DK428478A - Fremgangsmaade til fremstilling af cyclopeptider af somatostatintypen samt syreadditionssalte og komplekser deraf - Google Patents

Fremgangsmaade til fremstilling af cyclopeptider af somatostatintypen samt syreadditionssalte og komplekser deraf

Info

Publication number: DK428478A
Authority: DK; Denmark
Prior art keywords: cyclope; complex; preparation; additional salts; acid additional
Prior art date: 1977-09-28

Application number

DK428478A

Other languages

English (en)

Other versions

DK151034B (da

DK151034C (da

Inventor

H Rink

B Kamber

P Sieber

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-09-28

Filing date

1978-09-27

Publication date

1979-03-29

1978-09-27 Application filed by Ciba Geigy filed Critical Ciba Geigy

1979-03-29 Publication of DK428478A publication Critical patent/DK428478A/da

1987-10-12 Publication of DK151034B publication Critical patent/DK151034B/da

1988-02-22 Application granted granted Critical

1988-02-22 Publication of DK151034C publication Critical patent/DK151034C/da

Links

102000005157 Somatostatin Human genes 0.000 title 1
108010056088 Somatostatin Proteins 0.000 title 1
241000927721 Tritia Species 0.000 title 1
239000002253 acid Substances 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
229960000553 somatostatin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Zoology (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK428478A 1977-09-28 1978-09-27 Analogifremgangsmaade til fremstilling af somatostatinanaloge cyclopeptider eller fysiologisk taalelige syreadditionssalte eller komplekser deraf DK151034C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU78191A LU78191A1 (de)	1977-09-28	1977-09-28	Verfahren zur herstellung von neuen cyclopeptiden
LU78191		1977-09-28

Publications (3)

Publication Number	Publication Date
DK428478A true DK428478A (da)	1979-03-29
DK151034B DK151034B (da)	1987-10-12
DK151034C DK151034C (da)	1988-02-22

Family

ID=19728716

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK428478A DK151034C (da)	1977-09-28	1978-09-27	Analogifremgangsmaade til fremstilling af somatostatinanaloge cyclopeptider eller fysiologisk taalelige syreadditionssalte eller komplekser deraf

Country Status (18)

Country	Link
US (1)	US4238481A (da)
EP (1)	EP0001295B1 (da)
JP (1)	JPS5459293A (da)
AT (1)	AT370090B (da)
AU (1)	AU523050B2 (da)
CA (1)	CA1111841A (da)
DD (1)	DD140142A5 (da)
DE (1)	DE2861672D1 (da)
DK (1)	DK151034C (da)
ES (1)	ES473677A1 (da)
FI (1)	FI68246C (da)
HU (1)	HU184612B (da)
IE (1)	IE47380B1 (da)
IL (1)	IL55643A (da)
LU (1)	LU78191A1 (da)
NO (1)	NO148957C (da)
NZ (1)	NZ188517A (da)
ZA (1)	ZA785488B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4328214A (en) *	1979-07-04	1982-05-04	Ciba-Geigy Corporation	Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
NZ195303A (en) *	1979-10-31	1984-10-19	Merck & Co Inc	Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4369179A (en) *	1979-12-14	1983-01-18	Ciba-Geigy Corporation	Acylpeptides
DD155985A5 (de) *	1979-12-21	1982-07-21	Ciba Geigy Ag	Verfahren zur herstellung cyclischr octapeptide
US4360516A (en) *	1981-04-13	1982-11-23	Merck & Co., Inc.	Modified D-retro cyclic hexapeptide somatostatin analogs
ATE14226T1 (de) *	1981-12-24	1985-07-15	Ciba Geigy Ag	Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung.
HUT42101A (en) *	1985-01-07	1987-06-29	Sandoz Ag	Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4798821A (en) *	1987-03-02	1989-01-17	Merck & Co., Inc.	Antihypertensive therapy for diabetics
DE3822557C2 (de) *	1987-07-10	1998-07-02	Ciba Geigy Ag	Arzneimittel, enthaltend Somatostatine
JP2882679B2 (ja) *	1989-04-26	1999-04-12	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	線状ソマトスタチン類似体
US5633263A (en) *	1989-04-26	1997-05-27	The Administrators Of The Tulane Educational Fund	Linear somatostatin analogs
US5504069A (en) *	1993-02-11	1996-04-02	Biomeasure, Inc.	Inhibition of trauma-induced tumor growth
US5597894A (en) *	1995-06-05	1997-01-28	The Louisiana State University Medical Center Foundation	Multi-tyrosinated somatostatin analogs
RU2177006C2 (ru) *	1995-09-29	2001-12-20	Биомежер Инкорпорэйтед	Циклические пептидные аналоги соматостатина
CA2290592A1 (en) *	1997-05-13	1998-11-19	Michael Anthony Cawthorne	Somatostatin and somatostatin agonists for decreasing body weight
EP0981364B1 (en) *	1997-05-13	2006-03-01	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Method and compositions for treating hyperlipidemia
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
CA2289499C (en) *	1997-05-13	2010-02-23	Michael Anthony Cawthorne	Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x
US5968903A (en) *	1998-05-07	1999-10-19	Biomeasure, Incorporated	Inhibition of H. pylori proliferation
NZ530007A (en)	2001-06-08	2006-02-24	Sod Conseils Rech Applic	Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity
DE602004001727T2 (de) *	2003-04-07	2007-08-02	Novetide Ltd.	Verfahren zur herstellung cyclischer peptide
CA2523197C (en)	2003-04-22	2016-05-24	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Peptide vectors
WO2009150470A2 (en)	2008-06-12	2009-12-17	Syntaxin Limited	Suppression of cancers
EP2310028B1 (en)	2008-06-12	2016-11-16	Ipsen Bioinnovation Limited	Fusion proteins for use in the treatment of acromegaly
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
AU2011348220B2 (en)	2010-12-22	2017-09-07	The Salk Institute For Biological Studies	Cyclic CRF antagonist peptides
EP3007704B1 (en)	2013-06-13	2021-01-06	Antisense Therapeutics Ltd	Combination therapy for acromegaly
WO2025128794A1 (en)	2023-12-15	2025-06-19	Neurocrine Biosciences, Inc.	Fatty acid conjugated cyclic peptides
TW202544027A (zh)	2024-04-19	2025-11-16	美商紐羅克里生物科學有限公司	促皮質素釋放因子受體２（ｃｒｆｒ２）促效劑
WO2026064486A1 (en)	2024-09-20	2026-03-26	Neurocrine Biosciences, Inc.	Chemically modified peptides and use thereof
WO2026064495A1 (en)	2024-09-20	2026-03-26	Neurocrine Biosciences, Inc.	Chemically modified peptides and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4011182A (en) *	1975-03-21	1977-03-08	American Home Products Corporation	Cyclic undecapeptide analogs of somatostatin and intermediates
US4000259A (en) *	1975-06-16	1976-12-28	American Home Products Corporation	Cyclic dodecapeptide analogs of somatostatin and intermediates
NL7607987A (nl) *	1975-08-08	1977-02-10	Merck & Co Inc	Werkwijze voor het bereiden van peptiden.
US3988304A (en) *	1975-08-25	1976-10-26	American Home Products Corporation	Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
US4133805A (en) *	1975-12-16	1979-01-09	American Home Products Corporation	Cyclic undecapeptides related to somatostatin and intermediates therefor
US4054558A (en) *	1976-05-24	1977-10-18	American Home Products Corporation	Cyclic dodecapeptide and intermediates therefor
IE47421B1 (en) *	1977-06-08	1984-03-07	Merck & Co Inc	Somatostatin analogs,process for their preparation and pharmaceutical compositions containing them
US4115554A (en) *	1977-08-29	1978-09-19	Merck & Co., Inc.	Somatostatin analogs

1977
- 1977-09-28 LU LU78191A patent/LU78191A1/de unknown
1978
- 1978-09-15 US US05/942,565 patent/US4238481A/en not_active Expired - Lifetime
- 1978-09-25 DD DD78208064A patent/DD140142A5/de unknown
- 1978-09-25 FI FI782907A patent/FI68246C/fi not_active IP Right Cessation
- 1978-09-26 EP EP78100994A patent/EP0001295B1/de not_active Expired
- 1978-09-26 IL IL55643A patent/IL55643A/xx unknown
- 1978-09-26 DE DE7878100994T patent/DE2861672D1/de not_active Expired
- 1978-09-26 CA CA312,129A patent/CA1111841A/en not_active Expired
- 1978-09-26 ES ES473677A patent/ES473677A1/es not_active Expired
- 1978-09-27 HU HU78CI1860A patent/HU184612B/hu unknown
- 1978-09-27 NZ NZ188517A patent/NZ188517A/xx unknown
- 1978-09-27 DK DK428478A patent/DK151034C/da not_active IP Right Cessation
- 1978-09-27 AU AU40229/78A patent/AU523050B2/en not_active Expired
- 1978-09-27 NO NO783268A patent/NO148957C/no unknown
- 1978-09-27 AT AT0698278A patent/AT370090B/de not_active IP Right Cessation
- 1978-09-27 IE IE1931/78A patent/IE47380B1/en unknown
- 1978-09-27 ZA ZA00785488A patent/ZA785488B/xx unknown
- 1978-09-28 JP JP11983978A patent/JPS5459293A/ja active Granted

Also Published As

Publication number	Publication date
NO783268L (no)	1979-03-29
DK151034B (da)	1987-10-12
JPS6218560B2 (da)	1987-04-23
AU4022978A (en)	1980-04-03
ZA785488B (en)	1979-09-26
ATA698278A (de)	1982-07-15
NO148957B (no)	1983-10-10
AU523050B2 (en)	1982-07-08
DK151034C (da)	1988-02-22
EP0001295A2 (de)	1979-04-04
DD140142A5 (de)	1980-02-13
US4238481A (en)	1980-12-09
CA1111841A (en)	1981-11-03
HU184612B (en)	1984-09-28
FI782907A7 (fi)	1979-03-29
AT370090B (de)	1983-02-25
NO148957C (no)	1984-01-18
NZ188517A (en)	1981-04-24
EP0001295B1 (de)	1982-03-17
EP0001295A3 (en)	1979-06-13
IE47380B1 (en)	1984-03-07
IL55643A (en)	1981-12-31
ES473677A1 (es)	1980-05-16
FI68246B (fi)	1985-04-30
FI68246C (fi)	1985-08-12
DE2861672D1 (en)	1982-04-15
IL55643A0 (en)	1978-12-17
LU78191A1 (de)	1979-05-25
JPS5459293A (en)	1979-05-12
IE781931L (en)	1979-03-28

Legal Events

Date	Code	Title	Description
1991-05-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK149594C (da)	1987-03-16	Analogifremgangsmaade til fremstilling af dipeptidderivater eller syreadditionssalte heraf
DK347077A (da)	1978-02-05	Fremgangsmade til fremstilling af d (-)-3-hydroxysmorsyre
DK145260C (da)	1983-03-14	Analogifremgangsmaade til fremstilling af 4-acylamino-phenyl-ethanolaminer eller syreadditionssalte heraf
DK360278A (da)	1979-02-17	Fremgangsmaade til fremstilling af cycloalkylidenmethylhylphenyleddikesyrederivater
DK472678A (da)	1979-06-28	Fremgangsmaade til fremstilling af substituerede mercaptosyreamider
DK251677A (da)	1977-12-10	N-phosphonomethylen-monoaminoalkanmono- og-polyphosphonsyrer og n-phosphomethylendiaminoalkan-polyphosphonsyrer samt fremgangsmade til fremstilling deraf
DK496977A (da)	1978-05-10	Fremgangsmaade til fremstilling af 0-alkylerede hydroxylaminer og syreadditionssalte deraf
DK353577A (da)	1978-08-12	7-acylamido-3-cephem-4-carboxylsyrederivater samt fremgangsmaade til fremstilling deraf
FI782853A7 (fi)	1979-03-20	Kiselsyrabaserade antiskumprodukter med foerbaettrad stabilitet
DK136478A (da)	1978-09-30	N-sulfoalkan-aminoalkanphosphonsyrer alkalimetalsalte deraf samt en fremgangsmaade til fremstilling af disse forbindelser
DK158670C (da)	1991-01-07	Fremgangsmaade til fremstilling af 6beta-halogensubstituerede penicillansyrederivater
DK149231C (da)	1986-08-18	Analogifremgangsmaade til fremstilling af enkephalin-analoge tetrapeptidamider eller syreadditionssalte deraf
DK359577A (da)	1978-02-15	Fremgangsmade til fremstilling af 2-phenylaminoimidazolin-(2) og syreadditionssalte
DK537677A (da)	1978-06-04	Propionsyrederivater samt fremgangsmaade til deres fremstilling
DK540578A (da)	1979-07-01	Fremgangsmaade til fremstilling af aliphatiske diperoxydicarboxylsyrer
DK567778A (da)	1979-07-31	Fremgangsmaade til fremstilling af kvaternaere ammoniumsalte af phenylpropylaminer og phenylbutylaminer
DK142578C (da)	1981-07-20	Analogifremgangsmaade til fremstilling af 2,4-diamino-5-benzylpyrimidiner og syreadditionssalte deraf
DK333179A (da)	1980-02-11	Fremgangsmaade til fremstilling af substituerede anthranilsyreamider og salte deraf
DK319178A (da)	1979-01-19	Fremgangsmaade til fremstilling af acylamido-2-cephem-4-carboxylsyreforbindelser og salte
DK240678A (da)	1978-12-02	Fremgangsmaade til fremstilling af di og trifluormethylaminosyrer
DK451578A (da)	1979-04-12	Fremgangsmaade til fremstilling af somatostatinanaloge
DK143273C (da)	1981-11-30	Analogifremgangsmaade til fremstilling af amidinobenzyloyrimidiner og syreadditionssalte heraf
DK333279A (da)	1980-02-11	Fremgangsmaade til fremstilling af thiosubstitituerede diazacycloalkener og salte deraf
DK62878A (da)	1978-08-12	Fremgangsmaade til fremstilling af benzoheterocyclylglyoxylsyrederivater samt salte deraf
DK320578A (da)	1979-01-20	Mellemprodukt til fremstilling af hidtil ukendte oximderivater af 7-aminothiazolylacctamidocephalosporansyre samt fremgangsmaade til fremstilling af mellemprodukter