DK708188A - 5- og 6-leddede heterocycliske forbindelser og farmaceutisk acceptable saltderivater heraf til anvendelse ved behandling af aids - Google Patents
5- og 6-leddede heterocycliske forbindelser og farmaceutisk acceptable saltderivater heraf til anvendelse ved behandling af aidsInfo
- Publication number
- DK708188A DK708188A DK708188A DK708188A DK708188A DK 708188 A DK708188 A DK 708188A DK 708188 A DK708188 A DK 708188A DK 708188 A DK708188 A DK 708188A DK 708188 A DK708188 A DK 708188A
- Authority
- DK
- Denmark
- Prior art keywords
- dideoxy
- imino
- methyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000000565 5-membered heterocyclic compounds Chemical class 0.000 title 1
- 150000000644 6-membered heterocyclic compounds Chemical class 0.000 title 1
- 208000030507 AIDS Diseases 0.000 title 1
- OQEBIHBLFRADNM-LMVFSUKVSA-N (2s,3s,4r)-2-(hydroxymethyl)pyrrolidine-3,4-diol Chemical compound OC[C@@H]1NC[C@@H](O)[C@H]1O OQEBIHBLFRADNM-LMVFSUKVSA-N 0.000 abstract 1
- RVNSAAIWCWTCTJ-ARQDHWQXSA-N (2s,3s,4r)-2-[(1s)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol Chemical compound OC[C@@H](O)[C@@H]1NC[C@@H](O)[C@H]1O RVNSAAIWCWTCTJ-ARQDHWQXSA-N 0.000 abstract 1
- OQEBIHBLFRADNM-MROZADKFSA-N 1,4-Dideoxy-1,4-imino-D-ribitol Chemical compound OC[C@H]1NC[C@H](O)[C@@H]1O OQEBIHBLFRADNM-MROZADKFSA-N 0.000 abstract 1
- OQEBIHBLFRADNM-YUPRTTJUSA-N 2-hydroxymethyl-pyrrolidine-3,4-diol Chemical compound OC[C@@H]1NC[C@H](O)[C@H]1O OQEBIHBLFRADNM-YUPRTTJUSA-N 0.000 abstract 1
- OQEBIHBLFRADNM-UHFFFAOYSA-N D-iminoxylitol Natural products OCC1NCC(O)C1O OQEBIHBLFRADNM-UHFFFAOYSA-N 0.000 abstract 1
- LXBIFEVIBLOUGU-UHFFFAOYSA-N Deoxymannojirimycin Natural products OCC1NCC(O)C(O)C1O LXBIFEVIBLOUGU-UHFFFAOYSA-N 0.000 abstract 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13621987A | 1987-12-21 | 1987-12-21 | |
| US13621987 | 1987-12-21 | ||
| US07/249,144 US4999360A (en) | 1987-12-21 | 1988-09-26 | Method of inhibiting virus |
| US24914488 | 1988-09-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK708188D0 DK708188D0 (da) | 1988-12-20 |
| DK708188A true DK708188A (da) | 1989-06-22 |
| DK175113B1 DK175113B1 (da) | 2004-06-07 |
Family
ID=26834131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198807081A DK175113B1 (da) | 1987-12-21 | 1988-12-20 | Anvendelse af 5- og 6-leddede heterocycliske forbindelser til fremstilling af et præparat til behandling af patienter inficeret med HIV |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4999360A (da) |
| EP (1) | EP0322395B1 (da) |
| JP (1) | JP2538014B2 (da) |
| KR (1) | KR910009994B1 (da) |
| AT (1) | ATE87206T1 (da) |
| AU (1) | AU607834B2 (da) |
| CA (1) | CA1316929C (da) |
| DE (1) | DE3879653T2 (da) |
| DK (1) | DK175113B1 (da) |
| FI (1) | FI93210C (da) |
| IE (1) | IE63095B1 (da) |
| IL (1) | IL88742A (da) |
| NO (1) | NO172340C (da) |
| NZ (1) | NZ227410A (da) |
| OA (1) | OA08937A (da) |
| PT (1) | PT89267B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE135346T1 (de) * | 1988-11-03 | 1996-03-15 | Searle & Co | Dideoxy-l-arabinitol derivate als antivirus- verbindungen |
| US4894388A (en) * | 1988-12-22 | 1990-01-16 | Monsanto Company | Glycosidase inhibitors and use thereof |
| US5100797A (en) * | 1989-06-27 | 1992-03-31 | Monsanto Company | Fucosidase inhibitors |
| US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
| IT1239950B (it) * | 1990-03-28 | 1993-11-27 | Zambon Spa | Processo per la preparazione di composti con attivita' analgesica centrale |
| US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5290948A (en) * | 1990-09-17 | 1994-03-01 | Mcneilab, Inc. | Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof |
| GB9026271D0 (en) * | 1990-12-03 | 1991-01-16 | Alphey Thomas J W | Control of parasitic nematodes(a) |
| US5258518A (en) * | 1992-04-01 | 1993-11-02 | G. D. Searle & Co. | 2-substituted tertiary carbinol derivatives of deoxynojirimycin |
| US5451679A (en) * | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
| CZ120398A3 (cs) * | 1995-09-08 | 1998-12-16 | Novo Nordisk A/S | Použití 2-alkylpyrrolidinových derivátů pro přípravu léčiva pro léčbu diabetu, 2-alkylpyrrolidiné deriváty |
| CN102399228B (zh) * | 2010-09-08 | 2013-10-16 | 中国科学院成都生物研究所 | N-烷基多羟基哌啶衍生物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
| WO1987003903A1 (en) * | 1985-12-23 | 1987-07-02 | Fred Hutchinson Cancer Research Center | Regulating retroviral replication, infection, and pathogenesis |
-
1988
- 1988-09-26 US US07/249,144 patent/US4999360A/en not_active Expired - Lifetime
- 1988-12-20 KR KR1019880017028A patent/KR910009994B1/ko not_active Expired
- 1988-12-20 DE DE88870192T patent/DE3879653T2/de not_active Expired - Fee Related
- 1988-12-20 NZ NZ227410A patent/NZ227410A/en unknown
- 1988-12-20 OA OA59494A patent/OA08937A/xx unknown
- 1988-12-20 AU AU27068/88A patent/AU607834B2/en not_active Ceased
- 1988-12-20 AT AT88870192T patent/ATE87206T1/de not_active IP Right Cessation
- 1988-12-20 DK DK198807081A patent/DK175113B1/da not_active IP Right Cessation
- 1988-12-20 FI FI885880A patent/FI93210C/fi not_active IP Right Cessation
- 1988-12-20 PT PT89267A patent/PT89267B/pt active IP Right Revival
- 1988-12-20 JP JP63321868A patent/JP2538014B2/ja not_active Expired - Fee Related
- 1988-12-20 IE IE379488A patent/IE63095B1/en not_active IP Right Cessation
- 1988-12-20 IL IL88742A patent/IL88742A/xx not_active IP Right Cessation
- 1988-12-20 NO NO885655A patent/NO172340C/no not_active IP Right Cessation
- 1988-12-20 EP EP88870192A patent/EP0322395B1/en not_active Expired - Lifetime
- 1988-12-20 CA CA000586466A patent/CA1316929C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO172340B (no) | 1993-03-29 |
| EP0322395B1 (en) | 1993-03-24 |
| EP0322395A1 (en) | 1989-06-28 |
| FI885880A0 (fi) | 1988-12-20 |
| FI885880L (fi) | 1989-06-22 |
| IL88742A0 (en) | 1989-07-31 |
| DK175113B1 (da) | 2004-06-07 |
| KR910009994B1 (ko) | 1991-12-10 |
| FI93210C (fi) | 1995-03-10 |
| IE63095B1 (en) | 1995-03-22 |
| NO885655L (no) | 1989-06-22 |
| KR890009389A (ko) | 1989-08-01 |
| AU2706888A (en) | 1989-06-22 |
| NZ227410A (en) | 1991-06-25 |
| IL88742A (en) | 1993-08-18 |
| IE883794L (en) | 1989-06-21 |
| ATE87206T1 (de) | 1993-04-15 |
| DE3879653D1 (de) | 1993-04-29 |
| NO885655D0 (no) | 1988-12-20 |
| AU607834B2 (en) | 1991-03-14 |
| DE3879653T2 (de) | 1993-10-14 |
| JPH01230517A (ja) | 1989-09-14 |
| US4999360A (en) | 1991-03-12 |
| NO172340C (no) | 1993-07-07 |
| CA1316929C (en) | 1993-04-27 |
| PT89267B (pt) | 1993-12-31 |
| PT89267A (pt) | 1989-12-29 |
| JP2538014B2 (ja) | 1996-09-25 |
| DK708188D0 (da) | 1988-12-20 |
| OA08937A (fr) | 1989-10-31 |
| FI93210B (fi) | 1994-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |
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