DK646688D0 - Farmaceutiske praeparater - Google Patents

Farmaceutiske praeparater

Info

Publication number
DK646688D0
DK646688D0 DK646688A DK646688A DK646688D0 DK 646688 D0 DK646688 D0 DK 646688D0 DK 646688 A DK646688 A DK 646688A DK 646688 A DK646688 A DK 646688A DK 646688 D0 DK646688 D0 DK 646688D0
Authority
DK
Denmark
Prior art keywords
melphalan
pharmaceutical preparations
hydrochloride
substantially pure
mephalan
Prior art date
Application number
DK646688A
Other languages
English (en)
Other versions
DK646688A (da
DK172794B1 (da
Inventor
Stephen William Poole
Timothy Paul Stanley
Geoffrey Divall
Terence William Packham
Joseph Knight
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK646688D0 publication Critical patent/DK646688D0/da
Publication of DK646688A publication Critical patent/DK646688A/da
Application granted granted Critical
Publication of DK172794B1 publication Critical patent/DK172794B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
DK198806466A 1987-11-19 1988-11-18 Farmaceutisk melphalanpræparat, fremgangsmåde til fremstilling heraf og fremgangsmåde til fremstilling af i det væsentlige DK172794B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878727157A GB8727157D0 (en) 1987-11-19 1987-11-19 Pharmaceutical formulations
GB8727157 1987-11-19

Publications (3)

Publication Number Publication Date
DK646688D0 true DK646688D0 (da) 1988-11-18
DK646688A DK646688A (da) 1989-05-20
DK172794B1 DK172794B1 (da) 1999-07-19

Family

ID=10627252

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198806466A DK172794B1 (da) 1987-11-19 1988-11-18 Farmaceutisk melphalanpræparat, fremgangsmåde til fremstilling heraf og fremgangsmåde til fremstilling af i det væsentlige

Country Status (22)

Country Link
US (1) US4997651A (da)
EP (1) EP0317281B1 (da)
JP (1) JP2693191B2 (da)
KR (1) KR970002607B1 (da)
AT (1) ATE83922T1 (da)
AU (1) AU619781B2 (da)
CA (1) CA1341114C (da)
DE (1) DE3877151T2 (da)
DK (1) DK172794B1 (da)
ES (1) ES2052745T3 (da)
FI (2) FI90204C (da)
GB (1) GB8727157D0 (da)
GR (1) GR3007287T3 (da)
HK (1) HK108994A (da)
HU (3) HU203197B (da)
IE (1) IE63996B1 (da)
IL (1) IL88419A (da)
LV (1) LV10179B (da)
NZ (2) NZ239867A (da)
PT (1) PT89028B (da)
SG (1) SG73894G (da)
ZA (1) ZA888674B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407672A (en) * 1993-04-08 1995-04-18 Cornell Research Foundation, Inc. Enhancing the anti-tumor effect of melphalan with L-amino acid oxidase
US5695751A (en) * 1993-04-08 1997-12-09 Cornell Research Foundation, Inc. Enhancing delivery of large neutral amino acid drugs
US6020004A (en) * 1997-04-17 2000-02-01 Amgen Inc. Biodegradable microparticles for the sustained delivery of therapeutic drugs
US5980904A (en) * 1998-11-18 1999-11-09 Amway Corporation Skin whitening composition containing bearberry extract and a reducing agent
GB2386066A (en) * 2002-02-28 2003-09-10 Norbrook Lab Ltd Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species
AU2003253681B2 (en) * 2002-06-24 2008-05-01 Research Development Foundation Treatment of human multiple myeloma by Curcumin
EP1694335A4 (en) 2003-08-26 2008-12-31 Res Dev Foundation OSTEOCLASTOGENESIS INHIBITORS AND USES THEREOF
US8501818B2 (en) 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US8501817B2 (en) 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US7872050B2 (en) 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
AR066943A1 (es) * 2008-06-10 2009-09-23 Eriochem Sa Una composicion farmaceutica de melfalano
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
KR101522918B1 (ko) * 2009-05-29 2015-05-27 사이덱스 파마슈티칼스, 인크. 사이클로덱스트린 유도체를 포함하는 주사용 멜팔란 조성물 및 이의 제조 및 사용 방법
AR077384A1 (es) 2010-07-05 2011-08-24 Eriochem Sa Una formulacion farmaceutica inyectable de melfalano.
US8921596B2 (en) * 2010-11-04 2014-12-30 Emcure Pharmaceuticals, Ltd. Process for the preparation of melphalan hydrochloride
SI3228319T1 (sl) 2011-04-28 2020-10-30 Oncopeptides Ab Liofiliziran pripravek citotoksičnih dipeptidov
JP6284945B2 (ja) * 2012-10-26 2018-02-28 オンコペプティデス エービーＯｎｃｏｐｅｐｔｉｄｅｓ ＡＢ メルファランフルフェナミドの凍結乾燥製剤
EP2970102B1 (en) 2013-03-11 2019-05-08 Biophore India Pharmaceuticals Pvt. Ltd. An improved process for the synthesis of melphalan and the hydrochloride salt
ITMI20130896A1 (it) 2013-05-31 2014-12-01 Farmabios Spa Processo di purificazione di melphalan
US10576101B2 (en) 2015-03-06 2020-03-03 Leadiant Biosciences Sa Roneparstat combined therapy of multiple myeloma
WO2017002030A1 (en) * 2015-06-30 2017-01-05 Leiutis Pharmaceuticals Pvt Ltd Stable liquid formulations of melphalan
JP7464995B2 (ja) * 2018-03-29 2024-04-10 プロジェクト ファーマシューティクス ゲーエムベーハー 液体薬学的製剤
US10682326B1 (en) 2019-06-03 2020-06-16 Shilpa Medicare Limited Stable melphalan liquid injectable formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB750155A (en) * 1953-03-17 1956-06-13 Nat Res Dev Substituted alanines
US3032585A (en) * 1954-12-03 1962-05-01 Nat Res Dev Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine
DE1292660B (de) * 1963-04-24 1969-04-17 Ural Polytechnitscheskij I Im Verfahren zur Herstellung von p-(Bis-ª‰-chloraethyl-amino)-phenylalanin-hydrochlorid
US4029778A (en) * 1969-01-23 1977-06-14 Aktiebolaget Leo Cortical steroid nitrogen mustard compositions and treatment therewith
RO57195A2 (da) * 1970-11-30 1974-09-01
FR2285855A1 (fr) * 1974-09-25 1976-04-23 Kohjin Co Composition therapeutique lyophilisee a base de sel de cyclocytidine et son procede de preparation
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
US4696814A (en) * 1985-08-21 1987-09-29 Warner-Lambert Company Parenteral phenytoin compositions
JPS62192357A (ja) * 1986-02-19 1987-08-22 Kureha Chem Ind Co Ltd Ｎ−フタロイル−ｐ−ニトロ−Ｌ−フエニルアラニンの製造方法

Also Published As

Publication number Publication date
HUT48198A (en) 1989-05-29
GR3007287T3 (da) 1993-07-30
DK646688A (da) 1989-05-20
FI102275B1 (fi) 1998-11-13
DK172794B1 (da) 1999-07-19
HU203197B (en) 1991-06-28
FI924668A0 (fi) 1992-10-15
DE3877151D1 (de) 1993-02-11
ATE83922T1 (de) 1993-01-15
US4997651A (en) 1991-03-05
EP0317281B1 (en) 1992-12-30
DE3877151T2 (de) 1993-07-15
FI102275B (fi) 1998-11-13
AU619781B2 (en) 1992-02-06
KR970002607B1 (ko) 1997-03-06
LV10179B (en) 1995-06-20
HU206671B (en) 1992-12-28
AU2574888A (en) 1989-05-25
PT89028B (pt) 1993-02-26
ZA888674B (en) 1990-07-25
NZ239867A (en) 1992-11-25
IE883447L (en) 1989-05-19
EP0317281A3 (en) 1989-08-09
IL88419A (en) 1993-03-15
FI885358A0 (fi) 1988-11-18
JPH01153628A (ja) 1989-06-15
HU9100335D0 (en) 1991-08-28
CA1341114C (en) 2000-10-10
ES2052745T3 (es) 1994-07-16
FI924668L (fi) 1992-10-15
JP2693191B2 (ja) 1997-12-24
HK108994A (en) 1994-10-14
PT89028A (pt) 1988-12-01
FI90204B (fi) 1993-09-30
GB8727157D0 (en) 1987-12-23
IL88419A0 (en) 1989-06-30
FI885358L (fi) 1989-05-20
HU207286B (en) 1993-03-29
HU910336D0 (en) 1991-08-28
EP0317281A2 (en) 1989-05-24
SG73894G (en) 1994-11-25
FI90204C (fi) 1994-01-10
IE63996B1 (en) 1995-06-28
KR890007729A (ko) 1989-07-05
LV10179A (lv) 1994-10-20
NZ227004A (en) 1992-11-25

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired