DZ2188A1 - Dérivés de quinoxalinedone, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant. - Google Patents

Dérivés de quinoxalinedone, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant.

Info

Publication number: DZ2188A1
Authority: DZ; Algeria
Prior art keywords: quinoxalinedone; intermediates; derivatives; processes; preparation
Prior art date: 1996-03-09

Application number

DZ970034A

Other languages

English (en)

Inventor

David John Bull

Christopher Lee Carr

Michael Jonathan Fray

Elizabeth Colette

Louise Gautier

Charles Eric Mowbray

Alan Stobie

Original Assignee

Pfizer Res & Dev Company N V S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-09

Filing date

1997-03-05

Publication date

2002-12-02

1997-03-05 Application filed by Pfizer Res & Dev Company N V S filed Critical Pfizer Res & Dev Company N V S

2002-12-02 Application granted granted Critical

2002-12-02 Publication of DZ2188A1 publication Critical patent/DZ2188A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Luminescent Compositions (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DZ970034A 1996-03-09 1997-03-05 Dérivés de quinoxalinedone, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant. DZ2188A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9605027.3A GB9605027D0 (en)	1996-03-09	1996-03-09	Quinoxalinediones

Publications (1)

Publication Number	Publication Date
DZ2188A1 true DZ2188A1 (fr)	2002-12-02

Family

ID=10790134

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DZ970034A DZ2188A1 (fr)	1996-03-09	1997-03-05	Dérivés de quinoxalinedone, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant.

Country Status (42)

Country	Link
US (1)	US6376490B1 (fr)
EP (1)	EP0885212B1 (fr)
JP (1)	JP3110467B2 (fr)
KR (1)	KR100288099B1 (fr)
CN (1)	CN1103770C (fr)
AP (1)	AP767A (fr)
AR (1)	AR006119A1 (fr)
AT (1)	ATE208773T1 (fr)
AU (1)	AU717972B2 (fr)
BG (1)	BG63340B1 (fr)
BR (1)	BR9707851A (fr)
CA (1)	CA2248366C (fr)
CO (1)	CO4770976A1 (fr)
CZ (1)	CZ292792B6 (fr)
DE (1)	DE69708269T2 (fr)
DK (1)	DK0885212T3 (fr)
DZ (1)	DZ2188A1 (fr)
EA (1)	EA001730B1 (fr)
ES (1)	ES2163742T3 (fr)
GB (1)	GB9605027D0 (fr)
HN (1)	HN1998000034A (fr)
HR (1)	HRP970132A2 (fr)
HU (1)	HUP9900975A3 (fr)
ID (1)	ID18112A (fr)
IL (1)	IL125491A (fr)
IS (1)	IS4811A (fr)
MA (1)	MA26422A1 (fr)
NO (1)	NO984058L (fr)
NZ (1)	NZ331060A (fr)
OA (1)	OA10850A (fr)
PE (2)	PE43398A1 (fr)
PL (1)	PL329032A1 (fr)
PT (1)	PT885212E (fr)
SI (1)	SI0885212T1 (fr)
SK (1)	SK283467B6 (fr)
TN (1)	TNSN97044A1 (fr)
TR (1)	TR199801782T2 (fr)
TW (1)	TW454004B (fr)
UY (1)	UY24482A1 (fr)
WO (1)	WO1997032873A1 (fr)
YU (2)	YU39698A (fr)
ZA (1)	ZA971987B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP982A (en) *	1997-02-27	2001-07-16	Pfizer	Quinoxalinediones.
CN1121403C (zh) *	1997-02-27	2003-09-17	辉瑞大药厂	喹喔啉二酮
US6340758B1 (en) *	1997-05-16	2002-01-22	Warner-Lambert Company	Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
DE10005150A1 (de)	2000-02-07	2001-08-09	Merck Patent Gmbh	Verfahren zur Herstellung von 5-Arylnicotinaldehyden
WO2001087855A1 (fr) *	2000-05-19	2001-11-22	Yamanouchi Pharmaceutical Co., Ltd.	Derives de triazole
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2005006945A2 (fr) *	2003-07-03	2005-01-27	The Salk Institute For Biological Studies	Procedes de traitement de troubles neurologiques et composes utiles a cet effet
MY145368A (en)	2004-01-13	2012-01-31	Nissan Chemical Ind Ltd	Aminoquinoxaline compounds and polyaminoquinoxaline compounds, and use thereof
EP1713101B1 (fr)	2004-02-06	2012-10-31	Yamaguchi University	Électrode pour dispositif de stockage d'énergie et procédé de production de cette électrode
JP2007223901A (ja) *	2004-03-24	2007-09-06	Takeda Chem Ind Ltd	複素環化合物およびその用途
US20060211739A1 (en) *	2005-02-08	2006-09-21	Arturo Perez-Medrano	Use of selective P2X7 receptor antagonists
WO2007112347A1 (fr) *	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Inhibiteurs de la dipeptidyl peptidase
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
JP5523107B2 (ja)	2006-11-30	2014-06-18	プロビオドルグエージー	グルタミニルシクラーゼの新規阻害剤
CA2686816A1 (fr)	2007-01-16	2008-07-24	The Johns Hopkins University	Utilisation de divers antagonistes de recepteur de glutamate pour retarder ou prevenir l'activite plaquettaire ou pour traiter ou prevenir une maladie ou un trouble thrombotique
EP2481408A3 (fr)	2007-03-01	2013-01-09	Probiodrug AG	Nouvelle utilisation d'inhibiteurs glutaminyle cyclase
WO2008128985A1 (fr)	2007-04-18	2008-10-30	Probiodrug Ag	Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase
CN101679383B (zh) *	2007-05-17	2014-10-29	株式会社半导体能源研究所	三唑衍生物，和使用三唑衍生物的发光元件、发光器件和电子器件
MX2012002993A (es)	2009-09-11	2012-04-19	Probiodrug Ag	Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
US8269019B2 (en)	2010-03-10	2012-09-18	Probiodrug Ag	Inhibitors
WO2011131748A2 (fr)	2010-04-21	2011-10-27	Probiodrug Ag	Nouveaux inhibiteurs
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
CA2900300A1 (fr) *	2013-02-07	2014-08-14	Merck Patent Gmbh	Derives d'acetylene substitues et leur utilisation a titre de modulateurs allosteriques positifs du mglur4
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej
CN111548320B (zh) *	2019-10-09	2023-03-24	贵州大学	一类1，3，4-噁二唑酰肼类化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE194985T1 (de) *	1990-11-06	2000-08-15	Yamanouchi Pharma Co Ltd	Kondensiertes pyrazinderivat
DE4217952A1 (de) *	1992-05-30	1993-12-02	Basf Ag	Chinoxalin-2,3(1H,4H)-dione
GB9418443D0 (en)	1994-09-13	1994-11-02	Pfizer Ltd	Therapeutic agents
DE4439492A1 (de) *	1994-10-25	1996-05-02	Schering Ag	Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
CN1121403C (zh) *	1997-02-27	2003-09-17	辉瑞大药厂	喹喔啉二酮

1996
- 1996-03-09 GB GBGB9605027.3A patent/GB9605027D0/en active Pending
1997
- 1997-02-05 TW TW086101412A patent/TW454004B/zh not_active IP Right Cessation
- 1997-02-27 CZ CZ19982864A patent/CZ292792B6/cs not_active IP Right Cessation
- 1997-02-27 BR BR9707851A patent/BR9707851A/pt not_active Application Discontinuation
- 1997-02-27 AT AT97908156T patent/ATE208773T1/de not_active IP Right Cessation
- 1997-02-27 WO PCT/EP1997/000995 patent/WO1997032873A1/fr not_active Ceased
- 1997-02-27 ES ES97908156T patent/ES2163742T3/es not_active Expired - Lifetime
- 1997-02-27 DE DE69708269T patent/DE69708269T2/de not_active Expired - Fee Related
- 1997-02-27 EP EP97908156A patent/EP0885212B1/fr not_active Expired - Lifetime
- 1997-02-27 SI SI9730225T patent/SI0885212T1/xx unknown
- 1997-02-27 IL IL12549197A patent/IL125491A/xx not_active IP Right Cessation
- 1997-02-27 YU YU39698A patent/YU39698A/sh unknown
- 1997-02-27 HU HU9900975A patent/HUP9900975A3/hu unknown
- 1997-02-27 JP JP09531429A patent/JP3110467B2/ja not_active Expired - Fee Related
- 1997-02-27 EA EA199800702A patent/EA001730B1/ru not_active IP Right Cessation
- 1997-02-27 AU AU20231/97A patent/AU717972B2/en not_active Ceased
- 1997-02-27 NZ NZ331060A patent/NZ331060A/xx unknown
- 1997-02-27 PL PL97329032A patent/PL329032A1/xx unknown
- 1997-02-27 TR TR1998/01782T patent/TR199801782T2/xx unknown
- 1997-02-27 CN CN97192923A patent/CN1103770C/zh not_active Expired - Fee Related
- 1997-02-27 PT PT97908156T patent/PT885212E/pt unknown
- 1997-02-27 CA CA002248366A patent/CA2248366C/fr not_active Expired - Fee Related
- 1997-02-27 DK DK97908156T patent/DK0885212T3/da active
- 1997-02-27 SK SK1214-98A patent/SK283467B6/sk unknown
- 1997-02-27 KR KR1019980707063A patent/KR100288099B1/ko not_active Expired - Fee Related
- 1997-03-05 MA MA24514A patent/MA26422A1/fr unknown
- 1997-03-05 TN TNTNSN97044A patent/TNSN97044A1/fr unknown
- 1997-03-05 AR ARP970100888A patent/AR006119A1/es unknown
- 1997-03-05 DZ DZ970034A patent/DZ2188A1/fr active
- 1997-03-06 PE PE1997000162A patent/PE43398A1/es not_active Application Discontinuation
- 1997-03-06 UY UY24482A patent/UY24482A1/es not_active IP Right Cessation
- 1997-03-06 AP APAP/P/1997/000947A patent/AP767A/en active
- 1997-03-07 ZA ZA971987A patent/ZA971987B/xx unknown
- 1997-03-07 HR HR9605027.3A patent/HRP970132A2/xx not_active Application Discontinuation
- 1997-03-07 ID IDP970725A patent/ID18112A/id unknown
- 1997-03-10 CO CO97012901A patent/CO4770976A1/es unknown
1998
- 1998-02-19 HN HN1998000034A patent/HN1998000034A/es unknown
- 1998-02-23 PE PE1998000128A patent/PE58199A1/es not_active Application Discontinuation
- 1998-02-24 YU YU41199A patent/YU41199A/sh unknown
- 1998-07-27 IS IS4811A patent/IS4811A/is unknown
- 1998-08-28 OA OA9800155A patent/OA10850A/en unknown
- 1998-09-03 NO NO984058A patent/NO984058L/no unknown
- 1998-09-04 US US09/157,806 patent/US6376490B1/en not_active Expired - Fee Related
- 1998-09-09 BG BG102760A patent/BG63340B1/bg unknown

Also Published As

Publication number	Publication date
KR100288099B1 (ko)	2001-05-02
ATE208773T1 (de)	2001-11-15
DE69708269T2 (de)	2002-07-25
DE69708269D1 (de)	2001-12-20
AU2023197A (en)	1997-09-22
YU41199A (sh)	2001-09-28
AP767A (en)	1999-09-29
YU39698A (sh)	1999-03-04
CZ286498A3 (cs)	1999-07-14
WO1997032873A1 (fr)	1997-09-12
BG102760A (en)	1999-09-30
UY24482A1 (es)	2000-09-29
SI0885212T1 (en)	2002-02-28
GB9605027D0 (en)	1996-05-08
PE43398A1 (es)	1998-08-29
AU717972B2 (en)	2000-04-06
HUP9900975A2 (hu)	1999-07-28
DK0885212T3 (da)	2002-03-25
PT885212E (pt)	2002-02-28
SK283467B6 (sk)	2003-08-05
CO4770976A1 (es)	1999-04-30
IL125491A0 (en)	1999-03-12
ID18112A (id)	1998-03-05
OA10850A (en)	2001-08-16
TR199801782T2 (xx)	1998-12-21
HUP9900975A3 (en)	2001-12-28
CZ292792B6 (cs)	2003-12-17
NO984058D0 (no)	1998-09-03
KR19990087614A (ko)	1999-12-27
CN1213369A (zh)	1999-04-07
TW454004B (en)	2001-09-11
EP0885212B1 (fr)	2001-11-14
CA2248366C (fr)	2002-06-04
MA26422A1 (fr)	2004-12-20
CA2248366A1 (fr)	1997-09-12
AP9700947A0 (en)	1997-04-30
SK121498A3 (en)	2000-10-09
JPH11506123A (ja)	1999-06-02
BR9707851A (pt)	1999-07-27
EP0885212A1 (fr)	1998-12-23
HRP970132A2 (en)	1998-06-30
IL125491A (en)	2003-07-06
JP3110467B2 (ja)	2000-11-20
IS4811A (is)	1998-07-27
NO984058L (no)	1998-11-06
EA001730B1 (ru)	2001-08-27
AR006119A1 (es)	1999-08-11
ES2163742T3 (es)	2002-02-01
EA199800702A1 (ru)	1999-04-29
PE58199A1 (es)	1999-06-11
US6376490B1 (en)	2002-04-23
TNSN97044A1 (fr)	2005-03-15
HN1998000034A (es)	1999-02-09
NZ331060A (en)	2000-01-28
PL329032A1 (en)	1999-03-01
ZA971987B (en)	1998-09-07
BG63340B1 (bg)	2001-10-31
CN1103770C (zh)	2003-03-26

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DZ2890A1 (fr)	2003-12-15	4-Carboxamino-2-substitué-1,2,3,4-tétrahydroquinoléines, procédé pour leur préparation et compositions pharmaceutiques les contenant.
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DZ2407A1 (fr)	2003-01-04	Dérivés de sulfonylurée procédé pour leur préparation et compositions pharmaceutiques les contenant
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EP0718287A3 (fr)	1997-01-29	Dérivés de pipérazine, médicaments les contenant, leur application, et procédés pour leur préparation
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MA26559A1 (fr)	2004-12-20	Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation
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