DK507986A - Thieno-isoxazoler eller -pyrazoler og farmaceutisk acceptable syreadditionssalte deraf, fremgangsmaade og mellemprodukt til deres fremstilling samt deres anvendelse som antihypertensive midler - Google Patents

Thieno-isoxazoler eller -pyrazoler og farmaceutisk acceptable syreadditionssalte deraf, fremgangsmaade og mellemprodukt til deres fremstilling samt deres anvendelse som antihypertensive midler

Info

Publication number
DK507986A
DK507986A DK507986A DK507986A DK507986A DK 507986 A DK507986 A DK 507986A DK 507986 A DK507986 A DK 507986A DK 507986 A DK507986 A DK 507986A DK 507986 A DK507986 A DK 507986A
Authority
DK
Denmark
Prior art keywords
isoxazoles
thieno
pyrazoles
intermediates
procedures
Prior art date
Application number
DK507986A
Other languages
English (en)
Other versions
DK507986D0 (da
Inventor
Helen Hu Ong
Christine Mary Yasenchak
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK507986D0 publication Critical patent/DK507986D0/da
Publication of DK507986A publication Critical patent/DK507986A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK507986A 1985-10-24 1986-10-23 Thieno-isoxazoler eller -pyrazoler og farmaceutisk acceptable syreadditionssalte deraf, fremgangsmaade og mellemprodukt til deres fremstilling samt deres anvendelse som antihypertensive midler DK507986A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/791,019 US4728651A (en) 1985-10-24 1985-10-24 Antihypertensive thieno-isoxazoles and -pyrazoles

Publications (2)

Publication Number Publication Date
DK507986D0 DK507986D0 (da) 1986-10-23
DK507986A true DK507986A (da) 1987-04-25

Family

ID=25152414

Family Applications (1)

Application Number Title Priority Date Filing Date
DK507986A DK507986A (da) 1985-10-24 1986-10-23 Thieno-isoxazoler eller -pyrazoler og farmaceutisk acceptable syreadditionssalte deraf, fremgangsmaade og mellemprodukt til deres fremstilling samt deres anvendelse som antihypertensive midler

Country Status (10)

Country Link
US (1) US4728651A (da)
EP (1) EP0221414A1 (da)
JP (1) JPS62103086A (da)
KR (1) KR870004037A (da)
AU (1) AU6433786A (da)
DK (1) DK507986A (da)
HU (1) HU198058B (da)
IL (1) IL80394A0 (da)
PT (1) PT83606B (da)
ZA (1) ZA868065B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808663D0 (en) * 1998-04-23 1998-06-24 Merck Sharp & Dohme Therapeutic agents
US7125903B1 (en) * 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
EE200200133A (et) * 1999-09-14 2003-04-15 Aventis Pharmaceuticals Inc. Asendamata tienoisoksasoolfenoksüetüül- ja propüülderivaadid ning nende kasutamine D4 antagonistidena
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
ES2209995T3 (es) * 1999-09-14 2004-07-01 Aventis Pharmaceuticals Inc. Derivados de propilo sustituidos con tienoisoxazolil- y tienopirrazolil-fenoxi, utiles en calidad de antagonistas d4.
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
DE60120748T2 (de) 2000-11-10 2007-05-16 Eli Lilly And Co., Indianapolis 3-substituierte oxindolderivate als beta-3-agonisten
DE60215028T2 (de) * 2001-08-14 2007-03-15 Eli Lilly And Co., Indianapolis Indol derivate als beta-3-adrenerge agonisten zur behandlung von typ 2 diabetes
US6911463B2 (en) 2001-08-14 2005-06-28 Eli Lilly And Company 3-substituted oxindole β-3 agonists
DE60225174T2 (de) 2001-11-20 2009-02-12 Eli Lilly And Co., Indianapolis Beta-3 adrenergische agonisten
JP2005514366A (ja) 2001-11-20 2005-05-19 イーライ・リリー・アンド・カンパニー ３−置換オキシインドールβ３アゴニスト
EP1467733A1 (en) 2002-01-11 2004-10-20 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists
KR20040020457A (ko) * 2002-08-30 2004-03-09 주식회사 대웅 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법
WO2014144169A1 (en) 2013-03-15 2014-09-18 Epizyme, Inc. Carm1 inhibitors and uses thereof
CN113072562B (zh) * 2021-04-06 2022-01-14 山东大学 一种GSK-3β抑制剂及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655661A (en) * 1968-05-22 1972-04-11 Frosst & Co Charles E Benzothiadiazole compounds
AU518487B2 (en) * 1975-07-16 1981-10-01 Boehringer Ingelheim International Gmbh 5-aryl-thieno-(2,3-e)-4,1-oxazepin-2-ones
US4245104A (en) * 1978-12-01 1981-01-13 Hoffmann-La Roche Inc. Isoxazolines and isoxazolidines
US4247704A (en) * 1979-05-29 1981-01-27 Hoffmann-La Roche Inc. Hexahydro thieno imadazole intermediates for the synthesis of biotin
DE2926517A1 (de) * 1979-06-30 1981-01-15 Beiersdorf Ag Substituierte 3-aryl-pyrazole und 5-aryl-isoxazole und verfahren zu ihrer herstellung
CA1156661A (en) * 1980-02-25 1983-11-08 Hoffmann-La Roche Limited Phenoxy-aminopropanol derivatives
DE3101456A1 (de) * 1981-01-19 1982-09-02 Basf Ag, 6700 Ludwigshafen Phenylpiperazinyl-propanole von hetarylphenolen, ihre herstellung und diese enthaltende therapeutische mittel
JPS5846079A (ja) * 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類

Also Published As

Publication number Publication date
US4728651A (en) 1988-03-01
HU198058B (en) 1989-07-28
JPS62103086A (ja) 1987-05-13
HUT45061A (en) 1988-05-30
AU6433786A (en) 1987-04-30
PT83606B (en) 1988-11-15
EP0221414A1 (en) 1987-05-13
PT83606A (en) 1986-11-01
DK507986D0 (da) 1986-10-23
IL80394A0 (en) 1987-01-30
KR870004037A (ko) 1987-05-07
ZA868065B (en) 1987-06-24

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