CL2016000313A1 - Compuestos de benzoxaborol tricíclicos y usos de los mismos - Google Patents

Compuestos de benzoxaborol tricíclicos y usos de los mismos

Info

Publication number
CL2016000313A1
CL2016000313A1 CL2016000313A CL2016000313A CL2016000313A1 CL 2016000313 A1 CL2016000313 A1 CL 2016000313A1 CL 2016000313 A CL2016000313 A CL 2016000313A CL 2016000313 A CL2016000313 A CL 2016000313A CL 2016000313 A1 CL2016000313 A1 CL 2016000313A1
Authority
CL
Chile
Prior art keywords
benzoxaborol compounds
micobacterial
compounds
tricyclic benzoxaborol
tricyclic
Prior art date
Application number
CL2016000313A
Other languages
English (en)
Inventor
M R K Dickon Alley
Vincent S Hernandez
Jacob J Plattner
Xianfeng Li
David Barros-Aguirre
Ilaria Giordano
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip No 2 Ltd, Anacor Pharmaceuticals Inc filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of CL2016000313A1 publication Critical patent/CL2016000313A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPUESTOS DERIVADOS DE BENZOXABOROL TRICICLICOS; SAL; COMPOSICION FARMACEUTICA; COMBINACION; FORMULACION FARMACEUTICA; METODO PARA ANIQUILAR Y/O INHIBIR LA REPLICACION DE MICOBACTERIAS; METODO PARA TRATAR UNA IMFECCION MICOBACTERIANA; Y USO PARA EL TRATAMIENTO DE UNA INFECCION MICOBACTERIANA TAL COMO MYCOBACTERIUM TUBERCULOSIS.
CL2016000313A 2013-08-09 2016-02-08 Compuestos de benzoxaborol tricíclicos y usos de los mismos CL2016000313A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361864496P 2013-08-09 2013-08-09
US201361918976P 2013-12-20 2013-12-20

Publications (1)

Publication Number Publication Date
CL2016000313A1 true CL2016000313A1 (es) 2016-09-23

Family

ID=52462052

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016000313A CL2016000313A1 (es) 2013-08-09 2016-02-08 Compuestos de benzoxaborol tricíclicos y usos de los mismos

Country Status (35)

Country Link
US (5) US20160251380A1 (es)
EP (2) EP3030519B1 (es)
JP (2) JP6499175B2 (es)
KR (1) KR102093783B1 (es)
CN (2) CN105492388B (es)
AP (1) AP2016009046A0 (es)
AU (2) AU2014305792C1 (es)
BR (1) BR112016002651B1 (es)
CA (1) CA2919888C (es)
CL (1) CL2016000313A1 (es)
CR (1) CR20160064A (es)
CY (1) CY1125030T1 (es)
DK (1) DK3030519T3 (es)
DO (1) DOP2016000045A (es)
EA (1) EA032844B1 (es)
ES (1) ES2905413T3 (es)
HR (1) HRP20220384T1 (es)
HU (1) HUE057365T2 (es)
IL (1) IL243874B (es)
LT (1) LT3030519T (es)
MX (1) MX375556B (es)
MY (1) MY175823A (es)
NZ (1) NZ716350A (es)
PE (1) PE20160752A1 (es)
PH (1) PH12016500234B1 (es)
PL (1) PL3030519T3 (es)
PT (1) PT3030519T (es)
RS (1) RS62887B1 (es)
SA (1) SA516370551B1 (es)
SG (2) SG10201914073PA (es)
SI (1) SI3030519T1 (es)
SM (1) SMT202200113T1 (es)
UA (1) UA116908C2 (es)
WO (1) WO2015021396A2 (es)
ZA (1) ZA201600792B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR094961A1 (es) * 2013-03-15 2015-09-09 Lilly Co Eli 1-hidroxi-benzooxaboroles como agentes antiparasitarios
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
CN106459097A (zh) 2014-07-01 2017-02-22 第三共株式会社 作为抗菌剂的三环苯并氧杂硼杂环戊烯类
MA41495A (fr) * 2015-02-12 2017-12-19 Anacor Pharmaceuticals Inc Composés benzoxaborole et leurs utilisations
PE20190119A1 (es) 2016-05-12 2019-01-17 Anacor Pharmaceuticals Inc Esteres de oxaborol y sus usos
CN109387594B (zh) * 2017-08-08 2021-01-19 武汉武药科技有限公司 一种分离和分析贝达喹啉光学异构体的方法
ES2949908T3 (es) * 2018-01-09 2023-10-03 Halcyon Labs Private Ltd Proceso para la preparación de Crisaborol y sus intermedios
EP4164645A4 (en) * 2020-06-15 2024-07-10 The Global Alliance for TB Drug Development, Inc. COMBINED ANTIBACTERIAL COMPOSITION AND ANTIBACTERIAL THERAPY METHOD
CN111606850B (zh) * 2020-07-07 2023-07-25 安徽贝克生物制药有限公司 贝达喹啉及其中间体的制备方法
US11793808B2 (en) 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
CA3239097A1 (en) 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections
JP2025520237A (ja) * 2022-06-23 2025-07-03 ミクウルク ファーマシューティカルズ， インコーポレイテッド ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物
WO2024208907A1 (en) 2023-04-05 2024-10-10 Glaxosmithkline Intellectual Property (No. 2) Limited Synthesis of 3-(aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3h)-ol
CN117379430B (zh) * 2023-10-11 2026-07-21 深圳市第三人民医院(深圳市肝病研究所) 一种地拉韦啶的用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024753A1 (en) 1996-12-02 1998-06-11 Chisso Corporation Optically active nitro alcohol derivatives, optically active amino alcohol derivates, and process for preparing the same
US7446236B2 (en) 2002-12-02 2008-11-04 Solvias Ag Catalytic hydrogenation of carbon-heteroatom double bonds
ES2872962T3 (es) 2005-02-16 2021-11-03 Anacor Pharmaceuticals Inc Boronoftalidas para uso terapéutico
US7767657B2 (en) 2005-02-16 2010-08-03 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
JP5084717B2 (ja) 2005-03-08 2012-11-28 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ キラル・ビスオキサゾリン触媒
CN101505603A (zh) * 2005-12-30 2009-08-12 安纳考尔医药公司 含硼的小分子
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
SG172040A1 (en) 2008-12-17 2011-07-28 Anacor Pharmaceuticals Inc Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
AU2011237681B2 (en) * 2010-04-07 2015-01-22 Glaxosmithkline Llc Process for preparing benzoxaboroles
DK2613788T3 (en) * 2010-09-07 2017-08-07 Anacor Pharmaceuticals Inc BENZOXABOROLD DERIVATIVES FOR TREATMENT OF BACTERIA INFECTIONS
US8530452B2 (en) * 2011-12-22 2013-09-10 Micurx Pharmaceuticals, Inc. Tricyclic boron compounds for antimicrobial therapy
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
MA41495A (fr) * 2015-02-12 2017-12-19 Anacor Pharmaceuticals Inc Composés benzoxaborole et leurs utilisations

Also Published As

Publication number Publication date
RS62887B1 (sr) 2022-03-31
SA516370551B1 (ar) 2017-10-31
US20160251380A1 (en) 2016-09-01
CN110003253A (zh) 2019-07-12
CN105492388B (zh) 2018-12-21
AU2014305792A1 (en) 2016-03-10
WO2015021396A2 (en) 2015-02-12
CN110003253B (zh) 2022-03-18
PE20160752A1 (es) 2016-08-17
SG11201600787PA (en) 2016-03-30
AP2016009046A0 (en) 2016-02-29
US20210053999A1 (en) 2021-02-25
HK1219939A1 (zh) 2017-04-21
ES2905413T3 (es) 2022-04-08
JP6764970B2 (ja) 2020-10-07
US20200095266A1 (en) 2020-03-26
PT3030519T (pt) 2022-01-27
DK3030519T3 (da) 2022-01-31
EP3030519A2 (en) 2016-06-15
CN105492388A (zh) 2016-04-13
DOP2016000045A (es) 2016-04-29
SI3030519T1 (sl) 2022-04-29
MX375556B (es) 2025-03-06
HUE057365T2 (hu) 2022-05-28
JP2019123727A (ja) 2019-07-25
CA2919888C (en) 2022-10-18
US10858376B2 (en) 2020-12-08
AU2017210567B2 (en) 2019-08-01
KR102093783B1 (ko) 2020-03-26
AU2014305792B2 (en) 2017-05-04
HRP20220384T1 (hr) 2022-07-22
AU2014305792C1 (en) 2018-07-05
US20180044355A1 (en) 2018-02-15
SG10201914073PA (en) 2020-03-30
WO2015021396A9 (en) 2016-02-11
PH12016500234B1 (en) 2019-01-30
KR20160038901A (ko) 2016-04-07
CR20160064A (es) 2016-06-01
PL3030519T3 (pl) 2022-05-23
WO2015021396A3 (en) 2015-10-29
US20190241586A1 (en) 2019-08-08
IL243874B (en) 2018-11-29
JP2016527321A (ja) 2016-09-08
IL243874A0 (en) 2016-04-21
UA116908C2 (uk) 2018-05-25
US10308668B2 (en) 2019-06-04
BR112016002651B1 (pt) 2022-11-29
NZ716350A (en) 2022-12-23
MX2016001732A (es) 2016-05-18
EP3030519A4 (en) 2017-03-08
US10526352B2 (en) 2020-01-07
EP3030519B1 (en) 2022-01-05
PH12016500234A1 (en) 2016-05-16
ZA201600792B (en) 2022-05-25
EA032844B1 (ru) 2019-07-31
MY175823A (en) 2020-07-10
EP4029870A1 (en) 2022-07-20
CA2919888A1 (en) 2015-02-12
JP6499175B2 (ja) 2019-04-10
LT3030519T (lt) 2022-04-11
SMT202200113T1 (it) 2022-05-12
EA201690135A1 (ru) 2016-07-29
BR112016002651A2 (pt) 2017-08-01
CY1125030T1 (el) 2023-03-24
AU2017210567A1 (en) 2017-08-24

Similar Documents

Publication Publication Date Title
ECSP24031979A (es) Compuestos terapéuticamente activos y sus métodos de uso
CL2018003681A1 (es) Derivados de ácido borónico y usos terapéuticos de los mismos
UY36342A (es) Nuevos derivados de aminoalquilbenzotiazepinas y usos de los mismos
CL2017003404A1 (es) Compuestos antibacterianos
CO2017001994A2 (es) Compuestos activos hacia bromodominios
SV2015005115A (es) Derivados de la pirazolopirrolidina y su uso en el tratamiento de enfermedades
GT201600183A (es) Compuestos orgánicos de monobactam para el tratamiento de infecciones bacterianas
CL2014002093A1 (es) Compuestos derivados piperidinopirimidinicos; composicion farmaceutica que los comprende; uso en el tratamiento de infecciones viricas.
MX395458B (es) Metodos novedosos
ECSP14017269A (es) Compuestos para tratar la atrofia muscular espinal
UY35663A (es) Derivados de piperidinil-indol como inhibidores del factor de complemento b y usos de los mismos
CL2015003801A1 (es) Formulaciones de anticuerpos y metodos
MX376329B (es) Composiciones farmaceuticas de compuestos terapeuticamente activos y sus metodos de uso.
CL2015000608A1 (es) Formulaciones de daptomicina y usos de la misma
GT201700194A (es) Formulación de combinación de tesofensina y betabloqueante
MX2013012289A (es) Triazolopiridinas.
GT201600269A (es) Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble
UY35274A (es) Compuestos y métodos para tratar infecciones bacterianas
DOP2016000170A (es) Compuestos derivados de hidroxiformamida y usos del mismo
DOP2016000297A (es) Composiciones farmacéuticas útiles para tratar enfermedades infecciosas
SV2017005466A (es) Pirazolpiridinaminas como inhibidores de mknk1 y mknk2
DOP2018000049A (es) Compuestos para uso en aplicaciones antibacterianas
DOP2015000298A (es) Compuestos nuevos para el tratamiento del cáncer
GT201700016A (es) [1,2,4] triazolo [4,3 -b] piridazinas para su uso en el tratamiento de enfermedades proliferativas
CL2014001862A1 (es) Compuestos derivados de morofolinilo sustituido, útiles como inhibidores de mogat-2; composicion farmaceutica que los comprende; uso en el tratamiento de hipertrigliceridemia.