ECSP055743A - Nuevo proceso para la sintesis industrial de tetraésteres del acido 5-[bis(carboximetil)amino]-3-carboximetil-4-ciano-2- tiofeno carboxílico y aplicación para la síntesis de sales bivalentes de acido ranelico y sus hidratos - Google Patents
Nuevo proceso para la sintesis industrial de tetraésteres del acido 5-[bis(carboximetil)amino]-3-carboximetil-4-ciano-2- tiofeno carboxílico y aplicación para la síntesis de sales bivalentes de acido ranelico y sus hidratosInfo
- Publication number
- ECSP055743A ECSP055743A EC2005005743A ECSP055743A ECSP055743A EC SP055743 A ECSP055743 A EC SP055743A EC 2005005743 A EC2005005743 A EC 2005005743A EC SP055743 A ECSP055743 A EC SP055743A EC SP055743 A ECSP055743 A EC SP055743A
- Authority
- EC
- Ecuador
- Prior art keywords
- carboximetil
- synthesis
- acid
- bivalent
- application
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- DJSXNILVACEBLP-UHFFFAOYSA-N ranelic acid Chemical class OC(=O)CN(CC(O)=O)C=1SC(C(O)=O)=C(CC(O)=O)C=1C#N DJSXNILVACEBLP-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZHEZAQJNZMLYBA-UHFFFAOYSA-J distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate;octahydrate Chemical compound O.O.O.O.O.O.O.O.[Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N ZHEZAQJNZMLYBA-UHFFFAOYSA-J 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940079488 strontium ranelate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Proceso para la síntesis industrial de los compuestos de fórmula (I): donde R y R', que son iguales o diferentes, cada uno representa un grupo alquilo (C1-C6) lineal o ramificado.La aplicación a la síntesis de sales bivalentes del ácido ranélico y más especialmente de ranelato de estroncio y sus hidratos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211765A FR2844797B1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP055743A true ECSP055743A (es) | 2005-07-06 |
Family
ID=29415191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005005743A ECSP055743A (es) | 2002-09-24 | 2005-04-22 | Nuevo proceso para la sintesis industrial de tetraésteres del acido 5-[bis(carboximetil)amino]-3-carboximetil-4-ciano-2- tiofeno carboxílico y aplicación para la síntesis de sales bivalentes de acido ranelico y sus hidratos |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US7091364B2 (es) |
| EP (1) | EP1403265B1 (es) |
| JP (1) | JP4136866B2 (es) |
| KR (1) | KR100551502B1 (es) |
| CN (1) | CN1280286C (es) |
| AP (1) | AP1972A (es) |
| AR (1) | AR041357A1 (es) |
| AT (1) | ATE449767T1 (es) |
| AU (2) | AU2003299095A1 (es) |
| BR (1) | BR0304203A (es) |
| CA (1) | CA2442881C (es) |
| CY (1) | CY1109831T1 (es) |
| DE (1) | DE60330213D1 (es) |
| DK (1) | DK1403265T3 (es) |
| EA (1) | EA007108B1 (es) |
| EC (1) | ECSP055743A (es) |
| ES (1) | ES2337348T3 (es) |
| FR (1) | FR2844797B1 (es) |
| GE (1) | GEP20074139B (es) |
| HR (1) | HRP20050361B1 (es) |
| IL (1) | IL167315A (es) |
| IS (1) | IS2728B (es) |
| MA (1) | MA26100A1 (es) |
| ME (1) | ME00453B (es) |
| MX (1) | MXPA03008647A (es) |
| MY (1) | MY134924A (es) |
| NO (1) | NO328626B1 (es) |
| NZ (1) | NZ528401A (es) |
| OA (1) | OA12932A (es) |
| PL (1) | PL215879B1 (es) |
| PT (1) | PT1403265E (es) |
| RS (1) | RS51551B (es) |
| SG (1) | SG110069A1 (es) |
| SI (1) | SI1403265T1 (es) |
| TN (1) | TNSN05088A1 (es) |
| UA (1) | UA79157C2 (es) |
| WO (1) | WO2004029034A1 (es) |
| ZA (1) | ZA200307411B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844795B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| ATE342722T1 (de) * | 2003-05-07 | 2006-11-15 | Osteologix As | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
| DK1622630T3 (da) * | 2003-05-07 | 2012-12-17 | Osteologix As | P009368epdk1 |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| PL1732575T3 (pl) | 2004-02-26 | 2011-05-31 | Osteologix As | Związki zawierające stron do stosowania w zapobieganiu lub leczeniu stanów nekrotycznych kości |
| US8658206B2 (en) | 2004-06-25 | 2014-02-25 | Mokwalo SA | Compositions comprising strontium and vitamin D and uses thereof |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CN100391955C (zh) * | 2005-04-30 | 2008-06-04 | 河北医科大学 | 一种雷尼酸锶中间体的合成方法 |
| US20070292535A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating arthritic and or osteoporitic conditions |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| US20120123131A1 (en) * | 2008-08-22 | 2012-05-17 | Koilpillai Joseph Prabahar | Process for the preparation of strontium ranelate |
| CN101665483B (zh) * | 2008-09-01 | 2013-01-23 | 河北医科大学 | 一种雷尼酸锶中间体化合物ⅱ的合成方法 |
| WO2011124992A1 (en) * | 2010-03-24 | 2011-10-13 | Actavis Group Ptc Ehf | Substantially pure strontium ranelate |
| CN101812048B (zh) * | 2010-04-06 | 2012-11-14 | 浙江东亚药业有限公司 | 雷尼酸锶及其水合物的合成方法 |
| EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
| WO2013113319A1 (en) | 2012-01-31 | 2013-08-08 | Pharmathen S.A. | Process for the preparation of strontium ranelate, intermediate or hydrates thereof |
| ES2505716T3 (es) | 2013-01-21 | 2015-09-04 | Galenicum Health S.L. | Composiciones farmacéuticas que comprenden una sal de ácido |
| GB201310126D0 (en) * | 2013-06-06 | 2013-07-24 | Univ Leicester | Novel pyrrole derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3624304A1 (de) | 1986-07-18 | 1988-01-28 | Bayer Ag | Fungizide verwendung von substituierten thienylaminen |
| GB8715925D0 (en) * | 1987-07-07 | 1987-08-12 | Shell Int Research | Thiapentanamide derivatives |
| FR2651497B1 (fr) * | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| DE19528380A1 (de) * | 1995-08-02 | 1997-02-06 | Hoechst Ag | Heterogene Vinylacetat/Ethylen-Dispersion |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| DE19650196A1 (de) * | 1996-12-04 | 1998-06-10 | Bayer Ag | Thienylsulfonylamino(thio)carbonylverbindungen |
| US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
-
2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/sr unknown
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Ceased
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active Expired - Fee Related
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
-
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
-
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown
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