ECSP034551A - Secretagogos de hormona del crecimiento - Google Patents
Secretagogos de hormona del crecimientoInfo
- Publication number
- ECSP034551A ECSP034551A EC2003004551A ECSP034551A ECSP034551A EC SP034551 A ECSP034551 A EC SP034551A EC 2003004551 A EC2003004551 A EC 2003004551A EC SP034551 A ECSP034551 A EC SP034551A EC SP034551 A ECSP034551 A EC SP034551A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- aryl
- hydrogen
- group
- optionally substituted
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 17
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001041 indolyl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto de fórmula I: en la que: R1 es NhR10 O alquil C1-C6-NHR10; (gráfico), R10 se selecciona entre el grupo compuesto por hidrógeno, alquilo C1-C6, alquil C1-C6 (OH), alquilidenil C1-C6 (OH) RII, y un grupo protector de amino: RII se selecciona entre el grupo compuesto por alquilo C1-C6, alquenilo C2-C6, alquil C1-C6(0) alquilo C1-C6, C(0) 0-alquilo C1-C6, arilo y alquil C1-C6-arilo; R2 se selecciona entre hidrógeno, alquilo C1-C6, arilo y alquil C1-C6 arilo; R3 se selecciona entre el grupo compuesto por arilo opcionalmente sustituido, alquil C1-C6-arilo, alquil C1-C6(0)-alquil C1-C6 arilo, cicloalquilo C3-C8, (alquil C1-C6) cicloalilo C3-C8, indolilo, indolinilo, (alquil C1-C6) indolilo; R4 es hidrógeno, alquilo C1, C6, arilo y alquil C1-C6-arilo; W es -CH2C2C6H4-o-(CH2) m, donde m es un número seleccionado de 1 a 4: R6 y R7 se seleccionan independientemente entre el grupo compuesto por hidrógeno, alquilo C2-C6, alquenilo C1-C6, o R6 y R7 junto con el átomo del carbono al que están unidos pueden formar un anillo carbocíclico de hasta 8 átomos que opcionalmente está parcialmente insaturado; R8 se selecciona entre el grupo compuesto por hidrógeno, alquilo C1-C6, alquilo C1-C6, arilo y alquil C1-C6, alquenilo C1-C6 arilo; R9se selecciona entre el grupo compuesto por hidrógeno, alquilo C1-C6 alquenilo C2-C6, alquinilo C2-C6, cicloalquilo C3-C8, cicloalquenilo C3-C8, ciano, arilo opcionalmente sustituido, -0-arilo opcionalmente sustituido, -N- arilo opcionalmente sustituido, -S- arilo opcionalmente sustituido-aril-arilo (K1) (K2), -O-aril-arilo (K1) (K2). -N-aril-aril(k1) (K2), -O-alquilo C1-C6, y alquil C1-C6 arilo, donde K1 es halo o - CF3 y K2 es hidrógeno, halo 0 -CF3; y Q es S-(0) 2-o-C(0)-; o una sal o solvato farmaceúticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24045600P | 2000-10-13 | 2000-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034551A true ECSP034551A (es) | 2003-05-26 |
Family
ID=22906598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2003004551A ECSP034551A (es) | 2000-10-13 | 2003-04-10 | Secretagogos de hormona del crecimiento |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1326851B1 (es) |
| JP (1) | JP2004511552A (es) |
| KR (1) | KR20030042014A (es) |
| CN (1) | CN1469871A (es) |
| AT (1) | ATE270280T1 (es) |
| AU (2) | AU2002211219B2 (es) |
| BR (1) | BR0114630A (es) |
| CA (1) | CA2419388A1 (es) |
| CZ (1) | CZ20031029A3 (es) |
| DE (1) | DE60104141T2 (es) |
| DZ (1) | DZ3482A1 (es) |
| EA (1) | EA006102B1 (es) |
| EC (1) | ECSP034551A (es) |
| ES (1) | ES2223926T3 (es) |
| HR (1) | HRP20030288B1 (es) |
| HU (1) | HUP0301351A3 (es) |
| IL (1) | IL154809A0 (es) |
| MX (1) | MXPA03003217A (es) |
| NO (1) | NO20031687L (es) |
| NZ (1) | NZ524232A (es) |
| PL (1) | PL361675A1 (es) |
| PT (1) | PT1326851E (es) |
| SK (1) | SK4182003A3 (es) |
| TR (1) | TR200402046T4 (es) |
| WO (1) | WO2002032888A1 (es) |
| ZA (1) | ZA200301720B (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1497316B1 (en) * | 2002-04-09 | 2006-07-05 | Eli Lilly And Company | Growth hormone secretagogues |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2005028438A1 (ja) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| NZ562766A (en) | 2005-05-30 | 2011-03-31 | Banyu Pharma Co Ltd | Piperidine derivatives as histamine-H3 receptor antagonists |
| EP1916239A4 (en) | 2005-08-10 | 2009-10-21 | Banyu Pharma Co Ltd | PYRIDOLVERBINDUNG |
| AU2006282260A1 (en) | 2005-08-24 | 2007-03-01 | Msd K.K. | Phenylpyridone derivative |
| US20090264426A1 (en) | 2005-09-07 | 2009-10-22 | Shunji Sakuraba | Bicyclic aromatic substituted pyridone derivative |
| US8293900B2 (en) | 2005-09-29 | 2012-10-23 | Merck Sharp & Dohme Corp | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| US20080255084A1 (en) | 2005-10-21 | 2008-10-16 | Randy Lee Webb | Combination of Organic Compounds |
| EP1944301A4 (en) | 2005-10-27 | 2012-01-04 | Msd Kk | NEW BENZOXATHIIN DERIVATIVES |
| CA2629018C (en) | 2005-11-10 | 2013-12-31 | Banyu Pharmaceutical Co., Ltd. | Aza-substituted spiro derivative |
| EP2698157B1 (en) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
| WO2008038692A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| US8106086B2 (en) | 2007-04-02 | 2012-01-31 | Msd K.K. | Indoledione derivative |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2264026A4 (en) | 2008-03-06 | 2012-03-28 | Msd Kk | ALKYLAMINOPYRIDINDERIVATE |
| JPWO2009119726A1 (ja) | 2008-03-28 | 2011-07-28 | Ｍｓｄ株式会社 | メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体 |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US20110071129A1 (en) | 2008-06-19 | 2011-03-24 | Makoto Ando | Spirodiamine-diaryl ketoxime derivative |
| EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| WO2010013595A1 (ja) | 2008-07-30 | 2010-02-04 | 萬有製薬株式会社 | ５員－５員又は５員－６員縮環シクロアルキルアミン誘導体 |
| US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| MX2011004551A (es) | 2008-10-30 | 2011-05-25 | Merck Sharp & Dohme | Antagonistas del receptor de orexina de isonicotinamida. |
| CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8314250B2 (en) * | 2009-11-24 | 2012-11-20 | Hoffmann-La Roche Inc. | Sultam derivatives |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CA2826649C (en) | 2011-02-25 | 2016-07-26 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| RU2015106909A (ru) | 2012-08-02 | 2016-09-27 | Мерк Шарп И Доум Корп. | Антидиабетические трициклические соединения |
| BR112015019836A2 (pt) | 2013-02-22 | 2017-07-18 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| MX389591B (es) | 2014-08-29 | 2025-03-20 | Tes Pharma S R L | INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA |
| MX2019004321A (es) | 2016-10-14 | 2019-06-12 | Tes Pharma S R L | Inhibidores de la acido alfa-amino-beta-carboximuconico semialdehido descarboxilasa. |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| CN118496217A (zh) | 2018-11-20 | 2024-08-16 | Tes制药有限责任公司 | α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂 |
| US12331018B2 (en) | 2019-02-13 | 2025-06-17 | Merck Sharp & Dohme Llc | Pyrrolidine orexin receptor agonists |
| EP3924058B1 (en) | 2019-02-13 | 2026-01-07 | Merck Sharp & Dohme LLC | 5-alkyl pyrrolidine orexin receptor agonists |
| US12312332B2 (en) | 2019-08-08 | 2025-05-27 | Merck Sharp & Dohme Llc | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
| US20230365533A1 (en) | 2020-08-18 | 2023-11-16 | Merck Sharp & Dohme Llc | Bicycloheptane pyrrolidine orexin receptor agonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998018815A1 (en) * | 1996-10-25 | 1998-05-07 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
| UA53716C2 (uk) * | 1997-06-25 | 2003-02-17 | Пфайзер Продактс Інк. | Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти) |
-
2001
- 2001-10-09 BR BR0114630-0A patent/BR0114630A/pt not_active IP Right Cessation
- 2001-10-09 HU HU0301351A patent/HUP0301351A3/hu unknown
- 2001-10-09 CN CNA018172822A patent/CN1469871A/zh active Pending
- 2001-10-09 TR TR2004/02046T patent/TR200402046T4/xx unknown
- 2001-10-09 CZ CZ20031029A patent/CZ20031029A3/cs unknown
- 2001-10-09 CA CA002419388A patent/CA2419388A1/en not_active Abandoned
- 2001-10-09 IL IL15480901A patent/IL154809A0/xx unknown
- 2001-10-09 JP JP2002536270A patent/JP2004511552A/ja active Pending
- 2001-10-09 SK SK418-2003A patent/SK4182003A3/sk unknown
- 2001-10-09 AU AU2002211219A patent/AU2002211219B2/en not_active Ceased
- 2001-10-09 DZ DZ013482A patent/DZ3482A1/fr active
- 2001-10-09 HR HR20030288A patent/HRP20030288B1/xx not_active IP Right Cessation
- 2001-10-09 PT PT01979233T patent/PT1326851E/pt unknown
- 2001-10-09 AT AT01979233T patent/ATE270280T1/de not_active IP Right Cessation
- 2001-10-09 NZ NZ524232A patent/NZ524232A/en unknown
- 2001-10-09 WO PCT/US2001/027756 patent/WO2002032888A1/en not_active Ceased
- 2001-10-09 KR KR10-2003-7005203A patent/KR20030042014A/ko not_active Withdrawn
- 2001-10-09 AU AU1121902A patent/AU1121902A/xx active Pending
- 2001-10-09 MX MXPA03003217A patent/MXPA03003217A/es unknown
- 2001-10-09 ES ES01979233T patent/ES2223926T3/es not_active Expired - Lifetime
- 2001-10-09 EA EA200300462A patent/EA006102B1/ru not_active IP Right Cessation
- 2001-10-09 PL PL01361675A patent/PL361675A1/xx not_active Application Discontinuation
- 2001-10-09 DE DE60104141T patent/DE60104141T2/de not_active Expired - Lifetime
- 2001-10-09 EP EP01979233A patent/EP1326851B1/en not_active Expired - Lifetime
-
2003
- 2003-02-28 ZA ZA200301720A patent/ZA200301720B/en unknown
- 2003-04-10 EC EC2003004551A patent/ECSP034551A/es unknown
- 2003-04-11 NO NO20031687A patent/NO20031687L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0114630A (pt) | 2003-07-01 |
| CN1469871A (zh) | 2004-01-21 |
| DE60104141D1 (de) | 2004-08-05 |
| HRP20030288B1 (en) | 2005-02-28 |
| HUP0301351A3 (en) | 2007-05-29 |
| EP1326851B1 (en) | 2004-06-30 |
| EP1326851A1 (en) | 2003-07-16 |
| HUP0301351A2 (hu) | 2003-11-28 |
| AU2002211219B2 (en) | 2006-09-14 |
| KR20030042014A (ko) | 2003-05-27 |
| NO20031687L (no) | 2003-05-08 |
| PL361675A1 (en) | 2004-10-04 |
| JP2004511552A (ja) | 2004-04-15 |
| NO20031687D0 (no) | 2003-04-11 |
| CA2419388A1 (en) | 2002-04-25 |
| HRP20030288A2 (en) | 2004-02-29 |
| EA200300462A1 (ru) | 2003-08-28 |
| CZ20031029A3 (cs) | 2003-09-17 |
| MXPA03003217A (es) | 2003-06-06 |
| EA006102B1 (ru) | 2005-08-25 |
| ZA200301720B (en) | 2004-06-21 |
| WO2002032888A1 (en) | 2002-04-25 |
| PT1326851E (pt) | 2004-11-30 |
| ES2223926T3 (es) | 2005-03-01 |
| HK1058194A1 (en) | 2004-05-07 |
| DZ3482A1 (fr) | 2002-04-25 |
| SK4182003A3 (en) | 2004-01-08 |
| TR200402046T4 (tr) | 2004-10-21 |
| ATE270280T1 (de) | 2004-07-15 |
| IL154809A0 (en) | 2003-10-31 |
| AU1121902A (en) | 2002-04-29 |
| NZ524232A (en) | 2005-01-28 |
| DE60104141T2 (de) | 2005-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP034551A (es) | Secretagogos de hormona del crecimiento | |
| CO4790091A1 (es) | Derivados sustituidos de acido 3-sulfonil-propionico | |
| CO4950563A1 (es) | Nuevos compuestos | |
| UY28878A1 (es) | Compuestos de aril-o heteroarilamida ortosustituidos y composiciones | |
| AR029216A1 (es) | Compuestos inhibidores no peptidicos de la union celular dependiente de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias; composicion farmaceutica y procedimiento de tratamiento | |
| AR008377A1 (es) | Un compuesto derivado de la 3-aroilbencilpiridazinona, una composicion farmaceutica particularmente para el tratamiento de enfermedades inflamatorias o autoinmunes que contiene dicho compuesto | |
| SG165154A1 (en) | Ester compound and medical use thereof | |
| PE49696A1 (es) | Compuesto carbociclico | |
| DOP2005000071A (es) | "compuestos de metil-aril o heteroaril-amida sustituida" | |
| DE60315615D1 (de) | Tricyclische verbindungen auf thiophengrundlage und pharmazeutische zusammensetzungen, die diese enthalten | |
| PE20021004A1 (es) | Derivados de piperidina como inhibidores de la ccr5 | |
| AR064253A1 (es) | Compuestos de biciclocarboxiamida sustituidos composiciones farmaceuticas y una combinacion que los incluye y su uso en fabaricacion de un medicamento para el tratamiento de enfermedades mediadas por la actividad del receptor vr1 | |
| ES2095942T3 (es) | Derivados de bencenoacetamida inhibidores del vih. | |
| TW200612920A (en) | Novel imidazolidine derivatives | |
| AR033300A1 (es) | Compuestos de cefem | |
| ES2143644T3 (es) | Procedimiento para elaborar compuestos antimicrobianos. | |
| TW200509942A (en) | Substituted 1,4-diazepines and uses thereof | |
| HU9300176D0 (en) | Method for producing unsaturated 17beta-substituted 3-carboxy steroides | |
| AR025296A1 (es) | MÉTODO PARA INHIBIR LA POLIMERIZACIoN PREMATURA DE MONoMEROS VINIL AROMÁTICOS Y COMPOSICIoN DE MONoMEROS VINIL AROMÁTICOS Y DEL INHIBIDOR. | |
| CO5700768A2 (es) | Derivados de benzoxazina y sus usos | |
| WO2004080408A3 (en) | Method of treating cancer with azaspirane compositions | |
| UY23452A1 (es) | Procedimiento para la preparacion de derivados de ciclohexano y tetrahidropirano | |
| DK0988312T3 (da) | 17beta-allyloxy(thio)alkyl-androstanderivater til modulering af meiose | |
| CO4650039A1 (es) | Benzotiofenos amorfos, procedimientos de preparacion y procedimientos de uso | |
| ATE356816T1 (de) | Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren |