DK669889A - Insulinderivater, deres fremstilling og anvendelse - Google Patents

Insulinderivater, deres fremstilling og anvendelse Download PDF

Info

Publication number: DK669889A
Authority: DK; Denmark
Prior art keywords: basic; amino acid; insulin derivatives; insulin; preparation
Prior art date: 1988-12-29

Application number

DK669889A

Other languages

English (en)

Other versions

DK173178B1 (da

DK669889D0 (da

Inventor

Laszlo Vertesy

Karl Geisen

Guenther Johannes Riess

Klaus Sauber

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-29

Filing date

1989-12-28

Publication date

1990-06-30

1989-12-28 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-12-28 Publication of DK669889D0 publication Critical patent/DK669889D0/da

1990-06-30 Publication of DK669889A publication Critical patent/DK669889A/da

2000-03-06 Application granted granted Critical

2000-03-06 Publication of DK173178B1 publication Critical patent/DK173178B1/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 2
239000004475 Arginine Substances 0.000 abstract 1
101001011741 Bos taurus Insulin Proteins 0.000 abstract 1
150000008575 L-amino acids Chemical class 0.000 abstract 1
150000001371 alpha-amino acids Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
150000001408 amides Chemical group 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
IXIBAKNTJSCKJM-BUBXBXGNSA-N bovine insulin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 IXIBAKNTJSCKJM-BUBXBXGNSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003111 delayed effect Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
150000002148 esters Chemical group 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
150000002596 lactones Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
125000000962 organic group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

DK198906698A 1988-12-29 1989-12-28 Insulinderivater samt disse forbindelsers fysiologisk tålelige salte, fremgangsmåde til fremstilling deraf, anvendelse af d DK173178B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3844211		1988-12-29
DE3844211A DE3844211A1 (de)	1988-12-29	1988-12-29	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (3)

Publication Number	Publication Date
DK669889D0 DK669889D0 (da)	1989-12-28
DK669889A true DK669889A (da)	1990-06-30
DK173178B1 DK173178B1 (da)	2000-03-06

Family

ID=6370457

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198906698A DK173178B1 (da)	1988-12-29	1989-12-28	Insulinderivater samt disse forbindelsers fysiologisk tålelige salte, fremgangsmåde til fremstilling deraf, anvendelse af d

Country Status (20)

Country	Link
US (1)	US5506202A (da)
EP (1)	EP0376156B1 (da)
JP (1)	JP3129722B2 (da)
KR (1)	KR900009698A (da)
AT (1)	ATE136038T1 (da)
AU (1)	AU623963B2 (da)
CA (1)	CA2006818C (da)
DE (2)	DE3844211A1 (da)
DK (1)	DK173178B1 (da)
ES (1)	ES2085271T3 (da)
FI (1)	FI102843B (da)
GR (1)	GR3019560T3 (da)
HU (1)	HU205172B (da)
IE (1)	IE73672B1 (da)
IL (1)	IL92905A (da)
NO (1)	NO180379C (da)
NZ (1)	NZ231944A (da)
PH (1)	PH27425A (da)
PT (1)	PT92757B (da)
ZA (1)	ZA899946B (da)

Families Citing this family (45)

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DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
DE3936876A1 (de) *	1989-11-06	1991-05-23	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
TW224471B (da) *	1991-11-26	1994-06-01	Lilly Co Eli
US6251856B1 (en)	1995-03-17	2001-06-26	Novo Nordisk A/S	Insulin derivatives
CA2215694A1 (en) *	1995-03-17	1996-09-26	Novo Nordisk A/S	Insulin derivatives
US6444641B1 (en)	1997-10-24	2002-09-03	Eli Lilly Company	Fatty acid-acylated insulin analogs
US6746853B1 (en)	1999-05-19	2004-06-08	Xencor, Inc.	Proteins with insulin-like activity useful in the treatment of diabetes
US6323311B1 (en)	1999-09-22	2001-11-27	University Of Utah Research Foundation	Synthesis of insulin derivatives
AU2002346490A1 (en) *	2001-12-20	2003-07-09	Eli Lilly And Company	Insulin molecule having protracted time action
WO2004096854A2 (en) *	2003-04-29	2004-11-11	Eli Lilly And Company	Insulin analogs having protracted time action
CN101291683B (zh) *	2004-11-24	2011-08-17	纽普罗研究有限公司	治疗疾病的方法和组合物
US7833513B2 (en)	2004-12-03	2010-11-16	Rhode Island Hospital	Treatment of Alzheimer's Disease
TWI376234B (en) *	2005-02-01	2012-11-11	Msd Oss Bv	Conjugates of a polypeptide and an oligosaccharide
PL373543A1 (pl) *	2005-03-10	2006-09-18	Instytut Biotechnologii i Antybiotyków	Kompozycja farmaceutyczna zawierająca biosyntetyczny analog insuliny ludzkiej, oraz jej zastosowanie w terapii cukrzycy
US20060212009A1 (en) *	2005-03-16	2006-09-21	Accisano Nicholas G Iii	Drainage catheter hub with rotatable lever handle
US7824367B2 (en) *	2005-08-17	2010-11-02	Merit Medical Systems, Inc.	Drainage catheter with locking hub
US8343914B2 (en) *	2006-01-06	2013-01-01	Case Western Reserve University	Fibrillation resistant proteins
CA2647835A1 (en) *	2006-03-28	2007-10-04	Neopro Labs, Llc	Methods and compositions for treating conditions
DE102006031962A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
DE102006031955A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
CN101573133B (zh) *	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
US9233226B2 (en) *	2006-08-22	2016-01-12	Merit Medical Systems, Inc.	Drainage catheter with pig-tail straightener
CN101541830A (zh)	2006-09-22	2009-09-23	诺沃-诺迪斯克有限公司	蛋白酶抗性的胰岛素类似物
EP2074140B8 (en) *	2006-10-04	2015-10-28	Case Western Reserve University	Fibrillation-resistant insulin and insulin analogues
WO2008132224A2 (en)	2007-04-30	2008-11-06	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
EP2152725A1 (en)	2007-05-17	2010-02-17	Neopro Labs, LLC	Crystalline and amorphous forms of peptide
AU2008257505B2 (en) *	2007-06-01	2013-05-16	Novo Nordisk A/S	Stable non-aqueous pharmaceutical compositions
WO2009012472A2 (en) *	2007-07-18	2009-01-22	Neopro Labs, Llc	Methods and compositions for treating conditions
CN101970477B (zh)	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
WO2009129250A2 (en) *	2008-04-14	2009-10-22	Case Western Reserve University	Meal-time insulin analogues of enhanced stability
AU2009240636A1 (en) *	2008-04-22	2009-10-29	Case Western Reserve University	Isoform-specific insulin analogues
PL219335B1 (pl) *	2008-07-04	2015-04-30	Inst Biotechnologii I Antybiotyków	Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
US9200053B2 (en)	2008-07-31	2015-12-01	Case Western Reserve University	Insulin analogues containing penta-fluoro-Phenylalanine at position B24
KR20120129875A (ko)	2008-07-31	2012-11-28	케이스 웨스턴 리저브 유니버시티	염소화 아미노산을 갖는 인슐린 유사체
PH12011502708B1 (en)	2009-07-06	2017-11-10	Sanofi Aventis Deutschland	Insulin preparations containing methionine
US8399407B2 (en) *	2009-09-17	2013-03-19	Case Western Reserve University	Non-standard insulin analogues
RU2012123642A (ru)	2009-12-11	2014-01-20	Кейз Вестерн Ризев Юнивесити	Аналоги инсулина, содержащие хлорированные аминокислоты
EP2836508B1 (en)	2012-04-11	2016-06-29	Novo Nordisk A/S	Insulin formulations
CA2926701A1 (en)	2013-10-07	2015-04-16	Novo Nordisk A/S	Novel derivative of an insulin analogue
AU2015328222B9 (en)	2014-10-06	2020-12-24	Case Western Reserve University	Biphasic single-chain insulin analogues
GB2549275B (en) *	2016-04-11	2018-05-09	Tectonic Facades Ltd	Construction assembly
WO2018085566A2 (en)	2016-11-03	2018-05-11	Merit Medical Systems, Inc.	Drainage catheter
ES2886837T3 (es)	2016-12-16	2021-12-21	Novo Nordisk As	Composiciones farmacéuticas que contienen insulina
WO2024137820A1 (en) *	2022-12-20	2024-06-27	The Board Of Trustees Of The Leland Stanford Junior University	Insulin receptor antagonist

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55138393A (en) *	1979-04-13	1980-10-29	Shionogi & Co Ltd	Semisynthesis of insulin
IE50892B1 (en) *	1980-02-11	1986-08-06	Novo Industri As	Process for preparing insulin esters
DE3327709A1 (de) *	1983-07-29	1985-02-07	Hoechst Ag, 6230 Frankfurt	Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
US4946828A (en) *	1985-03-12	1990-08-07	Novo Nordisk A/S	Novel insulin peptides
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
DE3541856A1 (de) *	1985-11-27	1987-06-04	Hoechst Ag	Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3636903A1 (de) *	1985-12-21	1987-07-02	Hoechst Ag	Fusionsproteine mit eukaryotischem ballastanteil
DE3545595A1 (de) *	1985-12-21	1987-06-25	Behringwerke Ag	Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung
DK437786D0 (da) *	1986-09-12	1986-09-12	Nordisk Gentofte	Insulinprecursorer
DE3805150A1 (de) *	1987-04-11	1988-10-20	Hoechst Ag	Gentechnologisches verfahren zur herstellung von polypeptiden
DE3714866A1 (de) *	1987-05-05	1988-11-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser

1988
- 1988-12-29 DE DE3844211A patent/DE3844211A1/de not_active Withdrawn
1989
- 1989-12-21 AT AT89123616T patent/ATE136038T1/de not_active IP Right Cessation
- 1989-12-21 EP EP89123616A patent/EP0376156B1/de not_active Expired - Lifetime
- 1989-12-21 NZ NZ231944A patent/NZ231944A/en unknown
- 1989-12-21 DE DE58909633T patent/DE58909633D1/de not_active Expired - Lifetime
- 1989-12-21 ES ES89123616T patent/ES2085271T3/es not_active Expired - Lifetime
- 1989-12-27 PH PH39804A patent/PH27425A/en unknown
- 1989-12-27 KR KR1019890019607A patent/KR900009698A/ko not_active Withdrawn
- 1989-12-27 FI FI896279A patent/FI102843B/fi not_active IP Right Cessation
- 1989-12-27 HU HU896781A patent/HU205172B/hu not_active IP Right Cessation
- 1989-12-27 IL IL9290589A patent/IL92905A/en unknown
- 1989-12-27 JP JP01336787A patent/JP3129722B2/ja not_active Expired - Lifetime
- 1989-12-28 PT PT92757A patent/PT92757B/pt not_active IP Right Cessation
- 1989-12-28 CA CA002006818A patent/CA2006818C/en not_active Expired - Lifetime
- 1989-12-28 DK DK198906698A patent/DK173178B1/da not_active IP Right Cessation
- 1989-12-28 ZA ZA899946A patent/ZA899946B/xx unknown
- 1989-12-28 IE IE420089A patent/IE73672B1/en not_active IP Right Cessation
- 1989-12-28 NO NO895296A patent/NO180379C/no not_active IP Right Cessation
- 1989-12-29 AU AU47332/89A patent/AU623963B2/en not_active Ceased
1995
- 1995-05-16 US US08/442,296 patent/US5506202A/en not_active Expired - Lifetime
1996
- 1996-04-05 GR GR960400943T patent/GR3019560T3/el unknown

Also Published As

Publication number	Publication date
IE73672B1 (en)	1997-07-02
CA2006818C (en)	2000-05-23
AU4733289A (en)	1990-07-05
EP0376156A3 (de)	1991-05-02
PT92757A (pt)	1990-06-29
ATE136038T1 (de)	1996-04-15
JPH02225498A (ja)	1990-09-07
ZA899946B (en)	1990-09-26
CA2006818A1 (en)	1990-06-29
DE58909633D1 (de)	1996-05-02
FI896279A0 (fi)	1989-12-27
EP0376156B1 (de)	1996-03-27
US5506202A (en)	1996-04-09
GR3019560T3 (en)	1996-07-31
HU896781D0 (en)	1990-03-28
DE3844211A1 (de)	1990-07-05
HU205172B (en)	1992-03-30
JP3129722B2 (ja)	2001-01-31
PH27425A (en)	1993-06-21
NZ231944A (en)	1993-02-25
FI102843B1 (fi)	1999-02-26
PT92757B (pt)	1995-12-29
FI102843B (fi)	1999-02-26
ES2085271T3 (es)	1996-06-01
EP0376156A2 (de)	1990-07-04
IL92905A0 (en)	1990-09-17
AU623963B2 (en)	1992-05-28
KR900009698A (ko)	1990-07-05
NO895296L (no)	1990-07-02
NO180379B (no)	1996-12-30
DK173178B1 (da)	2000-03-06
DK669889D0 (da)	1989-12-28
HUT53150A (en)	1990-09-28
NO180379C (no)	1997-04-09
IL92905A (en)	1994-10-21
IE894200L (en)	1990-06-29
NO895296D0 (no)	1989-12-28

Legal Events

Date	Code	Title	Description
2010-01-18	PUP	Patent expired