NO20044039L - Konjugatorer av terapeutiske eller cytotoksiske midler og biologisk aktive peptider. - Google Patents
Konjugatorer av terapeutiske eller cytotoksiske midler og biologisk aktive peptider.Info
- Publication number
- NO20044039L NO20044039L NO20044039A NO20044039A NO20044039L NO 20044039 L NO20044039 L NO 20044039L NO 20044039 A NO20044039 A NO 20044039A NO 20044039 A NO20044039 A NO 20044039A NO 20044039 L NO20044039 L NO 20044039L
- Authority
- NO
- Norway
- Prior art keywords
- therapeutic
- biologically active
- cytotoxic agents
- conjugators
- active peptides
- Prior art date
Links
- 229940127089 cytotoxic agent Drugs 0.000 title abstract 2
- 239000002254 cytotoxic agent Substances 0.000 title abstract 2
- 231100000599 cytotoxic agent Toxicity 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36083102P | 2002-03-01 | 2002-03-01 | |
| PCT/US2003/006657 WO2003074551A2 (en) | 2002-03-01 | 2003-03-03 | Conjugates of therapeutic or cytotoxic agents and biologically active peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20044039L true NO20044039L (no) | 2004-09-29 |
Family
ID=27789031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20044039A NO20044039L (no) | 2002-03-01 | 2004-09-24 | Konjugatorer av terapeutiske eller cytotoksiske midler og biologisk aktive peptider. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7771727B2 (no) |
| EP (1) | EP1487493B1 (no) |
| JP (1) | JP4477881B2 (no) |
| KR (1) | KR101003622B1 (no) |
| CN (2) | CN102133407A (no) |
| AT (1) | ATE455561T1 (no) |
| AU (1) | AU2003220011B2 (no) |
| BR (1) | BR0308090A (no) |
| CA (1) | CA2476182A1 (no) |
| CO (1) | CO5611160A2 (no) |
| DE (1) | DE60331049D1 (no) |
| DK (1) | DK1487493T3 (no) |
| ES (1) | ES2339934T3 (no) |
| IL (1) | IL163573A0 (no) |
| IS (1) | IS7431A (no) |
| MX (1) | MXPA04008419A (no) |
| NO (1) | NO20044039L (no) |
| NZ (1) | NZ534719A (no) |
| PL (1) | PL373567A1 (no) |
| WO (1) | WO2003074551A2 (no) |
| ZA (1) | ZA200406614B (no) |
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| SI1545613T1 (sl) | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| RU2324701C2 (ru) * | 2003-03-20 | 2008-05-20 | Ниппон Каяку Кабусики Кайся | Мицеллярный препарат, содержащий малорастворимый в воде противораковый агент, содержащее его противораковое средство и новый блок-сополимер |
| CA2524255C (en) | 2003-03-21 | 2014-02-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| NZ564694A (en) * | 2003-04-22 | 2009-11-27 | Sod Conseils Rech Applic | Peptide vectors |
| US20060281897A1 (en) * | 2003-08-22 | 2006-12-14 | Andre Trouet | Potentialization of the activation of high molecular weight prodrugs |
| EP1680073B1 (en) | 2003-10-21 | 2013-01-02 | IGF Oncology, LLC | Compounds and method for treating cancer |
| US9011880B2 (en) | 2003-10-21 | 2015-04-21 | Igf Oncology, Llc | Compounds and methods for treating cancer |
| JP4820758B2 (ja) * | 2004-09-22 | 2011-11-24 | 日本化薬株式会社 | 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤 |
| CA2582552A1 (en) | 2004-10-21 | 2006-05-04 | Igf Oncology, Llc | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
| EP1809291A4 (en) * | 2004-11-03 | 2012-04-04 | Forhumantech Co Ltd | PHARMACEUTICAL COMPOSITIONS FOR TRANSDERMAL LEVY |
| WO2007021674A2 (en) * | 2005-08-09 | 2007-02-22 | Millennium Pharmaceuticals, Inc. | Method of acylating maytansinol with chiral amino acids |
| WO2007123391A1 (en) | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene. |
| KR20090009241A (ko) * | 2006-05-18 | 2009-01-22 | 니폰 가야꾸 가부시끼가이샤 | 포도필로톡신류의 고분자 결합체 |
| EP1857548A1 (en) | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Means and method for inducing exon-skipping |
| AU2007280690C1 (en) | 2006-07-31 | 2012-08-23 | Curevac Gmbh | Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant |
| AU2007282224B2 (en) | 2006-08-11 | 2013-08-29 | Vico Therapeutics B.V. | Methods and means for treating DNA repeat instability associated genetic disorders |
| ES2584840T3 (es) * | 2006-10-03 | 2016-09-29 | Nippon Kayaku Kabushiki Kaisha | Compuesto de un derivado de resorcinol con un polímero |
| CA2693742A1 (en) * | 2007-07-12 | 2009-01-15 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs, tissues or tumor cells |
| WO2009008727A2 (en) | 2007-07-12 | 2009-01-15 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs or tissues |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| US8703878B2 (en) * | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
| AU2008317566B2 (en) | 2007-10-26 | 2014-05-01 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| EP2176408B9 (en) | 2008-01-31 | 2015-11-11 | Curevac GmbH | NUCLEIC ACIDS COMPRISING FORMULA (NuGiXmGnNv)a AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENTS /ADJUVANTS |
| NZ587178A (en) | 2008-02-08 | 2011-11-25 | Prosensa Holding Bv | Methods and means for treating dna repeat instability associated genetic disorders |
| WO2009116509A1 (ja) * | 2008-03-18 | 2009-09-24 | 日本化薬株式会社 | 生理活性物質の高分子結合体 |
| WO2009136572A1 (ja) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
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| WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| CN101439182B (zh) * | 2008-12-18 | 2012-02-01 | 北京大学 | 一种生长抑素受体介导的肿瘤靶向药物组合物 |
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| EP2641605B1 (en) | 2010-11-17 | 2018-03-07 | Nippon Kayaku Kabushiki Kaisha | Polymer derivative of cytidine metabolism antagonist |
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| CN112251436A (zh) | 2012-01-27 | 2021-01-22 | 比奥马林技术公司 | 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸 |
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| US9981046B2 (en) | 2012-05-15 | 2018-05-29 | Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. | Drug-conjugates, conjugation methods, and uses thereof |
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| BR112016003361A2 (pt) | 2013-08-21 | 2017-11-21 | Curevac Ag | vacina do vírus sincicial respiratório (rsv) |
| JP6835590B2 (ja) | 2014-01-12 | 2021-02-24 | アイジーエフ オンコロジー、 エルエルシー | インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用 |
| CA2936286A1 (en) | 2014-04-01 | 2015-10-08 | Curevac Ag | Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant |
| CN105198966B (zh) * | 2014-06-26 | 2019-06-21 | 中国人民解放军军事医学科学院毒物药物研究所 | GnRH类似物-细胞毒分子缀合物、其制备方法及用途 |
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| CA2955569C (en) * | 2014-08-06 | 2023-02-14 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
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| CN110357947B (zh) * | 2019-03-08 | 2023-05-26 | 南京恒远科技开发有限公司 | 一种combretastatin A4衍生物 |
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| CN118252943B (zh) * | 2023-10-25 | 2024-09-20 | 常州市智态生创科技有限公司 | 一种短肽偶联药物及其制备方法和应用 |
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-
2003
- 2003-03-03 EP EP03716299A patent/EP1487493B1/en not_active Expired - Lifetime
- 2003-03-03 AT AT03716299T patent/ATE455561T1/de active
- 2003-03-03 AU AU2003220011A patent/AU2003220011B2/en not_active Ceased
- 2003-03-03 DE DE60331049T patent/DE60331049D1/de not_active Expired - Lifetime
- 2003-03-03 DK DK03716299.7T patent/DK1487493T3/da active
- 2003-03-03 US US10/506,223 patent/US7771727B2/en not_active Expired - Fee Related
- 2003-03-03 IL IL16357303A patent/IL163573A0/xx unknown
- 2003-03-03 JP JP2003573017A patent/JP4477881B2/ja not_active Expired - Lifetime
- 2003-03-03 CA CA002476182A patent/CA2476182A1/en not_active Abandoned
- 2003-03-03 MX MXPA04008419A patent/MXPA04008419A/es active IP Right Grant
- 2003-03-03 PL PL03373567A patent/PL373567A1/xx not_active Application Discontinuation
- 2003-03-03 WO PCT/US2003/006657 patent/WO2003074551A2/en not_active Ceased
- 2003-03-03 KR KR1020047013597A patent/KR101003622B1/ko not_active Expired - Fee Related
- 2003-03-03 BR BRPI0308090-0A patent/BR0308090A/pt not_active IP Right Cessation
- 2003-03-03 NZ NZ534719A patent/NZ534719A/en not_active IP Right Cessation
- 2003-03-03 ES ES03716299T patent/ES2339934T3/es not_active Expired - Lifetime
- 2003-03-03 CN CN2010106215969A patent/CN102133407A/zh active Pending
- 2003-03-03 CN CNA038099276A patent/CN1649625A/zh active Pending
-
2004
- 2004-08-19 ZA ZA200406614A patent/ZA200406614B/en unknown
- 2004-08-31 IS IS7431A patent/IS7431A/is unknown
- 2004-09-24 NO NO20044039A patent/NO20044039L/no not_active Application Discontinuation
- 2004-09-29 CO CO04097209A patent/CO5611160A2/es not_active Application Discontinuation
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2009
- 2009-08-25 US US12/547,096 patent/US20090324620A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003074551A8 (en) | 2005-11-03 |
| EP1487493A2 (en) | 2004-12-22 |
| DE60331049D1 (de) | 2010-03-11 |
| WO2003074551A3 (en) | 2004-03-25 |
| US7771727B2 (en) | 2010-08-10 |
| EP1487493A4 (en) | 2006-08-30 |
| MXPA04008419A (es) | 2004-11-26 |
| IL163573A0 (en) | 2005-12-18 |
| KR101003622B1 (ko) | 2010-12-24 |
| WO2003074551A2 (en) | 2003-09-12 |
| AU2003220011A1 (en) | 2003-09-16 |
| US20060009622A1 (en) | 2006-01-12 |
| ATE455561T1 (de) | 2010-02-15 |
| PL373567A1 (en) | 2005-09-05 |
| JP4477881B2 (ja) | 2010-06-09 |
| ES2339934T3 (es) | 2010-05-27 |
| CN1649625A (zh) | 2005-08-03 |
| NZ534719A (en) | 2008-02-29 |
| US20090324620A1 (en) | 2009-12-31 |
| CO5611160A2 (es) | 2006-02-28 |
| AU2003220011B2 (en) | 2008-05-29 |
| DK1487493T3 (da) | 2010-05-25 |
| JP2006510571A (ja) | 2006-03-30 |
| ZA200406614B (en) | 2006-06-28 |
| BR0308090A (pt) | 2006-04-11 |
| CA2476182A1 (en) | 2003-09-12 |
| IS7431A (is) | 2004-08-31 |
| KR20040088568A (ko) | 2004-10-16 |
| EP1487493B1 (en) | 2010-01-20 |
| CN102133407A (zh) | 2011-07-27 |
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