EA201270077A1 - Соединения и способы лечения гриппа - Google Patents

Соединения и способы лечения гриппа

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Publication number
EA201270077A1
EA201270077A1 EA201270077A EA201270077A EA201270077A1 EA 201270077 A1 EA201270077 A1 EA 201270077A1 EA 201270077 A EA201270077 A EA 201270077A EA 201270077 A EA201270077 A EA 201270077A EA 201270077 A1 EA201270077 A1 EA 201270077A1
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Eurasian Patent Office
Prior art keywords
methods
connections
lower alkyl
treating
treating influenza
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EA201270077A
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English (en)
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EA030679B1 (ru
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Жан-Франсуа Россиньоль
Дж. Эдвард Сэмпл
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РОМАРК ЛЭБОРЕТЕРИЗ Эл.Си.
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Publication of EA201270077A1 publication Critical patent/EA201270077A1/ru
Publication of EA030679B1 publication Critical patent/EA030679B1/ru

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/20—Antivirals for DNA viruses
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    • H10F55/00—Radiation-sensitive semiconductor devices covered by groups H10F10/00, H10F19/00 or H10F30/00 being structurally associated with electric light sources and electrically or optically coupled thereto
    • H10F55/18—Radiation-sensitive semiconductor devices covered by groups H10F10/00, H10F19/00 or H10F30/00 being structurally associated with electric light sources and electrically or optically coupled thereto wherein the radiation-sensitive semiconductor devices and the electric light source share a common body having dual-functionality of light emission and light detection
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Virology (AREA)
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  • Pulmonology (AREA)
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  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Composite Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Изобретение относится к способам лечения и предотвращения инфекции гриппа посредством ингибирования процессов созревания НА вируса гриппа с применением соединений формулы I. Оно также относится к комбинациям для лечения и предотвращения инфекции гриппа, содержащим соединения формулы I и другие средствагде один из R, R, Rявляется ОН или OC(=O)Q, где Q является R, ORили NHR; Rявляется низшим алкилом, арилом или гетероарилом и, необязательно, является замещенным; R, Rи оставшиеся из R, Rи Rявляются, независимо, Н, галогеном, низшим алкокси или низшим алкилом; и Rявляется NO, и Rявляется Н, или Rявляется Н, и Rявляется SOR, где Rявляется низшим алкилом, арилом или гетероарилом и, необязательно, является замещенным.
EA201270077A 2009-06-26 2010-06-23 Соединения и способы лечения гриппа EA030679B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22089109P 2009-06-26 2009-06-26
PCT/US2010/039638 WO2010151577A1 (en) 2009-06-26 2010-06-23 Compounds and methods for treating influenza

Publications (2)

Publication Number Publication Date
EA201270077A1 true EA201270077A1 (ru) 2012-12-28
EA030679B1 EA030679B1 (ru) 2018-09-28

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EA201270077A EA030679B1 (ru) 2009-06-26 2010-06-23 Соединения и способы лечения гриппа

Country Status (16)

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US (6) US9023877B2 (ru)
EP (2) EP2445349B1 (ru)
JP (3) JP5932640B2 (ru)
KR (4) KR20180032689A (ru)
CN (2) CN108042535A (ru)
AP (1) AP2012006064A0 (ru)
AU (2) AU2010264479B2 (ru)
BR (2) BRPI1014322A2 (ru)
CA (3) CA2766642C (ru)
EA (1) EA030679B1 (ru)
ES (1) ES2914949T3 (ru)
HK (1) HK1255283A1 (ru)
MX (2) MX391013B (ru)
PT (1) PT2445349T (ru)
WO (1) WO2010151577A1 (ru)
ZA (1) ZA201200263B (ru)

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