DK496681A - Fremgangsmaade til fremstilling af i 5-stilling substituerede 2,4-diminopyri idiner - Google Patents

Fremgangsmaade til fremstilling af i 5-stilling substituerede 2,4-diminopyri idiner

Info

Publication number: DK496681A
Authority: DK; Denmark
Prior art keywords: diminopyri; idines; preparing substituted; substituted; preparing
Prior art date: 1980-11-11

Application number

DK496681A

Other languages

English (en)

Other versions

DK172884B1 (da

Inventor

S M Daluge

P M Skonezny

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-11-11

Filing date

1981-11-10

Publication date

1982-05-12

1981-11-10 Application filed by Wellcome Found filed Critical Wellcome Found

1982-05-12 Publication of DK496681A publication Critical patent/DK496681A/da

1999-09-06 Application granted granted Critical

1999-09-06 Publication of DK172884B1 publication Critical patent/DK172884B1/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK198104966A 1980-11-11 1981-11-10 Analogifremgangsmåde til fremstilling af i 5-stilling substituerede 2,4-diaminopyrimidiner og mellemprodukter til anvendels DK172884B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8036135		1980-11-11
GB8036135		1980-11-11

Publications (2)

Publication Number	Publication Date
DK496681A true DK496681A (da)	1982-05-12
DK172884B1 DK172884B1 (da)	1999-09-06

Family

ID=10517217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198104966A DK172884B1 (da)	1980-11-11	1981-11-10	Analogifremgangsmåde til fremstilling af i 5-stilling substituerede 2,4-diaminopyrimidiner og mellemprodukter til anvendels

Country Status (35)

Country	Link
US (4)	US4438267A (da)
EP (1)	EP0051879B1 (da)
JP (1)	JPS57114581A (da)
KR (1)	KR880001736B1 (da)
AR (1)	AR245447A1 (da)
AU (1)	AU549449B2 (da)
CA (1)	CA1186310A (da)
CS (1)	CS273153B2 (da)
CY (1)	CY1419A (da)
DD (1)	DD201896A5 (da)
DE (1)	DE3173752D1 (da)
DK (1)	DK172884B1 (da)
EG (1)	EG16107A (da)
ES (5)	ES8307759A1 (da)
FI (1)	FI76333C (da)
GB (1)	GB2087881B (da)
GR (1)	GR81317B (da)
HK (1)	HK23388A (da)
HU (1)	HU188762B (da)
IE (1)	IE52128B1 (da)
IL (1)	IL64256A (da)
IT (1)	IT1210589B (da)
MC (1)	MC1418A1 (da)
MY (1)	MY8600678A (da)
NO (2)	NO160137C (da)
NZ (1)	NZ198932A (da)
PH (2)	PH25053A (da)
PL (4)	PL139523B1 (da)
PT (1)	PT73960B (da)
RU (1)	RU1819264C (da)
SG (1)	SG62686G (da)
SU (4)	SU1424732A3 (da)
YU (5)	YU42444B (da)
ZA (1)	ZA817780B (da)
ZM (1)	ZM9481A1 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4438267A (en) *	1980-11-11	1984-03-20	Daluge Susan M	Monoheteroring compounds and their use
US4590271A (en) *	1982-05-01	1986-05-20	Burroughs Wellcome Co.	2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
DK190983A (da) *	1982-05-01	1983-11-02	Wellcome Found	2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
ZA833067B (en) *	1982-05-01	1984-12-24	Wellcome Found	Antibacterial compounds
US4587341A (en) *	1982-05-07	1986-05-06	Burroughs Wellcome Co.	2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
CA1244028A (en) *	1983-04-14	1988-11-01	Hans Maag	Pyrimidine derivatives
GB8603962D0 (en) *	1986-02-18	1986-03-26	Wellcome Found	Chemical compositions
GB8603964D0 (en) *	1986-02-18	1986-03-26	Cooper Animal Health Ltd	Compositions
LU86703A1 (fr) *	1986-12-08	1988-07-14	Oreal	Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
GB8903978D0 (en) *	1989-02-22	1989-04-05	Coopers Animal Health	Chemical compositions
GB9000241D0 (en) *	1990-01-05	1990-03-07	Coopers Animal Health	Pharmaceutical use
RU95113597A (ru) *	1992-12-02	1997-06-10	ФМК Корпорейшн (US)	Инсектицидная композиция, способы борьбы с насекомыми
KR100224135B1 (ko) *	1993-01-28	1999-10-15	다께다 구니오	퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
US5707996A (en) *	1995-11-06	1998-01-13	Macleod Pharmaceuticals, Inc.	Pharmaceutical solution and methods for preparation thereof
CA2238521C (en) *	1995-12-04	2005-08-16	F. Hoffmann-La Roche Ag	Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
RU2141322C1 (ru) *	1997-08-12	1999-11-20	Голощапов Николай Михайлович	Иммуномодулятор с антимикобактериальной активностью "изофон", способ его получения и применения
GB0016877D0 (en) *	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
WO2002010156A1 (en) *	2000-07-29	2002-02-07	Arpida Ag	Benzofuran derivatives and their use as antibacterial agents
WO2003003006A2 (en) *	2001-06-29	2003-01-09	Ab Science	New potent, selective and non toxic c-kit inhibitors
PT1401416E (pt)	2001-06-29	2007-02-28	Ab Science	Utilização de inibidores de c-kit para tratar doenças inflamatórias intestinais (dii)
ATE330608T1 (de) *	2001-06-29	2006-07-15	Ab Science	Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
ES2274993T3 (es) *	2001-06-29	2007-06-01	Ab Science	Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas.
DE60225590T2 (de) *	2001-09-20	2008-09-25	Ab Science	C-kithemmer zur behandlung von bakteriellen infektionen
CA2460845A1 (en) *	2001-09-20	2003-03-27	Ab Science	Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
EP1461032B1 (en) *	2001-09-20	2008-07-16	AB Science	Use of c-kit inhibitors for promoting hair growth
CN100443482C (zh)	2003-07-11	2008-12-17	阿皮德公开股份有限公司	苯并呋喃衍生物及其在制备治疗由细菌引起的感染的药物中的用途
CN101115746A (zh) *	2005-02-18	2008-01-30	阿皮德公开股份有限公司	用于制备苯并呋喃的新方法
AU2006286576B2 (en) *	2005-09-01	2012-06-14	F. Hoffmann-La Roche Ag	Diaminopyrimidines as P2X3 and P3X2/3 modulators
WO2010003084A2 (en) *	2008-07-02	2010-01-07	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors
EP2440533B1 (en) *	2009-06-12	2015-09-23	Socpra-Sciences Et Génie S.E.C.	Guanine riboswitch binding compounds and their use as antibiotics
CN102649786B (zh) *	2011-02-28	2014-08-27	郑州福源动物药业有限公司	一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
CN103755684B (zh) *	2014-02-10	2015-09-09	青岛蔚蓝生物股份有限公司	一种巴喹普林的制备方法
US12595261B2 (en)	2019-06-06	2026-04-07	Beijing Tide Pharmaceutical Co., Ltd.	P2X3 and/or P2X2/3 receptor antagonist, pharmaceutical composition containing same, and use thereof
CN110818694B (zh) *	2019-11-18	2023-04-21	上海医药工业研究院有限公司	艾拉普林中间体及其应用
WO2022217295A1 (en) *	2021-04-09	2022-10-13	The Trustees Of The University Of Pennsylvania	Control of protein expression with tmp-protac compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3049544A (en) *		1962-08-14		Method for the preparation of
DE1303727B (de)	1959-09-03	1976-02-05	Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London	Alpha-Arylidensubstituierte Propioni-Irile
US3956327A (en) *	1969-03-06	1976-05-11	Burroughs Wellcome Co.	Method of preparing 2,4-diamino-5-benzyl pyrimidines
BE792096A (fr) *	1971-12-01	1973-05-30	Hoffmann La Roche	Nouvelles benzylpyrimidines
GB1468374A (en)	1974-03-06	1977-03-23	Wellcome Found	Process for preparing a pyrimidine derivative
US4039543A (en)	1974-12-24	1977-08-02	Hoffmann-La Roche Inc.	Benzylpyrimidines
GB1582245A (en) *	1976-06-09	1981-01-07	Wellcome Found	Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
DE2730467A1 (de) *	1977-07-06	1979-01-18	Basf Ag	Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4258045A (en) *	1979-11-30	1981-03-24	Merck & Co., Inc.	Inhibitor of dihydrofolate reductase
US4438267A (en) *	1980-11-11	1984-03-20	Daluge Susan M	Monoheteroring compounds and their use

1981
- 1981-11-09 US US06/319,644 patent/US4438267A/en not_active Expired - Lifetime
- 1981-11-10 CS CS825781A patent/CS273153B2/cs unknown
- 1981-11-10 GR GR66482A patent/GR81317B/el unknown
- 1981-11-10 PL PL1981233754A patent/PL139523B1/pl unknown
- 1981-11-10 NO NO813804A patent/NO160137C/no not_active IP Right Cessation
- 1981-11-10 PL PL1981239280A patent/PL139828B1/pl unknown
- 1981-11-10 SU SU813358051A patent/SU1424732A3/ru active
- 1981-11-10 KR KR1019810004348A patent/KR880001736B1/ko not_active Expired
- 1981-11-10 IE IE2631/81A patent/IE52128B1/en not_active IP Right Cessation
- 1981-11-10 ZA ZA817780A patent/ZA817780B/xx unknown
- 1981-11-10 EG EG653/81A patent/EG16107A/xx active
- 1981-11-10 CA CA000389807A patent/CA1186310A/en not_active Expired
- 1981-11-10 DK DK198104966A patent/DK172884B1/da active Protection Beyond IP Right Term
- 1981-11-10 PT PT73960A patent/PT73960B/pt unknown
- 1981-11-10 IL IL64256A patent/IL64256A/xx not_active IP Right Cessation
- 1981-11-10 JP JP56180271A patent/JPS57114581A/ja active Granted
- 1981-11-10 DD DD81234745A patent/DD201896A5/de not_active IP Right Cessation
- 1981-11-10 GB GB8133833A patent/GB2087881B/en not_active Expired
- 1981-11-10 PL PL1981239278A patent/PL139827B1/pl unknown
- 1981-11-10 ES ES506969A patent/ES8307759A1/es not_active Expired
- 1981-11-10 AU AU77334/81A patent/AU549449B2/en not_active Expired
- 1981-11-10 NZ NZ198932A patent/NZ198932A/en unknown
- 1981-11-10 FI FI813546A patent/FI76333C/fi not_active IP Right Cessation
- 1981-11-10 IT IT8149676A patent/IT1210589B/it active
- 1981-11-10 PL PL1981239279A patent/PL139427B1/pl unknown
- 1981-11-10 MC MC811560A patent/MC1418A1/fr unknown
- 1981-11-10 HU HU813359A patent/HU188762B/hu unknown
- 1981-11-10 YU YU2663/81A patent/YU42444B/xx unknown
- 1981-11-11 CY CY141981A patent/CY1419A/xx unknown
- 1981-11-11 EP EP81109631A patent/EP0051879B1/en not_active Expired
- 1981-11-11 DE DE8181109631T patent/DE3173752D1/de not_active Expired
- 1981-11-11 ZM ZM94/81A patent/ZM9481A1/xx unknown
1983
- 1983-01-27 SU SU833543245A patent/SU1318148A3/ru active
- 1983-01-31 SU SU833547444A patent/SU1306473A3/ru active
- 1983-04-02 ES ES521203A patent/ES8405379A1/es not_active Expired
- 1983-04-02 ES ES521202A patent/ES521202A0/es active Granted
- 1983-04-02 ES ES521201A patent/ES521201A0/es active Granted
- 1983-04-02 ES ES521204A patent/ES8405380A1/es not_active Expired
- 1983-09-07 PH PH29503A patent/PH25053A/en unknown
- 1983-09-07 PH PH29502A patent/PH22654A/en unknown
- 1983-10-03 YU YU01982/83A patent/YU198283A/xx unknown
- 1983-10-03 YU YU1983/83A patent/YU43551B/xx unknown
- 1983-10-03 YU YU01981/83A patent/YU198183A/xx unknown
- 1983-10-31 US US06/546,850 patent/US4587342A/en not_active Expired - Lifetime
- 1983-12-30 US US06/567,248 patent/US4603136A/en not_active Expired - Lifetime
1986
- 1986-02-02 RU SU863552053A patent/RU1819264C/ru active
- 1986-03-12 US US06/839,463 patent/US4761475A/en not_active Expired - Lifetime
- 1986-07-17 SG SG626/86A patent/SG62686G/en unknown
- 1986-12-30 MY MY678/86A patent/MY8600678A/xx unknown
1987
- 1987-01-14 SU SU874028793A patent/SU1535379A3/ru active
1988
- 1988-03-30 HK HK233/88A patent/HK23388A/en not_active IP Right Cessation
- 1988-06-17 AR AR88311165A patent/AR245447A1/es active
- 1988-07-26 YU YU144288A patent/YU46697B/sh unknown
1994
- 1994-12-29 NO NO1994029C patent/NO1994029I1/no unknown

Also Published As

Publication number	Publication date
SU1535379A3 (ru)	1990-01-07
NZ198932A (en)	1985-05-31
YU144288A (en)	1990-04-30
YU198383A (en)	1984-04-30
RU1819264C (ru)	1993-05-30
PL139427B1 (en)	1987-01-31
ZA817780B (en)	1983-06-29
YU42444B (en)	1988-08-31
PL239278A1 (en)	1983-08-01
SU1306473A3 (ru)	1987-04-23
YU46697B (sh)	1994-04-05
US4603136A (en)	1986-07-29
MC1418A1 (fr)	1982-10-18
ES8405378A1 (es)	1984-06-01
FI813546L (fi)	1982-05-12
ES8405377A1 (es)	1984-06-01
GR81317B (da)	1984-12-11
ES521204A0 (es)	1984-06-01
PH22654A (en)	1988-10-28
IE52128B1 (en)	1987-06-24
PT73960B (en)	1983-11-23
NO160137C (no)	1989-03-15
ES521203A0 (es)	1984-06-01
IE812631L (en)	1982-05-11
AR245447A1 (es)	1994-01-31
CS825781A2 (en)	1990-07-12
US4587342A (en)	1986-05-06
MY8600678A (en)	1986-12-31
US4761475A (en)	1988-08-02
FI76333C (fi)	1988-10-10
GB2087881B (en)	1985-05-15
SG62686G (en)	1987-03-27
KR880001736B1 (ko)	1988-09-10
NO1994029I1 (no)	1994-12-29
GB2087881A (en)	1982-06-03
NO813804L (no)	1982-05-12
DD201896A5 (de)	1983-08-17
ES521201A0 (es)	1984-06-01
KR830007628A (ko)	1983-11-04
PL233754A1 (en)	1983-08-01
EP0051879B1 (en)	1986-02-05
YU266381A (en)	1984-04-30
AU549449B2 (en)	1986-01-30
PL139828B1 (en)	1987-02-28
SU1318148A3 (ru)	1987-06-15
US4438267A (en)	1984-03-20
PL239280A1 (en)	1983-08-01
DK172884B1 (da)	1999-09-06
PL239279A1 (en)	1983-08-01
PL139523B1 (en)	1987-01-31
IL64256A (en)	1988-01-31
YU198283A (en)	1984-04-30
PT73960A (en)	1981-12-01
YU43551B (en)	1989-08-31
HU188762B (en)	1986-05-28
IT1210589B (it)	1989-09-14
EP0051879A2 (en)	1982-05-19
ES8405380A1 (es)	1984-06-01
ZM9481A1 (en)	1983-11-21
ES506969A0 (es)	1983-07-01
DE3173752D1 (en)	1986-03-20
ES8405379A1 (es)	1984-06-01
FI76333B (fi)	1988-06-30
JPH0474351B2 (da)	1992-11-26
ES8307759A1 (es)	1983-07-01
SU1424732A3 (ru)	1988-09-15
EP0051879A3 (en)	1982-08-04
ES521202A0 (es)	1984-06-01
EG16107A (en)	1987-10-30
NO160137B (no)	1988-12-05
CS273153B2 (en)	1991-03-12
IL64256A0 (en)	1982-02-28
AU7733481A (en)	1982-05-20
CA1186310A (en)	1985-04-30
PH25053A (en)	1991-01-28
HK23388A (en)	1988-04-08
IT8149676A0 (it)	1981-11-10
JPS57114581A (en)	1982-07-16
PL139827B1 (en)	1987-02-28
YU198183A (en)	1984-04-30
CY1419A (en)	1988-04-22

Legal Events

Date

Code

Title

Description

2007-09-17

CTFF

Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2000 00006

Filing date: 20000306

Extension date: 20060927

2007-11-12

CTFW

Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn