DK49492A - Trifluormethansulfonater og fremgangsmaade til fremstilling deraf - Google Patents

Trifluormethansulfonater og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK49492A
Authority: DK; Denmark
Prior art keywords: alkyl; aryl; substituted; ring atoms; compounds
Prior art date: 1983-02-02

Application number

DK049492A

Other languages

English (en)

Other versions

DK49492D0 (da

DK173770B1 (da

Inventor

Hansjoerg Urbach

Rainer Henning

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-02-02

Filing date

1992-04-13

Publication date

1992-04-13

1992-04-13 Application filed by Hoechst Ag filed Critical Hoechst Ag

1992-04-13 Publication of DK49492D0 publication Critical patent/DK49492D0/da

1992-04-13 Publication of DK49492A publication Critical patent/DK49492A/da

2001-09-24 Application granted granted Critical

2001-09-24 Publication of DK173770B1 publication Critical patent/DK173770B1/da

Links

238000000034 method Methods 0.000 title 1
125000006413 ring segment Chemical group 0.000 abstract 3
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 2
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
230000036772 blood pressure Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical class OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK199200494A 1983-02-02 1992-04-13 Trifluormethansulfonater og fremgangsmåde til fremstilling deraf DK173770B1 (da)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE19833303344 DE3303344A1 (de)	1983-02-02	1983-02-02	Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3303344		1983-02-02
DK45584		1984-02-01
DK045584A DK166619C (da)	1983-02-02	1984-02-01	Fremgangsmaade til fremstilling af n-alkylerede aminosyrer og estere deraf
DK49492		1992-04-13

Publications (3)

Publication Number	Publication Date
DK49492D0 DK49492D0 (da)	1992-04-13
DK49492A true DK49492A (da)	1992-04-13
DK173770B1 DK173770B1 (da)	2001-09-24

Family

ID=6189750

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK045584A DK166619C (da)	1983-02-02	1984-02-01	Fremgangsmaade til fremstilling af n-alkylerede aminosyrer og estere deraf
DK199200494A DK173770B1 (da)	1983-02-02	1992-04-13	Trifluormethansulfonater og fremgangsmåde til fremstilling deraf

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK045584A DK166619C (da)	1983-02-02	1984-02-01	Fremgangsmaade til fremstilling af n-alkylerede aminosyrer og estere deraf

Country Status (14)

Country	Link
EP (1)	EP0117448B1 (da)
JP (2)	JPS59172442A (da)
KR (1)	KR910008135B1 (da)
AT (1)	ATE21890T1 (da)
AU (2)	AU566053B2 (da)
CA (2)	CA1292236C (da)
DE (2)	DE3303344A1 (da)
DK (2)	DK166619C (da)
ES (1)	ES529302A0 (da)
GR (1)	GR79751B (da)
IE (1)	IE56751B1 (da)
IL (1)	IL70847A (da)
PT (1)	PT78047B (da)
ZA (1)	ZA84740B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3648935A (en) *	1970-02-04	1972-03-14	Amchem Prod	Spray apparatus with movable head
DE3303344A1 (de) *	1983-02-02	1984-08-02	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
US4801721A (en) *	1984-08-16	1989-01-31	Ryan James W	Stereospecific synthesis of carboxyalkyl peptides
DE3431591A1 (de) *	1984-08-28	1986-03-13	Diamalt AG, 8000 München	Verfahren zur herstellung von aminoverbindungen aus hydroxylverbindungen
JPS63170344A (ja) *	1987-01-09	1988-07-14	Daicel Chem Ind Ltd	アミノ酸エステルのｎ−アルキル化法
JP2535001B2 (ja) *	1987-01-13	1996-09-18	ダイセル化学工業株式会社	Ｎ−アルキル化アミノ酸エステルの製法
FR2620699B1 (fr) *	1987-09-17	1990-06-01	Adir	Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
US5055588A (en) *	1988-07-06	1991-10-08	Daicel Chemical Industries Ltd.	Process for preparing N-substituted amino acid esters
SE0000382D0 (sv)	2000-02-07	2000-02-07	Astrazeneca Ab	New process
CN1585744A (zh)	2001-03-27	2005-02-23	兰贝克赛实验室有限公司	贝那普利的制备方法
CN101511782B (zh) *	2006-09-12	2013-08-07	和光纯药工业株式会社	磺酸酯的制造方法
DK2935222T3 (da)	2012-12-21	2019-01-07	Epizyme Inc	Prmt5-inhibitorer og anvendelser deraf

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3419595A (en) *	1965-03-05	1968-12-31	Minnesota Mining & Mfg	Fluorocarbon fluoroalkanesulfonates
NL144484B (nl) *	1967-07-26	1975-01-15	Merck & Co Inc	Werkwijze ter bereiding van een geneesmiddel met anti-anflammatoire werking, alsmede werkwijze ter bereiding van de anti-inflammatoir werkzame aralkylmercaptoaminozuren.
GB1572185A (en) *	1975-10-25	1980-07-23	Beecham Group Ltd	Intermediates for the preparation of 12-azaprostaglandins
DE3044236A1 (de)	1980-11-25	1982-06-16	Hoechst Ag, 6000 Frankfurt	Aminosaeurederivate und verfahren zu ihrer herstellung
DE2937779A1 (de)	1979-09-19	1981-04-09	Hoechst Ag, 6000 Frankfurt	Aminosaeurederivate und verfahren zu ihrer herstellung
FR2503155A2 (fr)	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2487829A2 (fr)	1979-12-07	1982-02-05	Science Union & Cie	Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en)	1980-04-02	1988-01-20	Warner Lambert Co	Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en)	1980-10-06	1982-09-21	Warner-Lambert Company	Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
DE3177130D1 (de)	1980-08-30	1990-01-11	Hoechst Ag	Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
US4344949A (en)	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
FR2492381A1 (fr)	1980-10-21	1982-04-23	Science Union & Cie	Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
LU88621I2 (fr)	1980-10-23	1995-09-01	Schering Corp	Sandopril
US4374847A (en)	1980-10-27	1983-02-22	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
DE3226768A1 (de)	1981-11-05	1983-05-26	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3151690A1 (de)	1981-12-29	1983-07-07	Hoechst Ag, 6230 Frankfurt	"neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung"
DE3210496A1 (de)	1982-03-23	1983-10-06	Hoechst Ag	Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211397A1 (de)	1982-03-27	1983-11-10	Hoechst Ag, 6230 Frankfurt	Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3211676A1 (de)	1982-03-30	1983-10-06	Hoechst Ag	Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
DE3227055A1 (de)	1982-07-20	1984-01-26	Hoechst Ag, 6230 Frankfurt	Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
DE3242151A1 (de)	1982-11-13	1984-05-17	Hoechst Ag, 6230 Frankfurt	Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3246503A1 (de)	1982-12-16	1984-06-20	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3246757A1 (de)	1982-12-17	1984-06-20	Hoechst Ag, 6230 Frankfurt	Neue 2-azabicyclo(2.2.1)heptan-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(2.2.1)heptan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3303344A1 (de) *	1983-02-02	1984-08-02	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern

1983
- 1983-02-02 DE DE19833303344 patent/DE3303344A1/de not_active Withdrawn
1984
- 1984-01-31 EP EP84100935A patent/EP0117448B1/de not_active Expired
- 1984-01-31 DE DE8484100935T patent/DE3460578D1/de not_active Expired
- 1984-01-31 ES ES529302A patent/ES529302A0/es active Granted
- 1984-01-31 KR KR1019840000443A patent/KR910008135B1/ko not_active Expired
- 1984-01-31 AT AT84100935T patent/ATE21890T1/de not_active IP Right Cessation
- 1984-02-01 IE IE244/84A patent/IE56751B1/en not_active IP Right Cessation
- 1984-02-01 ZA ZA84740A patent/ZA84740B/xx unknown
- 1984-02-01 DK DK045584A patent/DK166619C/da not_active IP Right Cessation
- 1984-02-01 JP JP59015297A patent/JPS59172442A/ja active Granted
- 1984-02-01 CA CA 446562 patent/CA1292236C/en not_active Expired - Lifetime
- 1984-02-01 AU AU23998/84A patent/AU566053B2/en not_active Expired
- 1984-02-01 GR GR73674A patent/GR79751B/el unknown
- 1984-02-01 IL IL70847A patent/IL70847A/xx not_active IP Right Cessation
- 1984-02-01 PT PT78047A patent/PT78047B/pt unknown
1987
- 1987-09-11 AU AU78304/87A patent/AU588483B2/en not_active Expired
1988
- 1988-09-12 CA CA000577190A patent/CA1267903A/en not_active Expired - Lifetime
1992
- 1992-04-13 DK DK199200494A patent/DK173770B1/da not_active IP Right Cessation
- 1992-10-28 JP JP4289760A patent/JPH06102646B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR850000384A (ko)	1985-02-27
EP0117448B1 (de)	1986-09-03
IL70847A (en)	1991-04-15
GR79751B (da)	1984-10-31
ES8500215A1 (es)	1984-10-01
DK49492D0 (da)	1992-04-13
JPH06102646B2 (ja)	1994-12-14
KR910008135B1 (ko)	1991-10-10
DE3303344A1 (de)	1984-08-02
AU7830487A (en)	1987-12-17
DK45584A (da)	1984-08-03
ZA84740B (en)	1984-09-26
ATE21890T1 (de)	1986-09-15
DK166619C (da)	1993-11-08
IL70847A0 (en)	1984-05-31
PT78047B (de)	1986-07-15
IE56751B1 (en)	1991-12-04
DK173770B1 (da)	2001-09-24
CA1267903A (en)	1990-04-17
AU2399884A (en)	1984-08-09
IE840244L (en)	1984-08-02
JPH05320119A (ja)	1993-12-03
EP0117448A1 (de)	1984-09-05
ES529302A0 (es)	1984-10-01
JPS59172442A (ja)	1984-09-29
DK45584D0 (da)	1984-02-01
AU566053B2 (en)	1987-10-08
CA1292236C (en)	1991-11-19
JPH0587499B2 (da)	1993-12-16
AU588483B2 (en)	1989-09-14
PT78047A (de)	1984-03-01
DK166619B (da)	1993-06-21
DE3460578D1 (en)	1986-10-09

Legal Events

Date	Code	Title	Description
2001-09-24	B1	Patent granted (law 1993)
2004-02-16	PUP	Patent expired

Publication	Publication Date	Title
DK49492A (da)	1992-04-13	Trifluormethansulfonater og fremgangsmaade til fremstilling deraf
DK0599444T3 (da)	1998-09-21	Dobbeltvirkende inhibitorer
ES2060951T5 (es)	2001-10-16	Azaindenos.
IS3651A7 (is)	1991-06-12	Amínósýruafleiður og aðferð til framleiðslu þeirra
IE45086L (en)	1977-08-13	Amino acids.
DK330284A (da)	1985-01-07	2-azabicyclo(3.1.0)hexan-3-carboxylsyrederivater, fremgangsmaader til deres fremstilling, midler indeholdende disse og deres anvendelse, samt 2-azabicyclo(3.1.0)hexan-derivater, som mellemprodukter og deres fremstilling
DK81583D0 (da)	1983-02-23	Derivater af 3-hydroxysmoersyre og fremgangsmade til fremstilling deraf
TR199801419T2 (xx)	1998-10-21	S�lfone amino asit t�revleri ve ayn� i�erikte metaloproteinez �nleyicileri.
ATE199545T1 (de)	2001-03-15	Inhibitoren retroviraler proteasen
AU2443184A (en)	1984-08-16	Benzazocinones and benzazoninones
ES8801312A1 (es)	1987-12-16	Un procedimiento para preparar derivados de alanil-prolina.
CO4970744A1 (es)	2000-11-07	Caspasas y apoptosis
SE9802793D0 (sv)	1998-08-21	New compounds
ES552571A0 (es)	1987-12-01	Un procedimiento para la obtencion de derivados de b-lactama
DK603688A (da)	1989-05-01	Middel til behandling af blodhoejtryk og hjerteinsufficiens
Lukasiewicz et al.	1968	In Vitro Studies on the Mechanism of the Antifibrino-lytic Action of E-Aminocaproic Acid (EACA)
ES2010524A6 (es)	1989-11-16	Procedimiento de obtencion de una composicion farmaceutica a base de antagonistas de calcio de utilidad en el tratamiento de hipertension y fallo cardiaco congestivo.
ES550925A0 (es)	1987-09-01	Procedimiento para la obtencion de azolil-aroximetil-dimetilpentinoles
KR890003732A (ko)	1989-04-17	신규약제 화합물
ES8106493A1 (es)	1981-08-01	Nuevo procedimiento para la obtencion de n(25-3-mercapto-2- metil-propanoil)-l-prolina.
ATE25244T1 (de)	1987-02-15	Neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung.