DK56581A - Fremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf - Google Patents

Fremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf

Info

Publication number: DK56581A
Authority: DK; Denmark
Prior art keywords: amino; acceptable salts; procedure; preparation; pharmaceutical acceptable
Prior art date: 1980-02-12

Application number

DK56581A

Other languages

English (en)

Other versions

DK156400C (da

DK156400B (da

Inventor

R Sargas

R C Schnur

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-12

Filing date

1981-02-11

Publication date

1981-08-13

1981-02-11 Application filed by Pfizer filed Critical Pfizer

1981-08-13 Publication of DK56581A publication Critical patent/DK56581A/da

1989-08-14 Publication of DK156400B publication Critical patent/DK156400B/da

1990-01-08 Application granted granted Critical

1990-01-08 Publication of DK156400C publication Critical patent/DK156400C/da

Links

150000003839 salts Chemical class 0.000 title abstract 2
QAHZIGHCEBUNGT-QMGFNSACSA-N (5r,6s,7s,8r,9r)-6,7,8-trihydroxy-9-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)C[C@]11C(=O)NC(=O)N1 QAHZIGHCEBUNGT-QMGFNSACSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK056581A 1980-02-12 1981-02-11 Analogifremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf DK156400C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/120,944 US4248882A (en)	1980-02-12	1980-02-12	Treating diabetes-associated complications with hydantoin amines
US12094480		1980-02-12

Publications (3)

Publication Number	Publication Date
DK56581A true DK56581A (da)	1981-08-13
DK156400B DK156400B (da)	1989-08-14
DK156400C DK156400C (da)	1990-01-08

Family

ID=22393428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK056581A DK156400C (da)	1980-02-12	1981-02-11	Analogifremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf

Country Status (8)

Country	Link
US (1)	US4248882A (da)
EP (1)	EP0034063B1 (da)
JP (1)	JPS56127379A (da)
AT (1)	ATE3865T1 (da)
DE (1)	DE3160449D1 (da)
DK (1)	DK156400C (da)
GR (1)	GR73856B (da)
IE (1)	IE50895B1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU532110B2 (en) *	1979-11-13	1983-09-15	Ici Ltd.	Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
EP0065393B1 (en) *	1981-05-12	1984-12-27	Imperial Chemical Industries Plc	Pyrrole derivatives
US4556670A (en) *	1982-12-06	1985-12-03	Pfizer Inc.	Spiro-3-hetero-azolones for treatment of diabetic complications
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
US4464380A (en) *	1983-05-25	1984-08-07	Pfizer Inc.	Imidazolidinedione derivatives
DK277484A (da) *	1983-06-23	1984-12-24	Hoffmann La Roche	Thiazolidinderivater
EP0172352B1 (en) *	1984-06-22	1990-08-29	Beecham Group Plc	Active benzopyran compounds
WO1986000807A1 (en) *	1984-07-20	1986-02-13	Pfizer Inc.	Spiro-imidazolones for treatment of diabetes complications
ATE37371T1 (de) *	1984-08-20	1988-10-15	Pfizer	Verfahren zur herstellung asymmetrischer hydantoine.
US4966911A (en) *	1984-11-20	1990-10-30	Washington Research Foundation	Immunoregulatory agents
US5340829A (en) *	1984-11-20	1994-08-23	Washington Research Foundation	Immunoregulatory agents
JPH0772190B2 (ja) *	1985-02-26	1995-08-02	エーザイ株式会社	ヒダントイン誘導体
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
US4762839A (en) *	1985-06-06	1988-08-09	Tanabe Seiyaku Co., Ltd.	Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63126881A (ja) *	1986-11-14	1988-05-30	Sanwa Kagaku Kenkyusho Co Ltd	ヒダントイン誘導体、その塩、これらの製法並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPS63132889A (ja) *	1986-11-21	1988-06-04	Tanabe Seiyaku Co Ltd	キナゾリノン誘導体
FI901087A0 (fi) *	1987-09-04	1990-03-02	Pfizer	Azolidindionderivat.
US4952694A (en) *	1988-07-27	1990-08-28	Pfizer Inc.	Novel resolution process for racemic spiro-hydantoins
JPH05508386A (ja) *	1989-02-10	1993-11-25	ワシントン　リサーチ　ファンデション	免疫調整剤
JP2678499B2 (ja) *	1989-08-09	1997-11-17	日本臓器製薬株式会社	尿毒症毒素低下剤
JPH03215435A (ja) *	1990-01-12	1991-09-20	Sanwa Kagaku Kenkyusho Co Ltd	アルドース還元酵素阻害剤を主成分とする潰瘍治療剤
SK287922B6 (sk) *	2001-04-05	2012-04-03	Nissan Chemical Industries, Ltd.	Method for preparing a 7-qunolinyl-3,5-dihydroxyhept-6-enoate
WO2004028536A1 (en) *	2002-09-30	2004-04-08	Babizhayev Mark A	Method for topical treatment of eye disease and composition and device for said treatment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1135915B (de) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3534037A (en) *	1968-05-10	1970-10-13	Smithkline Corp	Spiro-(imidazolidine and pyrimidine-quinoline and cyclopropa(c)quinoline) compounds
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
US4117230A (en) *	1976-10-18	1978-09-26	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
US4177282A (en) *	1977-05-23	1979-12-04	Pfizer Inc.	Hydantoin therapeutic agents
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4176185A (en) *	1979-01-22	1979-11-27	Pfizer Inc.	Spiro-quinolylhydantoins
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives

1980
- 1980-02-12 US US06/120,944 patent/US4248882A/en not_active Expired - Lifetime
1981
- 1981-02-09 EP EP81300521A patent/EP0034063B1/en not_active Expired
- 1981-02-09 DE DE8181300521T patent/DE3160449D1/de not_active Expired
- 1981-02-09 AT AT81300521T patent/ATE3865T1/de not_active IP Right Cessation
- 1981-02-10 JP JP1886581A patent/JPS56127379A/ja active Granted
- 1981-02-11 GR GR64101A patent/GR73856B/el unknown
- 1981-02-11 IE IE261/81A patent/IE50895B1/en unknown
- 1981-02-11 DK DK056581A patent/DK156400C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3160449D1 (en)	1983-07-28
DK156400C (da)	1990-01-08
IE810261L (en)	1981-08-12
JPS56127379A (en)	1981-10-06
JPS6237636B2 (da)	1987-08-13
EP0034063B1 (en)	1983-06-22
ATE3865T1 (de)	1983-07-15
GR73856B (da)	1984-05-08
EP0034063A1 (en)	1981-08-19
US4248882A (en)	1981-02-03
IE50895B1 (en)	1986-08-06
DK156400B (da)	1989-08-14

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Legal Events

Date	Code	Title	Description
1991-10-21	PBP	Patent lapsed