DK65193A - 4,5-dihydro-2-(substitueret phenyl)-1,2,4-triazin-3,5(3h)-dionforbindelser, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse forbindelser - Google Patents

4,5-dihydro-2-(substitueret phenyl)-1,2,4-triazin-3,5(3h)-dionforbindelser, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse forbindelser

Info

Publication number
DK65193A
DK65193A DK065193A DK65193A DK65193A DK 65193 A DK65193 A DK 65193A DK 065193 A DK065193 A DK 065193A DK 65193 A DK65193 A DK 65193A DK 65193 A DK65193 A DK 65193A
Authority
DK
Denmark
Prior art keywords
compounds
dihydro
preparing
substituted phenyl
triazin
Prior art date
Application number
DK065193A
Other languages
English (en)
Other versions
DK65193D0 (da
Inventor
Gustaaf Maria Boeckx
Alfons Herman Marg Raeymaekers
Victor Sipido
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK65193D0 publication Critical patent/DK65193D0/da
Publication of DK65193A publication Critical patent/DK65193A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
DK065193A 1986-01-30 1993-06-04 4,5-dihydro-2-(substitueret phenyl)-1,2,4-triazin-3,5(3h)-dionforbindelser, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse forbindelser DK65193A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868602342A GB8602342D0 (en) 1986-01-30 1986-01-30 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones

Publications (2)

Publication Number Publication Date
DK65193D0 DK65193D0 (da) 1993-06-04
DK65193A true DK65193A (da) 1993-06-04

Family

ID=10592258

Family Applications (2)

Application Number Title Priority Date Filing Date
DK048187A DK169032B1 (da) 1986-01-30 1987-01-29 5,6-dihydro-2-(substitueret phenyl)-1,2,4-triazin-3,5(2H, 4H)-dioner, fremgangsmåde til fremstilling deraf og præparater indeholdende disse forbindelser
DK065193A DK65193A (da) 1986-01-30 1993-06-04 4,5-dihydro-2-(substitueret phenyl)-1,2,4-triazin-3,5(3h)-dionforbindelser, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse forbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK048187A DK169032B1 (da) 1986-01-30 1987-01-29 5,6-dihydro-2-(substitueret phenyl)-1,2,4-triazin-3,5(2H, 4H)-dioner, fremgangsmåde til fremstilling deraf og præparater indeholdende disse forbindelser

Country Status (21)

Country Link
US (3) US4767760A (da)
EP (1) EP0232932B1 (da)
JP (2) JPH0813806B2 (da)
CN (1) CN1017049B (da)
AT (1) ATE59644T1 (da)
AU (1) AU586731B2 (da)
CA (2) CA1288772C (da)
DE (1) DE3766839D1 (da)
DK (2) DK169032B1 (da)
ES (1) ES2031876T3 (da)
FI (1) FI94634C (da)
GB (1) GB8602342D0 (da)
GR (1) GR3001392T3 (da)
IE (1) IE59510B1 (da)
IL (1) IL81421A (da)
NO (1) NO172690C (da)
NZ (1) NZ218973A (da)
PT (1) PT84218B (da)
RU (1) RU2017736C1 (da)
SU (1) SU1595339A3 (da)
ZA (1) ZA87672B (da)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097779A (en) * 1976-04-05 1978-06-27 Gte Sylvania Incorporated Fluorescent lamp containing a cathode heater circuit disconnect device
US4156831A (en) * 1978-05-24 1979-05-29 Gte Sylvania Incorporated Fluorescent lamp having heater circuit disconnect device

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
DE3826058A1 (de) * 1988-07-30 1990-02-08 Bayer Ag Mittel gegen fischparasiten
EP0377903A3 (de) * 1989-01-09 1991-07-17 Bayer Ag Substituierte Hexahydro-1,2,4-triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
DE58905324D1 (de) * 1989-01-09 1993-09-23 Bayer Ag Mittel gegen protozoen bei insekten.
CN1044905A (zh) * 1989-02-16 1990-08-29 赫彻斯特股份公司 鱼和昆虫寄生虫对抗剂
CA2012004A1 (en) * 1989-03-15 1990-09-15 Frank Ellis Chemical compounds
DE4120138A1 (de) * 1991-06-19 1992-12-24 Bayer Ag Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
US5994355A (en) * 1993-10-15 1999-11-30 Takeda Chemical Industries, Ltd. 1, 2, 4-Triazin-3-one derivatives, production and use thereof
TW403741B (en) * 1993-10-15 2000-09-01 Takeda Chemical Industries Ltd Triazine derivative, production and use thereof
EP0737672B1 (en) * 1995-04-14 2001-10-04 Takeda Schering-Plough Animal Health K.K. Method of producing triazine derivatives
US5747476A (en) * 1996-07-17 1998-05-05 Mortar & Pestle Veterinary Pharmacy, Inc. Treatment of equine protozoal myeloencephalitis
US5985875A (en) * 1996-08-30 1999-11-16 Takeda Chemical Industries, Ltd. 1,2,4-triazine-3, 5-dione derivatives, their production and use thereof
WO1998043644A1 (en) * 1997-03-31 1998-10-08 David Granstrom Formulations and methods to treat and prevent equine protozoal myeloencephalitis
US5883095A (en) * 1997-08-07 1999-03-16 University Of Kentucky Research Foundation Formulations and methods to treat and prevent equine protozoal myeloencephalitis
US5830893A (en) * 1997-04-23 1998-11-03 Mortar & Pestle Veterinary Pharmacy, Inc. Treatment of equine protozoan myeloencephalitis using triazinediones
US6867207B2 (en) 1997-07-10 2005-03-15 Janssen Pharmaceutica N.V. IL-5 inhibiting 6-azauracil derivatives
WO1999002504A1 (en) 1997-07-10 1999-01-21 Janssen Pharmaceutica N.V. 6-azauracil derivatives as il-5 inhibitors
IL133916A0 (en) * 1997-07-10 2001-04-30 Janssen Pharmaceutica Nv Il-5 inhibiting 6-azauracil derivatives
TW450964B (en) 1997-08-29 2001-08-21 Takeda Schering Plough Animal Triazine derivatives, their production and use
WO2000006172A1 (en) * 1998-07-27 2000-02-10 Mortar & Pestle Veterinary Pharmacy, Inc. Treatment of equine protozoan myeloencephalitis using triazinediones
EP0987265A1 (en) 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
WO2000019964A2 (en) * 1998-10-08 2000-04-13 New Ace Research Company Novel compositions and methods for prevention and treatment of protozoal disease
CA2354511A1 (en) 1998-12-18 2000-06-29 Janssen Pharmaceutica N.V. Il-5 inhibiting 6-azauracil derivatives
TR200200310T2 (tr) 1999-08-06 2002-08-21 Janssen Pharmaceutica N.V. Interlökin-5 inhibe eden 6-azaurasil türevleri.
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
CN107746390B (zh) * 2017-11-21 2021-03-16 连云港市亚晖医药化工有限公司 抗球虫药地克珠利的制备方法
CN113999139A (zh) * 2021-12-03 2022-02-01 杭州臻峰科技有限公司 制备2，6-二氯-α-（4-氯代苯基） -4-硝基苯乙腈的方法
CN119161311B (zh) * 2024-11-20 2025-02-11 北京纳百生物科技有限公司 一种地克珠利抗原及其合成方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905971A (en) * 1971-03-29 1975-09-16 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
US3912723A (en) * 1971-03-29 1975-10-14 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
GB1448696A (en) * 1973-05-29 1976-09-08 Pfizer 2-phqnyl-astriazine-3,4-2h,4h-diones
DE3408924A1 (de) * 1984-03-12 1985-09-26 Hoechst Ag, 6230 Frankfurt Substituierte 2-phenyl-hexahydro-1,2,4-triazin-3,5-dione, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
CA1244024A (en) * 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
US4631278A (en) * 1984-08-01 1986-12-23 Janssen Pharmaceutica N.V. Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097779A (en) * 1976-04-05 1978-06-27 Gte Sylvania Incorporated Fluorescent lamp containing a cathode heater circuit disconnect device
US4156831A (en) * 1978-05-24 1979-05-29 Gte Sylvania Incorporated Fluorescent lamp having heater circuit disconnect device

Also Published As

Publication number Publication date
JPS62190174A (ja) 1987-08-20
DK65193D0 (da) 1993-06-04
CA1288772C (en) 1991-09-10
JP2622510B2 (ja) 1997-06-18
PT84218A (en) 1987-02-01
GR3001392T3 (en) 1992-09-11
FI870421A0 (fi) 1987-01-30
US4767760A (en) 1988-08-30
ZA87672B (en) 1988-09-28
DK48187A (da) 1987-07-31
NO870378L (no) 1987-07-31
CN87100531A (zh) 1987-09-02
IL81421A (en) 1991-11-21
PT84218B (pt) 1989-07-31
FI870421A7 (fi) 1987-07-31
JPH07285949A (ja) 1995-10-31
US4912106A (en) 1990-03-27
NO870378D0 (no) 1987-01-29
NO172690B (no) 1993-05-18
SU1595339A3 (ru) 1990-09-23
DK48187D0 (da) 1987-01-29
EP0232932B1 (en) 1991-01-02
IE870231L (en) 1987-07-30
FI94634B (fi) 1995-06-30
AU586731B2 (en) 1989-07-20
IL81421A0 (en) 1987-08-31
EP0232932A1 (en) 1987-08-19
ES2031876T3 (es) 1993-01-01
IE59510B1 (en) 1994-03-09
US4952570A (en) 1990-08-28
JPH0813806B2 (ja) 1996-02-14
FI94634C (fi) 1995-10-10
CN1017049B (zh) 1992-06-17
RU2017736C1 (ru) 1994-08-15
NO172690C (no) 1993-08-25
AU6813487A (en) 1987-08-06
GB8602342D0 (en) 1986-03-05
ATE59644T1 (de) 1991-01-15
NZ218973A (en) 1988-10-28
CA1302411C (en) 1992-06-02
DE3766839D1 (de) 1991-02-07
DK169032B1 (da) 1994-08-01

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