IT8149676A0 - Procedimento per la preparazione dicomposti pirimidinici dotati di attivita' farmacologica particolarmente per il trattamento di infezioni batteriche loro intermedi prodotto ottenuto e composizioni farmaceutiche che li contengono - Google Patents

Procedimento per la preparazione dicomposti pirimidinici dotati di attivita' farmacologica particolarmente per il trattamento di infezioni batteriche loro intermedi prodotto ottenuto e composizioni farmaceutiche che li contengono

Info

Publication number: IT8149676A0
Authority: IT; Italy
Prior art keywords: procedure; contain; preparation; treatment; pharmaceutical compositions
Prior art date: 1980-11-11

Application number

IT8149676A

Other languages

English (en)

Other versions

IT1210589B (it

Inventor

Susan Mary Daluge

Paul Marcel Skonezny

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-11-11

Filing date

1981-11-10

Publication date

1981-11-10

1981-11-10 Application filed by Wellcome Found filed Critical Wellcome Found

1981-11-10 Publication of IT8149676A0 publication Critical patent/IT8149676A0/it

1989-09-14 Application granted granted Critical

1989-09-14 Publication of IT1210589B publication Critical patent/IT1210589B/it

Links

208000035143 Bacterial infection Diseases 0.000 title 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
208000022362 bacterial infectious disease Diseases 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
230000000144 pharmacologic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IT8149676A 1980-11-11 1981-11-10 Procedimento per la preparazione dicomposti pirimidinici dotati di attivita' farmacologica particolarmente per il trattamento di infezioni batteriche loro intermedi prodotto ottenuto e composizioni farmaceutiche che li contengono IT1210589B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8036135		1980-11-11

Publications (2)

Publication Number	Publication Date
IT8149676A0 true IT8149676A0 (it)	1981-11-10
IT1210589B IT1210589B (it)	1989-09-14

Family

ID=10517217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8149676A IT1210589B (it)	1980-11-11	1981-11-10	Procedimento per la preparazione dicomposti pirimidinici dotati di attivita' farmacologica particolarmente per il trattamento di infezioni batteriche loro intermedi prodotto ottenuto e composizioni farmaceutiche che li contengono

Country Status (35)

Country	Link
US (4)	US4438267A (it)
EP (1)	EP0051879B1 (it)
JP (1)	JPS57114581A (it)
KR (1)	KR880001736B1 (it)
AR (1)	AR245447A1 (it)
AU (1)	AU549449B2 (it)
CA (1)	CA1186310A (it)
CS (1)	CS273153B2 (it)
CY (1)	CY1419A (it)
DD (1)	DD201896A5 (it)
DE (1)	DE3173752D1 (it)
DK (1)	DK172884B1 (it)
EG (1)	EG16107A (it)
ES (5)	ES8307759A1 (it)
FI (1)	FI76333C (it)
GB (1)	GB2087881B (it)
GR (1)	GR81317B (it)
HK (1)	HK23388A (it)
HU (1)	HU188762B (it)
IE (1)	IE52128B1 (it)
IL (1)	IL64256A (it)
IT (1)	IT1210589B (it)
MC (1)	MC1418A1 (it)
MY (1)	MY8600678A (it)
NO (2)	NO160137C (it)
NZ (1)	NZ198932A (it)
PH (2)	PH25053A (it)
PL (4)	PL139523B1 (it)
PT (1)	PT73960B (it)
RU (1)	RU1819264C (it)
SG (1)	SG62686G (it)
SU (4)	SU1424732A3 (it)
YU (5)	YU42444B (it)
ZA (1)	ZA817780B (it)
ZM (1)	ZM9481A1 (it)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4438267A (en) *	1980-11-11	1984-03-20	Daluge Susan M	Monoheteroring compounds and their use
US4590271A (en) *	1982-05-01	1986-05-20	Burroughs Wellcome Co.	2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
DK190983A (da) *	1982-05-01	1983-11-02	Wellcome Found	2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
ZA833067B (en) *	1982-05-01	1984-12-24	Wellcome Found	Antibacterial compounds
US4587341A (en) *	1982-05-07	1986-05-06	Burroughs Wellcome Co.	2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
CA1244028A (en) *	1983-04-14	1988-11-01	Hans Maag	Pyrimidine derivatives
GB8603962D0 (en) *	1986-02-18	1986-03-26	Wellcome Found	Chemical compositions
GB8603964D0 (en) *	1986-02-18	1986-03-26	Cooper Animal Health Ltd	Compositions
LU86703A1 (fr) *	1986-12-08	1988-07-14	Oreal	Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
GB8903978D0 (en) *	1989-02-22	1989-04-05	Coopers Animal Health	Chemical compositions
GB9000241D0 (en) *	1990-01-05	1990-03-07	Coopers Animal Health	Pharmaceutical use
RU95113597A (ru) *	1992-12-02	1997-06-10	ФМК Корпорейшн (US)	Инсектицидная композиция, способы борьбы с насекомыми
KR100224135B1 (ko) *	1993-01-28	1999-10-15	다께다 구니오	퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
US5707996A (en) *	1995-11-06	1998-01-13	Macleod Pharmaceuticals, Inc.	Pharmaceutical solution and methods for preparation thereof
CA2238521C (en) *	1995-12-04	2005-08-16	F. Hoffmann-La Roche Ag	Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
RU2141322C1 (ru) *	1997-08-12	1999-11-20	Голощапов Николай Михайлович	Иммуномодулятор с антимикобактериальной активностью "изофон", способ его получения и применения
GB0016877D0 (en) *	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
WO2002010156A1 (en) *	2000-07-29	2002-02-07	Arpida Ag	Benzofuran derivatives and their use as antibacterial agents
WO2003003006A2 (en) *	2001-06-29	2003-01-09	Ab Science	New potent, selective and non toxic c-kit inhibitors
PT1401416E (pt)	2001-06-29	2007-02-28	Ab Science	Utilização de inibidores de c-kit para tratar doenças inflamatórias intestinais (dii)
ATE330608T1 (de) *	2001-06-29	2006-07-15	Ab Science	Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
ES2274993T3 (es) *	2001-06-29	2007-06-01	Ab Science	Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas.
DE60225590T2 (de) *	2001-09-20	2008-09-25	Ab Science	C-kithemmer zur behandlung von bakteriellen infektionen
CA2460845A1 (en) *	2001-09-20	2003-03-27	Ab Science	Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
EP1461032B1 (en) *	2001-09-20	2008-07-16	AB Science	Use of c-kit inhibitors for promoting hair growth
CN100443482C (zh)	2003-07-11	2008-12-17	阿皮德公开股份有限公司	苯并呋喃衍生物及其在制备治疗由细菌引起的感染的药物中的用途
CN101115746A (zh) *	2005-02-18	2008-01-30	阿皮德公开股份有限公司	用于制备苯并呋喃的新方法
AU2006286576B2 (en) *	2005-09-01	2012-06-14	F. Hoffmann-La Roche Ag	Diaminopyrimidines as P2X3 and P3X2/3 modulators
WO2010003084A2 (en) *	2008-07-02	2010-01-07	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors
EP2440533B1 (en) *	2009-06-12	2015-09-23	Socpra-Sciences Et Génie S.E.C.	Guanine riboswitch binding compounds and their use as antibiotics
CN102649786B (zh) *	2011-02-28	2014-08-27	郑州福源动物药业有限公司	一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
CN103755684B (zh) *	2014-02-10	2015-09-09	青岛蔚蓝生物股份有限公司	一种巴喹普林的制备方法
US12595261B2 (en)	2019-06-06	2026-04-07	Beijing Tide Pharmaceutical Co., Ltd.	P2X3 and/or P2X2/3 receptor antagonist, pharmaceutical composition containing same, and use thereof
CN110818694B (zh) *	2019-11-18	2023-04-21	上海医药工业研究院有限公司	艾拉普林中间体及其应用
WO2022217295A1 (en) *	2021-04-09	2022-10-13	The Trustees Of The University Of Pennsylvania	Control of protein expression with tmp-protac compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3049544A (en) *		1962-08-14		Method for the preparation of
DE1303727B (de)	1959-09-03	1976-02-05	Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London	Alpha-Arylidensubstituierte Propioni-Irile
US3956327A (en) *	1969-03-06	1976-05-11	Burroughs Wellcome Co.	Method of preparing 2,4-diamino-5-benzyl pyrimidines
BE792096A (fr) *	1971-12-01	1973-05-30	Hoffmann La Roche	Nouvelles benzylpyrimidines
GB1468374A (en)	1974-03-06	1977-03-23	Wellcome Found	Process for preparing a pyrimidine derivative
US4039543A (en)	1974-12-24	1977-08-02	Hoffmann-La Roche Inc.	Benzylpyrimidines
GB1582245A (en) *	1976-06-09	1981-01-07	Wellcome Found	Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
DE2730467A1 (de) *	1977-07-06	1979-01-18	Basf Ag	Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4258045A (en) *	1979-11-30	1981-03-24	Merck & Co., Inc.	Inhibitor of dihydrofolate reductase
US4438267A (en) *	1980-11-11	1984-03-20	Daluge Susan M	Monoheteroring compounds and their use

1981
- 1981-11-09 US US06/319,644 patent/US4438267A/en not_active Expired - Lifetime
- 1981-11-10 CS CS825781A patent/CS273153B2/cs unknown
- 1981-11-10 GR GR66482A patent/GR81317B/el unknown
- 1981-11-10 PL PL1981233754A patent/PL139523B1/pl unknown
- 1981-11-10 NO NO813804A patent/NO160137C/no not_active IP Right Cessation
- 1981-11-10 PL PL1981239280A patent/PL139828B1/pl unknown
- 1981-11-10 SU SU813358051A patent/SU1424732A3/ru active
- 1981-11-10 KR KR1019810004348A patent/KR880001736B1/ko not_active Expired
- 1981-11-10 IE IE2631/81A patent/IE52128B1/en not_active IP Right Cessation
- 1981-11-10 ZA ZA817780A patent/ZA817780B/xx unknown
- 1981-11-10 EG EG653/81A patent/EG16107A/xx active
- 1981-11-10 CA CA000389807A patent/CA1186310A/en not_active Expired
- 1981-11-10 DK DK198104966A patent/DK172884B1/da active Protection Beyond IP Right Term
- 1981-11-10 PT PT73960A patent/PT73960B/pt unknown
- 1981-11-10 IL IL64256A patent/IL64256A/xx not_active IP Right Cessation
- 1981-11-10 JP JP56180271A patent/JPS57114581A/ja active Granted
- 1981-11-10 DD DD81234745A patent/DD201896A5/de not_active IP Right Cessation
- 1981-11-10 GB GB8133833A patent/GB2087881B/en not_active Expired
- 1981-11-10 PL PL1981239278A patent/PL139827B1/pl unknown
- 1981-11-10 ES ES506969A patent/ES8307759A1/es not_active Expired
- 1981-11-10 AU AU77334/81A patent/AU549449B2/en not_active Expired
- 1981-11-10 NZ NZ198932A patent/NZ198932A/en unknown
- 1981-11-10 FI FI813546A patent/FI76333C/fi not_active IP Right Cessation
- 1981-11-10 IT IT8149676A patent/IT1210589B/it active
- 1981-11-10 PL PL1981239279A patent/PL139427B1/pl unknown
- 1981-11-10 MC MC811560A patent/MC1418A1/fr unknown
- 1981-11-10 HU HU813359A patent/HU188762B/hu unknown
- 1981-11-10 YU YU2663/81A patent/YU42444B/xx unknown
- 1981-11-11 CY CY141981A patent/CY1419A/xx unknown
- 1981-11-11 EP EP81109631A patent/EP0051879B1/en not_active Expired
- 1981-11-11 DE DE8181109631T patent/DE3173752D1/de not_active Expired
- 1981-11-11 ZM ZM94/81A patent/ZM9481A1/xx unknown
1983
- 1983-01-27 SU SU833543245A patent/SU1318148A3/ru active
- 1983-01-31 SU SU833547444A patent/SU1306473A3/ru active
- 1983-04-02 ES ES521203A patent/ES8405379A1/es not_active Expired
- 1983-04-02 ES ES521202A patent/ES521202A0/es active Granted
- 1983-04-02 ES ES521201A patent/ES521201A0/es active Granted
- 1983-04-02 ES ES521204A patent/ES8405380A1/es not_active Expired
- 1983-09-07 PH PH29503A patent/PH25053A/en unknown
- 1983-09-07 PH PH29502A patent/PH22654A/en unknown
- 1983-10-03 YU YU01982/83A patent/YU198283A/xx unknown
- 1983-10-03 YU YU1983/83A patent/YU43551B/xx unknown
- 1983-10-03 YU YU01981/83A patent/YU198183A/xx unknown
- 1983-10-31 US US06/546,850 patent/US4587342A/en not_active Expired - Lifetime
- 1983-12-30 US US06/567,248 patent/US4603136A/en not_active Expired - Lifetime
1986
- 1986-02-02 RU SU863552053A patent/RU1819264C/ru active
- 1986-03-12 US US06/839,463 patent/US4761475A/en not_active Expired - Lifetime
- 1986-07-17 SG SG626/86A patent/SG62686G/en unknown
- 1986-12-30 MY MY678/86A patent/MY8600678A/xx unknown
1987
- 1987-01-14 SU SU874028793A patent/SU1535379A3/ru active
1988
- 1988-03-30 HK HK233/88A patent/HK23388A/en not_active IP Right Cessation
- 1988-06-17 AR AR88311165A patent/AR245447A1/es active
- 1988-07-26 YU YU144288A patent/YU46697B/sh unknown
1994
- 1994-12-29 NO NO1994029C patent/NO1994029I1/no unknown

Also Published As

Publication number	Publication date
SU1535379A3 (ru)	1990-01-07
NZ198932A (en)	1985-05-31
YU144288A (en)	1990-04-30
YU198383A (en)	1984-04-30
RU1819264C (ru)	1993-05-30
PL139427B1 (en)	1987-01-31
ZA817780B (en)	1983-06-29
YU42444B (en)	1988-08-31
PL239278A1 (en)	1983-08-01
SU1306473A3 (ru)	1987-04-23
YU46697B (sh)	1994-04-05
US4603136A (en)	1986-07-29
MC1418A1 (fr)	1982-10-18
ES8405378A1 (es)	1984-06-01
FI813546L (fi)	1982-05-12
ES8405377A1 (es)	1984-06-01
GR81317B (it)	1984-12-11
ES521204A0 (es)	1984-06-01
PH22654A (en)	1988-10-28
IE52128B1 (en)	1987-06-24
PT73960B (en)	1983-11-23
NO160137C (no)	1989-03-15
ES521203A0 (es)	1984-06-01
IE812631L (en)	1982-05-11
AR245447A1 (es)	1994-01-31
CS825781A2 (en)	1990-07-12
US4587342A (en)	1986-05-06
DK496681A (da)	1982-05-12
MY8600678A (en)	1986-12-31
US4761475A (en)	1988-08-02
FI76333C (fi)	1988-10-10
GB2087881B (en)	1985-05-15
SG62686G (en)	1987-03-27
KR880001736B1 (ko)	1988-09-10
NO1994029I1 (no)	1994-12-29
GB2087881A (en)	1982-06-03
NO813804L (no)	1982-05-12
DD201896A5 (de)	1983-08-17
ES521201A0 (es)	1984-06-01
KR830007628A (ko)	1983-11-04
PL233754A1 (en)	1983-08-01
EP0051879B1 (en)	1986-02-05
YU266381A (en)	1984-04-30
AU549449B2 (en)	1986-01-30
PL139828B1 (en)	1987-02-28
SU1318148A3 (ru)	1987-06-15
US4438267A (en)	1984-03-20
PL239280A1 (en)	1983-08-01
DK172884B1 (da)	1999-09-06
PL239279A1 (en)	1983-08-01
PL139523B1 (en)	1987-01-31
IL64256A (en)	1988-01-31
YU198283A (en)	1984-04-30
PT73960A (en)	1981-12-01
YU43551B (en)	1989-08-31
HU188762B (en)	1986-05-28
IT1210589B (it)	1989-09-14
EP0051879A2 (en)	1982-05-19
ES8405380A1 (es)	1984-06-01
ZM9481A1 (en)	1983-11-21
ES506969A0 (es)	1983-07-01
DE3173752D1 (en)	1986-03-20
ES8405379A1 (es)	1984-06-01
FI76333B (fi)	1988-06-30
JPH0474351B2 (it)	1992-11-26
ES8307759A1 (es)	1983-07-01
SU1424732A3 (ru)	1988-09-15
EP0051879A3 (en)	1982-08-04
ES521202A0 (es)	1984-06-01
EG16107A (en)	1987-10-30
NO160137B (no)	1988-12-05
CS273153B2 (en)	1991-03-12
IL64256A0 (en)	1982-02-28
AU7733481A (en)	1982-05-20
CA1186310A (en)	1985-04-30
PH25053A (en)	1991-01-28
HK23388A (en)	1988-04-08
JPS57114581A (en)	1982-07-16
PL139827B1 (en)	1987-02-28
YU198183A (en)	1984-04-30
CY1419A (en)	1988-04-22

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971125

Publication	Publication Date	Title
IT1210589B (it)	1989-09-14	Procedimento per la preparazione dicomposti pirimidinici dotati di attivita' farmacologica particolarmente per il trattamento di infezioni batteriche loro intermedi prodotto ottenuto e composizioni farmaceutiche che li contengono
NO180586C (no)	1997-05-14	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte imidazoler
FR2499990B1 (fr)	1986-06-20	Procede de preparation de derives d'acides quinoleinecarboxyliques, nouveaux produits ainsi obtenus et leur utilisation comme agents antibacteriens
IT1211468B (it)	1989-11-03	Alfa aril alfa feniletil 1h 1 24 triazolo 1 propanonitrili procedimento per la loro preparazione e impiego come fungicidi
IT8324207A0 (it)	1983-12-16	Carbossamido-derivati di 1,2,4-tiadiazolo [3,2-a] pirimidine e procedimento per la loro preparazione
FI96030B (fi)	1996-01-15	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen tetraliinien, kromaanien ja niitä läheisesti muistuttavien yhdisteiden valmistamiseksi sekä menetelmässä käyttökelpoisia välituotteita
IT7948347A0 (it)	1979-03-14	Preparazione perfezionamento nelle composizioni anti-virali particolarmente per il trattamento di infezioni rinovirali e procedimento per la loro
IL76561A (en)	1990-11-29	Pharmaceutical compositions containing ifn-ypsilon for the treatment of rheumatic diseases
AU550675B2 (en)	1986-03-27	Pharmaceutical compositions for the treatment of skin
FI891986A7 (fi)	1989-04-26	Farmaseuttiset koostumukset psoriasiksen hoitoon
IT8125570A0 (it)	1981-12-14	Composti ad attivita'antiinfiammatoria, processo per la loro preparazione e composizioni farmaceutiche relative
FI901883A0 (fi)	1990-04-12	Menetelmä terapeuttisesti vaikuttavien 2-substituoitujen N,N'-ditrimetoksibentsoyylipiperatsiinien valmistamiseksi
ITMI922742A0 (it)	1992-11-30	Composti ad attivita' terapeutica utili per il trattamento di malattieconnesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1143085B (it)	1986-10-22	Composti piranonici 6-sostituiti per il trattamento di condizioni di ipersensibilita' quali l'asma e procedimento per la loro preparazione
IT1162463B (it)	1987-04-01	Procedimento per la preparazione di cefalosporine e composizioni farmaceutiche che le contengono e prodotto ottenuto
BE860162A (fr)	1978-04-27	Derives actifs de l'uree leur procede de preparation ainsi que les compositions therapeutiques les contenant
EG18213A (en)	1992-09-30	Pharmaceutical formulation for the treatment of bacterial infections
IT1185525B (it)	1987-11-12	Derivait di amminodiarilsolfossidi,procedimento per la loro preparazione e composizioni farmaceutiche e pesticide che li contengono
FR2604707B1 (fr)	1989-06-09	Procede de preparation d'un compose therapeutique actif
IT8320468A0 (it)	1983-04-06	Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono.
FR2486526B1 (fr)	1986-04-04	Procede de preparation de derives de l'oxyde de diphenyle
FI882836A0 (fi)	1988-06-14	Menetelmä terapeuttisesti käyttökelpoisen (E)-2-(p-fluorifenetyyli)-3-fluoriallyyliamiinin valmistamiseksi
IT1167746B (it)	1987-05-13	Nitroimidazoli ad attivita' tricomonacida, procedimento per la loro preparazione e relative composizioni farmaceutiche
IT8249226A0 (it)	1982-10-07	Eventualmente sostituiti sell'anelderivati di 20,21-dinoreburnamenina lo e, procedimento ed intermedi di preparazione, applicazione come medicamenti e composizioni che li con tengono
IT1168068B (it)	1987-05-20	Composto ad attvita' antiinfiammatoria, disinfettante e antibatterica, procedimento per la sua preparazione e relative composizioni farmaceutiche