|
DK528285D0
(da)
*
|
1985-11-15 |
1985-11-15 |
Novo Industri As |
Peptider samt praeparater indeholdende disse
|
|
SE8505921D0
(sv)
*
|
1985-12-13 |
1985-12-13 |
Kabigen Ab |
A method to export gene products to the growth medium of gram negative bacteria
|
|
SE8601940D0
(sv)
*
|
1986-04-25 |
1986-04-25 |
Kabigen Ab |
Preparation of fused proteins, antibodies and processes therefor
|
|
US5985599A
(en)
*
|
1986-05-29 |
1999-11-16 |
The Austin Research Institute |
FC receptor for immunoglobulin
|
|
ATE243754T1
(de)
*
|
1987-05-21 |
2003-07-15 |
Micromet Ag |
Multifunktionelle proteine mit vorbestimmter zielsetzung
|
|
WO1988009343A1
(fr)
*
|
1987-05-29 |
1988-12-01 |
Sagami Chemical Research Center |
Proteine fusionnee contenant une lymphotoxine
|
|
US5243040A
(en)
*
|
1987-11-20 |
1993-09-07 |
Creative Biomolecules |
DNA encoding a protein which enables selective removal of immune complexes
|
|
US5084398A
(en)
*
|
1987-11-20 |
1992-01-28 |
Creative Biomolecules |
Selective removal of immune complexes
|
|
AU623361B2
(en)
*
|
1987-11-20 |
1992-05-14 |
Creative Biomolecules, Inc. |
Selective removal of immune complexes
|
|
SE8800981D0
(sv)
*
|
1988-03-17 |
1988-03-17 |
Nygren Per Ake |
A recombinant fusion protein, its use and a recombinant vector
|
|
SE509359C2
(sv)
*
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
GB8927008D0
(en)
*
|
1989-11-29 |
1990-01-17 |
Ciba Geigy |
Novel process for the production of unfused protein in e.coli
|
|
US5681814A
(en)
*
|
1990-06-07 |
1997-10-28 |
Genentech, Inc. |
Formulated IGF-I Composition
|
|
US5595887A
(en)
*
|
1990-07-16 |
1997-01-21 |
Bionebraska, Inc. |
Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
|
|
US6077694A
(en)
*
|
1990-09-21 |
2000-06-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for over-expression and rapid purification of biosynthetic proteins
|
|
US5863783A
(en)
*
|
1991-03-27 |
1999-01-26 |
Gist-Brocades, N.V. |
Cloning and expression of DNA molecules encoding arabinan-degrading enzymes of fungal origin
|
|
AU2368892A
(en)
*
|
1991-07-29 |
1993-03-02 |
British Bio-Technology Limited |
Igf-ii analogues
|
|
US5989887A
(en)
*
|
1992-11-25 |
1999-11-23 |
Dsm N.V. |
Cloning and expression of DNA molecules incoding arabinan-degrading enzymes of fungal origin
|
|
SE9504019D0
(sv)
*
|
1995-11-13 |
1995-11-13 |
Pharmacia Ab |
Method for production of proteins
|
|
US5917026A
(en)
*
|
1996-02-05 |
1999-06-29 |
Loewenadler; Bjoern |
Fusion proteins of immunopotentiating activity
|
|
US5962270A
(en)
*
|
1996-02-06 |
1999-10-05 |
Bionebraska, Inc. |
Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
|
|
WO1998011913A1
(fr)
*
|
1996-09-16 |
1998-03-26 |
Dalhousie University |
Utilisation de l'igf-i pour le traitement des polykistoses renales et des troubles associes
|
|
US6593290B1
(en)
|
1996-11-01 |
2003-07-15 |
Genentech, Inc. |
Treatment of inner ear hair cells
|
|
US6156728A
(en)
|
1996-11-01 |
2000-12-05 |
Genentech, Inc. |
Treatment of inner ear hair cells
|
|
US6121416A
(en)
|
1997-04-04 |
2000-09-19 |
Genentech, Inc. |
Insulin-like growth factor agonist molecules
|
|
US6420518B1
(en)
|
1997-04-04 |
2002-07-16 |
Genetech, Inc. |
Insulin-like growth factor agonist molecules
|
|
IL143834A0
(en)
|
1999-01-06 |
2002-04-21 |
Genentech Inc |
Insulin-like growth factor (igf) i mutant variants
|
|
DE60016560T2
(de)
|
1999-01-06 |
2005-12-15 |
Genentech, Inc., South San Francisco |
Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i)
|
|
DK1165119T3
(da)
|
1999-04-08 |
2003-12-15 |
Genentech Inc |
Sammensætning baseret på modsat ladede polypeptider
|
|
DE60133271T2
(de)
|
2000-05-16 |
2009-04-23 |
Genentech, Inc., South San Francisco |
Behandlung von knorpelerkrankungen
|
|
US20030157561A1
(en)
*
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
|
SE0200943D0
(sv)
|
2002-03-25 |
2002-03-25 |
Amersham Biosciences Ab |
Mutant protein
|
|
US20050003548A1
(en)
*
|
2002-07-22 |
2005-01-06 |
Nikolay Korokhov |
Targeted adenoviral vector displaying immunoglobulin-binding domain and uses thereof
|
|
ATE536186T1
(de)
|
2003-09-12 |
2011-12-15 |
Tercica Inc |
Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel
|
|
CA2541015A1
(fr)
*
|
2003-10-03 |
2005-04-14 |
Genentech, Inc. |
Proteines de liaison a l'igf
|
|
EP1732613A2
(fr)
|
2004-04-06 |
2006-12-20 |
Affibody AB |
Utilisation de conjugues comprenant un peptide capable de lier l'albumine serique pour la preparation de medicament
|
|
EP2465870A1
(fr)
|
2005-11-07 |
2012-06-20 |
Genentech, Inc. |
Polypeptides de liaison dotés de séquences hypvervariables VH/VL diversifiées et consensuelles
|
|
RU2470941C2
(ru)
|
2005-12-02 |
2012-12-27 |
Дженентек, Инк. |
Связывающие полипептиды и их применения
|
|
JP2008048607A
(ja)
|
2006-08-22 |
2008-03-06 |
Chisso Corp |
Fc結合ドメインとカルシウム結合発光蛋白質との融合蛋白質、それをコードする遺伝子およびそれらの用途
|
|
GB2442118B
(en)
*
|
2006-09-19 |
2011-08-17 |
Chisso Corp |
Process for production of recombinant proteins as a soluble form
|
|
WO2008127457A2
(fr)
|
2006-12-06 |
2008-10-23 |
Repligen Corporation |
Acides nucléiques codant pour la protéine recombinée a
|
|
US8198043B2
(en)
*
|
2006-12-08 |
2012-06-12 |
General Electric Company |
Two helix binders
|
|
US8592555B2
(en)
|
2008-08-11 |
2013-11-26 |
Emd Millipore Corporation |
Immunoglobulin-binding proteins with improved specificity
|
|
SG195555A1
(en)
*
|
2008-12-24 |
2013-12-30 |
Emd Millipore Corp |
Caustic stable chromatography ligands
|
|
US9403883B2
(en)
|
2009-03-24 |
2016-08-02 |
Kaneka Corporation |
Protein having affinity for immunoglobulin, and immunoglobulin-binding affinity ligand
|
|
JP5501439B2
(ja)
|
2009-04-02 |
2014-05-21 |
ロシュ グリクアート アクチェンゲゼルシャフト |
完全長抗体と単鎖Fabフラグメントとを含む多重特異的抗体
|
|
SG10201408401RA
(en)
|
2009-09-16 |
2015-01-29 |
Genentech Inc |
Coiled coil and/or tether containing protein complexes and uses thereof
|
|
JP5951509B2
(ja)
*
|
2010-03-08 |
2016-07-13 |
ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ |
免疫グロブリンGFc領域結合ポリペプチド
|
|
CN107188936B
(zh)
|
2010-03-24 |
2021-08-10 |
株式会社钟化 |
特异性结合免疫球蛋白的蛋白质以及免疫球蛋白结合性亲和配体
|
|
AR080793A1
(es)
|
2010-03-26 |
2012-05-09 |
Roche Glycart Ag |
Anticuerpos biespecificos
|
|
MX346731B
(es)
|
2010-04-23 |
2017-03-30 |
Genentech Inc * |
Producción de proteínas heteromultiméricas.
|
|
MX2013001267A
(es)
|
2010-08-13 |
2013-04-10 |
Genentech Inc |
ANTICUERPOS A IL-1ß E EIL-18 PARA TRATAMIENTO DE ENFERMEDAD.
|
|
WO2012025530A1
(fr)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann-La Roche Ag |
Anticorps bispécifiques comprenant un fragment fv stabilisé par bisulfure
|
|
CN103269762B
(zh)
|
2010-12-20 |
2016-01-27 |
通用电气健康护理生物科学股份公司 |
亲和色谱基质
|
|
EP2654915B1
(fr)
|
2010-12-20 |
2018-10-24 |
GE Healthcare BioProcess R&D AB |
Matrice de chromatographie par affinité
|
|
EP2655413B1
(fr)
|
2010-12-23 |
2019-01-16 |
F.Hoffmann-La Roche Ag |
Complexe polypeptide-polynucléotide et son utilisation dans l'administration d'une fraction effectrice ciblée
|
|
AR085138A1
(es)
|
2011-02-04 |
2013-09-11 |
Genentech Inc |
VARIANTES DE Fc Y METODOS PARA SU PRODUCCION
|
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
|
KR20140007394A
(ko)
*
|
2011-03-25 |
2014-01-17 |
가부시키가이샤 가네카 |
면역 글로불린 결합성 신규 폴리펩티드
|
|
SG10201604559TA
(en)
|
2011-06-08 |
2016-07-28 |
Emd Millipore Corp |
Chromatography matrices including novel staphylococcus aureus protein a based ligands
|
|
KR102492792B1
(ko)
|
2011-10-11 |
2023-01-30 |
제넨테크, 인크. |
이중특이적 항체의 개선된 어셈블리
|
|
CN104105711B
(zh)
|
2012-02-10 |
2018-11-30 |
弗·哈夫曼-拉罗切有限公司 |
单链抗体及其他异多聚体
|
|
WO2013147691A1
(fr)
|
2012-03-28 |
2013-10-03 |
Ge Healthcare Bio-Sciences Ab |
Matrice de chromatographie par affinité
|
|
MX2014014804A
(es)
|
2012-06-27 |
2015-02-12 |
Hoffmann La Roche |
Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
|
|
HK1207864A1
(zh)
|
2012-06-27 |
2016-02-12 |
F. Hoffmann-La Roche Ag |
用於选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
|
|
EP3019520B1
(fr)
|
2013-07-10 |
2019-12-11 |
GE Healthcare BioProcess R&D AB |
Polypeptides de liaison à une immunoglobuline mutante
|
|
JP6491600B2
(ja)
|
2013-09-27 |
2019-03-27 |
株式会社カネカ |
アルカリ水溶液を用いた多孔質セルロースビーズの製造方法
|
|
BR112016024462B1
(pt)
|
2014-05-06 |
2022-12-27 |
Genentech, Inc |
Métodos para a preparação de um anticorpo
|
|
US11566082B2
(en)
|
2014-11-17 |
2023-01-31 |
Cytiva Bioprocess R&D Ab |
Mutated immunoglobulin-binding polypeptides
|
|
ES2764111T3
(es)
|
2014-12-03 |
2020-06-02 |
Hoffmann La Roche |
Anticuerpos multiespecíficos
|
|
WO2016121701A1
(fr)
|
2015-01-26 |
2016-08-04 |
株式会社カネカ |
Matrice pour séparation par affinité destinée à la purification de protéines contenant la région variable de la chaîne kappa des immunoglobulines
|
|
CN108064286A
(zh)
|
2015-01-26 |
2018-05-22 |
株式会社钟化 |
突变型免疫球蛋白κ链可变区结合性肽
|
|
JP6424101B2
(ja)
*
|
2015-01-30 |
2018-11-14 |
Jnc株式会社 |
Fc結合ドメインとカルシウム結合発光蛋白質との融合蛋白質、それをコードする遺伝子およびそれらの用途
|
|
EP3255058B1
(fr)
|
2015-02-05 |
2021-03-24 |
Mitsubishi Chemical Corporation |
Protéine présentant une affinité pour l'immunoglobuline et milieu de séparation par affinité et colonne pour chromatographie en phase liquide l'utilisant
|
|
WO2017195638A1
(fr)
|
2016-05-09 |
2017-11-16 |
株式会社カネカ |
Procédé de purification d'un anticorps ou d'un fragment d'anticorps comportant une région variable de chaîne κ
|
|
JP7106187B2
(ja)
|
2016-05-11 |
2022-07-26 |
サイティバ・バイオプロセス・アールアンドディ・アクチボラグ |
分離マトリックスを保存する方法
|
|
JP7031934B2
(ja)
|
2016-05-11 |
2022-03-08 |
サイティバ・バイオプロセス・アールアンドディ・アクチボラグ |
分離マトリックス
|
|
US10889615B2
(en)
|
2016-05-11 |
2021-01-12 |
Cytiva Bioprocess R&D Ab |
Mutated immunoglobulin-binding polypeptides
|
|
US10703774B2
(en)
|
2016-09-30 |
2020-07-07 |
Ge Healthcare Bioprocess R&D Ab |
Separation method
|
|
ES2909833T3
(es)
|
2016-05-11 |
2022-05-10 |
Cytiva Bioprocess R & D Ab |
Método de limpieza y/o desinfección de una matriz de separación
|
|
US10654887B2
(en)
|
2016-05-11 |
2020-05-19 |
Ge Healthcare Bio-Process R&D Ab |
Separation matrix
|
|
ES2874974T3
(es)
|
2016-05-11 |
2021-11-05 |
Cytiva Bioprocess R & D Ab |
Matriz de separación
|
|
US10730908B2
(en)
|
2016-05-11 |
2020-08-04 |
Ge Healthcare Bioprocess R&D Ab |
Separation method
|
|
US12448411B2
(en)
|
2016-09-30 |
2025-10-21 |
Cytiva Bioprocess R&D Ab |
Separation method
|
|
CA3072288A1
(fr)
|
2017-08-07 |
2019-02-14 |
Repligen Corporation |
Proteines de liaison fc avec la cysteine dans la region helicoidale c-terminale
|
|
EP3521304B9
(fr)
|
2018-02-01 |
2023-10-04 |
Repligen Corporation |
Protéines de liaison fc avec la cystéine dans la région hélicoïdale c-terminale
|
|
GB202018588D0
(en)
|
2020-11-26 |
2021-01-13 |
Cytiva Bioprocess R & D Ab |
Separation matrix
|
|
GB202113626D0
(en)
|
2021-09-24 |
2021-11-10 |
Cytiva Bioprocess R & D Ab |
FC binding polypeptides
|
|
WO2026057420A1
(fr)
|
2024-09-10 |
2026-03-19 |
Cytiva Bioprocess R&D Ab |
Ligand d'affinité pour la purification d'anticorps d'isotype iga
|