10 | 2008-06-20 | Нэстек Фармасьютикал Кампани Инк. (Us) | Композиции и способ для облегченной чресслизистой доставки паратиреоидного гормона |
| GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| CN101534643A (zh) | 2006-09-15 | 2009-09-16 | 安佐制药股份有限公司 | 用于递送寡核苷酸的基于位阻酯的生物可降解连接体 |
| HRP20110368T1 (hr) | 2007-06-21 | 2011-06-30 | Technische Universitt Mnchen | Biološki aktivni proteini s povećanom stabilnošću in vivo i/ili in vitro |
| EP2175878A4 (fr) | 2007-07-11 | 2014-12-03 | Belrose Pharma Inc | Système d'administration de médicament polymérique contenant un groupement aromatique multi-substitué |
| CN101980725B (zh) * | 2008-02-01 | 2013-06-12 | 阿森迪斯药物股份有限公司 | 包含可自裂解的连接体的前药 |
| EP2288261A4 (fr) | 2008-05-23 | 2013-09-25 | Enzon Pharmaceuticals Inc | Systèmes polymères contenant un lieur disulfure intracellulaire libérable pour la délivrance d oligonucléotides |
| SI2393828T1 (sl) | 2009-02-03 | 2017-01-31 | Amunix Operating Inc. | Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo |
| US9173953B2 (en) | 2009-07-31 | 2015-11-03 | Ascendis Pharma As | Prodrugs containing an aromatic amine connected by an amido bond to a linker |
| US20120289571A1 (en) | 2009-12-31 | 2012-11-15 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates of aromatic amine containing compounds including releasable urea linker |
| US20130030359A1 (en) | 2010-01-22 | 2013-01-31 | Ascendis Pharma A/S | Dipeptide-based prodrug linkers for aromatic amine-containing drugs |
| US9561285B2 (en) | 2010-01-22 | 2017-02-07 | Ascendis Pharma As | Carrier-linked carbamate prodrug linkers |
| US9062094B2 (en) | 2010-01-22 | 2015-06-23 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
| EP3372617B1 (fr) | 2010-04-02 | 2024-07-24 | Amunix Pharmaceuticals, Inc. | Protéines de fusion liantes, conjugués protéines de fusion liantes-médicaments, conjugués xten-médicaments et procédés pour les préparer et les utiliser |
| JP5977229B2 (ja) | 2010-05-05 | 2016-08-24 | プロリンクス リミテッド ライアビリティ カンパニー | 巨大分子共役体からの徐放 |
| DK2566334T3 (en) | 2010-05-05 | 2018-07-23 | Prolynx Llc | MANAGED PHARMACEUTICAL RELEASE FROM SOLID CARRIERS |
| AU2011254564B2 (en) | 2010-05-21 | 2014-03-27 | Xl-Protein Gmbh | Biosynthetic proline/alanine random coil polypeptides and their uses |
| US8989456B2 (en) | 2010-06-30 | 2015-03-24 | Nec Solution Innovators, Ltd. | Attribute determining method, attribute determining apparatus, program, recording medium, and attribute determining system |
| US20140323402A1 (en) | 2011-08-12 | 2014-10-30 | Ascendis Phama A/S | Protein Carrier-Linked Prodrugs |
| WO2013024048A1 (fr) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Promédicaments liés à des excipients polymériques hyperbranchés |
| JP6092867B2 (ja) | 2011-08-12 | 2017-03-08 | アセンディス ファーマ エー／エス | 担体連結しているトレプロスチニルプロドラッグ |
| US20140249093A1 (en) | 2011-08-12 | 2014-09-04 | Ascendis Pharma A/S | Carrier-Linked Prodrugs Having Reversible Carboxylic Ester Linkages |
| WO2013036857A1 (fr) | 2011-09-07 | 2013-03-14 | Prolynx Llc | Coupleurs au sulfone |
| EP2841109A1 (fr) | 2012-04-25 | 2015-03-04 | Ascendis Pharma A/S | Promédicaments de médicaments comprenant des groupes hydroxyle |
| CN104955472A (zh) | 2012-10-17 | 2015-09-30 | 诺和诺德保健股份有限公司 | 用于生长激素递送的脂肪酸酰化的氨基酸 |
| AU2015299055C1 (en) | 2014-08-06 | 2021-05-06 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
| SMT202400423T1 (it) * | 2016-03-01 | 2024-11-15 | Ascendis Pharma Bone Diseases As | Profarmaci di pth |
| SMT202300124T1 (it) * | 2016-09-29 | 2023-05-12 | Ascendis Pharma Bone Diseases As | Composti pth con bassi rapporti picco/valle |
| HUE063235T2 (hu) * | 2016-09-29 | 2024-01-28 | Ascendis Pharma Bone Diseases As | Adagolási rendszer szabályozott leadású PTH vegyülethez |
| HUE070273T2 (hu) * | 2016-09-29 | 2025-05-28 | Ascendis Pharma Bone Diseases As | Szabályozott hatóanyag-leadású PTH vegyületek |
-
2019
- 2019-05-17 SM SM20250272T patent/SMT202500272T1/it unknown
- 2019-05-17 AU AU2019270464A patent/AU2019270464B2/en active Active
- 2019-05-17 KR KR1020257011726A patent/KR20250057068A/ko active Pending
- 2019-05-17 JP JP2020564461A patent/JP7542442B2/ja active Active
- 2019-05-17 ES ES19724825T patent/ES3041260T3/es active Active
- 2019-05-17 PT PT197248255T patent/PT3793587T/pt unknown
- 2019-05-17 KR KR1020207036187A patent/KR102797223B1/ko active Active
- 2019-05-17 DK DK19724825.5T patent/DK3793587T3/da active
- 2019-05-17 WO PCT/EP2019/062773 patent/WO2019219896A1/fr not_active Ceased
- 2019-05-17 SG SG11202010387QA patent/SG11202010387QA/en unknown
- 2019-05-17 SI SI201930948T patent/SI3793587T1/sl unknown
- 2019-05-17 CN CN201980041822.5A patent/CN112334152A/zh active Pending
- 2019-05-17 MY MYPI2020002535A patent/MY203421A/en unknown
- 2019-05-17 PL PL19724825.5T patent/PL3793587T3/pl unknown
- 2019-05-17 MX MX2020012179A patent/MX2020012179A/es unknown
- 2019-05-17 IL IL278717A patent/IL278717B2/en unknown
- 2019-05-17 RS RS20250926A patent/RS67222B1/sr unknown
- 2019-05-17 HR HRP20250963TT patent/HRP20250963T1/hr unknown
- 2019-05-17 CA CA3099620A patent/CA3099620A1/fr active Pending
- 2019-05-17 US US17/055,695 patent/US20210196801A1/en not_active Abandoned
- 2019-05-17 MY MYPI2024000638A patent/MY210601A/en unknown
- 2019-05-17 EP EP25186256.1A patent/EP4609879A3/fr active Pending
- 2019-05-17 LT LTEPPCT/EP2019/062773T patent/LT3793587T/lt unknown
- 2019-05-17 HU HUE19724825A patent/HUE072823T2/hu unknown
- 2019-05-17 EP EP19724825.5A patent/EP3793587B1/fr active Active
- 2019-05-17 FI FIEP19724825.5T patent/FI3793587T3/fi active
- 2019-05-17 MA MA69295A patent/MA69295B1/fr unknown
- 2019-05-17 BR BR112020022306-9A patent/BR112020022306A2/pt unknown
-
2024
- 2024-05-01 JP JP2024074268A patent/JP2024105390A/ja active Pending
- 2024-12-05 AU AU2024278156A patent/AU2024278156A1/en active Pending
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