DK528889A - Substituerede quinolinderivater og fremgangsmaade til fremstilling deraf, mellemprodukter til anvendelse ved deres fremstilling og farmaceutiske midler indeholdende derivaterne - Google Patents

Substituerede quinolinderivater og fremgangsmaade til fremstilling deraf, mellemprodukter til anvendelse ved deres fremstilling og farmaceutiske midler indeholdende derivaterne

Info

Publication number: DK528889A
Authority: DK; Denmark
Prior art keywords: alkoxy; alkyl; derivatives; intermediates; preparing
Prior art date: 1988-02-25

Application number

DK528889A

Other languages

English (en)

Other versions

DK166623B1 (da

DK528889D0 (da

Inventor

Robert John Ife

Thomas Henry Brown

Colin Andrew Leach

Original Assignee

Smithkline Beckman Intercredit

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-25

Filing date

1989-10-24

Publication date

1989-10-24

1989-10-24 Application filed by Smithkline Beckman Intercredit filed Critical Smithkline Beckman Intercredit

1989-10-24 Publication of DK528889A publication Critical patent/DK528889A/da

1989-10-24 Publication of DK528889D0 publication Critical patent/DK528889D0/da

1993-06-21 Application granted granted Critical

1993-06-21 Publication of DK166623B1 publication Critical patent/DK166623B1/da

Links

239000000543 intermediate Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000008177 pharmaceutical agent Substances 0.000 title abstract 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 cyano, hydroxyl Chemical group 0.000 abstract 1
230000027119 gastric acid secretion Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK528889A 1988-02-25 1989-10-24 Terapeutisk aktive 4-phenylamino-quinolinderivater, fremgangsmaader til fremstilling deraf samt farmaceutiske midler indeholdende derivaterne DK166623B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB888804444A GB8804444D0 (en)	1988-02-25	1988-02-25	Compounds
GB8804444		1988-02-25
PCT/EP1989/000175 WO1989008104A1 (en)	1988-02-25	1989-02-20	4-amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion
EP8900175		1989-02-20

Publications (3)

Publication Number	Publication Date
DK528889A true DK528889A (da)	1989-10-24
DK528889D0 DK528889D0 (da)	1989-10-24
DK166623B1 DK166623B1 (da)	1993-06-21

Family

ID=10632376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK528889A DK166623B1 (da)	1988-02-25	1989-10-24	Terapeutisk aktive 4-phenylamino-quinolinderivater, fremgangsmaader til fremstilling deraf samt farmaceutiske midler indeholdende derivaterne

Country Status (22)

Country	Link
US (1)	US5089504A (da)
EP (1)	EP0330485B1 (da)
JP (1)	JPH0774204B2 (da)
KR (1)	KR0159083B1 (da)
CN (2)	CN1027368C (da)
AU (1)	AU606508B2 (da)
CA (1)	CA1332839C (da)
CZ (1)	CZ398391A3 (da)
DE (1)	DE68906687T2 (da)
DK (1)	DK166623B1 (da)
ES (1)	ES2055037T3 (da)
FI (1)	FI93952C (da)
GB (1)	GB8804444D0 (da)
HU (1)	HU208814B (da)
IE (1)	IE63239B1 (da)
IL (1)	IL89346A (da)
MY (1)	MY105158A (da)
NZ (1)	NZ228098A (da)
PT (1)	PT89789B (da)
WO (1)	WO1989008104A1 (da)
ZA (1)	ZA891402B (da)
ZW (1)	ZW1989A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8918265D0 (en) *	1989-08-10	1989-09-20	Smithkline Beckman Intercredit	Compounds
JPH04211661A (ja) *	1990-03-28	1992-08-03	Otsuka Pharmaceut Co Ltd	キノリン誘導体及び該誘導体を含有する抗潰瘍剤
FI933376A0 (fi) *	1991-01-29	1993-07-28	Smithkline Beecham Intercredit	4-amino-3-acylkinolinderivater och deras anvaendning som inhibitorer avmagsyrasekretion
GB9126438D0 (en) *	1991-12-12	1992-02-12	Smithkline Beecham Intercredit	New quinoline derivatives
US5362743A (en) *	1993-03-09	1994-11-08	Pfizer Inc.	Aminoquinoline derivatives
US5556863A (en) *	1993-06-11	1996-09-17	Astra Aktiebolag	Compound for gastric acid secretion inhibition
SE9302005D0 (sv)	1993-06-11	1993-06-11	Ab Astra	New active compounds
IS4164A (is) *	1993-06-11	1994-12-12	Ab Astra	Efnasambönd sem hindra flæði magasýru
JP2002516323A (ja)	1998-05-23	2002-06-04	ビイクグルデンロンベルクヒエーミツシエフアブリークゲゼルシヤフトミツトベシユレンクテルハフツング	抗ヘリコバクター活性を有するキノリン−アミノメチル−ピリジル誘導体
US6852739B1 (en)	1999-02-26	2005-02-08	Nitromed Inc.	Methods using proton pump inhibitors and nitric oxide donors
HN2000000203A (es)	1999-11-30	2001-06-13	Pfizer Prod Inc	Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
UA80393C2 (uk)	2000-12-07	2007-09-25	Алтана Фарма Аг	Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
CA2467652A1 (en) *	2001-11-19	2003-05-30	Altana Pharma Ag	Reversible proton pump inhibitors for the treatment of airway disorders
MY140561A (en)	2002-02-20	2009-12-31	Nycomed Gmbh	Dosage form containing pde 4 inhibitor as active ingredient
EP1534278A4 (en)	2002-08-01	2006-09-06	Nitromed Inc	NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
ES2335498T3 (es)	2003-03-10	2010-03-29	Nycomed Gmbh	Nuevo proceso para la preparacion de reflumilast.
KR20060099524A (ko)	2003-11-03	2006-09-19	아스트라제네카 아베	무증상 위식도 역류의 치료를 위한 이미다조[1,2-ａ]피리딘유도체
US8663694B2 (en) *	2005-03-16	2014-03-04	Takeda Gmbh	Taste masked dosage form containing roflumilast
CN106496119A (zh) *	2016-10-17	2017-03-15	江南大学	一种n‑苯基‑8‑氨基喹啉的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2652398A (en) *	1949-11-17	1953-09-15	Endo Products Inc	N-substituted-2-amino (methyl) quinolines
US3470186A (en) *	1967-06-02	1969-09-30	American Cyanamid Co	Substituted 4-anilino-3-quinolinecarboxylic acids and esters
CA942748A (en) *	1970-09-18	1974-02-26	Venkatachala L. Narayanan	1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
US4343804A (en) *	1979-03-26	1982-08-10	A. H. Robins Company, Inc.	4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
ZA801526B (en) *	1979-03-26	1981-08-26	Robins Co Inc A H	4-amino-3-quinolinecarboxylic acids and esters-antisecretory, anti-ulcer compounds
GB8621425D0 (en) *	1986-09-05	1986-10-15	Smith Kline French Lab	Compounds
GB8804443D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
GB8804445D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
GB8804446D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds

1988
- 1988-02-25 GB GB888804444A patent/GB8804444D0/en active Pending
1989
- 1989-02-20 HU HU891463A patent/HU208814B/hu not_active IP Right Cessation
- 1989-02-20 ZW ZW19/89A patent/ZW1989A1/xx unknown
- 1989-02-20 IL IL8934689A patent/IL89346A/en not_active IP Right Cessation
- 1989-02-20 KR KR1019890701954A patent/KR0159083B1/ko not_active Expired - Fee Related
- 1989-02-20 JP JP1502451A patent/JPH0774204B2/ja not_active Expired - Lifetime
- 1989-02-20 AU AU31819/89A patent/AU606508B2/en not_active Ceased
- 1989-02-20 WO PCT/EP1989/000175 patent/WO1989008104A1/en not_active Ceased
- 1989-02-21 MY MYPI89000210A patent/MY105158A/en unknown
- 1989-02-21 CA CA000591638A patent/CA1332839C/en not_active Expired - Fee Related
- 1989-02-22 NZ NZ228098A patent/NZ228098A/xx unknown
- 1989-02-22 PT PT89789A patent/PT89789B/pt not_active IP Right Cessation
- 1989-02-23 US US07/314,726 patent/US5089504A/en not_active Expired - Lifetime
- 1989-02-23 ZA ZA891402A patent/ZA891402B/xx unknown
- 1989-02-23 EP EP89301804A patent/EP0330485B1/en not_active Expired - Lifetime
- 1989-02-23 ES ES89301804T patent/ES2055037T3/es not_active Expired - Lifetime
- 1989-02-23 DE DE89301804T patent/DE68906687T2/de not_active Expired - Fee Related
- 1989-02-23 IE IE56889A patent/IE63239B1/en not_active IP Right Cessation
- 1989-02-24 CN CN89100929A patent/CN1027368C/zh not_active Expired - Fee Related
- 1989-10-24 DK DK528889A patent/DK166623B1/da not_active IP Right Cessation
- 1989-10-24 FI FI895048A patent/FI93952C/fi not_active IP Right Cessation
1991
- 1991-12-20 CZ CS913983A patent/CZ398391A3/cs unknown
1994
- 1994-02-26 CN CN94102353A patent/CN1100414A/zh active Pending

Also Published As

Publication number	Publication date
GB8804444D0 (en)	1988-03-23
EP0330485B1 (en)	1993-05-26
HU208814B (en)	1994-01-28
US5089504A (en)	1992-02-18
FI93952B (fi)	1995-03-15
JPH02503318A (ja)	1990-10-11
CN1027368C (zh)	1995-01-11
CN1035501A (zh)	1989-09-13
NZ228098A (en)	1990-10-26
ZW1989A1 (en)	1989-09-13
ZA891402B (en)	1990-09-26
KR900700457A (ko)	1990-08-13
FI93952C (fi)	1995-06-26
CZ398391A3 (en)	1994-05-18
AU606508B2 (en)	1991-02-07
DK166623B1 (da)	1993-06-21
KR0159083B1 (ko)	1998-12-01
JPH0774204B2 (ja)	1995-08-09
PT89789A (pt)	1989-10-04
FI895048A0 (fi)	1989-10-24
IE890568L (en)	1989-08-25
HU891463D0 (en)	1990-01-28
ES2055037T3 (es)	1994-08-16
EP0330485A1 (en)	1989-08-30
AU3181989A (en)	1989-09-22
WO1989008104A1 (en)	1989-09-08
DE68906687D1 (de)	1993-07-01
IL89346A (en)	1994-01-25
CA1332839C (en)	1994-11-01
MY105158A (en)	1994-08-30
CN1100414A (zh)	1995-03-22
DK528889D0 (da)	1989-10-24
PT89789B (pt)	1994-05-31
DE68906687T2 (de)	1993-12-02
IE63239B1 (en)	1995-04-05
HUT53086A (en)	1990-09-28

Legal Events

Date	Code	Title	Description
1993-06-21	B1	Patent granted (law 1993)
2000-10-30	PBP	Patent lapsed

Publication	Publication Date	Title
DK528889A (da)	1989-10-24	Substituerede quinolinderivater og fremgangsmaade til fremstilling deraf, mellemprodukter til anvendelse ved deres fremstilling og farmaceutiske midler indeholdende derivaterne
NO882608D0 (no)	1988-06-14	Fremgangsmaate for fremstilling av terapeutisk aktive pyrazolopyrideirer.
FI885569A0 (fi)	1988-11-30	Vattenloesliga kamptothecinanaloger.
DK245888A (da)	1988-05-05	4-aminoquinolinderivater
NO903851D0 (no)	1990-09-04	Fremgangsmaate for fremstilling av n-substituerte-4-pyrimidinaminer og -pyrimidindiaminer, og deres anvendelse som medikamenter.
ATE175962T1 (de)	1999-02-15	Anilin derivate
DE69709568D1 (de)	2002-02-21	Halo-substituierte Protein Kinase C Inhibitoren
ES8802610A1 (es)	1988-09-16	Un metodo para preparar un compuesto quimico, inhibidor de las 5-lipoxigenasas,util para la terapia humana y veterinaria
DK495781A (da)	1982-05-12	Fremgangsmaade til fremstilling af n-substituerede omega-(2-oxoimidazolin-1-yl) alkansyrer og salte og estere deraf
DK157813C (da)	1990-07-16	Analogifremgangsmaade til fremstilling af n-(4-aminobenzoyl)-n'-benzyl bispidinderivater
DE68909107D1 (de)	1993-10-21	4-Amino-3-acylchinolin-Derivate und ihre Verwendung als Inhibitoren der Magensekretion.
ES2010284A6 (es)	1989-11-01	Procedimiento para preparar derivados de tiourea.
DK151965C (da)	1988-06-20	Analogifremgangsmaade til fremstilling af piperazinsubstituerede 3-alkyltheobrominforbindelser
DK335486A (da)	1987-01-17	Arylethanolhydroxylaminer, fremgangsmaader til deres fremstilling ogderes anvendelse til ydelsesforbedring
ATE100439T1 (de)	1994-02-15	2-(2-hydroxy-3-phenoxypropylamino)-ethoxybenzol derivate.
FI894068A0 (fi)	1989-08-30	Sulfonamider med tetrazolylrest, foerfarande foer deras tillverkning och laekemedel.
DK0401093T3 (da)	1995-07-10	Hidtil ukendte pyrrolidonderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende disse
SE8005687L (sv)	1981-02-14	Nya 10-halogen-e-homoeburnaner jemte sett for deras framstellning
SE8405429D0 (sv)	1984-10-30	Forfarande for framstellning av 7-acylindolin-2-oner
NO840732L (no)	1984-08-29	Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse n-(3-trifluormetylfenyl)-n`-propargylpiperazin
NO157214C (no)	1988-02-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolcarboxylsyrederivater.
DE3068456D1 (en)	1984-08-09	2-(n-(2-fluoro-6-bromophenyl)-n-(thiemyl-2-methyl)-amino)-2-imidazoline, its addition salts, pharmaceutical compositions containing them and processes for their preparation
DK31987A (da)	1987-07-23	1-acylaminomethyl-imidazo(1,2-a)-quinolin-derivater, fremgangsmaade til fremstilling deraf og laegemidler indeholdende saadanne derivater
AU4499393A (en)	1994-03-10	Novel oxazolidines
AR002015A1 (es)	1998-01-07	DERIVADOS DE ACIDO 8-OXO-5,8-DIHIDRO-6H-DIBENZO (a, g) QUINOLIZINA-13- PROPANOICO, PROCEDIMIENTO PARA SU PREPARACION Y MEDICAMENTO Y COMPOSICIONFARMACEUTICA QUE CONTIENEN A DICHOS DERIVADOS.