DOP2016000045A - Compuestos de benzoxaborol tricíclicos y usos de los mismos - Google Patents
Compuestos de benzoxaborol tricíclicos y usos de los mismosInfo
- Publication number
- DOP2016000045A DOP2016000045A DO2016000045A DO2016000045A DOP2016000045A DO P2016000045 A DOP2016000045 A DO P2016000045A DO 2016000045 A DO2016000045 A DO 2016000045A DO 2016000045 A DO2016000045 A DO 2016000045A DO P2016000045 A DOP2016000045 A DO P2016000045A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- same
- compounds
- benzoxaborol compounds
- tricyclic benzoxaborol
- tricyclic
- Prior art date
Links
- GDMJXXLVTYSBBE-UHFFFAOYSA-N 1,2-benzoxaborole Chemical class C1=CC=C2OB=CC2=C1 GDMJXXLVTYSBBE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 239000003926 antimycobacterial agent Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se proporcionan compuestos de la fórmula II: en donde X se selecciona a partir de cloro, flúor, bromo y yodo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3, -CH2CH3, CH2CH2CH3, o -CH(CH3)2,; composiciones que los contienen, su uso en terapia, incluyendo su uso como agentes anti-micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y métodos para la preparación de estos compuestos. FIG. 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361864496P | 2013-08-09 | 2013-08-09 | |
| US201361918976P | 2013-12-20 | 2013-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2016000045A true DOP2016000045A (es) | 2016-04-29 |
Family
ID=52462052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2016000045A DOP2016000045A (es) | 2013-08-09 | 2016-02-09 | Compuestos de benzoxaborol tricíclicos y usos de los mismos |
Country Status (35)
| Country | Link |
|---|---|
| US (5) | US20160251380A1 (es) |
| EP (2) | EP4029870A1 (es) |
| JP (2) | JP6499175B2 (es) |
| KR (1) | KR102093783B1 (es) |
| CN (2) | CN105492388B (es) |
| AP (1) | AP2016009046A0 (es) |
| AU (2) | AU2014305792C1 (es) |
| BR (1) | BR112016002651B1 (es) |
| CA (1) | CA2919888C (es) |
| CL (1) | CL2016000313A1 (es) |
| CR (1) | CR20160064A (es) |
| CY (1) | CY1125030T1 (es) |
| DK (1) | DK3030519T3 (es) |
| DO (1) | DOP2016000045A (es) |
| EA (1) | EA032844B1 (es) |
| ES (1) | ES2905413T3 (es) |
| HR (1) | HRP20220384T1 (es) |
| HU (1) | HUE057365T2 (es) |
| IL (1) | IL243874B (es) |
| LT (1) | LT3030519T (es) |
| MX (1) | MX375556B (es) |
| MY (1) | MY175823A (es) |
| NZ (1) | NZ716350A (es) |
| PE (1) | PE20160752A1 (es) |
| PH (1) | PH12016500234B1 (es) |
| PL (1) | PL3030519T3 (es) |
| PT (1) | PT3030519T (es) |
| RS (1) | RS62887B1 (es) |
| SA (1) | SA516370551B1 (es) |
| SG (2) | SG10201914073PA (es) |
| SI (1) | SI3030519T1 (es) |
| SM (1) | SMT202200113T1 (es) |
| UA (1) | UA116908C2 (es) |
| WO (1) | WO2015021396A2 (es) |
| ZA (1) | ZA201600792B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR094961A1 (es) * | 2013-03-15 | 2015-09-09 | Lilly Co Eli | 1-hidroxi-benzooxaboroles como agentes antiparasitarios |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| EA032844B1 (ru) | 2013-08-09 | 2019-07-31 | Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед | Трициклические соединения бензоксаборола и их применение |
| JP6605513B2 (ja) | 2014-07-01 | 2019-11-13 | 第一三共株式会社 | 抗菌剤としての三環式ベンゾオキサボロール |
| MA41494B1 (fr) * | 2015-02-12 | 2020-10-28 | Glaxosmithkline Ip No 2 Ltd | Composés benzoxaborole substitués en position 4 et utilisations associées |
| UA121354C2 (uk) | 2016-05-12 | 2020-05-12 | Анакор Фармасутікалз, Інк. | Нові сполуки для лікування паразитарних захворювань |
| CN109387594B (zh) * | 2017-08-08 | 2021-01-19 | 武汉武药科技有限公司 | 一种分离和分析贝达喹啉光学异构体的方法 |
| PL3737685T3 (pl) * | 2018-01-09 | 2023-10-02 | Halcyon Labs Private Limited | Sposób wytwarzania kryzaborolu i jego związków pośrednich |
| EP4164645A4 (en) * | 2020-06-15 | 2024-07-10 | The Global Alliance for TB Drug Development, Inc. | COMBINED ANTIBACTERIAL COMPOSITION AND ANTIBACTERIAL THERAPY METHOD |
| CN111606850B (zh) * | 2020-07-07 | 2023-07-25 | 安徽贝克生物制药有限公司 | 贝达喹啉及其中间体的制备方法 |
| US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
| AU2023287202A1 (en) * | 2022-06-23 | 2024-06-06 | Shanghai Micurx Pharmaceutical Co., Ltd. | Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same |
| CN119233977B (zh) * | 2022-06-23 | 2026-03-17 | 上海盟科药业股份有限公司 | 硼化合物的前药及其在治疗细菌感染中的用途 |
| EP4688794A1 (en) | 2023-04-05 | 2026-02-11 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Synthesis of 3-(aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3)-ol |
| CN117379430A (zh) * | 2023-10-11 | 2024-01-12 | 深圳市第三人民医院(深圳市肝病研究所) | 一种地拉韦啶的用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4967997A (en) | 1996-12-02 | 1998-06-29 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivates, and process for preparing the same |
| US7446236B2 (en) | 2002-12-02 | 2008-11-04 | Solvias Ag | Catalytic hydrogenation of carbon-heteroatom double bonds |
| NZ578297A (en) * | 2005-02-16 | 2010-11-26 | Anacor Pharmaceuticals Inc | Boron-containing small molecules |
| JP5084717B2 (ja) | 2005-03-08 | 2012-11-28 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | キラル・ビスオキサゾリン触媒 |
| EP1976536A4 (en) * | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
| CN101505603A (zh) * | 2005-12-30 | 2009-08-12 | 安纳考尔医药公司 | 含硼的小分子 |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JO3396B1 (ar) * | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| MX2011006334A (es) | 2008-12-17 | 2011-09-22 | Anacor Pharmaceuticals Inc | Polimorfos de (s)-3-amino-metil-7-(3-hidroxi-propoxi)-3h-benzo-[c] [1,2]-oxaborol-1-ol. |
| MX352607B (es) * | 2010-04-07 | 2017-11-30 | Glaxosmithkline Llc Star | Proceso para la preparacion de benzoxaboroles. |
| WO2012033858A2 (en) | 2010-09-07 | 2012-03-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US8530452B2 (en) * | 2011-12-22 | 2013-09-10 | Micurx Pharmaceuticals, Inc. | Tricyclic boron compounds for antimicrobial therapy |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| EA032844B1 (ru) | 2013-08-09 | 2019-07-31 | Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед | Трициклические соединения бензоксаборола и их применение |
| MA41494B1 (fr) * | 2015-02-12 | 2020-10-28 | Glaxosmithkline Ip No 2 Ltd | Composés benzoxaborole substitués en position 4 et utilisations associées |
-
2014
- 2014-08-08 EA EA201690135A patent/EA032844B1/ru unknown
- 2014-08-08 EP EP21214787.0A patent/EP4029870A1/en not_active Withdrawn
- 2014-08-08 HU HUE14834292A patent/HUE057365T2/hu unknown
- 2014-08-08 LT LTEPPCT/US2014/050370T patent/LT3030519T/lt unknown
- 2014-08-08 BR BR112016002651-9A patent/BR112016002651B1/pt active IP Right Grant
- 2014-08-08 EP EP14834292.6A patent/EP3030519B1/en active Active
- 2014-08-08 HR HRP20220384TT patent/HRP20220384T1/hr unknown
- 2014-08-08 SM SM20220113T patent/SMT202200113T1/it unknown
- 2014-08-08 MX MX2016001732A patent/MX375556B/es active IP Right Grant
- 2014-08-08 SG SG10201914073PA patent/SG10201914073PA/en unknown
- 2014-08-08 KR KR1020167006314A patent/KR102093783B1/ko active Active
- 2014-08-08 US US14/387,384 patent/US20160251380A1/en not_active Abandoned
- 2014-08-08 SI SI201431939T patent/SI3030519T1/sl unknown
- 2014-08-08 UA UAA201600796A patent/UA116908C2/uk unknown
- 2014-08-08 PE PE2016000234A patent/PE20160752A1/es unknown
- 2014-08-08 DK DK14834292.6T patent/DK3030519T3/da active
- 2014-08-08 SG SG11201600787PA patent/SG11201600787PA/en unknown
- 2014-08-08 RS RS20220108A patent/RS62887B1/sr unknown
- 2014-08-08 CA CA2919888A patent/CA2919888C/en active Active
- 2014-08-08 CN CN201480049562.3A patent/CN105492388B/zh active Active
- 2014-08-08 MY MYPI2016700458A patent/MY175823A/en unknown
- 2014-08-08 ES ES14834292T patent/ES2905413T3/es active Active
- 2014-08-08 AP AP2016009046A patent/AP2016009046A0/en unknown
- 2014-08-08 CN CN201811396796.1A patent/CN110003253B/zh active Active
- 2014-08-08 NZ NZ716350A patent/NZ716350A/en unknown
- 2014-08-08 AU AU2014305792A patent/AU2014305792C1/en active Active
- 2014-08-08 PT PT148342926T patent/PT3030519T/pt unknown
- 2014-08-08 PL PL14834292T patent/PL3030519T3/pl unknown
- 2014-08-08 WO PCT/US2014/050370 patent/WO2015021396A2/en not_active Ceased
- 2014-08-08 JP JP2016533471A patent/JP6499175B2/ja active Active
-
2016
- 2016-01-28 IL IL243874A patent/IL243874B/en active IP Right Grant
- 2016-02-03 PH PH12016500234A patent/PH12016500234B1/en unknown
- 2016-02-04 ZA ZA2016/00792A patent/ZA201600792B/en unknown
- 2016-02-07 SA SA516370551A patent/SA516370551B1/ar unknown
- 2016-02-08 CL CL2016000313A patent/CL2016000313A1/es unknown
- 2016-02-09 DO DO2016000045A patent/DOP2016000045A/es unknown
- 2016-02-09 CR CR20160064A patent/CR20160064A/es unknown
-
2017
- 2017-08-03 AU AU2017210567A patent/AU2017210567B2/en active Active
- 2017-10-24 US US15/792,251 patent/US10308668B2/en active Active
-
2019
- 2019-03-14 JP JP2019046582A patent/JP6764970B2/ja active Active
- 2019-04-16 US US16/385,547 patent/US10526352B2/en active Active
- 2019-11-26 US US16/695,253 patent/US10858376B2/en active Active
-
2020
- 2020-11-04 US US17/089,058 patent/US20210053999A1/en not_active Abandoned
-
2022
- 2022-03-01 CY CY20221100169T patent/CY1125030T1/el unknown
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