DK59691A - Fremgangsmaade til fremstilling af liposomer med forbedret stabilitet under toerring - Google Patents

Fremgangsmaade til fremstilling af liposomer med forbedret stabilitet under toerring Download PDF

Info

Publication number
DK59691A
DK59691A DK059691A DK59691A DK59691A DK 59691 A DK59691 A DK 59691A DK 059691 A DK059691 A DK 059691A DK 59691 A DK59691 A DK 59691A DK 59691 A DK59691 A DK 59691A
Authority
DK
Denmark
Prior art keywords
procedure
improved stability
stability under
under drying
preparing liposomes
Prior art date
Application number
DK059691A
Other languages
Danish (da)
English (en)
Other versions
DK59691D0 (da
Inventor
Paul Gardner Schmidt
Gary Fujii
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestar Inc filed Critical Vestar Inc
Publication of DK59691D0 publication Critical patent/DK59691D0/da
Publication of DK59691A publication Critical patent/DK59691A/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277Preparation processes; Proliposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/829Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Cosmetics (AREA)
DK059691A 1988-10-05 1991-04-04 Fremgangsmaade til fremstilling af liposomer med forbedret stabilitet under toerring DK59691A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25368088A 1988-10-05 1988-10-05
PCT/US1989/004222 WO1990003795A1 (fr) 1988-10-05 1989-10-03 Procede de fabrication de liposomes a stabilite amelioree pendant le sechage

Publications (2)

Publication Number Publication Date
DK59691D0 DK59691D0 (da) 1991-04-04
DK59691A true DK59691A (da) 1991-04-04

Family

ID=22961272

Family Applications (1)

Application Number Title Priority Date Filing Date
DK059691A DK59691A (da) 1988-10-05 1991-04-04 Fremgangsmaade til fremstilling af liposomer med forbedret stabilitet under toerring

Country Status (13)

Country Link
US (1) US5817334A (fr)
EP (1) EP0437479B1 (fr)
JP (1) JP2792702B2 (fr)
AT (1) ATE107502T1 (fr)
AU (1) AU612285B2 (fr)
CA (1) CA2000219A1 (fr)
DE (1) DE68916439T2 (fr)
DK (1) DK59691A (fr)
FI (1) FI902249A7 (fr)
IE (1) IE64559B1 (fr)
IL (1) IL91901A (fr)
NO (1) NO180363C (fr)
WO (1) WO1990003795A1 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
AU2583892A (en) * 1991-09-11 1993-04-05 Pitman-Moore, Inc. Method for enhancing the immune system in a host employing liposome-encapsulated polypeptides
JP3329554B2 (ja) * 1993-03-10 2002-09-30 千葉製粉株式会社 乾燥小胞体
DE4341472A1 (de) * 1993-12-02 1995-06-08 Schering Ag Verfahren zur Erhöhung der Stabilität von hydrophile Wirkstoffe enthaltenden Liposomensuspensionen
US5589189A (en) * 1994-09-14 1996-12-31 Nexstar Pharmaceuticals, Inc. Liposome dispersion
CA2202103C (fr) * 1996-04-11 2007-01-09 Toshiaki Tagawa Methode de preparation d'une vesicule fermee
RU2144352C1 (ru) * 1997-07-16 2000-01-20 Российский научно-исследовательский институт гематологии и трансфузиологии Способ получения лиофилизированных липосом
GB9813100D0 (en) * 1998-06-18 1998-08-19 Secr Defence Method of forming liposomes
BR0010459A (pt) * 1999-03-11 2002-02-05 Fujisawa Pharmaceutical Co Preparação de lipossoma contendo derivado de ácido pipecólico e preparação sólida
CA2309373A1 (fr) * 1999-05-27 2000-11-27 Johnson & Johnson Consumer Companies, Inc. Preparations topiques nouvelles
ES2251134T3 (es) * 1999-06-08 2006-04-16 Gentium S.P.A. Uso de complejos entre liposomas cationicos y polidesoxirribonucleotidos como medicamentos.
EP1192466B1 (fr) * 1999-06-23 2004-08-11 Cornell Research Foundation, Inc. Deshydration/rehydration de liposomes marques sur un dispositif d'essai
US6576460B1 (en) 1999-10-28 2003-06-10 Cornell Research Foundation, Inc. Filtration-detection device and method of use
WO2002038128A1 (fr) * 2000-11-10 2002-05-16 Japan Science And Technology Corporation Procede de preparation d'une dispersion de microsome
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
ES2387886T3 (es) * 2001-11-13 2012-10-03 Celator Pharmaceuticals, Inc. Composiciones que transportan lípidos con una mejor estabilidad sanguínea
ATE478337T1 (de) 2002-05-31 2010-09-15 Cornell Res Foundation Inc Methoden zum nachweis analyten in proben
DE10233632A1 (de) * 2002-07-24 2004-02-05 Wilex Ag Formulierungen von Phenylalanin-Derivaten
AU2003268087A1 (en) * 2002-08-23 2004-03-11 Ian Ma Liposomal gemcitabine compositions for better drug delivery
EP1585504A4 (fr) * 2002-11-06 2009-07-15 Azaya Therapeutics Inc Preparations liposomales d'agents pharmaceutiques stabilisees par des proteines
US7521187B2 (en) * 2002-12-23 2009-04-21 Vical Incorporated Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
AU2003293196A1 (en) * 2002-12-23 2004-07-29 Vical Incorporated Method for producing sterile polynucleotide based medicaments
WO2005020893A2 (fr) * 2003-08-06 2005-03-10 The Regents Of The University Of California Plaquettes therapeutiques et methodes correspondantes
EP1750673B1 (fr) * 2004-05-17 2009-12-02 Tekmira Pharmaceuticals Corporation Formulations liposomales comprenant de la dihydrosphingomyéline, et procedés d'utilisation correspondants
FR2870741B1 (fr) * 2004-05-25 2008-03-14 Coletica Sa Phase lamellaires hydratees ou liposomes, contenant une monoamine grasse ou un polymere cationique favorisant la penetration intercellulaire, et composition cosmetique ou pharmaceutique la contenant.
WO2006050327A2 (fr) * 2004-10-28 2006-05-11 Alza Corporation Formulations de liposomes lyophilises et methode associee
WO2006068759A2 (fr) * 2004-11-22 2006-06-29 Magellan Companies, Inc. Liposomes contenant des agents phytochimique et methodes de fabrication et d'utilisation desdits agents
EP1932517A3 (fr) * 2006-12-11 2008-07-16 Universiteit Utrecht Holding B.V. Liposomes contenant des dérivés de polyphénols et son procédé de post-chargement
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
US8962015B2 (en) * 2007-09-28 2015-02-24 Sdg, Inc. Orally bioavailable lipid-based constructs
CN101485629B (zh) * 2008-01-16 2013-01-23 沈阳药科大学 一种给药系统及其制备方法
JP5903268B2 (ja) * 2008-07-24 2016-04-13 アモーレパシフィック コーポレイションAmorepacific Corporation 多層ラメラ顆粒、及びこれを含有する皮膚外用剤組成物
US8765171B2 (en) * 2009-03-09 2014-07-01 The Regents Of The University Of California Methods and compositions for liposomal formulation of antigens and uses thereof
US9775819B2 (en) 2009-09-16 2017-10-03 R.P. Scherer Technologies, Llc Oral solid dosage form containing nanoparticles and process of formulating the same using fish gelatin
US9980765B2 (en) 2010-02-15 2018-05-29 The General Hospital Corporation Methods and devices for selective disruption of visceral fat by controlled cooling
EP2386647A1 (fr) * 2010-05-10 2011-11-16 Qiagen GmbH Procédé de transfection d'une cellule eucaryote
EP2471511A1 (fr) 2011-01-04 2012-07-04 Archivel Farma, SL Formulation de liposome adaptée pour le traitement ou la prévention de la tuberculose
SI2768484T1 (sl) * 2011-10-21 2019-12-31 Jazz Pharmaceuticals Research Llc Liofilizirani liposomi
US10076496B2 (en) * 2011-11-11 2018-09-18 The Chinese University Of Hong Kong Engineering of polymer-stabilized nanoparticles for drugs with Log P values below 6 by controlled antisolvent precipitation
EA022183B1 (ru) * 2012-12-24 2015-11-30 Общество С Ограниченной Ответственностью "Технология Лекарств" Способ получения липосомальной формы цитохрома с
CA2958768C (fr) 2014-08-28 2023-08-29 The General Hospital Corporation Suspensions injectables et procedes de fabrication et d'utilisation associes
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11564830B2 (en) 2016-02-26 2023-01-31 The General Hospital Corporation Medical ice slurry production and delivery systems and methods
JP2022542571A (ja) * 2019-07-24 2022-10-05 ザ ジェネラル ホスピタル コーポレイション カプセル化により異なる凝固点を有する物質を作製する方法
CN114886785B (zh) * 2022-06-07 2023-02-03 美尚(广州)化妆品股份有限公司 一种三元冻干组合物及其在冻干制剂中的应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
CH621479A5 (fr) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4460577A (en) * 1977-09-30 1984-07-17 Farmitalia Carlo Erba S.P.A. Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US4377567A (en) * 1978-10-02 1983-03-22 The Procter & Gamble Company Lipid membrane drug delivery
CA1173360A (fr) * 1979-06-22 1984-08-28 Jurg Schrank Produits pharmaceutiques
JPS574913A (en) * 1980-06-11 1982-01-11 Green Cross Corp:The Urokinase preparation for oral administration
US4460560A (en) * 1982-06-18 1984-07-17 University Of Southern California Drug delivery by polymeric carriers
US4568545A (en) * 1982-10-02 1986-02-04 Amano Seiyaku Kabushiki Kaisha Thrombolytic agent
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
US5008109A (en) * 1984-05-25 1991-04-16 Vestar, Inc. Vesicle stabilization
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
WO1986003938A1 (fr) * 1985-01-11 1986-07-17 The Regents Of The University Of California Procede de conservation de liposomes
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
CA1256372A (fr) * 1985-04-11 1989-06-27 Koichiro Miyazima Procede de production de composes de liposomes
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4766046A (en) * 1985-09-27 1988-08-23 Liposome Technology, Inc. Stabilized liposome/amphotericin composition and method
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
GB8604983D0 (en) * 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
KR900700079A (ko) * 1988-01-12 1990-08-11 후지하라 도미오 누출방지 리포좀 제제
JPH02273538A (ja) * 1989-04-13 1990-11-08 Fuji Photo Film Co Ltd リポソームの保存方法
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials

Also Published As

Publication number Publication date
IE64559B1 (en) 1995-08-23
JP2792702B2 (ja) 1998-09-03
AU612285B2 (en) 1991-07-04
WO1990003795A1 (fr) 1990-04-19
IL91901A0 (en) 1990-06-10
JPH04500803A (ja) 1992-02-13
IE893196L (en) 1990-04-05
US5817334A (en) 1998-10-06
NO180363C (no) 1997-04-09
CA2000219A1 (fr) 1990-04-05
EP0437479A4 (en) 1991-10-16
FI902249A0 (fi) 1990-05-04
EP0437479A1 (fr) 1991-07-24
DK59691D0 (da) 1991-04-04
NO180363B (no) 1996-12-30
DE68916439T2 (de) 1994-10-20
IL91901A (en) 1993-06-10
FI902249A7 (fi) 1990-05-04
AU4340089A (en) 1990-05-01
NO901852D0 (no) 1990-04-26
ATE107502T1 (de) 1994-07-15
NO901852L (no) 1990-08-01
DE68916439D1 (de) 1994-07-28
EP0437479B1 (fr) 1994-06-22

Similar Documents

Publication Publication Date Title
DK59691A (da) Fremgangsmaade til fremstilling af liposomer med forbedret stabilitet under toerring
ATE114156T1 (de) Herstellung von proteinen in aktiver form.
SE8903777D0 (sv) Liposome/doxorubicin, komposition och foerfarande
EP0158277A3 (fr) Préparations implantables à libération contrôlée de peptides régulateurs et procédé pour leur fabrication
IE881755L (en) Novel proteins with factor viii activity, process for their¹preparation using genetically engineered cells and¹pharmaceutical compositions containing them
DK164479C (da) Sucralfatsuspension og fremgangsmaade til fremstilling af denne
FI102036B1 (fi) Menetelmä rasvaliukoisten aineiden stabiilien valmisteiden valmistamiseksi
DK0406856T3 (da) Stabiliseret FGF-komposition og fremstilling heraf
ATE92930T1 (de) Saponinkomplexe mit phospholipiden und sie enthaltende pharmazeutische und kosmetische zusammensetzungen.
DE69530196D1 (de) Methode zum verhindern der aggregation von proteinen/peptiden bei rehydratation oder auftauen
KR950005324A (ko) 인슐린 제제
IT1232827B (it) Proteine biologicamente attive, formulazioni che le contengono e metodo per prepararle ed applicarle
ES8305501A1 (es) Procedimiento para preparar un material de referencia o control de hemoglobina.
ATE15901T1 (de) Lipide und proteine in teilchenform enthaltender stoff und verfahren zu seiner herstellung.
HUT39971A (en) Pesticide compositions containing 3,5-diaryl-1,2,4-triazole derivatives as active ingredients and process for preparing the active substances
JPS54147916A (en) Preparation of urokinase injection
HUT44414A (en) Pesticide comprising 1,2,3,6 tetrahydro-5-nitropyrimidine derivatives as active substance and process for preparing the active substance
HUP9900506A2 (hu) Protrombinszármazékok
ES8607984A1 (es) Un procedimiento para cargar un polimero insoluble en agua yesponjable en agua con acetato de metilhidroxiprogesterona
ES8404160A1 (es) Un procedimiento para producir productos de plantas aromaticas.
HUT34766A (en) Process for producing new, natural lb-rh antagonistic peptides and erivatives, ndpharmaceutical compositions containing them as active ingredients
DK0740547T3 (da) Liposomer indeholdende deri indkapslede proteiner, fremgangsmåde til deres fremstilling, samt farmaceutiske og kosmetiske p
HUT35155A (en) Pesticide composition containing heterocyclic nitro-methylene derivatives as active substances and process for preparing the active substance
JPS5569595A (en) Novel substance having fibrinolytic activity, remedy for thrombotic embolic disease comprising it, and its preparation
Salamah et al. Effect of the virulence associated 47 megadalton plasmid of Yersinia pestis on permeability to gentian violet and sensitivity to novobiocin