DK4055187T3 - Fremgangsmåder til analyse af nukleinsyremolekyler - Google Patents

Fremgangsmåder til analyse af nukleinsyremolekyler

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Publication number
DK4055187T3
DK4055187T3 DK20885631.0T DK20885631T DK4055187T3 DK 4055187 T3 DK4055187 T3 DK 4055187T3 DK 20885631 T DK20885631 T DK 20885631T DK 4055187 T3 DK4055187 T3 DK 4055187T3
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DK
Denmark
Prior art keywords
analysis
methods
nucleic acid
acid molecules
molecules
Prior art date
Application number
DK20885631.0T
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English (en)
Inventor
Maximilian Diehn
Arash Ash Alizadeh
David M Kurtz
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Univ Leland Stanford Junior
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Publication of DK4055187T3 publication Critical patent/DK4055187T3/da

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G—PHYSICS
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    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/20—Screening of libraries
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
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    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Epidemiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Primary Health Care (AREA)
  • Biomedical Technology (AREA)
  • Data Mining & Analysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Databases & Information Systems (AREA)
  • Library & Information Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
DK20885631.0T 2019-11-06 2020-11-06 Fremgangsmåder til analyse af nukleinsyremolekyler DK4055187T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962931688P 2019-11-06 2019-11-06
PCT/US2020/059526 WO2021092476A1 (en) 2019-11-06 2020-11-06 Methods and systems for analyzing nucleic acid molecules

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DK4055187T3 true DK4055187T3 (da) 2025-10-27

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DK20885631.0T DK4055187T3 (da) 2019-11-06 2020-11-06 Fremgangsmåder til analyse af nukleinsyremolekyler

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US (14) US20210172022A1 (da)
EP (3) EP4527945A3 (da)
JP (2) JP7825272B2 (da)
KR (1) KR20220094218A (da)
CN (3) CN118834950A (da)
AU (1) AU2020378435A1 (da)
BR (1) BR112022008752A2 (da)
CA (1) CA3156589A1 (da)
DE (1) DE112020005433T5 (da)
DK (1) DK4055187T3 (da)
ES (1) ES3041276T3 (da)
GB (4) GB2623904B (da)
MX (1) MX2022005588A (da)
WO (1) WO2021092476A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015229083B2 (en) 2014-03-14 2021-06-17 Caredx, Inc. Methods of monitoring immunosuppressive therapies in a transplant recipient
GB2623904B (en) 2019-11-06 2024-07-24 Univ Leland Stanford Junior Methods and systems for analyzing nucleic acid molecules
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
KR20230064172A (ko) * 2021-11-03 2023-05-10 주식회사 지씨지놈 세포유리 핵산단편 위치별 서열 빈도 및 크기를 이용한 암 진단 방법
MX2024006820A (es) * 2021-12-15 2024-08-15 Univ Johns Hopkins Mutacion del genoma completo de molecula unica y perfiles de fragmentacion de acido desoxirribonucleico (adn) libre de celula.
CN114974421B (zh) * 2022-05-20 2024-04-30 南开大学 基于扩散-降噪的单细胞转录组测序数据补插方法及系统
KR20230172174A (ko) * 2022-06-15 2023-12-22 주식회사 지씨지놈 무세포 핵산의 단일염기변이를 이용한 암 진단 및 암 종 예측방법
CN115181800B (zh) * 2022-07-11 2025-06-13 南京世和基因生物技术股份有限公司 基因标志物在非小细胞肺癌预后效果预测中的应用、预测装置以及计算机可读取介质
GB202212094D0 (en) * 2022-08-19 2022-10-05 Inivata Ltd Method of detecting cancer DNA in a sample
CN116466085A (zh) * 2022-11-28 2023-07-21 中国人民解放军海军军医大学第三附属医院 一种四基因的生物标志物组合及其在肝癌治疗中的应用
KR102630597B1 (ko) * 2023-08-22 2024-01-29 주식회사 지놈인사이트테크놀로지 종양 정보를 활용한 미세 잔존 질환 탐지 방법 및 장치
US20250137064A1 (en) * 2023-10-30 2025-05-01 Myriad Women's Health, Inc. Use of multi-nucleotide and structural variants for improved sensitivity and specificity of circulating tumor dna assays
WO2025096466A2 (en) * 2023-10-30 2025-05-08 Myriad Women's Health, Inc. Methods for improving minimal residual disease assays
WO2025245136A1 (en) * 2024-05-22 2025-11-27 Foresight Diagnostics Inc. Methods and systems for adjuvant therapy
WO2026019737A1 (en) * 2024-07-16 2026-01-22 Myriad Women's Health, Inc. Targeted depletion sequencing for use in minimum residual disease assays
WO2026072949A1 (en) * 2024-09-27 2026-04-02 Roche Sequencing Solutions, Inc. Multi-modal risk stratification of minimum residual disease

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA241076A (en) 1924-06-24 Carter Formby King Otis Calculating apparatus
CA233975A (en) 1923-09-04 Rightmire Franklin Anti-skid chain tightener
CA188298A (en) 1918-04-08 1919-01-14 William H. Bot Grain separator
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US6171856B1 (en) 1997-07-30 2001-01-09 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
DE10032165A1 (de) 2000-07-01 2002-01-10 Beiersdorf Ag Verwendung von physiologisch verträglichen Sulfinsäuren als Antioxidans oder Radikalfänger in kosmetischen oder dermatologischen Zubereitungen
WO2003056036A2 (en) 2001-12-21 2003-07-10 The Wellcome Trust Genes
EP3611273A1 (en) 2004-03-31 2020-02-19 The General Hospital Corporation Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US20130210645A1 (en) 2010-02-18 2013-08-15 The Johns Hopkins University Personalized tumor biomarkers
US20190010543A1 (en) * 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
EP2619327B1 (en) 2010-09-21 2014-10-22 Population Genetics Technologies LTD. Increasing confidence of allele calls with molecular counting
KR20140024270A (ko) 2010-12-30 2014-02-28 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
AU2012242847B2 (en) 2011-04-15 2017-01-19 The Johns Hopkins University Safe sequencing system
HUE053360T2 (hu) 2012-02-17 2021-06-28 Hutchinson Fred Cancer Res Kompozíciók és eljárások mutációk pontos azonosítására
ES2828661T3 (es) 2012-03-20 2021-05-27 Univ Washington Through Its Center For Commercialization Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
DE202013012824U1 (de) 2012-09-04 2020-03-10 Guardant Health, Inc. Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation
WO2014113204A1 (en) 2013-01-17 2014-07-24 Personalis, Inc. Methods and systems for genetic analysis
CA2899020C (en) 2013-02-01 2023-10-03 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
CN113337604A (zh) * 2013-03-15 2021-09-03 莱兰斯坦福初级大学评议会 循环核酸肿瘤标志物的鉴别和用途
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
CN113774132A (zh) 2014-04-21 2021-12-10 纳特拉公司 检测染色体片段中的突变和倍性
US10801067B2 (en) * 2014-05-09 2020-10-13 Eurofins Lifecodexx Gmbh Detection of DNA that originates from a specific cell-type and related methods
EP4170044B1 (en) * 2014-06-06 2026-03-11 Cornell University Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions
WO2015200869A1 (en) * 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
ES2925014T3 (es) 2014-09-12 2022-10-13 Univ Leland Stanford Junior Identificación y uso de ácidos nucleicos circulantes
WO2016049878A1 (zh) * 2014-09-30 2016-04-07 深圳华大基因科技有限公司 一种基于snp分型的亲子鉴定方法及应用
WO2016077408A1 (en) 2014-11-12 2016-05-19 Neogenomics Laboratories, Inc. Deep sequencing of peripheral blood plasma dna is reliable for confirming the diagnosis of myelodysplastic syndrome
CN107208156B (zh) 2015-02-09 2021-10-08 10X基因组学有限公司 用于使用变异识别数据来确定结构变异和定相的系统和方法
CN107708556B (zh) 2015-05-01 2022-01-04 夸登特健康公司 诊断方法
AU2016341198B2 (en) 2015-10-19 2023-03-09 Dovetail Genomics, Llc Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection
EP3845668A1 (en) 2015-10-30 2021-07-07 New England Biolabs, Inc. Compositions and methods for determining modified cytosines by sequencing
US10260088B2 (en) 2015-10-30 2019-04-16 New England Biolabs, Inc. Compositions and methods for analyzing modified nucleotides
CA3007426A1 (en) 2015-12-03 2017-06-08 Alfred Health Monitoring treatment or progression of myeloma
PL3387152T3 (pl) 2015-12-08 2022-05-09 Twinstrand Biosciences, Inc. Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego
WO2017136603A1 (en) 2016-02-02 2017-08-10 Guardant Health, Inc. Cancer evolution detection and diagnostic
US11479878B2 (en) * 2016-03-16 2022-10-25 Dana-Farber Cancer Institute, Inc. Methods for genome characterization
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
EP3465501A4 (en) 2016-05-27 2020-02-26 Personalis, Inc. PERSONALIZED GENTESTS
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
WO2018081161A1 (en) 2016-10-24 2018-05-03 Biomatrica, Inc. Stabilization of nucleic acids on paper
US11479807B2 (en) 2017-03-23 2022-10-25 University Of Washington Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
CN111278276B (zh) 2017-06-28 2023-05-26 美国陶氏益农公司 用于转基因表达的植物启动子
WO2019060640A1 (en) 2017-09-20 2019-03-28 Guardant Health, Inc. METHODS AND SYSTEMS FOR DIFFERENTIATING SOMATIC VARIANTS AND GERMINAL LINE VARIANTS
CN112020563A (zh) 2018-03-06 2020-12-01 癌症研究技术有限公司 变体检测的改进
CN109337983A (zh) * 2018-11-29 2019-02-15 优葆优保健康科技(宁波)有限公司 检测人甲状腺癌循环肿瘤dna的探针组合及其捕获测序系统
EP3914736B1 (en) * 2019-01-25 2023-12-20 Grail, LLC Detecting cancer, cancer tissue of origin, and/or a cancer cell type
KR102526916B1 (ko) * 2019-04-05 2023-05-02 주식회사 제놉시 Cfdna를 이용한 위암 진단방법
CN110055312B (zh) * 2019-04-09 2022-11-15 嘉兴雅康博医学检验所有限公司 用于检测egfr基因c797s和t790m顺反式突变的引物、探针及试剂盒
WO2021003485A1 (en) 2019-07-03 2021-01-07 The Board Of Trustees Of The Leland Stanford Junior University Methods to assess clinical outcome based upon updated probabilities and treatments thereof
GB2623904B (en) 2019-11-06 2024-07-24 Univ Leland Stanford Junior Methods and systems for analyzing nucleic acid molecules
AU2021227229A1 (en) 2020-02-24 2022-10-13 The Board Of Trustees Of The Leland Stanford Junior University Methods of analyzing cell free nucleic acids and applications thereof
GB2625469B (en) 2021-05-05 2025-05-07 Univ Leland Stanford Junior Methods and systems for analyzing nucleic acid molecules
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules

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