DK3880676T3 - 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-on-derivater som hpk1-inhibitorer til behandling af cancer - Google Patents

2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-on-derivater som hpk1-inhibitorer til behandling af cancer Download PDF

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Publication number
DK3880676T3
DK3880676T3 DK19813943.8T DK19813943T DK3880676T3 DK 3880676 T3 DK3880676 T3 DK 3880676T3 DK 19813943 T DK19813943 T DK 19813943T DK 3880676 T3 DK3880676 T3 DK 3880676T3
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Denmark
Prior art keywords
pyrrolo
pyridin
dihydro
cancer
derivatives
Prior art date
Application number
DK19813943.8T
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English (en)
Inventor
Rebecca Anne Gallego
Sajiv Krishnan Nair
Robert Steven Kania
Omar Khaled Ahmad
Ted William Johnson
Jamison Bryce Tuttle
Mehran Jalaie
Michele Ann Mctigue
Dahui Zhou
Bel Matthew L Del
Ru Zhou
Mingying He
Anne-Marie Dechert Schmitt
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Pfizer
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Application filed by Pfizer filed Critical Pfizer
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Publication of DK3880676T3 publication Critical patent/DK3880676T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK19813943.8T 2018-11-15 2019-11-12 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-on-derivater som hpk1-inhibitorer til behandling af cancer DK3880676T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862767602P 2018-11-15 2018-11-15
US201962909970P 2019-10-03 2019-10-03
PCT/IB2019/059702 WO2020100027A1 (en) 2018-11-15 2019-11-12 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-one derivatives as hpk1 inhibitors for the treatment of cancer

Publications (1)

Publication Number Publication Date
DK3880676T3 true DK3880676T3 (da) 2023-09-04

Family

ID=68771726

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Application Number Title Priority Date Filing Date
DK19813943.8T DK3880676T3 (da) 2018-11-15 2019-11-12 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-on-derivater som hpk1-inhibitorer til behandling af cancer

Country Status (38)

Country Link
US (1) US11142525B2 (da)
EP (1) EP3880676B1 (da)
JP (1) JP7118267B2 (da)
KR (1) KR20210090675A (da)
CN (1) CN113316576A (da)
AU (1) AU2019378184B2 (da)
BR (1) BR112021008991A2 (da)
CA (1) CA3061392A1 (da)
CL (1) CL2021001190A1 (da)
CO (1) CO2021006114A2 (da)
CR (1) CR20210251A (da)
CU (1) CU20210035A7 (da)
CY (1) CY1126663T1 (da)
DK (1) DK3880676T3 (da)
DO (1) DOP2021000088A (da)
EC (1) ECSP21034668A (da)
ES (1) ES2958948T3 (da)
FI (1) FI3880676T3 (da)
GE (2) GEAP202215630A (da)
HR (1) HRP20231089T1 (da)
HU (1) HUE063367T2 (da)
IL (1) IL283149A (da)
LT (1) LT3880676T (da)
MD (1) MD3880676T2 (da)
MX (1) MX2021005754A (da)
PE (1) PE20211868A1 (da)
PH (1) PH12021551117A1 (da)
PL (1) PL3880676T3 (da)
PT (1) PT3880676T (da)
PY (1) PY1996328A (da)
RS (1) RS64655B1 (da)
SG (1) SG11202104394XA (da)
SI (1) SI3880676T1 (da)
TW (1) TWI718758B (da)
UA (1) UA127426C2 (da)
UY (1) UY38471A (da)
WO (1) WO2020100027A1 (da)
ZA (1) ZA202103099B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4371987B9 (en) 2018-10-31 2025-11-26 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
EP3873608A1 (en) 2018-10-31 2021-09-08 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
US11453681B2 (en) 2019-05-23 2022-09-27 Gilead Sciences, Inc. Substituted eneoxindoles and uses thereof
US12215105B2 (en) * 2019-09-13 2025-02-04 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
EP4143186A1 (en) * 2020-05-01 2023-03-08 Pfizer Inc. Azalactam compounds as hpk1 inhibitors
CN112409268A (zh) * 2020-12-03 2021-02-26 西南交通大学 靶向Fam20C抑制剂的制备及其抗三阴性乳腺癌作用
CN117295737A (zh) * 2021-03-05 2023-12-26 林伯士萨顿公司 Hpk1拮抗剂和其用途
WO2022213062A1 (en) 2021-03-29 2022-10-06 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
CN117460732A (zh) * 2021-06-11 2024-01-26 杭州中美华东制药有限公司 吡咯并吡啶酮类化合物及其制备方法和用途
WO2023001794A1 (en) 2021-07-20 2023-01-26 Astrazeneca Ab Substituted pyrazine-2-carboxamides as hpk1 inhibitors for the treatment of cancer
EP4380565A4 (en) * 2021-08-03 2025-05-21 Nimbus Saturn, Inc. HPK1 antagonists and their uses
WO2023023942A1 (en) * 2021-08-24 2023-03-02 Biofront Ltd (Cayman) Hpk1 inhibitors, compositions comprising hpk1 inhibitor, and methods of using the same
CN118103369A (zh) * 2021-09-03 2024-05-28 浙江海正药业股份有限公司 吡啶并内酰胺类衍生物及其制备方法和用途
US20240409559A1 (en) * 2021-10-05 2024-12-12 Pfizer Inc. Crystalline form of azalactam compound
CN114767676B (zh) 2022-04-22 2024-04-19 珠海宇繁生物科技有限责任公司 Hpk1激酶抑制剂在预防和/或治疗人的病原体感染中的应用
KR102855849B1 (ko) 2022-11-25 2025-09-08 충남대학교산학협력단 이미다조피리딘 유도체, 이를 유효성분으로 포함하는 약제학적 조성물 및 이를 이용하는 암의 치료 방법

Family Cites Families (12)

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US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
BRPI0814441A2 (pt) * 2007-07-19 2015-07-14 Schering Corp Compostos de amida heterocíclica como inibidores de proteína cinase
KR102537985B1 (ko) 2016-09-12 2023-05-30 인테그랄 헬스 인코퍼레이티드 Gpr120 조정제로서 유용한 단환형 화합물
EP3596075B1 (en) 2017-03-15 2023-10-11 F. Hoffmann-La Roche AG Azaindoles as inhibitors of hpk1
CN109265443B (zh) 2017-07-18 2022-11-29 南京圣和药业股份有限公司 作为ask抑制剂的杂环化合物及其应用
EP3743063A4 (en) 2018-01-26 2021-10-20 Nurix Therapeutics, Inc. CBL-B INHIBITORS AND THEIR METHODS OF USE

Also Published As

Publication number Publication date
KR20210090675A (ko) 2021-07-20
AU2019378184A1 (en) 2021-05-27
IL283149A (en) 2021-06-30
DOP2021000088A (es) 2021-06-30
UA127426C2 (uk) 2023-08-16
TWI718758B (zh) 2021-02-11
CO2021006114A2 (es) 2021-05-31
CY1126663T1 (el) 2026-02-25
MD3880676T2 (ro) 2023-12-31
LT3880676T (lt) 2023-09-25
CN113316576A (zh) 2021-08-27
US11142525B2 (en) 2021-10-12
RS64655B1 (sr) 2023-10-31
AU2019378184B2 (en) 2022-09-15
PL3880676T3 (pl) 2023-12-11
UY38471A (es) 2020-06-30
SG11202104394XA (en) 2021-05-28
JP2022507231A (ja) 2022-01-18
PY1996328A (es) 2021-05-21
MX2021005754A (es) 2021-08-11
GEAP202215630A (en) 2022-06-27
CU20210035A7 (es) 2021-12-08
JP7118267B2 (ja) 2022-08-15
CR20210251A (es) 2021-07-14
GEP20227434B (en) 2022-10-25
CL2021001190A1 (es) 2021-12-24
BR112021008991A2 (pt) 2021-08-10
CA3061392A1 (en) 2020-05-15
PT3880676T (pt) 2023-10-04
EP3880676B1 (en) 2023-08-02
SI3880676T1 (sl) 2023-10-30
ZA202103099B (en) 2023-11-29
WO2020100027A1 (en) 2020-05-22
HUE063367T2 (hu) 2024-01-28
US20200172539A1 (en) 2020-06-04
ES2958948T3 (es) 2024-02-16
EP3880676A1 (en) 2021-09-22
HRP20231089T1 (hr) 2023-12-22
PE20211868A1 (es) 2021-09-21
TW202031657A (zh) 2020-09-01
ECSP21034668A (es) 2021-06-30
FI3880676T3 (fi) 2023-09-15
PH12021551117A1 (en) 2021-11-22

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