BG102873A - Indole derivatives useful as endothelium receptor antagonists - Google Patents

Indole derivatives useful as endothelium receptor antagonists

Info

Publication number: BG102873A
Authority: BG; Bulgaria
Prior art keywords: alkyl; conh; individually; optionally; mean
Prior art date: 1996-05-09

Application number

BG102873A

Other languages

Bulgarian (bg)

English (en)

Inventor

David RAWSON

Kevin DACK

Roger DICKINSON

Kim James

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-09

Filing date

1998-10-27

Publication date

1999-11-30

1998-10-27 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

1999-11-30 Publication of BG102873A publication Critical patent/BG102873A/xx

Links

229940054051 antipsychotic indole derivative Drugs 0.000 title 1
210000003038 endothelium Anatomy 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 3
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
208000001647 Renal Insufficiency Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
201000006370 kidney failure Diseases 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
208000002815 pulmonary hypertension Diseases 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1
125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

BG102873A 1996-05-09 1998-10-27 Indole derivatives useful as endothelium receptor antagonists BG102873A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9609641.7A GB9609641D0 (en)	1996-05-09	1996-05-09	Compounds useful in therapy
PCT/EP1997/001882 WO1997043260A1 (fr)	1996-05-09	1997-04-11	Derives d'indole utiles en tant qu'antagonistes du recepteur de l'endotheline

Publications (1)

Publication Number	Publication Date
BG102873A true BG102873A (en)	1999-11-30

Family

ID=10793387

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102873A BG102873A (en)	1996-05-09	1998-10-27	Indole derivatives useful as endothelium receptor antagonists

Country Status (42)

Country	Link
US (4)	US6017945A (fr)
EP (1)	EP0901470B1 (fr)
JP (1)	JP3245179B2 (fr)
KR (1)	KR100331217B1 (fr)
CN (1)	CN1124262C (fr)
AP (1)	AP830A (fr)
AR (1)	AR007030A1 (fr)
AT (1)	ATE263151T1 (fr)
AU (1)	AU717849B2 (fr)
BG (1)	BG102873A (fr)
BR (1)	BR9709072A (fr)
CA (1)	CA2253876A1 (fr)
CO (1)	CO4650036A1 (fr)
CZ (1)	CZ292928B6 (fr)
DE (1)	DE69728392T2 (fr)
DK (1)	DK0901470T3 (fr)
DZ (1)	DZ2227A1 (fr)
EA (1)	EA001471B1 (fr)
ES (1)	ES2218675T3 (fr)
GB (1)	GB9609641D0 (fr)
HN (1)	HN1997000058A (fr)
HR (1)	HRP970249B1 (fr)
HU (1)	HUP9901245A3 (fr)
ID (1)	ID16878A (fr)
IL (1)	IL125903A0 (fr)
IS (1)	IS1856B (fr)
MA (1)	MA26428A1 (fr)
NO (1)	NO312547B1 (fr)
NZ (1)	NZ332640A (fr)
OA (1)	OA10896A (fr)
PE (1)	PE65098A1 (fr)
PL (1)	PL329725A1 (fr)
PT (1)	PT901470E (fr)
SI (1)	SI0901470T1 (fr)
SK (1)	SK150398A3 (fr)
TN (1)	TNSN97078A1 (fr)
TR (1)	TR199802269T2 (fr)
TW (1)	TW491838B (fr)
UA (1)	UA50767C2 (fr)
UY (1)	UY24546A1 (fr)
WO (1)	WO1997043260A1 (fr)
ZA (1)	ZA973963B (fr)

Families Citing this family (41)

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GB9722287D0 (en)	1997-10-22	1997-12-17	Pfizer Ltd	Compounds useful in therapy
PT1154774E (pt)	1999-02-10	2005-10-31	Astrazeneca Ab	Derivados de quinazolina como inibidores de angiogenese
GB0016162D0 (en) *	2000-06-30	2000-08-23	Cancer Res Campaign Tech	Indole-3-acetic acid derivatives
US20050203166A1 (en) *	2000-06-30	2005-09-15	Cancer Research Technology Limited	Indole-3-acetic acid derivatives
TWI224101B (en)	2001-06-20	2004-11-21	Wyeth Corp	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US7074817B2 (en)	2001-06-20	2006-07-11	Wyeth	Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
AR037097A1 (es)	2001-10-05	2004-10-20	Novartis Ag	Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
UA80453C2 (en)	2002-12-10	2007-09-25		Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
EP1569900B1 (fr)	2002-12-10	2006-06-28	Wyeth	Derives substitues d'acides 3-carbonyl- indol-1-yl acetique comme inhibiteurs-1dd'activation plasminogenique
DE60324183D1 (en)	2002-12-10	2008-11-27	Wyeth Corp	Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1)
CA2509222A1 (fr)	2002-12-10	2004-06-24	Wyeth	Derives d'acide indole oxo-acetyl amino acetique substitue comme inhibiteurs d'inhibiteur-1 de l'activateur du plasminogene (pai-1)
CA2509170A1 (fr)	2002-12-10	2004-06-24	Wyeth	Derives substitues de l'acide acetique de 3-alkyle et 3-arylalkyle 1h-indol-1-yle en tant qu'inhibiteurs de l'inhibiteur des activateurs du plasminogene (pai-1)
CN1742007A (zh) *	2003-01-22	2006-03-01	伊莱利利公司	甾族激素核受体的吲哚衍生物调控剂
US7442805B2 (en)	2003-09-25	2008-10-28	Wyeth	Substituted sulfonamide-indoles
US7332521B2 (en)	2003-09-25	2008-02-19	Wyeth	Substituted indoles
US7351726B2 (en)	2003-09-25	2008-04-01	Wyeth	Substituted oxadiazolidinediones
US7534894B2 (en)	2003-09-25	2009-05-19	Wyeth	Biphenyloxy-acids
US7342039B2 (en)	2003-09-25	2008-03-11	Wyeth	Substituted indole oximes
US7420083B2 (en)	2003-09-25	2008-09-02	Wyeth	Substituted aryloximes
US7446201B2 (en)	2003-09-25	2008-11-04	Wyeth	Substituted heteroaryl benzofuran acids
US7163954B2 (en)	2003-09-25	2007-01-16	Wyeth	Substituted naphthyl benzothiophene acids
US7582773B2 (en)	2003-09-25	2009-09-01	Wyeth	Substituted phenyl indoles
US7141592B2 (en)	2003-09-25	2006-11-28	Wyeth	Substituted oxadiazolidinediones
US7411083B2 (en)	2003-09-25	2008-08-12	Wyeth	Substituted acetic acid derivatives
US7265148B2 (en)	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7268159B2 (en)	2003-09-25	2007-09-11	Wyeth	Substituted indoles
JP2005109006A (ja) *	2003-09-29	2005-04-21	Tdk Corp	高電圧貫通型コンデンサ及びマグネトロン
HN2004000536A (es)	2003-12-16	2009-02-18	Wyeth Corp	Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
AU2005277137A1 (en)	2004-08-23	2006-03-02	Wyeth	Pyrrolo-naphthyl acids as PAI-1 inhibitors
CN101044127A (zh)	2004-08-23	2007-09-26	惠氏公司	用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸
WO2006023865A1 (fr)	2004-08-23	2006-03-02	Wyeth	Acides d'oxazolo-naphthyl utilises en tant modulateurs de l'inhibiteur de type-1 (pai-1) de l'activateur de plasminogene utiles dans le traitement de la thrombose et des maladies cardio-vasculaires
BRPI0614340A2 (pt)	2005-08-17	2011-04-12	Wyeth Corp	indóis substituìdos e métodos de seu uso
SG174050A1 (en) *	2006-04-13	2011-09-29	Actelion Pharmaceuticals Ltd	Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
DE102008030206A1 (de)	2008-06-25	2009-12-31	Bayer Schering Pharma Aktiengesellschaft	3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung
DE102008030207A1 (de)	2008-06-25	2009-12-31	Bayer Schering Pharma Aktiengesellschaft	Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung
EP3519816A4 (fr)	2016-09-29	2020-05-06	The Regents of the University of California	Composés pour l'augmentation de la plasticité neuronale
CN106674065A (zh) *	2016-12-07	2017-05-17	贵州大学	一种5‑卤代‑2‑烷氧基‑4‑甲苯磺酰氯制备方法
GB201817038D0 (en) *	2018-10-19	2018-12-05	Inflazome Ltd	Novel processes
KR102946120B1 (ko)	2019-02-27	2026-03-30	더 리젠츠 오브 더 유니버시티 오브 캘리포니아	뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클
IL313455A (en)	2021-12-15	2024-08-01	Delix Therapeutics Inc	Phenoxy and benzyloxy modified psychroplastogens and their uses
CN117263832B (zh) *	2023-08-18	2026-02-03	辽宁龙田化工科技有限公司	一种2-氯-4-甲磺酰基苯甲酸合成方法

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US5245046A (en) *	1988-11-14	1993-09-14	The Upjohn Company	α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
US5468898A (en)	1990-09-10	1995-11-21	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Substituted naphthylene compounds exhibiting selective leukotriene B4 antagonist activity
ZA939516B (en) *	1992-12-22	1994-06-06	Smithkline Beecham Corp	Endothelin receptor antagonists
PT617001E (pt) *	1993-03-19	2000-06-30	Merck & Co Inc	Derivados do acido fenoxifenilacetico
GB9317096D0 (en) *	1993-08-17	1993-09-29	Pfizer Ltd	Indoles

1996
- 1996-05-09 GB GBGB9609641.7A patent/GB9609641D0/en active Pending
1997
- 1997-04-01 TW TW086104171A patent/TW491838B/zh not_active IP Right Cessation
- 1997-04-11 JP JP54042397A patent/JP3245179B2/ja not_active Expired - Fee Related
- 1997-04-11 SI SI9730646T patent/SI0901470T1/xx unknown
- 1997-04-11 CZ CZ19983582A patent/CZ292928B6/cs not_active IP Right Cessation
- 1997-04-11 IL IL12590397A patent/IL125903A0/xx unknown
- 1997-04-11 ES ES97920690T patent/ES2218675T3/es not_active Expired - Lifetime
- 1997-04-11 HU HU9901245A patent/HUP9901245A3/hu unknown
- 1997-04-11 KR KR1019980709023A patent/KR100331217B1/ko not_active Expired - Fee Related
- 1997-04-11 PL PL97329725A patent/PL329725A1/xx unknown
- 1997-04-11 AT AT97920690T patent/ATE263151T1/de not_active IP Right Cessation
- 1997-04-11 TR TR1998/02269T patent/TR199802269T2/xx unknown
- 1997-04-11 UA UA98115906A patent/UA50767C2/uk unknown
- 1997-04-11 EA EA199800908A patent/EA001471B1/ru not_active IP Right Cessation
- 1997-04-11 NZ NZ332640A patent/NZ332640A/en unknown
- 1997-04-11 AU AU26978/97A patent/AU717849B2/en not_active Ceased
- 1997-04-11 US US09/147,096 patent/US6017945A/en not_active Expired - Fee Related
- 1997-04-11 CA CA002253876A patent/CA2253876A1/fr not_active Abandoned
- 1997-04-11 DE DE1997628392 patent/DE69728392T2/de not_active Expired - Fee Related
- 1997-04-11 WO PCT/EP1997/001882 patent/WO1997043260A1/fr not_active Ceased
- 1997-04-11 SK SK1503-98A patent/SK150398A3/sk unknown
- 1997-04-11 DK DK97920690T patent/DK0901470T3/da active
- 1997-04-11 BR BR9709072A patent/BR9709072A/pt active Search and Examination
- 1997-04-11 CN CN97194016A patent/CN1124262C/zh not_active Expired - Fee Related
- 1997-04-11 EP EP97920690A patent/EP0901470B1/fr not_active Expired - Lifetime
- 1997-04-11 PT PT97920690T patent/PT901470E/pt unknown
- 1997-04-29 HN HN1997000058A patent/HN1997000058A/es unknown
- 1997-05-02 PE PE1997000345A patent/PE65098A1/es not_active Application Discontinuation
- 1997-05-07 UY UY24546A patent/UY24546A1/es not_active IP Right Cessation
- 1997-05-07 TN TNTNSN97078A patent/TNSN97078A1/fr unknown
- 1997-05-07 DZ DZ970074A patent/DZ2227A1/fr active
- 1997-05-07 AR ARP970101888A patent/AR007030A1/es not_active Application Discontinuation
- 1997-05-07 CO CO97024471A patent/CO4650036A1/es unknown
- 1997-05-07 MA MA24599A patent/MA26428A1/fr unknown
- 1997-05-07 ID IDP971517A patent/ID16878A/id unknown
- 1997-05-08 ZA ZA973963A patent/ZA973963B/xx unknown
- 1997-05-08 AP APAP/P/1997/000982A patent/AP830A/en active
- 1997-05-09 HR HR970249A patent/HRP970249B1/xx not_active IP Right Cessation
1998
- 1998-08-28 IS IS4838A patent/IS1856B/is unknown
- 1998-10-09 OA OA9800192A patent/OA10896A/en unknown
- 1998-10-27 BG BG102873A patent/BG102873A/xx unknown
- 1998-11-09 NO NO19985225A patent/NO312547B1/no not_active IP Right Cessation
1999
- 1999-10-07 US US09/414,361 patent/US6136843A/en not_active Expired - Fee Related
2000
- 2000-04-24 US US09/556,651 patent/US6306852B1/en not_active Expired - Fee Related
2001
- 2001-01-09 US US09/756,835 patent/US6384070B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6384070B2 (en)	2002-05-07
AU2697897A (en)	1997-12-05
NO312547B1 (no)	2002-05-27
CN1216531A (zh)	1999-05-12
KR100331217B1 (ko)	2002-05-09
US6306852B1 (en)	2001-10-23
JP3245179B2 (ja)	2002-01-07
MA26428A1 (fr)	2004-12-20
BR9709072A (pt)	1999-08-03
OA10896A (en)	2001-10-11
NO985225L (no)	1998-11-09
EP0901470A1 (fr)	1999-03-17
HUP9901245A3 (en)	2002-01-28
ID16878A (id)	1997-11-20
US6017945A (en)	2000-01-25
KR20000010879A (ko)	2000-02-25
CO4650036A1 (es)	1998-09-03
TW491838B (en)	2002-06-21
PE65098A1 (es)	1998-10-29
NO985225D0 (no)	1998-11-09
WO1997043260A1 (fr)	1997-11-20
CZ358298A3 (cs)	1999-08-11
HRP970249A2 (en)	1998-06-30
IS1856B (is)	2003-02-21
ZA973963B (en)	1998-11-09
DE69728392T2 (de)	2005-01-13
SI0901470T1 (en)	2004-08-31
CA2253876A1 (fr)	1997-11-20
AU717849B2 (en)	2000-04-06
UY24546A1 (es)	2000-09-29
CN1124262C (zh)	2003-10-15
HRP970249B1 (en)	2003-06-30
EA001471B1 (ru)	2001-04-23
DK0901470T3 (da)	2004-07-12
JPH11508285A (ja)	1999-07-21
AP830A (en)	2000-05-03
HUP9901245A2 (hu)	1999-08-30
ATE263151T1 (de)	2004-04-15
US6136843A (en)	2000-10-24
NZ332640A (en)	2001-03-30
HK1019149A1 (en)	2000-01-14
CZ292928B6 (cs)	2004-01-14
ES2218675T3 (es)	2004-11-16
TNSN97078A1 (fr)	2005-03-15
AP9700982A0 (en)	1997-07-31
US20010014677A1 (en)	2001-08-16
HN1997000058A (es)	1997-06-26
UA50767C2 (uk)	2002-11-15
PL329725A1 (en)	1999-04-12
EA199800908A1 (ru)	1999-06-24
IS4838A (is)	1998-08-28
DZ2227A1 (fr)	2002-12-25
IL125903A0 (en)	1999-04-11
SK150398A3 (en)	1999-03-12
EP0901470B1 (fr)	2004-03-31
AR007030A1 (es)	1999-10-13
GB9609641D0 (en)	1996-07-10
PT901470E (pt)	2004-07-30
TR199802269T2 (xx)	2001-12-21
DE69728392D1 (de)	2004-05-06

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