DZ2227A1 - Dérivés d'indole nouveaux, procédé pour leur préparation et formulations pharmaceutiques les contenant. - Google Patents

Dérivés d'indole nouveaux, procédé pour leur préparation et formulations pharmaceutiques les contenant.

Info

Publication number
DZ2227A1
DZ2227A1 DZ970074A DZ970074A DZ2227A1 DZ 2227 A1 DZ2227 A1 DZ 2227A1 DZ 970074 A DZ970074 A DZ 970074A DZ 970074 A DZ970074 A DZ 970074A DZ 2227 A1 DZ2227 A1 DZ 2227A1
Authority
DZ
Algeria
Prior art keywords
preparation
pharmaceutical formulations
formulations containing
indole derivatives
new indole
Prior art date
Application number
DZ970074A
Other languages
English (en)
Inventor
David James Rawson
Kevin Nep Dack
Roger Peter Dickinson
James Kim
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DZ2227A1 publication Critical patent/DZ2227A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DZ970074A 1996-05-09 1997-05-07 Dérivés d'indole nouveaux, procédé pour leur préparation et formulations pharmaceutiques les contenant. DZ2227A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9609641.7A GB9609641D0 (en) 1996-05-09 1996-05-09 Compounds useful in therapy

Publications (1)

Publication Number Publication Date
DZ2227A1 true DZ2227A1 (fr) 2002-12-25

Family

ID=10793387

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ970074A DZ2227A1 (fr) 1996-05-09 1997-05-07 Dérivés d'indole nouveaux, procédé pour leur préparation et formulations pharmaceutiques les contenant.

Country Status (42)

Country Link
US (4) US6017945A (fr)
EP (1) EP0901470B1 (fr)
JP (1) JP3245179B2 (fr)
KR (1) KR100331217B1 (fr)
CN (1) CN1124262C (fr)
AP (1) AP830A (fr)
AR (1) AR007030A1 (fr)
AT (1) ATE263151T1 (fr)
AU (1) AU717849B2 (fr)
BG (1) BG102873A (fr)
BR (1) BR9709072A (fr)
CA (1) CA2253876A1 (fr)
CO (1) CO4650036A1 (fr)
CZ (1) CZ292928B6 (fr)
DE (1) DE69728392T2 (fr)
DK (1) DK0901470T3 (fr)
DZ (1) DZ2227A1 (fr)
EA (1) EA001471B1 (fr)
ES (1) ES2218675T3 (fr)
GB (1) GB9609641D0 (fr)
HN (1) HN1997000058A (fr)
HR (1) HRP970249B1 (fr)
HU (1) HUP9901245A3 (fr)
ID (1) ID16878A (fr)
IL (1) IL125903A0 (fr)
IS (1) IS1856B (fr)
MA (1) MA26428A1 (fr)
NO (1) NO312547B1 (fr)
NZ (1) NZ332640A (fr)
OA (1) OA10896A (fr)
PE (1) PE65098A1 (fr)
PL (1) PL329725A1 (fr)
PT (1) PT901470E (fr)
SI (1) SI0901470T1 (fr)
SK (1) SK150398A3 (fr)
TN (1) TNSN97078A1 (fr)
TR (1) TR199802269T2 (fr)
TW (1) TW491838B (fr)
UA (1) UA50767C2 (fr)
UY (1) UY24546A1 (fr)
WO (1) WO1997043260A1 (fr)
ZA (1) ZA973963B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722287D0 (en) * 1997-10-22 1997-12-17 Pfizer Ltd Compounds useful in therapy
EE05345B1 (et) 1999-02-10 2010-10-15 Astrazeneca Ab Kinasoliini derivaadid angiogeneesi inhibiitoritena
GB0016162D0 (en) * 2000-06-30 2000-08-23 Cancer Res Campaign Tech Indole-3-acetic acid derivatives
US20050203166A1 (en) * 2000-06-30 2005-09-15 Cancer Research Technology Limited Indole-3-acetic acid derivatives
US7074817B2 (en) 2001-06-20 2006-07-11 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
EP1569899B1 (fr) 2002-12-10 2006-06-28 Wyeth Derives substitues de l'acide 3-alkyl- et 3-arylalkyl-1h-indol-1-yl-acetique en tant qu'inhibiteurs de l'inhibiteur de l'activateur du plasminogene-1 (pai-1)
US7078429B2 (en) 2002-12-10 2006-07-18 Wyeth Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
WO2004052854A2 (fr) 2002-12-10 2004-06-24 Wyeth Derives d'acide 1h-indol-3-yl glyoxylique a substitution aryle, aryloxy et alkyloxy en tant qu'inhibiteurs de l'inhibiteur de l'activateur du plasminogene-1 (pai-1)
WO2004052856A1 (fr) 2002-12-10 2004-06-24 Wyeth Derives d'acide indole oxo-acetyl amino acetique substitue comme inhibiteurs d'inhibiteur-1 de l'activateur du plasminogene (pai-1)
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
BRPI0406883A (pt) * 2003-01-22 2006-01-03 Lilly Co Eli Composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um composto
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
JP2005109006A (ja) * 2003-09-29 2005-04-21 Tdk Corp 高電圧貫通型コンデンサ及びマグネトロン
HN2004000536A (es) * 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
WO2006023864A1 (fr) 2004-08-23 2006-03-02 Wyeth Acides pyrrolo-naphtyliques en tant qu’inhibiteurs du pai-1
WO2006023866A2 (fr) 2004-08-23 2006-03-02 Wyeth Acides thiazolo-naphthyliques
MX2007002178A (es) 2004-08-23 2007-04-02 Wyeth Corp Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares.
US7683091B2 (en) 2005-08-17 2010-03-23 Wyeth Substituted indoles and methods of their use
WO2007119214A2 (fr) * 2006-04-13 2007-10-25 Actelion Pharmaceuticals Ltd Traitement précoce de fibrose pulmonaire idiopathique
DE102008030207A1 (de) 2008-06-25 2009-12-31 Bayer Schering Pharma Aktiengesellschaft Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung
DE102008030206A1 (de) 2008-06-25 2009-12-31 Bayer Schering Pharma Aktiengesellschaft 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung
EP3519816A4 (fr) 2016-09-29 2020-05-06 The Regents of the University of California Composés pour l'augmentation de la plasticité neuronale
CN106674065A (zh) * 2016-12-07 2017-05-17 贵州大学 一种5‑卤代‑2‑烷氧基‑4‑甲苯磺酰氯制备方法
GB201817038D0 (en) * 2018-10-19 2018-12-05 Inflazome Ltd Novel processes
KR102946120B1 (ko) 2019-02-27 2026-03-30 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클
WO2022221415A2 (fr) 2021-04-13 2022-10-20 The Regents Of The University Of California Composés tétracycliques pour le traitement de troubles cérébraux
JP2025502615A (ja) 2021-12-15 2025-01-28 デリックス セラピューティクス,インク. フェノキシおよびベンジルオキシ置換サイコプラストゲンならびにその使用
CN117263832B (zh) * 2023-08-18 2026-02-03 辽宁龙田化工科技有限公司 一种2-氯-4-甲磺酰基苯甲酸合成方法

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BE637355A (fr) * 1962-09-14
DE1950346B2 (de) * 1968-10-08 1973-06-28 Sumitomo Chemical Co 2-indolylessigsaeureverbindungen und diese verbindungen enthaltende arzneipraeparate
US4397079A (en) * 1981-03-30 1983-08-09 International Business Machines Corp. Process for improving the yield of integrated devices including Schottky barrier diodes
US5245046A (en) * 1988-11-14 1993-09-14 The Upjohn Company α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
AU8641991A (en) 1990-09-10 1992-03-30 Rhone-Poulenc Rorer International (Holdings) Inc. Substituted bicyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity
ZA939516B (en) * 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
ES2141197T3 (es) * 1993-03-19 2000-03-16 Merck & Co Inc Derivados del acido fenoxifenilacetico.
GB9317096D0 (en) * 1993-08-17 1993-09-29 Pfizer Ltd Indoles

Also Published As

Publication number Publication date
AR007030A1 (es) 1999-10-13
ID16878A (id) 1997-11-20
TNSN97078A1 (fr) 2005-03-15
ATE263151T1 (de) 2004-04-15
ZA973963B (en) 1998-11-09
CN1124262C (zh) 2003-10-15
US6384070B2 (en) 2002-05-07
HRP970249B1 (en) 2003-06-30
HRP970249A2 (en) 1998-06-30
CZ358298A3 (cs) 1999-08-11
HUP9901245A2 (hu) 1999-08-30
SK150398A3 (en) 1999-03-12
KR100331217B1 (ko) 2002-05-09
EP0901470B1 (fr) 2004-03-31
IL125903A0 (en) 1999-04-11
DE69728392T2 (de) 2005-01-13
HN1997000058A (es) 1997-06-26
HUP9901245A3 (en) 2002-01-28
CN1216531A (zh) 1999-05-12
EP0901470A1 (fr) 1999-03-17
UY24546A1 (es) 2000-09-29
ES2218675T3 (es) 2004-11-16
OA10896A (en) 2001-10-11
EA199800908A1 (ru) 1999-06-24
IS4838A (is) 1998-08-28
US20010014677A1 (en) 2001-08-16
PL329725A1 (en) 1999-04-12
AU717849B2 (en) 2000-04-06
DE69728392D1 (de) 2004-05-06
HK1019149A1 (en) 2000-01-14
AU2697897A (en) 1997-12-05
KR20000010879A (ko) 2000-02-25
JP3245179B2 (ja) 2002-01-07
BG102873A (en) 1999-11-30
AP9700982A0 (en) 1997-07-31
AP830A (en) 2000-05-03
DK0901470T3 (da) 2004-07-12
CZ292928B6 (cs) 2004-01-14
MA26428A1 (fr) 2004-12-20
NO985225D0 (no) 1998-11-09
SI0901470T1 (en) 2004-08-31
CO4650036A1 (es) 1998-09-03
US6017945A (en) 2000-01-25
EA001471B1 (ru) 2001-04-23
NO312547B1 (no) 2002-05-27
TR199802269T2 (xx) 2001-12-21
PT901470E (pt) 2004-07-30
JPH11508285A (ja) 1999-07-21
TW491838B (en) 2002-06-21
PE65098A1 (es) 1998-10-29
IS1856B (is) 2003-02-21
US6306852B1 (en) 2001-10-23
WO1997043260A1 (fr) 1997-11-20
UA50767C2 (uk) 2002-11-15
US6136843A (en) 2000-10-24
CA2253876A1 (fr) 1997-11-20
BR9709072A (pt) 1999-08-03
GB9609641D0 (en) 1996-07-10
NO985225L (no) 1998-11-09
NZ332640A (en) 2001-03-30

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