DK464787D0 - Cis-platinkomplekser, deres fremstilling og anvendelse samt forprodukter og mellemprodukter ved fremstillingen heraf - Google Patents

Cis-platinkomplekser, deres fremstilling og anvendelse samt forprodukter og mellemprodukter ved fremstillingen heraf

Info

Publication number: DK464787D0
Authority: DK; Denmark
Prior art keywords: group; hydrogen atom; formula; fashion; bonded
Prior art date: 1986-09-08

Application number

DK464787A

Other languages

English (en)

Other versions

DK464787A (da

DK168387B1 (da

Inventor

Cenek Kolar

Konard Dehmel

Hans Peter Kraemer

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-08

Filing date

1987-09-07

Publication date

1987-09-07

1987-09-07 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1987-09-07 Publication of DK464787D0 publication Critical patent/DK464787D0/da

1988-03-09 Publication of DK464787A publication Critical patent/DK464787A/da

1994-03-21 Application granted granted Critical

1994-03-21 Publication of DK168387B1 publication Critical patent/DK168387B1/da

Links

238000004519 manufacturing process Methods 0.000 title 2
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical class N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
QZTKDVCDBIDYMD-UHFFFAOYSA-N 2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid Chemical compound NC(=O)CN(CC(O)=O)CC(O)=O QZTKDVCDBIDYMD-UHFFFAOYSA-N 0.000 abstract 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
229910002651 NO3 Inorganic materials 0.000 abstract 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
229930182473 O-glycoside Natural products 0.000 abstract 1
150000008444 O-glycosides Chemical class 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
SUSAGCZZQKACKE-UHFFFAOYSA-N cyclobutane-1,2-dicarboxylic acid Chemical compound OC(=O)C1CCC1C(O)=O SUSAGCZZQKACKE-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
-1 oxalic Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK464787A 1986-09-08 1987-09-07 Cis-Platinkomplekser, deres fremstilling og mellemprodukter til fremstilling heraf DK168387B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3630497		1986-09-08
DE19863630497 DE3630497A1 (de)	1986-09-08	1986-09-08	Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel

Publications (3)

Publication Number	Publication Date
DK464787D0 true DK464787D0 (da)	1987-09-07
DK464787A DK464787A (da)	1988-03-09
DK168387B1 DK168387B1 (da)	1994-03-21

Family

ID=6309120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK464787A DK168387B1 (da)	1986-09-08	1987-09-07	Cis-Platinkomplekser, deres fremstilling og mellemprodukter til fremstilling heraf

Country Status (15)

Country	Link
US (1)	US5091521A (da)
EP (1)	EP0263956B1 (da)
JP (1)	JPS6368546A (da)
AT (1)	ATE68500T1 (da)
AU (1)	AU611394B2 (da)
CA (1)	CA1313655C (da)
DE (2)	DE3630497A1 (da)
DK (1)	DK168387B1 (da)
ES (1)	ES2039220T3 (da)
FI (1)	FI86304C (da)
GR (1)	GR3003522T3 (da)
MX (1)	MX8132A (da)
NO (1)	NO174055C (da)
PT (1)	PT85655B (da)
ZA (1)	ZA876619B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU593608B2 (en) *	1986-10-07	1990-02-15	Board Of Regents, The University Of Texas System	Hydrophobic CIS-platinum complexes efficiently incorporated into liposomes
DE3887194T2 (de) *	1987-05-08	1994-07-28	Sankyo Co	Antitumor-Platinkomplexe, deren Herstellung und deren therapeutische Verwendung.
US4956459A (en) *	1987-07-17	1990-09-11	Georgetown University	Platinum compounds suitable for use as pharmaceuticals
IT1216687B (it) *	1988-04-01	1990-03-08	Boehringer Biochemia Srl	Complessi di platino (ii), loro preparazione e impiego come antitumorali.
DE3834098A1 (de) *	1988-10-07	1990-04-19	Behringwerke Ag	Cis-platin-komplexe mit einem 1,3-diaminopropan-derivat als liganden, verfahren zu ihrer herstellung und diese verbindung enthaltende pharmazeutische mittel
US5871710A (en) *	1992-09-04	1999-02-16	The General Hospital Corporation	Graft co-polymer adducts of platinum (II) compounds
IT1273391B (it) *	1994-03-31	1997-07-08	Boehringer Mannheim Italia	Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono
AU2701395A (en) *	1994-06-27	1996-01-19	General Hospital Corporation, The	Graft co-polymer adducts of platinum (ii) compounds
US5760480A (en) *	1995-09-20	1998-06-02	Advanced Micro Devics, Inc.	Low RC interconnection
US6235782B1 (en)	1998-11-12	2001-05-22	Rifat Pamukcu	Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en)	1998-11-12	2001-05-22	Cell Pathways, Inc.	Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
RU2178702C1 (ru) *	2001-02-21	2002-01-27	Общество с ограниченной ответственностью "Нобель"	Антираковое средство
US7208611B2 (en) *	2005-02-23	2007-04-24	Xenoport, Inc.	Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use
AU2008331439B9 (en) *	2007-12-07	2014-04-10	Prana Biotechnology Ltd	Compounds for therapy and diagnosis
JP5844642B2 (ja)	2009-02-04	2016-01-20	ザブリガムアンドウィメンズホスピタルインコーポレイテッドＴｈｅＢｒｉｇｈａｍａｎｄＷｏｍｅｎ’ｓＨｏｓｐｉｔａｌ，Ｉｎｃ．	ナノスケール白金化合物およびその使用方法
ES2704303T3 (es)	2010-08-24	2019-03-15	Dana Farber Cancer Inst Inc	Procedimientos para la predicción de una respuesta contra el cáncer
EP4563709A3 (en)	2011-06-17	2025-09-03	Myriad Genetics, Inc.	Methods and materials for assessing allelic imbalance
CN107267598B (zh)	2011-12-21	2022-03-25	美瑞德生物工程公司	用于评估杂合性丢失的方法与材料
WO2013130347A1 (en)	2012-02-23	2013-09-06	The Children's Hospital Corporation	Methods for predicting anti-cancer response
ES2658867T3 (es)	2012-06-07	2018-03-12	Institut Curie	Métodos para detectar la inactivación de la ruta de recombinación homóloga (BRCA1/2) en tumores humanos
WO2014160080A1 (en)	2013-03-14	2014-10-02	Children's Medical Center Corporation	Cancer diagnosis, treatment selection and treatment
EP3080292B1 (en)	2013-12-09	2022-02-02	Institut Curie	Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
EP4234711B1 (en)	2014-08-15	2025-05-28	Myriad Genetics, Inc.	Methods and materials for assessing homologous recombination deficiency
CN108602759B (zh) *	2016-01-29	2023-10-27	阿克苏诺贝尔化学品国际有限公司	制备烷醇胺烷基酰胺和多元醇的组合物的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7807334A (nl) *	1978-07-06	1980-01-08	Tno	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
NL8204067A (nl) *	1982-10-21	1984-05-16	Tno	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
US4500465A (en) *	1982-06-28	1985-02-19	Engelhard Corporation	Solubilized platinum (II) complexes
DE3503620A1 (de) *	1984-06-30	1986-01-23	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von 1-azidoaldosen
DE3432320A1 (de) *	1984-09-03	1986-03-13	Behringwerke Ag, 3550 Marburg	Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
JPS6259294A (ja) *	1985-09-09	1987-03-14	Ajinomoto Co Inc	白金錯体および抗腫瘍剤
US4760157A (en) *	1986-01-31	1988-07-26	American Cyanamid Company	(2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes

1986
- 1986-09-08 DE DE19863630497 patent/DE3630497A1/de not_active Withdrawn
1987
- 1987-09-02 EP EP87112768A patent/EP0263956B1/de not_active Expired - Lifetime
- 1987-09-02 DE DE8787112768T patent/DE3773829D1/de not_active Expired - Lifetime
- 1987-09-02 AT AT87112768T patent/ATE68500T1/de not_active IP Right Cessation
- 1987-09-02 ES ES198787112768T patent/ES2039220T3/es not_active Expired - Lifetime
- 1987-09-04 CA CA000546144A patent/CA1313655C/en not_active Expired - Fee Related
- 1987-09-04 ZA ZA876619A patent/ZA876619B/xx unknown
- 1987-09-04 FI FI873841A patent/FI86304C/fi not_active IP Right Cessation
- 1987-09-07 JP JP62222163A patent/JPS6368546A/ja active Pending
- 1987-09-07 PT PT85655A patent/PT85655B/pt not_active IP Right Cessation
- 1987-09-07 AU AU78103/87A patent/AU611394B2/en not_active Ceased
- 1987-09-07 DK DK464787A patent/DK168387B1/da active
- 1987-09-07 MX MX813287A patent/MX8132A/es unknown
- 1987-09-07 NO NO873721A patent/NO174055C/no unknown
1990
- 1990-08-28 US US07/576,185 patent/US5091521A/en not_active Expired - Fee Related
1992
- 1992-01-08 GR GR910401654T patent/GR3003522T3/el unknown

Also Published As

Publication number	Publication date
US5091521A (en)	1992-02-25
PT85655B (pt)	1990-05-31
FI873841A0 (fi)	1987-09-04
AU611394B2 (en)	1991-06-13
NO873721D0 (no)	1987-09-07
EP0263956A2 (de)	1988-04-20
DE3630497A1 (de)	1988-03-10
FI86304C (fi)	1992-08-10
ATE68500T1 (de)	1991-11-15
ES2039220T3 (es)	1993-09-16
JPS6368546A (ja)	1988-03-28
DE3773829D1 (de)	1991-11-21
DK464787A (da)	1988-03-09
FI873841A7 (fi)	1988-03-09
EP0263956B1 (de)	1991-10-16
ZA876619B (en)	1988-04-27
AU7810387A (en)	1988-03-10
CA1313655C (en)	1993-02-16
PT85655A (de)	1987-10-01
GR3003522T3 (da)	1993-03-16
DK168387B1 (da)	1994-03-21
MX8132A (es)	1994-02-28
EP0263956A3 (en)	1988-10-05
NO873721L (no)	1988-03-09
FI86304B (fi)	1992-04-30
NO174055C (no)	1994-03-09
NO174055B (no)	1993-11-29

Publication	Publication Date	Title
DK464787A (da)	1988-03-09	Cis-platinkomplekser, deres fremstilling og anvendelse samt forprodukter og mellemprodukter ved fremstillingen heraf
PT72305A (de)	1981-02-01	Neue sulfonamide verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
IS2657A7 (is)	1982-01-10	Ný samsetning efnis
FI843765L (fi)	1985-03-27	Kramp motverkande sulfamatderivat.
ES546648A0 (es)	1986-03-01	Procedimiento para preparar complejos de cis-platino
DK570689A (da)	1990-05-15	Imidazolderivater
GB1419080A (en)	1975-12-24	Chemical compounds having juvenile hormone activity
ATE108440T1 (de)	1994-07-15	Arylaralkylether, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
GB1363267A (en)	1974-08-14	Phenoxyalkylamines process for their preparation and applications
JPS5543077A (en)	1980-03-26	Preparation of 1,3-dithiolan-2-ylidenemalonate derivative
ES8705362A1 (es)	1987-05-01	Un procedimiento para la preparacion de nuevas aminas terciarias
EP0281412A3 (en)	1988-12-21	Novel organic platinum complex pharmaceutical compositions containing same and a process for the preparation thereof
SE8205867L (sv)	1983-04-23	Nya 4-fenyl-4-oxo-2-butensyraderivat, deras salter, framstellning derav, anvendning derav som lekemedel och kompositioner innehallande dem
MY110450A (en)	1998-05-30	Imidazolylmethyl-pyridines, their production their use as pharmaceuticals and pharmaceutical compositions containing them
JPS5772970A (en)	1982-05-07	Azolylalkyl derivatives, manufacture and use as fungicide
HUT49283A (en)	1989-09-28	Process for production of medical compositions applicable for treatment of peptical ulcer
ZA859706B (en)	1986-10-29	Organic compounds and their pharmaceutical use
IT8621999A1 (it)	1988-04-14	Derivati pirido-benzotiazinici ad attività antibatterica ed a lunga durata di azione
GB2022413B (en)	1983-02-16	Compositions containing cyclopentyl compounds
ES420718A1 (es)	1976-11-16	Procedimiento para la obtencion de dibenzazecinas.
ES488388A1 (es)	1980-10-01	Procedimiento de preparacion de derivados hidroxilados del tiazol
JPS56120669A (en)	1981-09-22	Allophanoylpiperazine compound and analgesic agent containing the same as active constituent
KR890005027A (ko)	1989-05-11	페녹시알킬카복실산 유도체 및 그의 제조방법
ES420717A1 (es)	1977-03-01	Procedimiento para la obtencion de dibenzazecinas.
GB1017450A (en)	1966-01-19	2-amino-4-alkoxy-úË-triazines